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Research Article

Application of iontophoresis in ophthalmic practice: an innovative strategy to deliver drugs into the eye

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Article: 2165736 | Received 10 Oct 2022, Accepted 02 Jan 2023, Published online: 11 Jan 2023

References

  • Abdel-Aty A, Kombo N. (2021). Factors affecting the resolution of acute non-infectious anterior scleritis. Br J Ophthalmol 106:1672–7.
  • Anderson OA, Bainbridge JW, Shima DT. (2010). Delivery of anti-angiogenic molecular therapies for retinal disease. Drug Discov Today 15:1–12.
  • Anonymous. (2007). The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 5:75–92.
  • Arboleda A, Kowalczuk L, Savoldelli M, et al. (2014). Evaluating in vivo delivery of riboflavin with coulomb-controlled iontophoresis for corneal collagen cross-linking: a pilot study. Invest Ophthalmol Vis Sci 55:2731–8.
  • Barber AJ. (2003). A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 27:283–90.
  • Barza M, Peckman C, Baum J. (1986). Transscleral iontophoresis of cefazolin, ticarcillin, and gentamicin in the rabbit. Ophthalmology 93:133–9.
  • Behar-Cohen FF, El Aouni A, Gautier S, et al. (2002). Transscleral Coulomb-controlled iontophoresis of methylprednisolone into the rabbit eye: influence of duration of treatment, current intensity and drug concentration on ocular tissue and fluid levels. Exp Eye Res 74:51–9.
  • Behar-Cohen FF, Parel JM, Pouliquen Y, et al. (1997). Iontophoresis of dexamethasone in the treatment of endotoxin-induced-uveitis in rats. Exp Eye Res 65:533–45.
  • Behar-Cohen FF, Savoldelli M, Parel JM, et al. (1998). Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis. Invest Ophthalmol Vis Sci 39:897–904.
  • Byrne JD, Yeh JJ, DeSimone JM. (2018). Use of iontophoresis for the treatment of cancer. J Control Release 284:144–51.
  • Cabrera FJ, Wang DC, Reddy K, et al. (2019). Challenges and opportunities for drug delivery to the posterior of the eye. Drug Discov Today 24:1679–84.
  • Chaudhry SG, Fung AT. (2021). Cytomegalovirus retinitis following dexamethasone intravitreal implant. Am J Ophthalmol Case Rep 22:101055.
  • Chen Y, Kalia YN. (2018). Short-duration ocular iontophoresis of ionizable aciclovir prodrugs: a new approach to treat herpes simplex infections in the anterior and posterior segments of the eye. Int J Pharm 536:292–300.
  • Cheung N, Mitchell P, Wong TY. (2010). Diabetic retinopathy. Lancet 376:124–36.
  • Chopra P, Hao J, Li SK. (2010). Iontophoretic transport of charged macromolecules across human sclera. Int J Pharm 388:107–13.
  • Choy CK, Benzie IF, Cho P. (2000). Ascorbic acid concentration and total antioxidant activity of human tear fluid measured using the FRASC assay. Invest Ophthalmol Vis Sci 41:3293–8.
  • Cohen AE, Assang C, Patane MA, et al. (2012). Evaluation of dexamethasone phosphate delivered by ocular iontophoresis for treating noninfectious anterior uveitis. Ophthalmology 119:66–73.
  • de Smet MD, Taylor SR, Bodaghi B, et al. (2011). Understanding uveitis: the impact of research on visual outcomes. Prog Retin Eye Res 30:452–70.
  • Del Amo EM, Urtti A. (2008). Current and future ophthalmic drug delivery systems. A shift to the posterior segment. Drug Discov Today 13:135–43.
  • Dong A, Xie B, Shen J, et al. (2009). Oxidative stress promotes ocular neovascularization. J Cell Physiol 219:544–52.
  • Doshi RR, Bakri SJ, Fung AE. (2011). Intravitreal injection technique. Semin Ophthalmol 26:104–13.
  • Dutta Majumder P, Agrawal R, McCluskey P, et al. (2020). Current approach for the diagnosis and management of noninfective scleritis. Asia Pac J Ophthalmol (Phila) 10:212–23.
  • Eljarrat-Binstock E, Domb AJ. (2006). Iontophoresis: a non-invasive ocular drug delivery. J Control Release 110:479–89.
  • Eljarrat-Binstock E, Pe’er J, Domb AJ. (2010). New techniques for drug delivery to the posterior eye segment. Pharm Res 27:530–43.
  • Eljarrat-Binstock E, Raiskup F, Frucht-Pery J, et al. (2004). Hydrogel probe for iontophoresis drug delivery to the eye. J Biomater Sci Polym Ed 15:397–413.
  • Fujihara T, Nagano T, Endo K, et al. (2000). Lactoferrin protects against UV-B irradiation-induced corneal epithelial damage in rats. Cornea 19:207–11.
  • Gaudana R, Ananthula HK, Parenky A, et al. (2010). Ocular drug delivery. Aaps J 12:348–60.
  • Gayton JL. (2009). Etiology, prevalence, and treatment of dry eye disease. Clin Ophthalmol 3:405–12.
  • Glover JM, Leeds JM, Mant TG, et al. (1997). Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302). J Pharmacol Exp Ther 282:1173–80.
  • Gratieri T, Santer V, Kalia YN. (2017). Basic principles and current status of transcorneal and transscleral iontophoresis. Expert Opin Drug Deliv 14:1091–102.
  • Grossman R, Lee DA. (1989). Transscleral and transcorneal iontophoresis of ketoconazole in the rabbit eye. Ophthalmology 96:724–9.
  • Guffey JS, Rutherford MJ, Payne W, et al. (1999). Skin pH changes associated with iontophoresis. J Orthop Sports Phys Ther 29:656–60.
  • Guigui A, Mazet R, Blaise S, et al. (2020). Treprostinil hydrogel iontophoresis in systemic sclerosis-related digital skin ulcers: a safety study. J Clin Pharmacol 60:758–67.
  • Güngör S, Delgado-Charro MB, Ruiz-Perez B, et al. (2010). Trans-scleral iontophoretic delivery of low molecular weight therapeutics. J Control Release 147:225–31.
  • Hao J, Li SK, Liu CY, et al. (2009). Electrically assisted delivery of macromolecules into the corneal epithelium. Exp Eye Res 89:934–41.
  • Hayden B, Jockovich ME, Murray TG, et al. (2006). Iontophoretic delivery of carboplatin in a murine model of retinoblastoma. Invest Ophthalmol Vis Sci 47:3717–21.
  • Hayden BC, Jockovich ME, Murray TG, et al. (2004). Pharmacokinetics of systemic versus focal Carboplatin chemotherapy in the rabbit eye: possible implication in the treatment of retinoblastoma. Invest Ophthalmol Vis Sci 45:3644–9.
  • Hill JM, Shimomura Y, Dudley JB, et al. (1987). Timolol induces HSV-1 ocular shedding in the latently infected rabbit. Invest Ophthalmol Vis Sci 28:585–90.
  • Horwath-Winter J, Schmut O, Haller-Schober EM, et al. (2005). Iodide iontophoresis as a treatment for dry eye syndrome. Br J Ophthalmol 89:40–4.
  • Hughes L, Maurice DM. (1984). A fresh look at iontophoresis. Arch Ophthalmol 102:1825–9.
  • Jiang C, Jiang X, Wang X, et al. (2021). Transdermal iontophoresis delivery system for terazosin hydrochloride: an in vitro and in vivo study. Drug Deliv 28:454–62.
  • Jung JH, Chiang B, Grossniklaus HE, et al. (2018). Ocular drug delivery targeted by iontophoresis in the suprachoroidal space using a microneedle. J Control Release 277:14–22.
  • Karpiński TM. (2018). Selected medicines used in iontophoresis. Pharmaceutics 10:204.
  • Koevary SB, Nussey J, Lake S. (2002). Accumulation of topically applied porcine insulin in the retina and optic nerve in normal and diabetic rats. Invest Ophthalmol Vis Sci 43:797–804.
  • Kralinger MT, Voigt M, Kieselbach G, et al. (2003). Ocular delivery of acetylsalicylic acid by repetitive coulomb-controlled iontophoresis. Ophthalmic Res 35:102–10.
  • Kubo Y, Akanuma SI, Hosoya KI. (2018). Recent advances in drug and nutrient transport across the blood-retinal barrier. Expert Opin Drug Metab Toxicol 14:513–31.
  • Kwon BS, Gangarosa LP, Burch KD, et al. (1981). Induction of ocular herpes simplex virus shedding by iontophoresis of epinephrine into rabbit cornea. Invest Ophthalmol Vis Sci 21:442–9.
  • Lam TT, Fu J, Chu R, et al. (1994). Intravitreal delivery of ganciclovir in rabbits by transscleral iontophoresis. J Ocul Pharmacol 10:571–5.
  • Lam TT, Fu J, Tso MO. (1991). A histopathologic study of retinal lesions inflicted by transscleral iontophoresis. Graefes Arch Clin Exp Ophthalmol 229:389–94.
  • Lashay A, Faghihi H, Mirshahi A, et al. (2020). Safety of intravitreal injection of Stivant, a biosimilar to bevacizumab, in rabbit eyes. J Ophthalmic Vis Res 15:341–50.
  • Li SK, Hao J. (2018). Transscleral passive and iontophoretic transport: theory and analysis. Expert Opin Drug Deliv 15:283–99.
  • Li SK, Liddell MR, Wen H. (2011). Effective electrophoretic mobilities and charges of anti-VEGF proteins determined by capillary zone electrophoresis. J Pharm Biomed Anal 55:603–7.
  • Marshall LL, Roach JM. (2016). Treatment of dry eye disease. Consult Pharm 31:96–106.
  • Mautone L, Skevas C, Spitzer MS. (2021). Treatment of postoperative endophthalmitis: operate or only inject? Ophthalmologe 118:219–29.
  • Miserocchi E, Fogliato G, Modorati G, et al. (2013). Review on the worldwide epidemiology of uveitis. Eur J Ophthalmol 23:705–17.
  • Mofidfar M, Abdi B, Ahadian S, et al. (2021). Drug delivery to the anterior segment of the eye: a review of current and future treatment strategies. Int J Pharm 607:120924.
  • Molokhia S, Papangkorn K, Butler C, et al. (2020). Transscleral iontophoresis for noninvasive ocular drug delivery of macromolecules. J Ocul Pharmacol Ther 36:247–56.
  • Moser M, Buchberger W, Mayer H, et al. (1991). Influence of an iodine-drinking cure on the antioxidative status of diabetic patients. Wien Klin Wochenschr 103:183–6.
  • Muñoz-Fernández S, Martín-Mola E. (2006). Uveitis. Best Pract Res Clin Rheumatol 20:487–505.
  • Murthy SI, Sabhapandit S, Balamurugan S, et al. (2020). Scleritis: differentiating infectious from non-infectious entities. Indian J Ophthalmol 68:1818–28.
  • Myles ME, Neumann DM, Hill JM. (2005). Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresis. Adv Drug Deliv Rev 57:2063–79.
  • Narayana RVL, Jana P, Tomar N, et al. (2021). Carboplatin- and etoposide-loaded lactoferrin protein nanoparticles for targeting cancer stem cells in retinoblastoma in vitro. Invest Ophthalmol Vis Sci 62:13.
  • Nevares A, Raut R, Libman B, et al. (2020). Noninfectious autoimmune scleritis: recognition, systemic associations, and therapy. Curr Rheumatol Rep 22:11.
  • O’Neil EC, Huang J, Suhler EB, et al. (2018). Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial. Br J Ophthalmol 102:1011–3.
  • Ortiz MV, Dunkel IJ. (2016). Retinoblastoma. J Child Neurol 31:227–36.
  • Pandey PC, Shukla S, Skoog SA, et al. (2019). Current advancements in transdermal biosensing and targeted drug delivery. Sensors 19:1028.
  • Parkinson TM, Ferguson E, Febbraro S, et al. (2003). Tolerance of ocular iontophoresis in healthy volunteers. J Ocul Pharmacol Ther 19:145–51.
  • Patane MA, Cohen A, From S, et al. (2011). Ocular iontophoresis of EGP-437 (dexamethasone phosphate) in dry eye patients: results of a randomized clinical trial. Clin Ophthalmol 5:633–43.
  • Patane MA, Schubert W, Sanford T, et al. (2013). Evaluation of ocular and general safety following repeated dosing of dexamethasone phosphate delivered by transscleral iontophoresis in rabbits. J Ocul Pharmacol Ther 29:760–9.
  • Perez VL, Wirostko B, Korenfeld M, et al. (2020). Ophthalmic drug delivery using iontophoresis: recent clinical applications. J Ocul Pharmacol Ther 36:75–87.
  • Pescina S, Ferrari G, Govoni P, et al. (2010). In-vitro permeation of bevacizumab through human sclera: effect of iontophoresis application. J Pharm Pharmacol 62:1189–94.
  • Pescina S, Govoni P, Antopolsky M, et al. (2015). Permeation of proteins, oligonucleotide and dextrans across ocular tissues: experimental studies and a literature update. J Pharm Sci 104:2190–202.
  • Port AD, Orlin A, Kiss S, et al. (2017). Cytomegalovirus retinitis: a review. J Ocul Pharmacol Ther 33:224–34.
  • Raghava S, Hammond M, Kompella UB. (2004). Periocular routes for retinal drug delivery. Expert Opin Drug Deliv 1:99–114.
  • Rahić O, Tucak A, Omerović N, et al. (2020). Novel drug delivery systems fighting glaucoma: formulation obstacles and solutions. Pharmaceutics 13:28.
  • Rao R, Honavar SG. (2017). Retinoblastoma. Indian J Pediatr 84:937–44.
  • Rieger G, Klieber M, Schimetta W, et al. (2010). The effect of iodide iontophoresis on the antioxidative capacity of the tear fluid. Graefes Arch Clin Exp Ophthalmol 248:1639–46.
  • Rong S, Wang C, Han B, et al. (2017). Iontophoresis-assisted accelerated riboflavin/ultraviolet A scleral cross-linking: a potential treatment for pathologic myopia. Exp Eye Res 162:37–47.
  • Rootman DS, Jantzen JA, Gonzalez JR, et al. (1988). Pharmacokinetics and safety of transcorneal iontophoresis of tobramycin in the rabbit. Invest Ophthalmol Vis Sci 29:1397–401.
  • Ruiz-Moreno JM, Thillaye B, de Kozak Y. (1992). Retino-choroidal changes in endotoxin-induced uveitis in the rat. Ophthalmic Res 24:162–8.
  • Saeedi P, Petersohn I, Salpea P, et al. (2019). Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9(th) edition. Diabetes Res Clin Pract 157:107843.
  • Sarraf D, Lee DA. (1994). The role of iontophoresis in ocular drug delivery. J Ocul Pharmacol 10:69–81.
  • Sheppard J, Garg S, Lievens C, et al. (2020). Iontophoretic dexamethasone phosphate compared to topical prednisolone acetate 1% for noninfectious anterior segment uveitis. Am J Ophthalmol 211:76–86.
  • Stern ME, Beuerman RW, Fox RI, et al. (1998). The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17:584–9.
  • Suzuki K, Namba K, Mizuuchi K, et al. (2021). Development of cytomegalovirus retinitis after negative conversion of cytomegalovirus antigenemia due to systemic antiviral therapy. Graefes Arch Clin Exp Ophthalmol 259:971–8.
  • Teo ZL, Tham YC, Yu M, et al. (2021). Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis. Ophthalmology 128:1580–91.
  • Thrimawithana TR, Young S, Bunt CR, et al. (2011). Drug delivery to the posterior segment of the eye. Drug Discov Today 16:270–7.
  • Tomi M, Hosoya K. (2010). The role of blood-ocular barrier transporters in retinal drug disposition: an overview. Expert Opin Drug Metab Toxicol 6:1111–24.
  • Vaka SR, Sammeta SM, Day LB, et al. (2008). Transcorneal iontophoresis for delivery of ciprofloxacin hydrochloride. Curr Eye Res 33:661–7.
  • Varela-Fernández R, Díaz-Tomé V, Luaces-Rodríguez A, et al. (2020). Drug delivery to the posterior segment of the eye: biopharmaceutic and pharmacokinetic considerations. Pharmaceutics 12:269.
  • Vinciguerra P, Montericcio A, Catania F, et al. (2021). New perspectives in keratoconus treatment: an update on iontophoresis-assisted corneal collagen crosslinking. Int Ophthalmol 41:1909–16.
  • Voigt M, de Kozak Y, Halhal M, et al. (2002). Down-regulation of NOSII gene expression by iontophoresis of anti-sense oligonucleotide in endotoxin-induced uveitis. Biochem Biophys Res Commun 295:336–41.
  • Voigt M, Kralinger M, Kieselbach G, et al. (2002). Ocular aspirin distribution: a comparison of intravenous, topical, and coulomb-controlled iontophoresis administration. Invest Ophthalmol Vis Sci 43:3299–306.
  • Wirostko B, Wong TY, Simó R. (2008). Vascular endothelial growth factor and diabetic complications. Prog Retin Eye Res 27:608–21.
  • Yannuzzi NA, Si N, Relhan N, et al. (2017). Endophthalmitis after clear corneal cataract surgery: outcomes over two decades. Am J Ophthalmol 174:155–9.
  • Yavuz B, Kompella UB. (2017). Ocular drug delivery. Handb Exp Pharmacol 242:57–93.
  • Yoshizumi MO, Lee DA, Sarraf DA, et al. (1995). Ocular toxicity of iontophoretic foscarnet in rabbits. J Ocul Pharmacol Ther 11:183–9.
  • Yoshizumi MO, Roca JA, Lee DA, et al. (1996). Ocular iontophoretic supplementation of intravenous foscarnet therapy. Am J Ophthalmol 122:86–90.
  • Zhao F, Fan S, Ghate D, et al. (2022). A hydrogel ionic circuit based high-intensity iontophoresis device for intraocular macromolecule and nanoparticle delivery. Adv Mater 34:e2107315.