370
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

VDR promotes nucleus pulposus cell mitophagy as a protective mechanism against oxidative stress injury

, , , &
Pages 316-327 | Received 02 Feb 2022, Accepted 22 Jun 2022, Published online: 04 Jul 2022

References

  • DePalma MJ, Ketchum JM, Saullo T. What is the source of chronic low back pain and does age play a role? Pain Med. 2011;12(2):224–233.
  • Ohtori S, Inoue G, Miyagi M, et al. Pathomechanisms of discogenic low back pain in humans and animal models. Spine J. 2015;15(6):1347–1355.
  • Du XF, Cui HT, Pan HH, et al. Role of the miR-133a-5p/FBXO6 axis in the regulation of intervertebral disc degeneration. J Orthop Translat. 2021;29:123–133. others
  • Vo NV, Hartman RA, Yurube T, et al. Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration. Spine J. 2013;13(3):331–341.
  • Vo NV, Hartman RA, Patil PR, et al. Molecular mechanisms of biological aging in intervertebral discs. J Orthop Res. 2016;34(8):1289–1306.
  • Feng Y, Egan B, Wang J. Genetic factors in intervertebral disc degeneration. Genes Dis. 2016;3(3):178–185.
  • Hanaei S, Abdollahzade S, Khoshnevisan A, et al. Genetic aspects of intervertebral disc degeneration. Rev Neurosci. 2015;26(5):581–606.
  • He R, Wang Z, Cui M, et al. HIF1A alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy. Autophagy. 2021;17(11):3338–3360.
  • Xiang Q, Kang L, Wang J, et al. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. 2020;53:102679.
  • Guo Y, Tian L, Liu X, et al. ERRFI1 inhibits proliferation and inflammation of nucleus pulposus and is negatively regulated by miR-2355-5p in intervertebral disc degeneration. Spine. 2019;44(15):E873–e881.
  • Seol D, Coleman MC, Martin JA, et al. Targeting oxidative stress with amobarbital to prevent intervertebral disc degeneration: part I. in vitro and ex vivo studies. Spine J. 2021;21(6):1021–1030.
  • Lin J, Zheng X, Zhang Z, et al. Inhibition of LRRK2 restores parkin-mediated mitophagy and attenuates intervertebral disc degeneration. Osteoarthritis Cartilage. 2021;29(4):579–591.
  • Wu T, Li X, Jia X, et al. Krüppel like factor 10 prevents intervertebral disc degeneration via TGF-β signaling pathway both in vitro and in vivo. J Orthop Translat. 2021;29:19–29.
  • Nasto LA, Robinson AR, Ngo K, et al. Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. J Orthop Res. 2013;31(7):1150–1157. others
  • Feng C, Yang M, Lan M, et al. ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration. Oxid Med Cell Longev. 2017;2017:5601593. 2017:
  • Lan T, Zheng YC, Li ND, et al. CRISPR/dCas9-Mediated parkin inhibition impairs mitophagy and aggravates apoptosis of rat nucleus pulposus cells under oxidative stress. Front Mol Biosci. 2021;8:674632.
  • Withanage ND, Perera S, Peiris H, et al. Serum 25-hydroxyvitamin D, serum calcium and vitamin D receptor (VDR) polymorphisms in a selected population with lumbar disc herniation-A case control study. PLoS One. 2018;13(10):e0205841.
  • Xu HW, Yi YY, Zhang SB, et al. Does vitamin D status influence lumbar disc degeneration and low back pain in postmenopausal women? A retrospective single-center study. Menopause. 2020;27(5):586–592.
  • Krasowska K, Skrobot W, Liedtke E, et al. The preoperative supplementation with vitamin D attenuated pain intensity and reduced the level of pro-inflammatory markers in patients after posterior lumbar interbody fusion. Front Pharmacol. 2019;10:527.
  • Griffith JF, Wang YX, Antonio GE, et al. Modified pfirrmann grading system for lumbar intervertebral disc degeneration. Spine. 2007;32(24):E708–12.
  • Suzuki S, Fujita N, Hosogane N, et al. Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration. Arthritis Res Ther. 2015;17:316. others
  • Song Z, Xiao C, Jia X, et al. Vitamin D/VDR protects against diabetic kidney disease by restoring podocytes autophagy. Diabetes Metab Syndr Obes. 2021;14:1681–1693.
  • Kong C, Wang C, Shi Y, et al. Active vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK-mTOR signaling pathway. Biochem Cell Biol. 2020;98(3):434–442.
  • Zhao J, Yang M, Shao J, et al. Association between VDR FokI polymorphism and intervertebral disk degeneration. Genomics Proteomics Bioinformatics. 2015;13(6):371–376.
  • Jiang Z, Lu W, Zeng Q, et al. High glucose-induced excessive reactive oxygen species promote apoptosis through mitochondrial damage in rat cartilage endplate cells. J Orthop Res. 2018;36(9):2476–2483.
  • Song Y, Li S, Geng W, et al. Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. Redox Biol. 2018;19:339–353. others
  • Chen F, Liu H, Wang X, et al. Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc. Osteoarthritis Cartilage. 2020;28(8):1121–1132.
  • Lin J, Zhuge J, Zheng X, et al. Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration via the AMPK signaling pathway. Free Radic Biol Med. 2020;150:109–119.
  • Yang S, Zhang F, Ma J, et al. Intervertebral disc ageing and degeneration: the antiapoptotic effect of oestrogen. Ageing Res Rev. 2020;57:100978.
  • Chen J, Xie JJ, Jin MY, et al. Zhang XL and others. Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration. Cell Death Dis. 2018;9(2):56.
  • Sun Z, Tang X, Wang H, et al. LncRNA H19 aggravates intervertebral disc degeneration by promoting the autophagy and apoptosis of nucleus pulposus cells via the miR-139/CXCR4/NF-κB axis. Stem Cells Dev. 2021;30(14):736–748.
  • Zhan S, Wang K, Xiang Q, et al. Zhang Y and others. lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells. J Cell Physiol. 2020;235(3):2195–2208.
  • Zhang Z, Xu T, Chen J, et al. Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration. Cell Death Dis. 2018;9(10):980.
  • Wang Y, Shen J, Chen Y, et al. PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy. Biochem Biophys Res Commun. 2018;504(2):406–414.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.