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Original Articles

Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury

, , , , , ORCID Icon, , , , , , & show all
Pages 411-426 | Received 22 Apr 2022, Accepted 08 Sep 2022, Published online: 17 Oct 2022

References

  • Bleicher RJ, Moran MS, Ruth K, et al. The impact of radiotherapy delay in breast conservation patients not receiving chemotherapy and the rationale for dichotomizing the radiation oncology time-dependent standard into two quality measures. Ann Surg Oncol. 2021;28(S3):572–573.
  • Safavi AH, Mak DY, Boldt RG, et al. Stereotactic ablative radiotherapy in T1-2N0M0 small cell lung cancer: a systematic review and meta-analysis. Lung Cancer. 2021;160:179–186.
  • Andruska N, Stowe HB, Crockett C, et al. A practical approach to challenging scenarios. J Thorac Oncol. 2021;16(7):1075–1085.
  • Shen J, Yang D, Chen M, et al. Hypofractionated volumetric-modulated arc radiotherapy for patients with non-small-cell lung cancer not suitable for surgery or conventional chemoradiotherapy or SBRT. Front Oncol. 2021;11:644852.
  • Mihai AM, Armstrong PJ, Hickey D, et al. Late toxicity and long-term local control in patients with ultra-central lung tumours treated by intensity-modulated radiotherapy-based stereotactic ablative body radiotherapy with homogenous dose prescription. Clin Oncol (R Coll Radiol). 2021;33(10):627–637.
  • Liu Z, Liang X, Li X, et al. MiRNA-21 functions in ionizing radiation-induced epithelium-to-mesenchymal transition (EMT) by downregulating PTEN. Toxicol Res. 2019;8(3):328–340.
  • Kainthola A, Haritwal T, Tiwari M, et al. Immunological aspect of radiation-induced pneumonitis, current treatment strategies, and future prospects. Front Immunol. 2017;8:506.
  • Ward HE, Kemsley L, Davies L, et al. The effect of steroids on radiation-induced lung disease in the rat. Radiat Res. 1993;136(1):22–28.
  • Arroyo-Hernandez M, Maldonado F, Lozano-Ruiz F, et al. Radiation-induced lung injury: current evidence. BMC Pulm Med. 2021;21(1):9.
  • Hanania AN, Mainwaring W, Ghebre YT, et al. Radiation-induced lung injury: assessment and management. Chest. 2019;156(1):150–162.
  • Zhao W, Robbins ME. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications. Curr Med Chem. 2009;16(2):130–143.
  • Jiang F, Liu GS, Dusting GJ, et al. NADPH oxidase-dependent redox signaling in TGF-beta-mediated fibrotic responses. Redox Biol. 2014;2:267–272.
  • Sheikholeslami S, Aryafar T, Abedi-Firouzjah R, et al. The role of melatonin on radiation-induced pneumonitis and lung fibrosis: a systematic review. Life Sci. 2021;281:119721.
  • Yahyapour R, Motevaseli E, Rezaeyan A, et al. Reduction-oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics. Clin Transl Oncol. 2018;20(8):975–988.
  • Liu T, Yang Q, Zheng H, et al. Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury. Biomaterials. 2021;277:121103.
  • Terasaki Y, Ohsawa I, Terasaki M, et al. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2011;301(4):L415–L426.
  • Suzuki T, Yamamoto M. Molecular basis of the Keap1–Nrf2 system. Free Radic Biol Med. 2015;88(Pt B):93–100.
  • Ebrahimpour A, Wang M, Li L, et al. Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway. J Inflamm. 2021;18(1):17.
  • Travis EL, Rachakonda G, Zhou X, et al. NRF2 deficiency reduces life span of mice administered thoracic irradiation. Free Radic Biol Med. 2011;51(6):1175–1183.
  • Tian X, Wang F, Luo Y, et al. Protective role of nuclear factor-erythroid 2-related factor 2 against radiation-induced lung injury and inflammation. Front Oncol. 2018;8:542.
  • Kavian N, Mehlal S, Jeljeli M, et al. The Nrf2-antioxidant response element signaling pathway controls fibrosis and autoimmunity in scleroderma. Front Immunol. 2018;9:1896.
  • Espinosa-Diez C, Miguel V, Vallejo S, et al. Role of glutathione biosynthesis in endothelial dysfunction and fibrosis. Redox Biol. 2018;14:88–99.
  • Ryan DG, Knatko EV, Casey AM, et al. Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response. iScience. 2022;25(2):103827.
  • Wu Q, Ma Y, Liu Y, et al. CB2R agonist JWH-133 attenuates chronic inflammation by restraining M1 macrophage polarization via Nrf2/HO-1 pathway in diet-induced obese mice. Life Sci. 2020;260:118424.
  • Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1–Nrf2–ARE pathway. Annu Rev Pharmacol Toxicol. 2007;47:89–116.
  • Wang X, Chen Z, Luo S, et al. Development of therapeutic small-molecule fluorophore for cell transplantation. Adv Funct Mater. 2016;26(46):8397–8407.
  • Wang J, Dai L, Yue X, et al. IR-61 improves voiding function via mitochondrial protection in diabetic rats. Front Pharmacol. 2021;12:608637.
  • Yue XF, Shen CX, Wang JW, et al. The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection. Asian J Androl. 2021;23(3):249–258.
  • Wang Y, Tang B, Long L, et al. Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages. Nat Commun. 2021;12(1):102.
  • Jin H, Yoo Y, Kim Y, et al. Radiation-induced lung fibrosis: preclinical animal models and therapeutic strategies. Cancers. 2020;12(6):1561.
  • Cheng P, Li S, Chen H. Macrophages in lung injury, repair, and fibrosis. Cells. 2021;10(2):436.
  • Zhang C, Liu T, Su Y, et al. A near-infrared fluorescent heptamethine indocyanine dye with preferential tumor accumulation for in vivo imaging. Biomaterials. 2010;31(25):6612–6617.
  • Szapiel SV, Elson NA, Fulmer JD, et al. Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. Am Rev Respir Dis. 1979;120(4):893–899.
  • Johnson S, Shaikh SB, Muneesa F, et al. Radiation induced apoptosis and pulmonary fibrosis: curcumin an effective intervention? Int J Radiat Biol. 2020;96(6):709–717.
  • Gao J, Peng S, Shan X, et al. Inhibition of AIM2 inflammasome-mediated pyroptosis by andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. Cell Death Dis. 2019;10(12):957.
  • Beach TA, Groves AM, Johnston CJ, et al. Recurrent DNA damage is associated with persistent injury in progressive radiation-induced pulmonary fibrosis. Int J Radiat Biol. 2018;94(12):1104–1115.
  • Nishida C, Tomonaga T, Izumi H, et al. Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation. Part Fibre Toxicol. 2022;19(1):8.
  • Murohashi K, Hara Y, Shinada K, et al. Clinical significance of serum hemeoxygenase-1 as a new biomarker for the patients with interstitial pneumonia. Can Respir J. 2018;2018:1–7.
  • Laskin DL, Malaviya R, Laskin JD. Role of macrophages in acute lung injury and chronic fibrosis induced by pulmonary toxicants. Toxicol Sci. 2019;168(2):287–301.
  • Lu L, Sun C, Su Q, et al. Radiation-induced lung injury: latest molecular developments, therapeutic approaches, and clinical guidance. Clin Exp Med. 2019;19(4):417–426.
  • Joshi N, Walter JM, Misharin AV. Alveolar macrophages. Cell Immunol. 2018;330:86–90.
  • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012;122(3):787–795.
  • Ying H, Fang M, Hang QQ, et al. Pirfenidone modulates macrophage polarization and ameliorates radiation-induced lung fibrosis by inhibiting the TGF-beta1/Smad3 pathway. J Cell Mol Med. 2021;25(18):8662–8675.
  • Ying H, Kang Y, Zhang H, et al. MiR-127 modulates macrophage polarization and promotes lung inflammation and injury by activating the JNK pathway. J Immunol. 2015;194(3):1239–1251.
  • Elkiki SM, Mansour HH, Anis LM, et al. Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF-beta/Smad 3 and TGF-beta/PDGF pathways in rats. Toxicol Mech Methods. 2021;31(7):538–545.
  • Eming SA, Murray PJ, Pearce EJ. Metabolic orchestration of the wound healing response. Cell Metab. 2021;33(9):1726–1743.
  • Chen C, Yang S, Zhang M, et al. Triptolide mitigates radiation-induced pneumonitis via inhibition of alveolar macrophages and related inflammatory molecules. Oncotarget. 2017;8(28):45133–45142.
  • Binatti E, Zoccatelli G, Zanoni F, et al. Effects of combination treatments with astaxanthin-loaded microparticles and pentoxifylline on intracellular ROS and radiosensitivity of J774A.1 macrophages. Molecules. 2021;26(17):5152.
  • Zhang L, Xu L, Chen H, et al. Structure-based molecular hybridization design of Keap1–Nrf2 inhibitors as novel protective agents of acute lung injury. Eur J Med Chem. 2021;222:113599.
  • Kobayashi EH, Suzuki T, Funayama R, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun. 2016;7:11624.
  • Artaud-Macari E, Goven D, Brayer S, et al. Nuclear factor erythroid 2-related factor 2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis. Antioxid Redox Signal. 2013;18(1):66–79.
  • Zhou W, Mo X, Cui W, et al. Nrf2 inhibits epithelial–mesenchymal transition by suppressing snail expression during pulmonary fibrosis. Sci Rep. 2016;6:38646.
  • Prestigiacomo V, Suter-Dick L. Nrf2 protects stellate cells from Smad-dependent cell activation. PLOS One. 2018;13(7):e0201044.
  • Bian C, Qin WJ, Zhang CY, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-beta/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018;129:446–453.

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