Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation

References

• Abd El-Alim SH, Kassem AA, Basha M, Salama A. (2019). Comparative study of liposomes, ethosomes and transfersomes as carriers for enhancing the transdermal delivery of diflunisal: in vitro and in vivo evaluation. Int J Pharm 563:1–15. Epub 2019 Apr 2. PMID: 30951860.
   PubMedGoogle Scholar
• Abdulbaqi IM, Darwis Y, Khan NA, et al. (2016). Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials. Int J Nanomedicine 11:2279–304. PMID: 27307730; PMCID: PMC4887071.
   PubMed Web of Science ®Google Scholar
• Abidin L, Mujeeb M, Imam SS, et al. (2016). Enhanced transdermal delivery of luteolin via non-ionic surfactant-based vesicle: quality evaluation and anti-arthritic assessment. Drug Deliv 23:1079–84. Epub 2014 Aug 12. PMID: 25116512.
   PubMed Web of Science ®Google Scholar
• Adin SN, Gupta I, Ahad A, et al. (2022c). A developed high-performance thin-layer chromatography method for the determination of baicalin in Oroxylum indicum L. and its antioxidant activity. JPC-J Planar Chromat 35:383–93.
   Web of Science ®Google Scholar
• Adin SN, Gupta I, Ali A, et al. (2022d). Investigation on utility of some novel terpenes on transungual delivery of fluconazole for the management of onychomycosis. J Cosmet Dermatol 5103–5110.
   Google Scholar
• Adin SN, Gupta I, Aqil M, et al. (2022a). BBD driven optimization of extraction of therapeutically active xanthanoid mangiferin from Mangifera indica L. leaves and its antioxidant activity. Pharmacogn Res 15:84–93.
   Web of Science ®Google Scholar
• Adin SN, Gupta I, Aqil M, Mujeeb M. (2022b). Computer-aided Box- Behnken outlook towards optimization of extraction of baicalin from Oroxylum indicum L. stem barks. Pharmacogn Mag 18:808–814.
   Google Scholar
• Adin SN, Gupta I, Aqil M, et al. (2023). Application of QbD based approach in development and validation of RP-HPLC method for simultaneous estimation of Methotrexate and Baicalin in Dual-Drug Loaded Liposomes. Biomed Chromatogr e5581. Epub ahead of print. PMID: 36609805.
   Google Scholar
• Almoallim H, Al Saleh J, Badsha H, et al. (2021). A review of the prevalence and unmet needs in the management of rheumatoid arthritis in Africa and the Middle East. Rheumatol Ther 8:1–16. Epub 2020 Nov 23. PMID: 33226566; PMCID: PMC7991016.
   PubMed Web of Science ®Google Scholar
• Bhattacharyya S, Ahmmed SM, Saha BP, Mukherjee PK. (2014). Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics. J Sci Food Agric 94:1380–8.
   PubMed Web of Science ®Google Scholar
• Carita AC, Eloy JO, Chorilli M, et al. (2018). Recent advances and perspectives in liposomes for cutaneous drug delivery. Curr Med Chem 25:606–35. PMID: 28990515.
   PubMed Web of Science ®Google Scholar
• El Maghraby GM, Williams AC, Barry BW. (2004). Interactions of surfactants (edge activators) and skin penetration enhancers with liposomes. Int J Pharm 276:143–61. PMID: 15113622.
   PubMed Web of Science ®Google Scholar
• Gupta I, Adin SN, Aqil M, Mujeeb M, Sultana Y. (2022e). Investigation on utility of some novel terpenes on transungual delivery of terbinafine for the management of onychomycosis. Dermatol Pract Concept. e2022202. doi: 10.5826/dpc.1204a202.
   Google Scholar
• Gupta I, Adin SN, Aqil M, et al. (2022a). Quality by design-based development and validation of an HPLC method for simultaneous estimation of pregabalin and piperine in dual drug-loaded liposomes. Biomed Chromatogr 37:e5510.
   PubMed Web of Science ®Google Scholar
• Gupta I, Adin SN, Aqil M, et al. (2022d). COMPUTER-AIDED BOX–BEHNKEN OUTLOOK TOWARDS OPTIMIZATION OF EXTRACTION OF PIPERINE FROM PIPER LONGUM L. FRUITS. World J Pharm Res 11:439–1455.
   Google Scholar
• Gupta I, Adin SN, Aqil M, Mujeeb M. (2022c). QbD-based extraction of Naringin from Citrus sinensis L. peel and its antioxidant activity. Pharmacogn Res 15:145–54.
   Web of Science ®Google Scholar
• Gupta I, Adin SN, Aqil M, Mujeeb M. (2022b). High-performance thin-layer chromatography method development and validation for quantification of naringin in different extracts of Citrus sinensis L. and its antioxidant activity. JPC-J Planar Chromat 35:463–71.
   Web of Science ®Google Scholar
• Han D, Chen C, Zhang C, et al. (2010). Determination of mangiferin in rat plasma by liquid-liquid extraction with UPLCeMS/MS. J Pharm Biomed Anal 51:260–3.
   PubMed Web of Science ®Google Scholar
• Hughes SD, Ketheesan N, Haleagrahara N. (2017). The therapeutic potential of plant flavonoids on rheumatoid arthritis. Crit Rev Food Sci Nutr 57:3601–13. PMID: 27874281.
   PubMed Web of Science ®Google Scholar
• Jyotshna, Khare P, Shanker K. (2016). Mangiferin: a review of sources and interventions for biological activities. Biofactors 42:504–14.
   PubMed Web of Science ®Google Scholar
• Liu XY, Xu L, Wang Y, et al. (2017). Protective effects of total flavonoids of Astragalus against adjuvant-induced arthritis in rats by regulating OPG/RANKL/NF-κB pathway. Int Immunopharmacol 44:105–14. Epub 2017 Jan 13. PMID: 28092862.
   PubMed Web of Science ®Google Scholar
• Luczkiewicz P, Kokotkiewicz A, Dampc A, Luczkiewicz M. (2014). Mangiferin: a promising therapeutic agent for rheumatoid arthritis treatment. Med Hypotheses 83:570–4.
   PubMed Web of Science ®Google Scholar
• Mir-Palomo S, Nácher A, Díez-Sales O, et al. (2016). Inhibition of skin inflammation by baicalin ultradeformable vesicles. Int J Pharm 511:23–9. Epub 2016 Jun 30. PMID: 27374324.
   PubMed Web of Science ®Google Scholar
• Moolakkadath T, Aqil M, Ahad A, et al. (2018). Development of transethosomes formulation for dermal fisetin delivery: Box-Behnken design, optimization, in vitro skin penetration, vesicles-skin interaction and dermatokinetic studies. Artif Cells Nanomed Biotechnol 46:755–65. Epub 2018 May 7. PMID: 29730964.
   PubMed Web of Science ®Google Scholar
• Qindeel M, Ullah MH, Ahmed N, et al. (2020). Recent trends, challenges and future outlook of transdermal drug delivery systems for rheumatoid arthritis therapy. J Control Release 327:595–615. Epub 2020 Sep 11. PMID: 32920080.
   PubMed Web of Science ®Google Scholar
• Song CK, Balakrishnan P, Shim CK, et al. (2012). A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: characterization and in vitro/in vivo evaluation. Colloids Surf B Biointerfaces 92:299–304. Epub 2011 Dec 17. PMID: 22205066.
   PubMed Web of Science ®Google Scholar
• Tang BZ, En QX, Tai PH. (2014). Ultrasound-assisted extraction of mangiferin from mango (Mangifera indica L.) leaves using response surface methodolo- gy. Molecules 19:1411–21.
   PubMed Web of Science ®Google Scholar
• Tekko IA, Chen G, Domínguez-Robles J, et al. (2020). Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate. Int J Pharm 586:119580. Epub 2020 Jun 25. PMID: 32593650.
   PubMed Web of Science ®Google Scholar
• Touitou E, Dayan N, Bergelson L, et al. (2000). Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release 65:403–18. PMID: 10699298.
   PubMed Web of Science ®Google Scholar
• Wei Y, Guo J, Zheng X, et al. (2014). Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes. Int J Nanomedicine 9:3623–30. PMID: 25120360; PMCID: PMC4128791.
   PubMed Web of Science ®Google Scholar