Inhibition of glutamine metabolism increases sensitivity to plasma-activated medium-induced cytotoxicity

References

• Miyamoto K, Ikehara S, Takei H, et al. Red blood cell coagulation induced by low-temperature plasma treatment. Arch Biochem Biophys. 2016;605:95–101. others doi:10.1016/j.abb.2016.03.023.
   PubMed Web of Science ®Google Scholar
• Cheng KY, Lin ZH, Cheng YP, et al. Wound healing in Streptozotocin-Induced diabetic rats using Atmospheric-Pressure argon plasma jet. Sci Rep. 2018;8(1):12214. doi:10.1038/s41598-018-30597-1.
   PubMedGoogle Scholar
• Choi JH, Song YS, Song K, et al. Skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes. Sci Rep. 2017;7(1):6146. doi:10.1038/s41598-017-06661-7.
   PubMedGoogle Scholar
• Bekeschus S. Medical gas plasma technology: roadmap on cancer treatment and immunotherapy. Redox Biol. 2023;65:102798. doi:10.1016/j.redox.2023.102798.
   PubMed Web of Science ®Google Scholar
• Jiang L, Zheng H, Lyu Q, et al. Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated ringer’s lactate. Redox Biol. 2021;43:101989. others doi:10.1016/j.redox.2021.101989.
   PubMed Web of Science ®Google Scholar
• Adachi T, Tanaka H, Nonomura S, et al. Plasma-activated medium induces A549 cell injury via a spiral apoptotic Cascade involving the mitochondrial-nuclear network. Free Radic Biol Med. 2015;79:28–44. doi:10.1016/j.freeradbiomed.2014.11.014.
   PubMed Web of Science ®Google Scholar
• Tanaka H, Mizuno M, Ishikawa K, et al. Molecular mechanisms of non-thermal plasma-induced effects in cancer cells. Biol Chem. 2018;400(1):87–91. doi:10.1515/hsz-2018-0199.
   PubMed Web of Science ®Google Scholar
• Kurake N, Tanaka H, Ishikawa K, et al. Cell survival of glioblastoma grown in medium containing hydrogen peroxide and/or nitrite, or in plasma-activated medium. Arch Biochem Biophys. 2016;605:102–108. doi:10.1016/j.abb.2016.01.011.
   PubMed Web of Science ®Google Scholar
• Ma Y, Ha CS, Hwang SW, et al. Non-thermal atmospheric pressure plasma preferentially induces apoptosis in p53-mutated cancer cells by activating ROS stress-response pathways. PLoS One. 2014;9(4):e91947. doi:10.1371/journal.pone.0091947.
   PubMed Web of Science ®Google Scholar
• Chauvin J, Gibot L, Griseti E, et al. Elucidation of in vitro cellular steps induced by antitumor treatment with plasma-activated medium. Sci Rep. 2019;9(1):4866. doi:10.1038/s41598-019-41408-6.
   PubMedGoogle Scholar
• Jo A, Bae JH, Yoon YJ, et al. Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells. Cell Death Dis. 2022;13(3):212. doi:10.1038/s41419-022-04660-9.
   PubMed Web of Science ®Google Scholar
• Hara H, Taniguchi M, Kobayashi M, et al. Plasma-activated medium-induced intracellular zinc liberation causes death of SH-SY5Y cells. Arch Biochem Biophys. 2015;584:51–60. doi:10.1016/j.abb.2015.08.014.
   PubMed Web of Science ®Google Scholar
• Kurake N, Ishikawa K, Tanaka H, et al. Non-thermal plasma-activated medium modified metabolomic profiles in the glycolysis of U251SP glioblastoma. Arch Biochem Biophys. 2019;662:83–92. doi:10.1016/j.abb.2018.12.001.
   PubMed Web of Science ®Google Scholar
• Liberti MV, Locasale JW. The warburg effect: how does it benefit cancer cells? Trends Biochem Sci. 2016;41(3):211–218. doi:10.1016/j.tibs.2015.12.001.
   PubMed Web of Science ®Google Scholar
• Pavlova NN, Thompson CB. The emerging hallmarks of cancer metabolism. Cell Metab. 2016;23(1):27–47. doi:10.1016/j.cmet.2015.12.006.
   PubMed Web of Science ®Google Scholar
• Matés JM, Campos-Sandoval JA, Santos-Jiménez JL, et al. Dysregulation of glutaminase and glutamine synthetase in cancer. Cancer Lett. 2019;467:29–39. doi:10.1016/j.canlet.2019.09.011.
   PubMed Web of Science ®Google Scholar
• Lee JS, Kang JH, Lee SH, et al. Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC. Cell Death Dis. 2016;7(12):e2511–e2511. doi:10.1038/cddis.2016.404.
   PubMedGoogle Scholar
• Gross MI, Demo SD, Dennison JB, et al. Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol Cancer Ther. 2014;13(4):890–901. others doi:10.1158/1535-7163.MCT-13-0870.
   PubMed Web of Science ®Google Scholar
• Yang WH, Qiu Y, Stamatatos O, et al. Enhancing the efficacy of glutamine metabolism inhibitors in cancer therapy. Trends Cancer. 2021;7(8):790–804. doi:10.1016/j.trecan.2021.04.003.
   PubMed Web of Science ®Google Scholar
• Kaushik N, Lee SJ, Choi TG, et al. Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells. Sci Rep. 2015;5(1):8726. doi:10.1038/srep08726.
   PubMedGoogle Scholar
• Nagaya M, Hara H, Kamiya T, et al. Inhibition of NAMPT markedly enhances plasma-activated medium-induced cell death in human breast cancer MDA-MB-231 cells. Arch Biochem Biophys. 2019;676:108155. doi:10.1016/j.abb.2019.108155.
   PubMed Web of Science ®Google Scholar
• Tanaka H, Mizuno M, Katsumata Y, et al. Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions. Sci Rep. 2019;9(1):13657. others doi:10.1038/s41598-019-50136-w.
   PubMedGoogle Scholar
• Liedtke KR, Bekeschus S, Kaeding A, et al. Non-thermal plasma-treated solution demonstrates antitumor activity against pancreatic cancer cells in vitro and in vivo. Sci Rep. 2017;7(1):8319. doi:10.1038/s41598-017-08560-3.
   PubMedGoogle Scholar
• Tanaka H, Nakamura K, Mizuno M, et al. Non-thermal atmospheric pressure plasma activates lactate in ringer’s solution for anti-tumor effects. Sci Rep. 2016;6(1):36282. doi:10.1038/srep36282.
   PubMedGoogle Scholar
• Mah LJ, El-Osta A, Karagiannis TC. gammaH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia. 2010;24(4):679–686. doi:10.1038/leu.2010.6.
   PubMed Web of Science ®Google Scholar
• Wu G, Fang YZ, Yang S, et al. Glutathione metabolism and its implications for health. J Nutr. 2004;134(3):489–492. doi:10.1093/jn/134.3.489.
   PubMed Web of Science ®Google Scholar
• Yi M, Zheng X, Niu M, et al. Combination strategies with PD-1/PD-L1 blockade: current advances and future directions. Mol Cancer. 2022;21(1):28. doi:10.1186/s12943-021-01489-2.
   PubMed Web of Science ®Google Scholar
• Ma C, Niu X, Luo J, et al. Combined effects of lapatinib and bortezomib in human epidermal receptor 2 (HER2)-overexpressing breast cancer cells and activity of bortezomib against lapatinib-resistant breast cancer cells. Cancer Sci. 2010;101(10):2220–2226. doi:10.1111/j.1349-7006.2010.01662.x.
   PubMed Web of Science ®Google Scholar
• Rashmi R, Jayachandran K, Zhang J, et al. Glutaminase inhibitors induce Thiol-Mediated oxidative stress and radiosensitization in treatment-Resistant cervical cancers. Mol Cancer Ther. 2020;19(12):2465–2475. others doi:10.1158/1535-7163.MCT-20-0271.
   PubMed Web of Science ®Google Scholar
• Gregory MA, Nemkov T, Park HJ, et al. Targeting glutamine metabolism and redox state for leukemia therapy. Clin Cancer Res. 2019;25(13):4079–4090. doi:10.1158/1078-0432.CCR-18-3223.
   PubMed Web of Science ®Google Scholar
• Daemen A, Liu B, Song K, et al. Pan-Cancer metabolic signature predicts Co-Dependency on glutaminase and De novo glutathione synthesis linked to a high-Mesenchymal cell state. Cell Metab. 2018;28(3):383–399.e9. others doi:10.1016/j.cmet.2018.06.003.
   PubMed Web of Science ®Google Scholar
• Xiang L, Mou J, Shao B, et al. Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization. Cell Death Dis. 2019;10(2):40. doi:10.1038/s41419-018-1291-5.
   PubMed Web of Science ®Google Scholar
• Morotti M, Zois CE, El-Ansari R, et al. Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer. Br J Cancer. 2021;124(2):494–505. others doi:10.1038/s41416-020-01113-y.
   PubMed Web of Science ®Google Scholar
• Boysen G, Jamshidi-Parsian A, Davis MA, et al. Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice. Int J Radiat Biol. 2019;95(4):436–442. doi:10.1080/09553002.2018.1558299.
   PubMed Web of Science ®Google Scholar
• Ma J, Zhang H, Cheng C, et al. Contribution of hydrogen peroxide to non-thermal atmospheric pressure plasma induced A549 lung cancer cell damage. Plasma Processes Polym. 2017;14(7):1600162. doi:10.1002/ppap.201600162.
   Web of Science ®Google Scholar
• Garten A, Petzold S, Körner A, et al. Nampt: linking NAD biology, metabolism and cancer. Trends Endocrinol Metab. 2009;20(3):130–138. doi:10.1016/j.tem.2008.10.004.
   PubMed Web of Science ®Google Scholar
• Wang B, Hasan MK, Alvarado E, et al. NAMPT over­expression in prostate cancer and its contribution to tumor cell survival and stress response. Oncogene. 2011;30(8):907–921. doi:10.1038/onc.2010.468.
   PubMed Web of Science ®Google Scholar
• Ishikawa K, Hosoi Y, Tanaka H, et al. Non-thermal plasma-activated lactate solution kills U251SP glioblastoma cells in an innate reductive manner with altered metabolism. Arch Biochem Biophys. 2020;688:108414. doi:10.1016/j.abb.2020.108414.
   PubMed Web of Science ®Google Scholar