691
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Melittin induces ferroptosis and ER stress-CHOP-mediated apoptosis in A549 cells

, , , , , & ORCID Icon show all
Pages 398-410 | Received 13 Jun 2022, Accepted 26 Sep 2022, Published online: 13 Oct 2022

References

  • Li Z, Yin C, Li B, et al. DUS4L silencing suppresses cell proliferation and promotes apoptosis in human lung adenocarcinoma cell line A549. Cancer Manag Res. 2020;12:9905–9913.
  • Cao L, Hong W, Cai P, et al. Cryptotanshinone strengthens the effect of gefitinib against non-small cell lung cancer through inhibiting transketolase. Eur J Pharmacol. 2021;890:173647.
  • Wang A, Zheng Y, Zhu W, et al. Melittin-based nano-delivery systems for cancer therapy. Biomolecules. 2022;12(1):118.
  • Ceremuga M, Stela M, Janik E, et al. Melittin-A natural peptide from bee venom which induces apoptosis in human leukaemia cells. Biomolecules. 2020;10(2):247.
  • Zarrinnahad H, Mahmoodzadeh A, Hamidi MP, et al. Apoptotic effect of melittin purified from Iranian honey bee venom on human cervical cancer HeLa cell line. Int J Pept Res Ther. 2018;24(4):563–570.
  • Zhang H, Zhao B, Huang C, et al. Melittin restores PTEN expression by down-regulating HDAC2 in human hepatocelluar carcinoma HepG2 cells. PLoS One. 2014;9(5):e95520.
  • Huh JE, Kang JW, Nam D, et al. Melittin suppresses VEGF-A-induced tumor growth by blocking VEGFR-2 and the COX-2-mediated MAPK signaling pathway. J Nat Prod. 2012;75(11):1922–1929.
  • Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072.
  • Kuang F, Liu J, Tang D, et al. Oxidative damage and antioxidant defense in ferroptosis. Front Cell Dev Biol. 2020;8:586578.
  • Zhou Y, Lin W, Rao T, et al. Ferroptosis and its potential role in the nervous system diseases. J Inflamm Res. 2022;15:1555–1574.
  • Dong L, Yang B, Zhang Y, et al. Ferroptosis contributes to methylmercury-induced cytotoxicity in rat primary astrocytes and Buffalo rat liver cells. Neurotoxicology. 2022;90:228–236.
  • Kagan VE, Mao G, Qu F, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017;13(1):81–90.
  • Hussain Y, Khan H, Efferth T, et al. Regulation of endoplasmic reticulum stress by hesperetin: focus on antitumor and cytoprotective effects. Phytomedicine. 2022;100:153985.
  • Wadgaonkar P, Chen F. Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis. Semin Cancer Biol. 2021;76:258–266.
  • Poliquin S, Kang JQ. Disruption of the ubiquitin-proteasome system and elevated endoplasmic reticulum stress in epilepsy. Biomedicines. 2022;10(3):647.
  • Kim C, Kim B. Anti-cancer natural products and their bioactive compounds inducing ER Stress-Mediated apoptosis: a review. Nutrients. 2018;10(8):1021.
  • Xia S, Duan W, Liu W, et al. GRP78 in lung cancer. J Transl Med. 2021;19(1):118.
  • Gu S, Chen C, Jiang X, et al. ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells. Chem Biol Interact. 2016;245:100–109.
  • Song J, Huang S, Zhang Z, et al. SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery. Drug Deliv. 2020;27(1):91–99.
  • Zhu S, Li X, Dang B, et al. Hydrogen sulfide protects retina from blue light-induced photodamage and degeneration via inhibiting ROS-mediated ER stress-CHOP apoptosis signal. Redox Rep. 2022;27(1):100–110.
  • Zhan Z, Xie X, Cao H, et al. Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy. 2014;10(2):257–268.
  • Zhu S, Li X, Wu F, et al. Blue light induces skin apoptosis and degeneration through activation of the endoplasmic reticulum stress-autophagy apoptosis axis: protective role of hydrogen sulfide. J Photochem Photobiol B. 2022;229:112426.
  • Wang Y, Zhang X, Wen Y, et al. Endoplasmic reticulum-mitochondria contacts: a potential therapy target for cardiovascular remodeling-associated diseases. Front Cell Dev Biol. 2021;9:774989.
  • Qiao D, Zhang Z, Zhang Y, et al. Regulation of endoplasmic reticulum stress-autophagy: a potential therapeutic target for ulcerative colitis. Front Pharmacol. 2021;12:697360.
  • Zhang SF, Chen Z. Melittin exerts an antitumor effect on non‑small cell lung cancer cells. Mol Med Rep. 2017;16(3):3581–3586.
  • Yu R, Wang M, Wang M, et al. Melittin suppresses growth and induces apoptosis of non-small-cell lung cancer cells via down-regulation of TGF-β-mediated ERK signal pathway. Braz J Med Biol Res. 2020;54(2):e9017.
  • Gao D, Zhang J, Bai L, et al. Melittin induces NSCLC apoptosis via inhibition of miR-183. Onco Targets Ther. 2018;11:4511–4523.
  • Kong GM, Tao WH, Diao YL, et al. Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway. World J Gastroenterol. 2016;22(11):3186–3195.
  • Hou T, Wang X, Ma Q, et al. Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond. J Physiol. 2014;592(17):3703–3713.
  • Kinowaki Y, Taguchi T, Onishi I, et al. Overview of ferroptosis and synthetic lethality strategies. Int J Mol Sci. 2021;22(17):3271.
  • Liu J, Kang R, Tang D. Signaling pathways and defense mechanisms of ferroptosis. Febs J. 2021;2021:febs.16059.
  • Han ML, Zhao YF, Tan CH, et al. Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells. Acta Pharmacol Sin. 2016;37(12):1606–1622.
  • Luo H, Li Z, Ge H, et al. HMGA2 upregulation mediates Cd-induced migration and invasion in A549 cells and in lung tissues of mice. Chem Biol Interact. 2017;277:1–7.
  • Zhang N, Huang J, Xu M, et al. LncRNA T-UCR Uc.339/miR-339/SLC7A11 axis regulates the metastasis of Ferroptosis-induced lung adenocarcinoma. J Cancer. 2022;13(6):1945–1957.
  • Zhu S, Li X, Dang B, et al. Lycium Barbarum polysaccharide protects HaCaT cells from PM2.5-induced apoptosis via inhibiting oxidative stress, ER stress and autophagy. Redox Rep. 2022;27(1):32–44.
  • Ruan F, Liu C, Wang Y, et al. Role of RNA m(6)a modification in titanium dioxide nanoparticle-induced acute pulmonary injury: an in vitro and in vivo study. Environ Pollut. 2022;311:119986.
  • Wang P, Liu D, Yan S, et al. The role of ferroptosis in the damage of human proximal tubule epithelial cells caused by perfluorooctane sulfonate. Toxics. 2022;10(8):436.
  • Li W, Li W, Leng Y, et al. Ferroptosis is involved in diabetes myocardial ischemia/reperfusion injury through endoplasmic reticulum stress. DNA Cell Biol. 2020;39(2):210–225.
  • Alakkal A, Thayyullathil F, Pallichankandy S, et al. Sanguinarine induces H(2)O(2)-dependent apoptosis and ferroptosis in human cervical cancer. Biomedicines. 2022;10(8):1795.
  • Chen P, Wu Q, Feng J, et al. Erianin, a novel dibenzyl compound in dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis. Signal Transduct Target Ther. 2020;5(1) 51.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.