Chlorogenic acid prevents paraquat-induced apoptosis via Sirt1-mediated regulation of redox and mitochondrial function

References

• Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, et al. Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol. 2008;38(1):13–71.
   PubMed Web of Science ®Google Scholar
• Sun B, Chen YG. Advances in the mechanism of paraquat-induced pulmonary injury. Eur Rev Med Pharmacol Sci. 2016;20(8):1597–1602.
   PubMed Web of Science ®Google Scholar
• Li C, Hu D, Xue W, et al. Treatment outcome of combined continuous venovenous hemofiltration and hemoperfusion in acute paraquat poisoning: a prospective controlled trial. Crit Care Med. 2018;46(1):100–107.
   PubMed Web of Science ®Google Scholar
• He F, Xu P, Zhang J, et al. Efficacy and safety of pulse immunosuppressive therapy with glucocorticoid and cyclophosphamide in patients with paraquat poisoning: a meta-analysis. Int Immunopharmacol. 2015;27(1):1–7.
   PubMed Web of Science ®Google Scholar
• Yeh ST, Guo HR, Su YS, et al. Protective effects of N-acetylcysteine treatment post acute paraquat intoxication in rats and in human lung epithelial cells. Toxicology. 2006;223(3):181–190.
   PubMed Web of Science ®Google Scholar
• Drechsel DA, Patel M. Paraquat-induced production of reactive oxygen species in brain mitochondria. Methods Enzymol. 2009;456:381–393 (Chapter 21).
   PubMed Web of Science ®Google Scholar
• Cochemé HM, Murphy MP. Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem. 2008;283(4):1786–1798.
   PubMed Web of Science ®Google Scholar
• Xu Y, Tai W, Qu X, et al. Rapamycin protects against paraquat-induced pulmonary fibrosis: activation of Nrf2 signaling pathway. Biochem Biophys Res Commun. 2017;490(2):535–540.
   PubMed Web of Science ®Google Scholar
• Podder B, Kim YS, Zerin T, et al. Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line. Food Chem Toxicol. 2012;50(9):3206–3214.
   PubMed Web of Science ®Google Scholar
• Chan PH. Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival in stroke. Ann N Y Acad Sci. 2005;1042:203–209.
   PubMed Web of Science ®Google Scholar
• Yang W, Tiffany-Castiglioni E. Paraquat-induced apoptosis in human neuroblastoma SH − SY5Y cells: involvement of p53 and mitochondria. J Toxicol Environ Health A. 2008;71(4):289–299.
   PubMed Web of Science ®Google Scholar
• Shin JW, Kwon SB, Bak Y, et al. BCI induces apoptosis via generation of reactive oxygen species and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. Sci China Life Sci. 2018;61(10):1243–1253.
   PubMed Web of Science ®Google Scholar
• Palikaras K, Lionaki E, Tavernarakis N. Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nat Cell Biol. 2018;20(9):1013–1022.
   PubMed Web of Science ®Google Scholar
• Naveed M, Hejazi V, Abbas M, et al. Chlorogenic acid (CGA): a pharmacological review and call for further research. Biomed Pharmacother. 2018;97:67–74.
   PubMed Web of Science ®Google Scholar
• Marques V, Farah A. Chlorogenic acids and related compounds in medicinal plants and infusions. Food Chem. 2009;113(4):1370–1376.
   Web of Science ®Google Scholar
• Tom EN, Girard-Thernier C, Demougeot C. The Janus face of chlorogenic acid on vascular reactivity: a study on rat isolated vessels. Phytomedicine. 2016;23(10):1037–1042.
   PubMed Web of Science ®Google Scholar
• Naso LG, Valcarcel M, Roura-Ferrer M, et al. Promising antioxidant and anticancer (human breast cancer) oxidovanadium (IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin. J Inorg Biochem. 2014;135:86–99.
   PubMed Web of Science ®Google Scholar
• Karunanidhi A, Thomas R, van Belkum A, et al. In vitro antibacterial and antibiofilm activities of chlorogenic acid against clinical isolates of Stenotrophomonas maltophilia including the trimethoprim/sulfamethoxazole resistant strain. BioMed Res Int. 2013;2013:392058.
   PubMedGoogle Scholar
• Shin HS, Satsu H, Bae MJ, et al. Anti-inflammatory effect of chlorogenic acid on the IL-8 production in Caco-2 cells and the dextran sulphate sodium-induced colitis symptoms in C57BL/6 mice. Food Chem. 2015;168:167–175.
   PubMed Web of Science ®Google Scholar
• Meng S, Cao J, Feng Q, et al. Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review. Evid Based Complement Alternat Med. 2013;2013:801457.
   PubMed Web of Science ®Google Scholar
• Mandrone M, Lorenzi B, Venditti A, et al. Antioxidant and anti-collagenase activity of Hypericum hircinum L. Ind Crops Prod. 2015;76:402–408.
   Web of Science ®Google Scholar
• Zhu L, Wang L, Cao F, et al. Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1alpha. J Hepatobiliary Pancreat Sci. 2018;25(3):195–205.
   PubMed Web of Science ®Google Scholar
• Tsai KL, Hung CH, Chan SH, et al. Chlorogenic acid protects against oxLDL-induced oxidative damage and mitochondrial dysfunction by modulating SIRT1 in endothelial cells. Mol Nutr Food Res. 2018;62(11):e1700928.
   PubMed Web of Science ®Google Scholar
• Singh CK, Chhabra G, Ndiaye MA, et al. The role of sirtuins in antioxidant and redox signaling. Antioxid Redox Signal. 2018;28(8):643–661.
   PubMed Web of Science ®Google Scholar
• Tynan RJ, Weidenhofer J, Hinwood M, et al. A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia. Brain Behav Immun. 2012;26(3):469–479.
   PubMed Web of Science ®Google Scholar
• Tagliarino C, Pink JJ, Dubyak GR, et al. Calcium is a key signaling molecule in beta-lapachone-mediated cell death. J Biol Chem. 2001;276(22):19150–19159.
   PubMed Web of Science ®Google Scholar
• Yu W, Zhang X, Wu H, et al. HO-1 is essential for tetrahydroxystilbene glucoside mediated mitochondrial biogenesis and anti-inflammation process in LPS-treated RAW264.7 macrophages. Oxid Med Cell Longev. 2017;2017:1818575.
   PubMedGoogle Scholar
• Chang LK, Johnson EM. Cyclosporin A inhibits caspase-independent death of NGF-deprived sympathetic neurons: a potential role for mitochondrial permeability transition. J Cell Biol. 2002;157(5):771–781.
   PubMed Web of Science ®Google Scholar
• Addabbo F, Ratliff B, Park HC, et al. The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach. Am J Pathol. 2009;174(1):34–43.
   PubMed Web of Science ®Google Scholar
• Sebastià J, Cristòfol R, Martín M, et al. Evaluation of fluorescent dyes for measuring intracellular glutathione content in primary cultures of human neurons and neuroblastoma SH − SY5Y. Cytometry A. 2003;51(1):16–25.
   PubMedGoogle Scholar
• Kim JY, Cho TJ, Woo BH, et al. Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells. Arch Oral Biol. 2012;57(8):1018–1025.
   PubMed Web of Science ®Google Scholar
• Zhou F, Yang X, Zhao H, et al. Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer. Theranostics. 2018;8(19):5200–5212.
   PubMed Web of Science ®Google Scholar
• Dou C, Ding N, Xing J, et al. Dihydroartemisinin attenuates lipopolysaccharide-induced osteoclastogenesis and bone loss via the mitochondria-dependent apoptosis pathway. Cell Death Dis. 2016;7:e2162.
   PubMed Web of Science ®Google Scholar
• Wu CC, Bratton SB. Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxid Redox Signal. 2013;19(6):546–558.
   PubMed Web of Science ®Google Scholar
• Chen G, Han Z, Feng D, et al. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Mol Cell. 2014;54(3):362–377.
   PubMed Web of Science ®Google Scholar
• Blanco-Ayala T, Andérica-Romero AC, Pedraza-Chaverri J. New insights into antioxidant strategies against paraquat toxicity. Free Radic Res. 2014;48(6):623–640.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Kim HK, Kwon JT, et al. Effect of MDR1 gene polymorphisms on mortality in paraquat intoxicated patients. Sci Rep. 2016;6(1):31765.
   Web of Science ®Google Scholar
• Wei M, Zheng Z, Shi L, et al. Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity by activating ERK/Nrf2 antioxidative pathway. Toxicol Sci. 2018;162(1):99–112.
   PubMed Web of Science ®Google Scholar
• Ji L, Jiang P, Lu B, et al. Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism. J Nutr Biochem. 2013;24(11):1911–1919.
   PubMed Web of Science ®Google Scholar
• Gonthier MP, Verny MA, Besson C, et al. Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J Nutr. 2003;133(6):1853–1859.
   PubMed Web of Science ®Google Scholar
• Ren J, Jiang X, Li C. Investigation on the absorption kinetics of chlorogenic acid in rats by HPLC. Arch Pharm Res. 2007;30(7):911–916.
   PubMed Web of Science ®Google Scholar
• Kumar G, Paliwal P, Mukherjee S, et al. Pharmacokinetics and brain penetration study of chlorogenic acid in rats. Xenobiotica. 2019;49(3):339–345.
   PubMed Web of Science ®Google Scholar
• Zhong S, Liu J, Ren X, et al. Pharmacokinetics and excretion of chlorogenic acid in beagle dogs. Pharmazie. 2008;63(7):520–524.
   PubMed Web of Science ®Google Scholar
• Seo HJ, Choi SJ, Lee JH. Paraquat induces apoptosis through cytochrome c release and ERK activation. Biomol Ther. 2014;22(6):503–509.
   PubMed Web of Science ®Google Scholar
• Han J, Zhang Z, Yang S, et al. Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway. Food Chem Toxicol. 2014;70:100–106.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhou L, Ruan Z, et al. Chlorogenic acid ameliorates intestinal mitochondrial injury by increasing antioxidant effects and activity of respiratory complexes. Biosci Biotechnol Biochem. 2016;80(5):962–971.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Ruan Z, Zhou L, et al. Chlorogenic acid ameliorates endotoxin-induced liver injury by promoting mitochondrial oxidative phosphorylation. Biochem Biophys Res Commun. 2016;469(4):1083–1089.
   PubMed Web of Science ®Google Scholar
• Zhivotovsky B, Orrenius S. Calcium and cell death mechanisms: a perspective from the cell death community. Cell Calcium. 2011;50(3):211–221.
   PubMed Web of Science ®Google Scholar
• Wang X, Hai C. Novel insights into redox system and the mechanism of redox regulation. Mol Biol Rep. 2016;43(7):607–628.
   PubMed Web of Science ®Google Scholar
• Shi A, Shi H, Wang Y, et al. Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury. Int Immunopharmacol. 2018;54:125–130.
   PubMed Web of Science ®Google Scholar
• Ding YW, Zhao GJ, Li XL, et al. SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro. Int J Mol Med. 2016;37(4):1049–1058.
   PubMed Web of Science ®Google Scholar
• Li Y, Shen G, Yu C, et al. Angiotensin II induces mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1–FoxO3a–MnSOD pathway. Biochem Biophys Res Commun. 2014;455(1–2):113–118.
   PubMed Web of Science ®Google Scholar
• Cui L, Guo J, Zhang Q, et al. Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity. Toxicol Lett. 2017;275:28–38.
   PubMed Web of Science ®Google Scholar
• Wang S, Wang J, Zhao A, et al. SIRT1 activation inhibits hyperglycemia-induced apoptosis by reducing oxidative stress and mitochondrial dysfunction in human endothelial cells. Mol Med Rep. 2017;16(3):3331–3338.
   PubMed Web of Science ®Google Scholar