Dissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis

References

• Abla MJ, Chaturvedula A, O’Mahony C, Banga AK. (2013). Transdermal delivery of methotrexate for pediatrics using silicon microneedles. Ther Deliv 4:543–51.
   PubMedGoogle Scholar
• Becciolini A, Biggioggero M, Favalli EG. (2016). The role of methotrexate as combination therapy with etanercept in rheumatoid arthritis: retrospective analysis of a local registry. J Int Med Res 44:113–18.
   PubMed Web of Science ®Google Scholar
• Bechard MA, Lemieux JR, Roth J, et al. (2014). Procedural pain and patient-reported side effects with weekly injections of subcutaneous methotrexate in children with rheumatic disorders. Pediatr Rheumatol Online J 12:54.
   PubMed Web of Science ®Google Scholar
• Bello AE, Perkins EL, Jay R, Efthimiou P. (2017). Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis. Open Access Rheumatol Res Rev 9:13.
   Google Scholar
• Cheng ZT, Lin H, Wang Z, et al. (2020). Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin. Drug Deliv Transl Res 10:1520–30.
   PubMed Web of Science ®Google Scholar
• Dale J, Alcorn N, Capell H, Madhok R. (2007). Combination therapy for rheumatoid arthritis: methotrexate and sulfasalazine together or with other DMARDs. Nat Clin Pract Rheumatol 3:450–8; quiz, following 478.
   PubMedGoogle Scholar
• Dong ZY, Zhao WM, Li YY, et al. (2020). Development and evaluation of new methods for protein quantification in dissolving microneedles formulations. J Pharm Biomed Anal 189:113453.
   PubMed Web of Science ®Google Scholar
• Donnelly RF, Singh TRR, Woolfson AD. (2010). Microneedle-based drug delivery systems: microfabrication, drug delivery, and safety. Drug Deliv 17:187–207.
   PubMed Web of Science ®Google Scholar
• Dos Santos AM, Carvalho FC, Teixeira DA, et al. (2017). Computational and experimental approaches for development of methotrexate nanosuspensions by bottom-up nanoprecipitation. Int J Pharm 524:330–8.
   PubMedGoogle Scholar
• Feng NB, Yang MD, Feng XR, et al. (2018). Reduction-responsive polypeptide nanogel for intracellular drug delivery in relieving collagen-induced arthritis. ACS Biomater Sci Eng 4:4154–62.
   PubMed Web of Science ®Google Scholar
• Gerards AH, de Lathouder S, de Groot ER, et al. (2003). Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis. Rheumatology (Oxford) 42:1189–96.
   PubMed Web of Science ®Google Scholar
• Gorantla S, Singhvi G, Rapalli VK, et al. (2020). Targeted drug-delivery systems in the treatment of rheumatoid arthritis: recent advancement and clinical status. Ther Deliv 11:269–84.
   PubMed Web of Science ®Google Scholar
• Grötsch B, Bozec A, Schett G. (2019). In vivo models of rheumatoid arthritis. Methods Mol Biol 1914:269–80.
   PubMedGoogle Scholar
• Guo Q, Wang YX, Xu D, et al. (2018). Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies [Review]. Bone Res 6:14.
   PubMed Web of Science ®Google Scholar
• Ita K. (2015). Transdermal delivery of drugs with microneedles – potential and challenges. Pharmaceutics 7:90–105.
   PubMed Web of Science ®Google Scholar
• Ito Y, Hamazaki N, Higashino H, et al. (2013). Recovery rate of rat skin micropores made by dissolving microneedles. J Drug Delivery Sci Technol 23:577–81.
   Web of Science ®Google Scholar
• Jacobse J, ten Voorde W, Rissmann R, et al. (2019). The effect of repeated methotrexate injections on the quality of life of children with rheumatic diseases. Eur J Pediatr 178:17–20.
   PubMed Web of Science ®Google Scholar
• Kalb RE, Strober B, Weinstein G, Lebwohl M. (2009). Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference. J Am Acad Dermatol 60:824–37.
   PubMed Web of Science ®Google Scholar
• Khan ZA, Tripathi R, Mishra B. (2012). Methotrexate: a detailed review on drug delivery and clinical aspects. Expert Opin Drug Deliv 9:151–69.
   PubMed Web of Science ®Google Scholar
• Li YY, Hu X, Dong ZY, et al. (2020). Dissolving microneedle arrays with optimized needle geometry for transcutaneous immunization. Eur J Pharm Sci 151:105361.
   PubMed Web of Science ®Google Scholar
• Lucas CJ, Dimmitt SB, Martin JH. (2019). Optimising low-dose methotrexate for rheumatoid arthritis – a review. Br J Clin Pharmacol 85:2228–34.
   PubMed Web of Science ®Google Scholar
• Mitragotri S, Yoo JW. (2011). Designing micro- and nano-particles for treating rheumatoid arthritis. Arch Pharm Res 34:1887–97.
   PubMed Web of Science ®Google Scholar
• Nguyen HX, Banga AK. (2018a). Delivery of methotrexate and characterization of skin treated by fabricated PLGA microneedles and fractional ablative laser. Pharm Res 35:20.
   PubMed Web of Science ®Google Scholar
• Nguyen HX, Banga AK. (2018b). Electrically and ultrasonically enhanced transdermal delivery of methotrexate. Pharmaceutics 10:117.
   PubMed Web of Science ®Google Scholar
• Rohr MK, Mikuls TR, Cohen SB, et al. (2017). Underuse of methotrexate in the treatment of rheumatoid arthritis: a national analysis of prescribing practices in the US. Arthritis Care Res (Hoboken) 69:794–800.
   PubMed Web of Science ®Google Scholar
• Rzepecka J, Pineda MA, Al-Riyami L, et al. (2015). Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome. J Autoimmun 60:59–73.
   PubMed Web of Science ®Google Scholar
• Shiozawa K, Yamane T, Murata M, et al. (2016). MMP-3 as a predictor for structural remission in RA patients treated with MTX monotherapy. Arthritis Res Ther 18:9.
   PubMed Web of Science ®Google Scholar
• Singka GSL, Abu Samah N, Zulfakar MH, et al. (2010). Enhanced topical delivery and anti-inflammatory activity of methotrexate from an activated nanogel. Eur J Pharm Biopharm 76:275–81.
   PubMed Web of Science ®Google Scholar
• Solomon DH, Curtis JR, Saag KG, et al. (2013). Cardiovascular risk in rheumatoid arthritis: comparing TNF-alpha blockade with nonbiologic DMARDs. Am J Med 126:9.
   Web of Science ®Google Scholar
• Tekko IA, Chen G, Domínguez-Robles J, et al. (2020a). Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate. Int J Pharm 586:119580.
   PubMed Web of Science ®Google Scholar
• Tekko IA, Permana AD, Vora L, et al. (2020b). Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis. Eur J Pharm Sci 152:105469.
   PubMed Web of Science ®Google Scholar
• Trotta M, Peira E, Carlotti ME, Gallarate M. (2004). Deformable liposomes for dermal administration of methotrexate. Int J Pharm 270:119–25.
   PubMed Web of Science ®Google Scholar
• Wang WY, Zhou H, Liu L. (2018). Side effects of methotrexate therapy for rheumatoid arthritis: a systematic review. Eur J Med Chem 158:502–16.
   PubMed Web of Science ®Google Scholar
• Wei F, Wang QY, Liu H, et al. (2022). High efficacy combined microneedles array with methotrexate nanocrystals for effective anti-rheumatoid arthritis. Int J Nanomed 17:2397–412.
   PubMed Web of Science ®Google Scholar
• Wilsdon TD, Hill CL. (2017). Managing the drug treatment of rheumatoid arthritis. Aust Prescr 40:51–8.
   PubMed Web of Science ®Google Scholar
• Wong TW, Zhao YL, Sen A, Hui SW. (2005). Pilot study of topical delivery of methotrexate by electroporation. Br J Dermatol 152:524–30.
   PubMed Web of Science ®Google Scholar
• Song X, Liang F, Liu N, et al. (2010). Therapeutic efficacy of experimental rheumatoid arthritis with low-dose methotrexate by increasing partially CD4 + CD25+ Treg cells and inducing Th1 to Th2 shift in both cells and cytokines. Biomed Pharmacother 64:463–71.
   PubMed Web of Science ®Google Scholar
• Zhang LJ, Guo RR, Wang SQ, et al. (2021). Fabrication, evaluation and applications of dissolving microneedles. Int J Pharm 604:120749.
   PubMedGoogle Scholar
• Zhao X, Li XF, Zhang P, et al. (2018). Tip-loaded fast-dissolving microneedle patches for photodynamic therapy of subcutaneous tumor. J Control Release 286:201–9.
   PubMed Web of Science ®Google Scholar