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Research Articles

Alpha-synuclein interaction with mitochondria is the final mechanism of ferroptotic death induced by erastin in SH-SY5Y cells

, , , , , , , & ORCID Icon show all
Pages 217-228 | Received 26 Sep 2023, Accepted 16 Feb 2024, Published online: 05 Apr 2024

References

  • Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072. doi: 10.1016/j.cell.2012.03.042.
  • Guiney SJ, Adlard PA, Bush AI, et al. Ferroptosis and cell death mechanisms in Parkinson’s disease. Neurochem Int. 2017;104:34–48. doi: 10.1016/j.neuint.2017.01.004.
  • Tang D, Chen X, Kang R, et al. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31(2):107–125. doi: 10.1038/s41422-020-00441-1.
  • Dixon SJ, Winter GE, Musavi LS, et al. Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. ACS Chem Biol. 2015;10(7):1604–1609. doi: 10.1021/acschembio.5b00245.
  • Pedrera L, Espiritu RA, Ros U, et al. Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death Differ. 2021;28(5):1644–1657. doi: 10.1038/s41418-020-00691-x.
  • Riegman M, Sagie L, Galed C, et al. Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture. Nat Cell Biol. 2020;22(9):1042–1048. doi: 10.1038/s41556-020-0565-1.
  • Gao M, Yi J, Zhu J, et al. Role of mitochondria in ferroptosis. Mol Cell. 2019;73(2):354–363.e3. doi: 10.1016/j.molcel.2018.10.042.
  • Wang H, Liu C, Zhao Y, et al. Mitochondria regulation in ferroptosis. Eur J Cell Biol. 2020;99(1):151058. doi: 10.1016/j.ejcb.2019.151058.
  • Abdalkader M, Lampinen R, Kanninen KM, et al. Targeting Nrf2 to suppress ferroptosis and mitochondrial dysfunction in neurodegeneration. Front Neurosci. 2018;12:466. Published 2018 Jul 10. doi: 10.3389/fnins.2018.00466.
  • Kinnally KW, Peixoto PM, Ryu SY, et al. Is mPTP the gatekeeper for necrosis, apoptosis, or both? Biochim Biophys Acta. 2011;1813(4):616–622. doi: 10.1016/j.bbamcr.2010.09.013.
  • Karch J, Molkentin JD. Regulated necrotic cell death: the passive aggressive side of bax and bak. Circ Res. 2015;116(11):1800–1809. doi: 10.1161/CIRCRESAHA.116.305421.
  • Ganguly U, Ganguly A, Sen O, et al. Dopamine cytotoxicity on SH-SY5Y cells: involvement of α-synuclein and relevance in the neurodegeneration of sporadic parkinson’s disease. Neurotox Res. 2019;35(4):898–907. doi: 10.1007/s12640-019-0001-0.
  • Ganguly U, Banerjee A, Chakrabarti SS, et al. Interaction of α-synuclein and parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of parkinson’s disease. Biochem J. 2020;477(6):1109–1122. doi: 10.1042/BCJ20190676.
  • Stockwell BR, Friedmann Angeli JP, Bayir H, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273–285. doi: 10.1016/j.cell.2017.09.021.
  • Kwon MY, Park E, Lee SJ, et al. Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death. Oncotarget. 2015;6(27):24393–24403. doi: 10.18632/oncotarget.5162.
  • Sakamuru S, Attene-Ramos MS, Xia M. Mitochondrial membrane potential assay. Methods Mol Biol. 2016;1473:17–22. doi: 10.1007/978-1-4939-6346-1_2.
  • Jana S, Sinha M, Chanda D, et al. Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: implications in dopamine cytotoxicity and pathogenesis of Parkinson’s disease. Biochim Biophys Acta. 2011;1812(6):663–673. doi: 10.1016/j.bbadis.2011.02.013.
  • Draper HH, Squires EJ, Mahmoodi H, et al. A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free Radic Biol Med. 1993;15(4):353–363. doi: 10.1016/0891-5849(93)90035-s.
  • Rahman I, Kode A, Biswas SK. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc. 2006;1(6):3159–3165. doi: 10.1038/nprot.2006.378.
  • Look MP, Rockstroh JK, Rao GS, et al. Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1 (HIV-1)-infection. Eur J Clin Nutr. 1997;51(4):266–272. doi: 10.1038/sj.ejcn.1600401.
  • Im K, Mareninov S, Diaz MFP, et al. An introduction to performing immunofluorescence staining. Methods Mol Biol. 2019;1897:299–311. doi: 10.1007/978-1-4939-8935-5_26.
  • Singh S, Ganguly U, Pal S, et al. Protective effects of cyclosporine a on neurodegeneration and motor impairment in rotenone-induced experimental models of Parkinson’s disease. Eur J Pharmacol. 2022;929:175129. doi: 10.1016/j.ejphar.2022.175129.
  • Redza-Dutordoir M, Averill-Bates DA. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta. 2016;1863(12):2977–2992. doi: 10.1016/j.bbamcr.2016.09.012.
  • Jelinek A, Heyder L, Daude M, et al. Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis. Free Radic Biol Med. 2018;117:45–57. doi: 10.1016/j.freeradbiomed.2018.01.019.
  • Basit F, van Oppen LM, Schöckel L, et al. Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. Cell Death Dis. 2017;8(3):e2716–e2716. Published 2017 Mar 30. doi: 10.1038/cddis.2017.133.
  • Seidlmayer LK, Juettner VV, Kettlewell S, et al. Distinct mPTP activation mechanisms in ischaemia-reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate. Cardiovasc Res. 2015;106(2):237–248. doi: 10.1093/cvr/cvv097.
  • Loor G, Kondapalli J, Iwase H, et al. Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion. Biochim Biophys Acta. 2011;1813(7):1382–1394. doi: 10.1016/j.bbamcr.2010.12.008.
  • Agostini F, Bubacco L, Chakrabarti S, et al. α-synuclein toxicity in Drosophila melanogaster is enhanced by the presence of iron: implications for parkinson’s disease. Antioxidants . 2023;12(2):261. Published 2023 Jan 24. doi: 10.3390/antiox12020261.
  • Tamburrino A, Churchill MJ, Wan OW, et al. Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of parkinson’s disease. Acta Neuropathol Commun. 2015;3(1):84. Published 2015 Dec 14. doi: 10.1186/s40478-015-0263-6.

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