Modulation of reactive oxygen species in cancers: recent advances

References

• Bayir H. Reactive oxygen species. Crit Care Med. 2005;33(12):S498–S501.
   PubMedGoogle Scholar
• Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem. 2015;30(1):11–26.
   PubMed Web of Science ®Google Scholar
• Riley PA. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol. 1994;65(1):27–33.
   PubMed Web of Science ®Google Scholar
• Arulselvan P, Fard MT, Tan WS, et al. Role of antioxidants and natural products in inflammation. Oxid Med Cell Longev. 2016;2016:5276130.
   PubMed Web of Science ®Google Scholar
• Poprac P, Jomova K, Simunkova M, et al. Targeting free radicals in oxidative stress-related human diseases. Trends Pharmacol Sci. 2017;38(7):592–607.
   PubMed Web of Science ®Google Scholar
• Di Meo S, Venditti P. Evolution of the knowledge of free radicals and other oxidants. Oxid Med Cell Longev. 2020;2020:9829176.
   PubMed Web of Science ®Google Scholar
• Biswas S, Das R, Banerjee ER. Role of free radicals in human inflammatory diseases. AIMS Biophysics. 2017;4(4):596–614.
   Google Scholar
• Khorobrykh S, Havurinne V, Mattila H, et al. Oxygen and ROS in photosynthesis. Plants. 2020;9(1):91.
   Google Scholar
• Nakamura H, Takada K. Reactive oxygen species in cancer: current findings and future directions. Cancer Sci. 2021;112(10):3945–3952.
   PubMed Web of Science ®Google Scholar
• Auten RL, Davis JM. Oxygen toxicity and reactive oxygen species: the devil is in the details. Pediatr Res. 2009;66(2):121–127.
   PubMed Web of Science ®Google Scholar
• Li R, Jia Z, Trush MA. Defining ROS in biology and medicine. React Oxyg Species (Apex). 2016;1(1):9–21.
   PubMedGoogle Scholar
• Patel R, Rinker L, Peng J, et al. Reactive oxygen species: the good and the bad. Reactive oxygen species (ROS) in living cells. Vol. 7. Norderstedt: BoD – Books on Demand; 2018.
   Google Scholar
• Krumova K, Cosa G. Overview of reactive oxygen species. Singlet oxygen: applications in biosciences and nanosciences. Vol. 1. London: Royal Society of Chemistry; 2016.
   Google Scholar
• Dayem AA, Hossain MK, Lee SB, et al. The role of reactive oxygen species (ROS) in the biological activities of metallic nanoparticles. Int J Mol Sci. 2017;18(1):120.
   PubMed Web of Science ®Google Scholar
• Jakubczyk K, Dec K, Kałduńsk J, et al. Reactive oxygen species - sources, functions, oxidative damage. Pol Merkur Lekarsk. 2020;48(284):124–127.
   PubMedGoogle Scholar
• Das K, Roychoudhury A. Reactive oxygen species (ROS) and response of antioxidants as ROS-scavengers during environmental stress in plants. Front Environ Sci. 2014;2:53.
   Google Scholar
• Pizzino G, Irrera N, Cucinotta M, et al. Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev. 2017;2017:8416763.
   PubMed Web of Science ®Google Scholar
• Sharma P, Jha AB, Dubey RS, et al. Reactive oxygen species, oxidative damage, and antioxidative defense mechanism in plants under stressful conditions. J Bot. 2012;2012:1–26.
   Google Scholar
• Forrester SJ, Kikuchi DS, Hernandes MS, et al. Reactive oxygen species in metabolic and inflammatory signaling. Circ Res. 2018;122(6):877–902.
   PubMed Web of Science ®Google Scholar
• Magder S. Reactive oxygen species: toxic molecules or spark of life? Crit Care. 2006;10(1):208.
   PubMedGoogle Scholar
• Willson R, Dunster CA, Forni LG, et al. Organic free radicals and proteins in biochemical injury: electron-or hydrogen-transfer reactions? Philos Trans Royal Soc Lond. 1985;311(1152):545–563.
   PubMed Web of Science ®Google Scholar
• Liou GY, Storz P. Reactive oxygen species in cancer. Free Radic Res. 2010;44(5):479–496.
   PubMed Web of Science ®Google Scholar
• Ozcan A, Ogun M. Biochemistry of reactive oxygen and nitrogen species. Basic principles and clinical significance of oxidative stress. Vol. 3. Norderstedt, Germany: BoD – Books on Demand; 2015. p. 37–58.
   Google Scholar
• Sarmiento-Salinas FL, Perez-Gonzalez A, Acosta-Casique A, et al. Reactive oxygen species: role in carcinogenesis, cancer cell signaling and tumor progression. Life Sci. 2021;284:119942.
   PubMed Web of Science ®Google Scholar
• Trachootham D, Lu W, Ogasawara MA, et al. Redox regulation of cell survival. Antioxid Redox Signal. 2008;10(8):1343–1374.
   PubMed Web of Science ®Google Scholar
• Rosa AC, Corsi D, Cavi N, et al. Superoxide dismutase administration: a review of proposed human uses. Molecules. 2021;26(7):1844.
   PubMedGoogle Scholar
• Glasauer A, Chandel NS. Ros. Curr Biol. 2013;23(3):R100–2.
   PubMedGoogle Scholar
• Russano M, Napolitano A, Ribelli G, et al. Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples. J Exp Clin Cancer Res. 2020;39(1):1–13.
   PubMedGoogle Scholar
• Li ZY, Yang Y, Ming M, et al. Mitochondrial ROS generation for regulation of autophagic pathways in cancer. Biochem Biophys Res Commun. 2011;414(1):5–8.
   PubMed Web of Science ®Google Scholar
• Kumari S, Badana AK, G MM, et al. Reactive oxygen species: a key constituent in cancer survival. Biomark Insights. 2018;13:1177271918755391.
   Web of Science ®Google Scholar
• Sharifi-Rad M, Anil Kumar NV, Zucca P, et al. Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases. Front Physiol. 2020;11:694.
   PubMed Web of Science ®Google Scholar
• Block K, Gorin Y. Aiding and abetting roles of NOX oxidases in cellular transformation. Nat Rev Cancer. 2012;12(9):627–637.
   PubMed Web of Science ®Google Scholar
• Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012;24(5):981–990.
   PubMed Web of Science ®Google Scholar
• Martin KR, Barrett JC. Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity. Hum Exp Toxicol. 2002;21(2):71–75.
   PubMed Web of Science ®Google Scholar
• Pinegin B, Vorobjeva N, Pashenkov M, et al. The role of mitochondrial ROS in antibacterial immunity. J Cell Physiol. 2018;233(5):3745–3754.
   PubMed Web of Science ®Google Scholar
• Yang Y, Karakhanova S, Hartwig W, et al. Mitochondria and mitochondrial ROS in cancer: novel targets for anticancer therapy. J Cell Physiol. 2016;231(12):2570–2581.
   PubMed Web of Science ®Google Scholar
• Tirichen H, Yaigoub H, Xu W, et al. Mitochondrial reactive oxygen species and their contribution in chronic kidney disease progression through oxidative stress. Front Physiol. 2021;12:398.
   Web of Science ®Google Scholar
• Diebold L, Chandel NS. Medicine, mitochondrial ROS regulation of proliferating cells. Free Radic Biol Med. 2016;100:86–93.
   PubMed Web of Science ®Google Scholar
• Sullivan LB, Chandel N. And metabolism, mitochondrial reactive oxygen species and cancer. Cancer Metab. 2014;2(1):1–12.
   PubMedGoogle Scholar
• Andreyev AY, Kushnareva YE, Starkov A. Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc). 2005;70(2):200–214.
   PubMed Web of Science ®Google Scholar
• Zhang J, Wang X, Vikash V, et al. ROS and ROS-Mediated cellular signaling. Oxid Med Cell Longev. 2016;2016:4350965.
   PubMed Web of Science ®Google Scholar
• Li X, Fang P, Mai J, et al. Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. J Hematol Oncol. 2013;6(1):19.
   PubMedGoogle Scholar
• Dunn JD, Alvarez LA, Zhang X, et al. Reactive oxygen species and mitochondria: a nexus of cellular homeostasis. Redox Biol. 2015;6:472–485.
   PubMed Web of Science ®Google Scholar
• Willems PHGM, Rossignol R, Dieteren CEJ, et al. Redox homeostasis and mitochondrial dynamics. Cell Metab. 2015;22(2):207–218.
   PubMed Web of Science ®Google Scholar
• Dunn JD, Alvarez LAJ, Zhan X, et al. Mitochondrial ROS control of cancer. Seminars in cancer biology. Amsterdam: Elsevier; 2017.
   Google Scholar
• Nickel A, Kohlhaas M, Maack C, et al. Mitochondrial reactive oxygen species production and elimination. J Mol Cell Cardiol. 2014;73:26–33.
   PubMed Web of Science ®Google Scholar
• Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 2014;94(3):909–950.
   PubMed Web of Science ®Google Scholar
• Murphy MP. How mitochondria produce reactive oxygen species. Biochem J. 2009;417(1):1–13.
   PubMed Web of Science ®Google Scholar
• Georgieva E, Ivanova D, Zhelev Z, et al. Mitochondrial dysfunction and redox imbalance as a diagnostic marker of “free radical diseases. Anticancer Res. 2017;37(10):5373–5381.
   PubMed Web of Science ®Google Scholar
• Grivennikova V, Vinogradov A. Mitochondrial production of reactive oxygen species. Biochemistry (Mosc). 2013;78(13):1490–1511.
   PubMedGoogle Scholar
• Daiber A. Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species. Biochim Biophys Acta. 2010;1797(6–7):897–906.
   PubMed Web of Science ®Google Scholar
• Annesley SJ, Fisher PR. Mitochondria in health and disease. Cells. 2019;8(7):680.
   PubMed Web of Science ®Google Scholar
• Pashkovskaia N, Gey U, Rödel G. Mitochondrial ROS direct the differentiation of murine pluripotent P19 cells. Stem Cell Res. 2018;30:180–191.
   PubMedGoogle Scholar
• Oyewole AO, Birch Machin MA. Mitochondria‐targeted antioxidants. FASEB J. 2015;29(12):4766–4771.
   PubMed Web of Science ®Google Scholar
• Choi TG, Kim S. Physiological functions of mitochondrial reactive oxygen species. Free Radic Med Biol. 2016 Nov;100:81-85, p1–p10.
   Google Scholar
• Brieger K, Schiavone S, Miller FJ, et al. Reactive oxygen species: from health to disease. Swiss Med Wkly. 2012;142:w13659.
   PubMed Web of Science ®Google Scholar
• Kawamura K, Qi F, Kobayashi J. Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production. J Radiat Res. 2018;59(2):ii91–ii97.
   PubMedGoogle Scholar
• Papa L, Manfredi G, Germain D, et al. SOD1, an unexpected novel target for cancer therapy. Genes Cancer. 2014;5(1–2):15–21.
   PubMedGoogle Scholar
• Li C, Zhou HM. The role of manganese superoxide dismutase in inflammation defense. Enzyme Res. 2011;2011:387176.
   PubMedGoogle Scholar
• Kim A. Modulation of MnSOD in cancer: epidemiological and experimental evidences. Toxicol Res. 2010;26(2):83–93.
   PubMedGoogle Scholar
• Griess B, Tom E, Domann F, et al. Extracellular superoxide dismutase and its role in cancer. Free Radic Biol Med. 2017;112:464–479.
   PubMed Web of Science ®Google Scholar
• Altenhöfer S, Kleikers PWM, Radermacher KA, et al. The NOX toolbox: validating the role of NADPH oxidases in physiology and disease. Cell Mol Life Sci. 2012;69(14):2327–2343.
   PubMed Web of Science ®Google Scholar
• Meitzler JL, Antony S, Wu Y, et al. NADPH oxidases: a perspective on reactive oxygen species production in tumor biology. Antioxid Redox Signal. 2014;20(17):2873–2889.
   PubMed Web of Science ®Google Scholar
• Bedard K, Lardy B, Krause KH. NOX family NADPH oxidases: not just in mammals. Biochimie. 2007;89(9):1107–1112.
   PubMed Web of Science ®Google Scholar
• Snezhkina AV, Kudryavtseva AV, Kardymon OL, et al. ROS generation and antioxidant defense systems in normal and malignant cells. Oxid Med Cell Longev. 2019;2019:6175804.
   PubMed Web of Science ®Google Scholar
• Panday A, Sahoo MK, Osorio D, et al. NADPH oxidases: an overview from structure to innate immunity-associated pathologies. Cell Mol Immunol. 2015;12(1):5–23.
   PubMed Web of Science ®Google Scholar
• Buvelot H, Jaquet V, Krause KH. Mammalian NADPH oxidases. Methods Mol Biol. 2019;1982:17–36.
   PubMedGoogle Scholar
• Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87(1):245–313.
   PubMed Web of Science ®Google Scholar
• Roy K, Wu Y, Meitzler JL, et al. NADPH oxidases and cancer. Clin Sci (Lond). 2015;128(12):863–875.
   PubMed Web of Science ®Google Scholar
• Parascandolo A, Laukkanen M, Signaling R. Carcinogenesis and reactive oxygen species signaling: interaction of the NADPH oxidase NOX1–5 and superoxide dismutase 1–3 signal transduction pathways. Inside Precision Med. 2019;30(3):443–486.
   Google Scholar
• Wiktorin GH, Aydin E, Hellstrand K, et al. NOX2-Derived reactive oxygen species in cancer. Oxid Med Cell Longev. 2020;2020:7095902.
   PubMed Web of Science ®Google Scholar
• Skonieczna M, Hejmo T, Poterala-Hejmo A, et al. NADPH oxidases: insights into selected functions and mechanisms of action in cancer and stem cells. Oxid Med Cell Longev. 2017;2017:9420539.
   PubMedGoogle Scholar
• Maraldi T, Angeloni C, Prata C, et al. NADPH oxidases: redox regulators of stem cell fate and function. Antioxidants (Basel). 2021;10(6):973.
   PubMedGoogle Scholar
• Mondol AS, Tonks NK, Kamata T, et al. Nox4 redox regulation of PTP1B contributes to the proliferation and migration of glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C. Free Radic Biol Med. 2014;67:285–291.
   PubMed Web of Science ®Google Scholar
• Mesfin FB, Al-Dhahir MA. Cancer, brain gliomas. Treasure Island (FL): Study Guide from StatPearls Publishing; 2017.
   Google Scholar
• Rinaldi M, Caffo M, Minutoli L, et al. ROS and brain gliomas: an overview of potential and innovative therapeutic strategies. Int J Mol Sci. 2016;17(6):984.
   PubMed Web of Science ®Google Scholar
• Little AC, Sulovari A, Danyal K, et al. Paradoxical roles of dual oxidases in cancer biology. Free Radic Biol Med. 2017;110:117–132.
   PubMed Web of Science ®Google Scholar
• Shah JP. Thyroid carcinoma: epidemiology, histology, and diagnosis. Clin Adv Hematol Oncol. 2015;13(4):3.
   PubMedGoogle Scholar
• Ameziane-El-Hassani R, Schlumberger M, Dupuy C. NADPH oxidases: new actors in thyroid cancer? Nat Rev Endocrinol. 2016;12(8):485–494.
   PubMed Web of Science ®Google Scholar
• Szanto I, Pusztaszeri M, Mavromati M. H2O2 metabolism in normal thyroid cells and in thyroid tumorigenesis: focus on NADPH oxidases. Antioxidants. 2019;8(5):126.
   Web of Science ®Google Scholar
• Lambeth JDJNRI. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol. 2004;4(3):181–189.
   PubMed Web of Science ®Google Scholar
• Song Y, Ruf J, Lothaire P, et al. Association of duoxes with thyroid peroxidase and its regulation in thyrocytes. J Clin Endocrinol Metab. 2010;95(1):375–382.
   PubMed Web of Science ®Google Scholar
• Weyemi U, Caillou B, Talbot M, et al. Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues. Endocr Relat Cancer. 2010;17(1):27–37.
   PubMed Web of Science ®Google Scholar
• Qi R, Zhou Y, Li X, et al. DUOX2 expression is increased in Barrett esophagus and cancerous tissues of stomach and Colon. Gastroenterol Res Pract. 2016;2016:1835684.
   PubMed Web of Science ®Google Scholar
• Si J, Fu X, Behar J, et al. NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-κBin Barrett’s esophageal adenocarcinoma cells. J Biol Chem. 2007;282(22):16244–16255.
   PubMed Web of Science ®Google Scholar
• Li D, Deconda D, Li A, et al. Effect of proton pump inhibitor therapy on NOX5, mPGES1 and iNOS expression in Barrett’s esophagus. Sci Rep. 2019;9(1):1–9.
   PubMed Web of Science ®Google Scholar
• Fu X, Beer DG, Behar J, et al. cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells. J Biol Chem. 2006;281(29):20368–20382.
   PubMed Web of Science ®Google Scholar
• Hong J, Resnick M, Behar J, et al. Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S. Am J Physiol Gastrointest Liver Physiol. 2010;299(3):G697–G706.
   PubMedGoogle Scholar
• Si J, Behar J, Wands J, et al. STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett’s esophageal adenocarcinoma cells. Am J Physiol Gastrointest Liver Physiol. 2008;294(1):G174–G183.
   PubMedGoogle Scholar
• Luxen S, Belinsky SA, Knaus UG. Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer. Cancer Res. 2008;68(4):1037–1045.
   PubMedGoogle Scholar
• van der Vliet A, Medicine J. NADPH oxidases in lung biology and pathology: host defense enzymes, and more. Free Radic Biol Med. 2008;44(6):938–955.
   PubMedGoogle Scholar
• Han M, Zhang T, Yang L, et al. Association between NADPH oxidase (NOX) and lung cancer: a systematic review and meta-analysis. J Thorac Dis. 2016;8(7):1704–1711.
   PubMedGoogle Scholar
• Zhu Z, Zheng Z, Liu J. Comparison of COVID-19 and lung cancer via reactive oxygen species signaling. Front Oncol. 2021;11:2467.
   Google Scholar
• Rudin CM, Brambilla E, Faivre-Finn C, et al. Small-cell lung cancer. Nat Rev Dis Primers. 2021;7(1):3–20.
   PubMed Web of Science ®Google Scholar
• Luxen S, Noack D, Frausto M, et al. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. J Cell Sci. 2009;122(Pt 8):1238–1247.
   PubMedGoogle Scholar
• Zeng C, Wu Q, Wang J, et al. NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells. Free Radic Biol Med. 2016;101:236–248.
   PubMed Web of Science ®Google Scholar
• Harper RW, Xu C, Eiserich JP, et al. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Lett. 2005;579(21):4911–4917.
   PubMed Web of Science ®Google Scholar
• Geiszt M, Witta J, Baff J, et al. Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J. 2003;17(11):1–14.
   PubMedGoogle Scholar
• Forteza R, Salathe M, Miot F, et al. Regulated hydrogen peroxide production by duox in human airway epithelial cells. Am J Respir Cell Mol Biol. 2005;32(5):462–469.
   PubMed Web of Science ®Google Scholar
• Wesley UV, Bove PF, Hristova M, et al. Airway epithelial cell migration and wound repair by ATP-mediated activation of dual oxidase 1. J Biol Chem. 2007;282(5):3213–3220.
   PubMedGoogle Scholar
• Malla RR, Raghu H, Rao JS, et al. Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells. Int J Oncol. 2010;37(6):1483–1493.
   PubMed Web of Science ®Google Scholar
• Ostrakhovitch EA, Li SSC. B.c.r. Li, and treatment, NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics. Breast Cancer Res Treat. 2010;119(3):773–786.
   PubMedGoogle Scholar
• Vaquero EC, Edderkaoui M, Pandol SJ, et al. Reactive oxygen species produced by NAD (P) H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem. 2004;279(33):34643–34654.
   PubMed Web of Science ®Google Scholar
• Hiraga R, Kato M, Miyagawa S, et al. Nox4-derived ROS signaling contributes to TGF-β-induced epithelial-mesenchymal transition in pancreatic cancer cells. Anticancer Res. 2013;33(10):4431–4438.
   PubMed Web of Science ®Google Scholar
• Wu Y, Antony S, Hewitt SM, et al. Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody. Int J Oncol. 2013;42(4):1229–1238.
   PubMedGoogle Scholar
• Choi J, Corder NLB, Koduru B, et al. Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma. Free Radic Biol Med. 2014;72:267–284.
   PubMed Web of Science ®Google Scholar
• Eun HS, Cho SY, Joo JS, et al. Gene expression of NOX family members and their clinical significance in hepatocellular carcinoma. Sci Rep. 2017;7(1):1–10.
   PubMedGoogle Scholar
• Chen S, Ling Q, Yu K, et al. Dual oxidase 1: a predictive tool for the prognosis of hepatocellular carcinoma patients. Oncol Rep. 2016;35(6):3198–3208.
   PubMed Web of Science ®Google Scholar
• Campisano S, Bertran E, Caballero-Díaz D, et al. Paradoxical role of the NADPH oxidase NOX4 in early preneoplastic stages of hepatocytes induced by amino acid deprivation. Biochim Biophys Acta Gen Subj. 2019;1863(4):714–722.
   PubMedGoogle Scholar
• Herranz-Itúrbide M, Peñuelas-Haro I, Espinosa-Sotelo R, et al. The TGF-β/NADPH oxidases axis in the regulation of liver cell biology in health and disease. Cells. 2021;10(9):2312.
   PubMed Web of Science ®Google Scholar
• Machlowska J, Baj J, Sitarz M, et al. Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci. 2020;21(11):4012.
   PubMed Web of Science ®Google Scholar
• Sitarz R, Skierucha M, Mielko J, et al. Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manag Res. 2018;10:239–248.
   PubMed Web of Science ®Google Scholar
• You X, Ma M, Hou G, et al. Gene expression and prognosis of NOX family members in gastric cancer. Onco Targets Ther. 2018;11:3065–3074.
   PubMed Web of Science ®Google Scholar
• Echizen K, Horiuchi K, Aoki Y, et al. NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells. Oncogene. 2019;38(22):4250–4263.
   PubMedGoogle Scholar
• Yamaura M, Mitsushita J, Furuta S, et al. NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression. Cancer Res. 2009;69(6):2647–2654.
   PubMed Web of Science ®Google Scholar
• de Melo FHM, Molognoni F, Jasiulionis MG. The role of oxidative stress in melanoma development, progression and treatment. Recent advances in the biology, therapy and management of melanoma. Norderstedt, Germany: BoD – Books on Demand; 2013. p. 83.
   Google Scholar
• Venza I, Venza M, Visalli M, et al. ROS as regulators of cellular processes in melanoma. Oxid Med Cell Longevity. 2021;2021:1208690.
   PubMedGoogle Scholar
• Liu F, Gomez Garcia AM, Meyskens FL. NADPH oxidase 1 overexpression enhances invasion via matrix metalloproteinase-2 and epithelial–mesenchymal transition in melanoma cells. J Invest Dermatol. 2012;132(8):2033–2041.
   PubMed Web of Science ®Google Scholar
• Antony S, Jiang G, Wu Y, et al. NADPH oxidase 5 (NOX5)—induced reactive oxygen signaling modulates normoxic HIF‐1α and p27Kip1 expression in malignant melanoma and other human tumors. Mol Carcinog. 2017;56(12):2643–2662.
   PubMedGoogle Scholar
• Carvalho LAC, Queijo RG, Baccaro ALB, et al. Redox-related proteins in melanoma progression. Antioxidants. 2022;11(3):438.
   Web of Science ®Google Scholar
• Döhner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373(12):1136–1152.
   PubMed Web of Science ®Google Scholar
• Kiffin R, Grauers Wiktorin H, Nilsson MS, et al. Anti-leukemic properties of histamine in monocytic leukemia: the role of NOX2. Front Oncol. 2018;8:218.
   PubMedGoogle Scholar
• Dakik H, El Dor M, Leclerc J, et al. Characterization of NADPH oxidase expression and activity in acute myeloid leukemia cell lines: a correlation with the differentiation status. Antioxidants. 2021;10(3):498.
   Google Scholar
• Hole PS, Darley RL, Tonks AJB. Do reactive oxygen species play a role in myeloid leukemias? J Am Soc Hematol. 2011;117(22):5816–5826.
   Google Scholar
• Adane B, Ye H, Khan N, et al. The hematopoietic oxidase NOX2 regulates self-renewal of leukemic stem cells. Cell Rep. 2019;27(1):238–254. e6.
   PubMedGoogle Scholar
• Zhou H, Xu RJP. Leukemia stem cells: the root of chronic myeloid leukemia. Protein Cell. 2015;6(6):403–412.
   PubMed Web of Science ®Google Scholar
• Naughton R, Quiney C, Turner SD, et al. Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway. Leukemia. 2009;23(8):1432–1440.
   PubMed Web of Science ®Google Scholar
• Lewis WD, Lilly S, Jones KL. Lymphoma: diagnosis and treatment. Am Fam Physician. 2020;101(1):34–41.
   PubMed Web of Science ®Google Scholar
• Gonçalves JDS, Carvalho FL, Coutinho ICdR, et al. NADPH oxidase 5 upregulation is associated with lymphoma aggressiveness. Rev Assoc Med Bras (1992). 2020;66(2):210–215.
   PubMed Web of Science ®Google Scholar
• Song X, Wang Z, Liang H, et al. Dioscin induces gallbladder cancer apoptosis by inhibiting ROS-mediated PI3K/AKT signalling. Int J Biol Sci. 2017;13(6):782–793.
   PubMed Web of Science ®Google Scholar
• Kanthan R, Senger JL, Ahmed S, et al. Gallbladder cancer in the 21st century. J Oncol. 2015;2015:1–26.
   Google Scholar
• Wang FT, Hassan M, Ansari KH, et al. Upregulated NOX1 expression in gallbladder cancer‑associated fibroblasts predicts a poor prognosis. Oncol Rep. 2019;42(4):1475–1486.
   PubMed Web of Science ®Google Scholar
• Zhan M, Wang H, Chen T, et al. NOX1 mediates chemoresistance via HIF1α/MDR1 pathway in gallbladder cancer. Biochem Biophys Res Commun. 2015;468(1–2):79–85.
   PubMedGoogle Scholar
• Capitanio U, Bensalah K, Bex A, et al. Epidemiology of renal cell carcinoma. Eur Urol. 2019;75(1):74–84.
   PubMed Web of Science ®Google Scholar
• Cairns P. Renal cell carcinoma. Cancer Biomark. 2011;9(1–6):461–473.
   Google Scholar
• Meitzler JL, Makhlouf HR, Antony S, et al. Decoding NADPH oxidase 4 expression in human tumors. Redox Biol. 2017;13:182–195.
   PubMed Web of Science ®Google Scholar
• Ravindran F, Choudhary B. Ovarian cancer: molecular classification and targeted therapy, in ovarian Cancer-Updates in tumour biology and therapeutics. London: IntechOpen; 2021.
   Google Scholar
• Liu WJ, Huang YX, Wang W, et al. NOX4 signaling mediates cancer development and therapeutic resistance through HER3 in ovarian cancer cells. Cells. 2021;10(7):1647.
   PubMedGoogle Scholar
• Hou D, Liu Z, Xu X, et al. Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer. Redox Biol. 2018;17:99–111.
   PubMed Web of Science ®Google Scholar
• Leslie S, Soon-Sutton TL, Sajjad H, et al. Prostate cancer. Treasure Island (FL): Study Guide from StatPearls Publishing; 2017.
   Google Scholar
• Holl M, Koziel R, Schäfer G, et al. ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells. Mol Carcinog. 2016;55(1):27–39.
   PubMedGoogle Scholar
• Itoh T, Terazawa R, Kojima K, et al. Cisplatin induces production of reactive oxygen species via NADPH oxidase activation in human prostate cancer cells. Free Radic Res. 2011;45(9):1033–1039.
   PubMed Web of Science ®Google Scholar
• Lim SD, Sun C, Lambeth JD, et al. Increased Nox1 and hydrogen peroxide in prostate cancer. Prostate. 2005;62(2):200–207.
   PubMed Web of Science ®Google Scholar
• Wu QQ, Zheng B, Weng GB, et al. Downregulated NOX4 underlies a novel inhibitory role of microRNA‐137 in prostate cancer. J Cell Biochem. 2019;120(6):10215–10227.
   PubMedGoogle Scholar
• Banskota S, Regmi SC, Kim JA. NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in Colon cancer cells through overexpression of MMP-7. Mol Cancer. 2015;14(1):1–14.
   PubMedGoogle Scholar
• Waghela BN, Vaidya FU, Pathak CJB. Upregulation of NOX-2 and Nrf-2 promotes 5-Fluorouracil resistance of human Colon carcinoma (HCT-116) cells. Biochemistry (Mosc). 2021;86(3):262–274.
   PubMed Web of Science ®Google Scholar
• Floyd RA. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J. 1990;4(9):2587–2597.
   PubMed Web of Science ®Google Scholar
• Tan BL, Norhaizan ME, Liew WPP, et al. Antioxidant and oxidative stress: a mutual interplay in age-related diseases. Front Pharmacol. 2018;9:1162.
   PubMed Web of Science ®Google Scholar
• Salehi B, Martorell M, Arbiser J, et al. Antioxidants: positive or negative actors? Biomolecules. 2018;8(4):124.
   PubMedGoogle Scholar
• Santos-Sánchez NF, Salas-Coronado R, Villanueva-Cañongo C, et al. Antioxidant compounds and their antioxidant mechanism. Antioxidants. 2019;10:1–29.
   Google Scholar
• Reczek CR, Chandel NS. The two faces of reactive oxygen species in cancer. Annu Rev Cancer Biol. 2017;1(1):79–98.
   Google Scholar
• Galadari S, Rahman A, Pallichankandy S, et al. Reactive oxygen species and cancer paradox: to promote or to suppress? Free Radic Biol Med. 2017;104:144–164.
   PubMed Web of Science ®Google Scholar
• Poljsak B, Šuput D, Milisav I, et al. Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxid Med Cell Longev. 2013;2013:1–11.
   Web of Science ®Google Scholar
• Morry J, Ngamcherdtrakul W, Yantasee W. Oxidative stress in cancer and fibrosis: opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles. Redox Biol. 2017;11:240–253.
   PubMed Web of Science ®Google Scholar
• Lü JM, Lin PH, Yao Q, et al. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med. 2010;14(4):840–860.
   PubMed Web of Science ®Google Scholar
• Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutr J. 2015;15(1):1–22.
   Web of Science ®Google Scholar
• Harrison IP, Selemidis S. Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets. Clin Exp Pharmacol Physiol. 2014;41(8):533–542.
   PubMed Web of Science ®Google Scholar
• George S, Abrahamse HJA. Redox potential of antioxidants in cancer progression and prevention. Antioxidants. 2020;9(11):1156.
   Google Scholar
• Birben E, Sahiner UM, Sackesen C, et al. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5(1):9–19.
   PubMedGoogle Scholar
• Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013;12(12):931–947.
   PubMed Web of Science ®Google Scholar
• Athreya K, Xavier M. Cancer. Nutr Cancer. 2017;69(8):1099–1104.
   PubMed Web of Science ®Google Scholar
• Lobo V, Patil A, Phatak A, et al. Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev. 2010;4(8):118–126.
   PubMedGoogle Scholar
• Cadenas E. Basic mechanisms of antioxidant activity. Biofactors. 1997;6(4):391–397.
   PubMedGoogle Scholar
• Bačić G, Spasojević I, Šećerov B, et al. Spin-trapping of oxygen free radicals in chemical and biological systems: new traps, radicals and possibilities. Spectrochim Acta Part A Mol Biomol Spectrosc. 2008;69(5):1354–1366.
   PubMed Web of Science ®Google Scholar
• Floyd R, Carney C. Society, free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann Neurol. 1992;32(S1):S22–S27.
   PubMedGoogle Scholar
• Rehorek D. Spin trapping of inorganic radicals. Chem Soc Rev. 1991;20(3):341–353.
   Web of Science ®Google Scholar
• Samuni A, Krishna CM, Mitchell JB, et al. Superoxide reaction with nitroxides. Free Radic Res Commun. 1990;9(3–6):241–249.
   PubMed Web of Science ®Google Scholar
• Swartz HM. Principles of the metabolism of nitroxides and their implications for spin trapping. Free Radic Res Commun. 1990;9(3–6):399–405.
   PubMed Web of Science ®Google Scholar
• Engman L, Persson J, Vessman K, et al. Organotellurium compounds as efficient retarders of lipid peroxidation in methanol. Free Radical Biology. 1995;19(4):441–452.
   PubMedGoogle Scholar
• Samuni A, Krishna CM, Riesz P, et al. A novel metal-free low molecular weight superoxide dismutase mimic. J Biol Chem. 1988;263(34):17921–17924.
   PubMed Web of Science ®Google Scholar
• Ladas EJ, Jacobson JS, Kennedy DD, et al. Antioxidants and cancer therapy: a systematic review. J Clin Oncol. 2004;22(3):517–528.
   PubMed Web of Science ®Google Scholar
• Chaiswing L, St Clair WH, St Clair DK, et al. Redox paradox: a novel approach to therapeutics-resistant cancer. Antioxid Redox Signal. 2018;29(13):1237–1272.
   PubMed Web of Science ®Google Scholar
• Moloney JN, Cotter TG. ROS signalling in the biology of cancer. Seminars in cell & developmental biology. Amsterdam, Netherlands: Elsevier; 2018.
   Google Scholar
• Aboelella NS, Brandle C, Kim T, et al. Oxidative stress in the tumor microenvironment and its relevance to cancer immunotherapy. Cancers. 2021;13(5):986.
   PubMed Web of Science ®Google Scholar
• Pelicano H, Feng L, Zhou Y, et al. Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem. 2003;278(39):37832–37839.
   PubMed Web of Science ®Google Scholar
• Rahal A, Kumar A, Singh V, et al. Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int. 2014;2014:1–19.
   Web of Science ®Google Scholar
• Laroussi M. Cold plasma in medicine and healthcare: the new frontier in low temperature plasma applications. Front Phys. 2020;8:74.
   Web of Science ®Google Scholar
• Kim SJ, Kim HS, Seo YR, et al. Understanding of ROS-inducing strategy in anticancer therapy. Oxid Med Cell Longevity. 2019;2019:1–12.
   Google Scholar
• Pike LS, Smift AL, Croteau NJ, et al. Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim Biophys Acta -Bioenerget. 2011;1807(6):726–734.
   Web of Science ®Google Scholar
• Trachootham D, Zhou Y, Zhang H, et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate. Cancer Cell. 2006;10(3):241–252.
   PubMed Web of Science ®Google Scholar
• Holmström KM, Finkel T. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol. 2014;15(6):411–421.
   PubMed Web of Science ®Google Scholar
• Datta A, Mishra S, Manna K, et al. Pro-oxidant therapeutic activities of cerium oxide nanoparticles in colorectal carcinoma cells. ACS Omega. 2020;5(17):9714–9723.
   PubMedGoogle Scholar
• Firczuk M, Bajor M, Graczyk-Jarzynka A, et al. Harnessing altered oxidative metabolism in cancer by augmented prooxidant therapy. Cancer Lett. 2020;471:1–11.
   PubMed Web of Science ®Google Scholar
• Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov. 2009;8(7):579–591.
   PubMed Web of Science ®Google Scholar
• Perillo B, Di Donato M, Pezone A, et al. ROS in cancer therapy: the bright side of the moon. Exp Mol Med. 2020;52(2):192–203.
   PubMed Web of Science ®Google Scholar
• He L, He T, Farrar S, et al. Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem. 2017;44(2):532–553.
   PubMedGoogle Scholar
• Choi DG, Venkatesan J, Shim MS. Selective anticancer therapy using pro-oxidant drug-loaded chitosan–fucoidan nanoparticles. Int J Mol Sci. 2019;20(13):3220.
   PubMedGoogle Scholar
• Ammendola S, d’Abusco AS. Oxidative stress, senescence and Mediterranean diet effects on osteoarthritis. Aging. Amsterdam, Netherlands: Elsevier; 2020. p. 73–81.
   Google Scholar
• Allen C, Her S, Jaffray D. Radiotherapy for cancer: present and future. Adv Drug Deliv Rev. 2017;109:1–2.
   PubMed Web of Science ®Google Scholar
• Craig DJ, Nanavaty NS, Devanaboyina M, et al. The abscopal effect of radiation therapy. Future Oncol. 2021;17(13):1683–1694.
   PubMed Web of Science ®Google Scholar
• Baskar R, Dai J, Wenlong N, et al. Biological response of cancer cells to radiation treatment. Front Mol Biosci. 2014;1:24.
   PubMed Web of Science ®Google Scholar
• Beaton L, Bandula S, Gaze MN, et al. How rapid advances in imaging are defining the future of precision radiation oncology. Br J Cancer. 2019;120(8):779–790.
   PubMed Web of Science ®Google Scholar
• Toy HI, Karakülah G, Kontou PI, et al. Investigating molecular determinants of cancer cell resistance to ionizing radiation through an integrative bioinformatics approach. Front Cell Dev Biol. 2021;9:770.
   Google Scholar
• Baskar R, Lee KA, Yeo R, et al. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 2012;9(3):193–199.
   PubMed Web of Science ®Google Scholar
• Wang Y, Qi H, Liu Y, et al. The double-edged roles of ROS in cancer prevention and therapy. Theranostics. 2021;11(10):4839–4857.
   PubMed Web of Science ®Google Scholar
• Gianfaldoni S, Gianfaldoni R, Wollina U, et al. An overview on radiotherapy: from its history to its current applications in dermatology. Open Access Maced J Med Sci. 2017;5(4):521–525.
   PubMedGoogle Scholar
• Jit BP, Pradhan B, Dash R, et al. Phytochemicals: potential therapeutic modulators of radiation induced signaling pathways. Antioxidants. 2021;11(1):49.
   Web of Science ®Google Scholar
• Chen HH, Kuo M. Improving radiotherapy in cancer treatment: promises and challenges. Oncotarget. 2017;8(37):62742–62758.
   PubMedGoogle Scholar
• Dubey P, Sertorio M, Takiar V. Therapeutic advancements in metal and metal oxide nanoparticle-based radiosensitization for head and neck cancer therapy. Cancers. 2022;14(3):514.
   PubMed Web of Science ®Google Scholar
• Baldacchino G, Brun E, Denden I, et al. Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O2 and radiosensitization by nanoparticles. Cancer Nano. 2019;10(1):1–21.
   Google Scholar
• Lousada CM, Soroka IL, Yagodzinskyy Y, et al. Gamma radiation induces hydrogen absorption by copper in water. Sci Rep. 2016;6(1):1–8.
   PubMedGoogle Scholar
• Caër LS. Water radiolysis: influence of oxide surfaces on H2 production under ionizing radiation. Water. 2011;3(1):235–253.
   Web of Science ®Google Scholar
• Hernandez C, Huebener P, Schwabe R. Damage-associated molecular patterns in cancer: a double-edged sword. Oncogene. 2016;35(46):5931–5941.
   PubMed Web of Science ®Google Scholar
• Grass GD, Krishna N, Kim S. The immune mechanisms of abscopal effect in radiation therapy. Curr Probl Cancer. 2016;40(1):10–24.
   PubMed Web of Science ®Google Scholar
• Kaminski JM, Shinohara E, Summers JB, et al. The controversial abscopal effect. Cancer Treat Rev. 2005;31(3):159–172.
   PubMed Web of Science ®Google Scholar
• Vénéreau E, Ceriotti C, Bianchi ME. DAMPs from cell death to new life. Front Immunol. 2015;6:422.
   PubMed Web of Science ®Google Scholar
• Jia P, Dai C, Cao P, et al. The role of reactive oxygen species in tumor treatment. RSC Adv. 2020;10(13):7740–7750.
   PubMed Web of Science ®Google Scholar
• Kwiatkowski S, Knap B, Przystupski D, et al. Photodynamic therapy–mechanisms, photosensitizers and combinations. Biomed Pharmacother. 2018;106:1098–1107.
   PubMed Web of Science ®Google Scholar
• Chilakamarthi U, Giribabu L. Photodynamic therapy: past, present and future. Chem Rec. 2017;17(8):775–802.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Li L. Photodynamic combinational therapy in cancer treatment. J Buon. 2018;23(3):561–567.
   PubMed Web of Science ®Google Scholar
• Dougherty TJ, Gomer CJ, Henderson BW, et al. Photodynamic therapy. J Natl Cancer Inst. 1998;90(12):889–905.
   PubMed Web of Science ®Google Scholar
• Agostinis P, Berg K, Cengel KA, et al. Photodynamic therapy of cancer: an update. CA Cancer J Clin. 2011;61(4):250–281.
   PubMed Web of Science ®Google Scholar
• Choudhary R, Reddy SS, Nagi R, et al. The effect of photodynamic therapy on oral-premalignant lesions: a systematic review. J Clin Exp Dent. 2022;14(3):e285–e292.
   PubMedGoogle Scholar
• Dobson J, de Queiroz GF, Golding JP. Golding, photodynamic therapy and diagnosis: principles and comparative aspects. Vet J. 2018;233:8–18.
   PubMed Web of Science ®Google Scholar
• van Straten D, Mashayekhi V, de Bruijn H, et al. Oncologic photodynamic therapy: basic principles, current clinical status and future directions. Cancers. 2017;9(12):19.
   PubMedGoogle Scholar
• Correia JH, Rodrigues JA, Pimenta S, et al. Photodynamic therapy review: principles, photosensitizers, applications, and future directions. Pharmaceutics. 2021;13(9):1332.
   PubMed Web of Science ®Google Scholar
• Josefsen LB, Boyle RW. Photodynamic therapy and the development of metal-based photosensitisers. Met-Based Drugs. 2008;2008:1–23.
   Google Scholar
• Banerjee SM, MacRobert AJ, Mosse CA, et al. Photodynamic therapy: inception to application in breast cancer. Breast. 2017;31:105–113.
   PubMed Web of Science ®Google Scholar
• Triesscheijn M, Baas P, Schellens JHM, et al. Photodynamic therapy in oncology. Oncologist. 2006;11(9):1034–1044.
   PubMed Web of Science ®Google Scholar
• McCaughan J. Aging, photodynamic therapy. Drugs Aging. 1999;15(1):49–68.
   PubMed Web of Science ®Google Scholar
• Li X, Lovell JF, Yoon J, et al. Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat Rev Clin Oncol. 2020;17(11):657–674.
   PubMed Web of Science ®Google Scholar
• Macdonald IJ, Dougherty TJ. Phthalocyanines, basic principles of photodynamic therapy. J Porphyrins Phthalocyanines. 2001;05(02):105–129.
   Google Scholar
• Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer. 2003;3(5):380–387.
   PubMed Web of Science ®Google Scholar
• Privat-Maldonado A, Schmidt A, Lin A, et al. ROS from physical plasmas: redox chemistry for biomedical therapy. Oxid Med Cell Longev. 2019;2019:1–29.
   Google Scholar
• Cheng X, Sherman J, Murphy W, et al. The effect of tuning cold plasma composition on glioblastoma cell viability. PLoS One. 2014;9(5):e98652.
   PubMed Web of Science ®Google Scholar
• Graves D. Polymers, reactive species from cold atmospheric plasma: implications for cancer therapy. Plasma Process Polym. 2014;11(12):1120–1127.
   Web of Science ®Google Scholar
• Chen Z, Cheng X, Lin L, et al. Cold atmospheric plasma discharged in water and its potential use in cancer therapy. J Phys D Appl Phys. 2017;50(1):015208.
   Google Scholar
• Gandhirajan RK, Endlich N, Bekeschus S, et al. Zebrafish larvae as a toxicity model in plasma medicine. Plasma Process Polym. 2021;18(3):2000188.
   Google Scholar
• Gandhirajan RK, Meyer D, Sagwal SK, et al. The amino acid metabolism is essential for evading physical plasma-induced tumour cell death. Br J Cancer. 2021;124(11):1854–1863.
   PubMed Web of Science ®Google Scholar
• Pasqual-Melo G, Nascimento T, Sanches LJ, et al. Plasma treatment limits cutaneous squamous cell carcinoma development in vitro and in vivo. Cancers. 2020;12(7):1993.
   PubMedGoogle Scholar
• Bekeschus S, Freund E, Wende K, et al. Hmox1 upregulation is a mutual marker in human tumor cells exposed to physical plasma-derived oxidants. Antioxidants. 2018;7(11):151.
   Web of Science ®Google Scholar
• Reiazi R, Akbari ME, Norozi A, et al. Application of cold atmospheric plasma (CAP) in cancer therapy: a review. Int J Cancer Manag. 2017;10(3):e8728.
   Google Scholar
• Keidar M. Technology, plasma for cancer treatment. Plasma Sources Sci Technol. 2015;24(3):033001.
   Google Scholar
• Dubey SK, Parab S, Alexander A, et al. Cold atmospheric plasma therapy in wound healing. Process Biochem. 2022;112:112–123.
   Web of Science ®Google Scholar
• Jung JM, Yoon HK, Jung CJ, et al. Cold plasma treatment promotes full-thickness healing of skin wounds in murine models. Int J Lower Extremity Wounds. 2021;15347346211002144.
   Web of Science ®Google Scholar
• Keidar M, Walk R, Shashurin A, et al. Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy. Br J Cancer. 2011;105(9):1295–1301.
   PubMed Web of Science ®Google Scholar
• Bekeschus S, Rödder K, Fregin B, et al. Toxicity and immunogenicity in murine melanoma following exposure to physical plasma-derived oxidants. Oxid Med Cell Longev. 2017;2017:1–12.
   Web of Science ®Google Scholar
• Pasqual-Melo G, Gandhirajan RK, Stoffels I, et al. Targeting malignant melanoma with physical plasmas. Clin Plasma Med. 2018;10:1–8.
   Web of Science ®Google Scholar
• Sagwal SK, Pasqual-Melo G, Bodnar Y, et al. Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16. Cell Death Dis. 2018;9(12):1179.
   PubMedGoogle Scholar
• Gandhirajan RK, Rödder K, Bodnar Y, et al. Cytochrome C oxidase inhibition and cold plasma-derived oxidants synergize in melanoma cell death induction. Sci Rep. 2018;8(1):1–12.
   PubMedGoogle Scholar
• Kim D, Gweon B, Kim DB, et al. A feasibility study for the cancer therapy using cold plasma. in 13th International Conference on Biomedical Engineering. 3- December 2008, Singapore: Springer; 2009.
   Google Scholar
• Braný D, Dvorská D, Halašová E, et al. Cold atmospheric plasma: a powerful tool for modern medicine. Int J Mol Sci. 2020;21(8):2932.
   PubMed Web of Science ®Google Scholar
• Izadjoo M, Zack S, Kim H, et al. Medical applications of cold atmospheric plasma: state of the science. J Wound Care. 2018;27(9):S4–S10.
   PubMedGoogle Scholar
• Bernhardt T, Semmler ML, Schäfer M, et al. Plasma medicine: applications of cold atmospheric pressure plasma in dermatology. Oxid Med Cell Longev. 2019;2019:1–10.
   Web of Science ®Google Scholar
• Malyavko A, Yan D, Wang Q, et al. Cold atmospheric plasma cancer treatment, direct versus indirect approaches. Mater Adv. 2020;1(6):1494–1505.
   Google Scholar
• Keidar M, Shashurin A, Volotskova O, et al. Cold atmospheric plasma in cancer therapy. Phys Plasmas. 2013;20(5):057101.
   Google Scholar
• Yan D, Sherman JH, Keidar MJO. Cold atmospheric plasma, a novel promising anti-cancer treatment modality. Oncotarget. 2017;8(9):15977–15995.
   PubMedGoogle Scholar
• Tornin J, Labay C, Tampieri F, et al. Evaluation of the effects of cold atmospheric plasma and plasma-treated liquids in cancer cell cultures. Nat Protoc. 2021;16(6):2826–2850.
   PubMed Web of Science ®Google Scholar
• Lin AG, Xiang B, Merlino DJ, et al. Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors. Oncoimmunology. 2018;7(9):e1484978.
   PubMed Web of Science ®Google Scholar
• Zafari P, Yadani Z, Akhavan-Niaki H, et al. Effect of cold atmospheric plasma on gene expression and methylation of genes involved in colorectal cancer. J Mazandaran Univ Med Sci. 2022;31(204):26–39.
   Google Scholar
• Huang P, Feng L, Oldham EA, et al. Superoxide dismutase as a target for the selective killing of cancer cells. Nature. 2000;407(6802):390–395.
   PubMed Web of Science ®Google Scholar
• Sun J, Wei Q, Zhou Y, et al. A systematic analysis of FDA-approved anticancer drugs. BMC Syst Biol. 2017;11(S5):1–17.
   PubMedGoogle Scholar