Increased production of 8-oxo-7,8-dihydroguanine in human urine, a novel biomarker of osteoporosis

References

• Peck WA. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. The Am J Med. 1993;94(6):646–650.
   PubMed Web of Science ®Google Scholar
• Cremers S, Garnero P. Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls. Drugs. 2006;66(16):2031–2058.
   PubMed Web of Science ®Google Scholar
• Hyeon S, Lee H, Yang Y, et al. Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation. Free Radic Biol Med. 2013;65:789–799.
   PubMed Web of Science ®Google Scholar
• Baek K, Oh K, Lee W, et al. Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures. Calcif Tissue Int. 2010;87(3):226–235.
   PubMed Web of Science ®Google Scholar
• Cervellati C, Bonaccorsi G, Cremonini E, et al. Bone mass density selectively correlates with serum markers of oxidative damage in post-menopausal women. Clin Chem Lab Med. 2013;51(2):333–338.
   PubMed Web of Science ®Google Scholar
• Cervellati C, Bonaccorsi G, Cremonini E, et al. Oxidative stress and bone resorption interplay as a possible trigger for postmenopausal osteoporosis. BioMed Res Int. 2014;2014:1–8.
   Web of Science ®Google Scholar
• Ibáñez L, Ferrándiz ML, Brines R, et al. Effects of Nrf2 deficiency on bone microarchitecture in an experimental model of osteoporosis. Oxid Med Cell Longev. 2014;2014:726590–726590.
   PubMed Web of Science ®Google Scholar
• Lean JM, Davies JT, Fuller K, et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest. 2003;112(6):915–923.
   PubMed Web of Science ®Google Scholar
• Darden A, Ries W, Wolf W, et al. Osteoclastic superoxide production and bone resorption: stimulation and inhibition by modulators of NADPH oxidase. J Bone Miner Res. 1996;11(5):671–675.
   PubMed Web of Science ®Google Scholar
• Poulsen HE, Specht E, Broedbaek K, et al. RNA modifications by oxidation: a novel disease mechanism? Free radic. Free Radic Biol Med. 2012;52(8):1353–1361.
   PubMed Web of Science ®Google Scholar
• Kong Q, Lin CL. Oxidative damage to RNA: mechanisms, consequences, and diseases. Cell Mol Life Sci. 2010;67(11):1817–1829.
   PubMed Web of Science ®Google Scholar
• Nunomura A, Moreira PI, Castellani RJ, et al. Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotox Res. 2012;22(3):231–248.
   PubMed Web of Science ®Google Scholar
• Gan W, Liu XL, Yu T, et al. Urinary 8-oxo-7,8-dihydroguanosine as a. Front Aging Neurosci. 2018;10(34):34.
   PubMedGoogle Scholar
• Broedbaek K, Siersma V, Henriksen T, et al. Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients. Diabetes Care. 2011;34(12):2594–2596.
   PubMed Web of Science ®Google Scholar
• Broedbaek K, Køster-Rasmussen R, Siersma V, et al. Urinary albumin and 8-oxo-7,8-dihydroguanosine as markers of mortality and cardiovascular disease during 19 years after diagnosis of type 2 diabetes – a comparative study of two markers to identify high risk patients. Redox Biol. 2017;13:363–369.
   PubMed Web of Science ®Google Scholar
• Gào X, Holleczek B, Cuk K, et al. Investigation on potential associations of oxidatively generated DNA/RNA damage with lung, colorectal, breast, prostate and total cancer incidence. Sci Rep. 2019;9(1):7109.
   PubMedGoogle Scholar
• Zhang X, Li L. The significance of 8-oxoGsn in aging-related diseases. Aging Dis. 2020;11(5):1329–1338.
   PubMed Web of Science ®Google Scholar
• Kanis JA, Mccloskey EV, Johansson H, et al. A reference standard for the description of osteoporosis. Bone. 2008;42(3):467–475.
   PubMed Web of Science ®Google Scholar
• DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44(3):837–845.
   PubMed Web of Science ®Google Scholar
• Maggio D, Barabani M, Pierandrei M, et al. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab. 2003;88(4):1523–1527.
   PubMed Web of Science ®Google Scholar
• Sánchez-Rodríguez M, Ruiz-Ramos M, Correa-Muñoz E, et al. Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes. BMC Musculoskelet Disord. 2007;8(1):124.
   PubMedGoogle Scholar
• Barciszewski J, Barciszewska MZ, Siboska G, et al. Some unusual nucleic acid bases are products of hydroxyl radical oxidation of DNA and RNA. Mol Biol Rep. 1999;26(4):231–238.
   PubMed Web of Science ®Google Scholar
• Hofer T, Badouard C, Bajak E, et al. Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA. Biol Chem. 2005;386(4):333–337.
   PubMed Web of Science ®Google Scholar
• Shen Z, Wu W, Hazen SL. Activated leukocytes oxidatively damage DNA, RNA, and the nucleotide Pool through halide-dependent formation of hydroxyl radical. Biochemistry. 2000;39(18):5474–5482.
   PubMed Web of Science ®Google Scholar
• Wamer W, Wei R. In vitro photooxidation of nucleic acids by ultraviolet a radiation. Photochem Photobiol. 1997;65(3):560–563.
   PubMed Web of Science ®Google Scholar
• Hofer T, Seo A, Prudencio M, et al. A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration. Biol Chem. 2006;387(1):103–111.
   PubMed Web of Science ®Google Scholar
• Yang R, Zhang J, Li J, et al. Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free Radic Biol Med. 2022;178:246–261.
   PubMed Web of Science ®Google Scholar
• Ho PJ, Yen ML, Tang BC, et al. H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline, in senescent human fetal mesenchymal stem cells. Antioxid Redox Signal. 2013;18(15):1895–1905.
   PubMed Web of Science ®Google Scholar
• Wauquier F, Leotoing L, Coxam V, et al. Oxidative stress in bone remodelling and disease. Trends Mol Med. 2009;15(10):468–477.
   PubMed Web of Science ®Google Scholar
• Zhou J, Ye S, Fujiwara T, et al. Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation. J Biol Chem. 2013;288(42):30064–30074.
   PubMed Web of Science ®Google Scholar
• Basu S, Michaëlsson K, Olofsson H, et al. Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun. 2001;288(1):275–279.
   PubMed Web of Science ®Google Scholar
• Taddei F, Hayakawa H, Bouton M, et al. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science. 1997;278(5335):128–130.
   PubMed Web of Science ®Google Scholar
• Jacob KD, Noren Hooten N, Trzeciak AR, et al. Markers of oxidant stress that are clinically relevant in aging and age-related disease. Mech Ageing Dev. 2013;134(3–4):139–157.
   PubMed Web of Science ®Google Scholar
• Larsen EL, Weimann A, Poulsen HE. Interventions targeted at oxidatively generated modifications of nucleic acids focused on urine and plasma markers. Free Radic Biol Med. 2019;145:256–283.
   PubMed Web of Science ®Google Scholar
• Dai D, Gan W, Hayakawa H, others., et al. Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells. Proc Natl Acad Sci USA. 2018;115(16):4218–4222.
   PubMed Web of Science ®Google Scholar
• Nunomura A, Perry G, Pappolla M, et al. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J. Neurosci. 1999;19(6):1959–1964.
   PubMed Web of Science ®Google Scholar
• Naka K, Muraguchi T, Hoshii T, et al. Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells. Antioxid Redox Signal. 2008;10(11):1883–1894.
   PubMed Web of Science ®Google Scholar
• Fukushima O, Gay CV. Ultrastructural localization of guanylate cyclase in bone cells. J Histochem Cytochem. 1991;39(4):529–535.
   PubMed Web of Science ®Google Scholar
• Ishii T, Igawa T, Hayakawa H, et al. PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions. J Biol Chem. 2020;295(34):12247–12261.
   PubMed Web of Science ®Google Scholar
• Tanaka M, Jaruga P, Küpfer P, et al. RNA oxidation catalyzed by cytochrome c leads to its depurination and cross-linking, which may facilitate cytochrome c release from mitochondria. Free Radic Biol Med. 2012;53(4):854–862.
   PubMed Web of Science ®Google Scholar
• Slemenda CW, Turner CH, Peacock M, et al. The genetics of proximal femur geometry, distribution of bone mass and bone mineral density. Osteoporosis Int. 1996;6(2):178–182.
   PubMed Web of Science ®Google Scholar
• Arden NK, Baker J, Hogg C, et al. The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res. 1996;11(4):530–534.
   PubMed Web of Science ®Google Scholar
• Almeida M, Han L, Martin-Millan M, et al. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007;282(37):27285–27297.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Zhang P, Tian W, et al. Application of bone turnover markers and DXA and QCT in an elderly chinese male population. Ann Palliat Med. 2021;10(6):6351–6358.
   PubMed Web of Science ®Google Scholar
• Botella S, Restituto P, Monreal I, et al. Traditional and novel bone remodeling markers in premenopausal and postmenopausal women. J Clin Endocrinol Metab. 2013;98(11):E1740–8.
   PubMed Web of Science ®Google Scholar
• Szpalski C, Barbaro M, Sagebin F, et al. Bone tissue engineering: current strategies and techniques–part II: Cell types. Tissue Eng Part B Rev. 2012;18(4):258–269.
   PubMed Web of Science ®Google Scholar