Utilization of experimental design in the formulation and optimization of hyaluronic acid–based nanoemulgel loaded with a turmeric–curry leaf oil nanoemulsion for gingivitis

References

• Alexander A, Khichariya A, Gupta S, et al. (2013). Recent expansions in an emergent novel drug delivery technology: Emulgel. J Control Release 171:1–15.
   PubMed Web of Science ®Google Scholar
• Alhakamy NA, Hosny KM, Aldryhim AY, et al. (2022). Development and optimization of ofloxacin as solid lipid nanoparticles for enhancement of its ocular activity. J Drug Deliv Sci and Technol 72:103373.
   Web of Science ®Google Scholar
• Ammon HP, Safayhi H, Mack T, Sabieraj J. (1993). Mechanism of anti‑inflammatory actions of curcumin and boswellic acids. J Ethnopharmacol 38:113–95.
   PubMed Web of Science ®Google Scholar
• Ashrafizadeh M, Rafiei H, Mohammadinejad R, et al. (2020). Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: a review. Phytother Res 34:1745–60.
   PubMed Web of Science ®Google Scholar
• Azeem A, Rizwan M, Ahmad FJ, et al. (2009). Nanoemulsion components screening and selection: a technical note. AAPS PharmSciTech 10:69–76.
   PubMed Web of Science ®Google Scholar
• Baiju RM, Peter E, Varghese NO, Sivaram R. (2017). Oral health and quality of life: current concepts. J Clin Diagn Res 11:ZE21–ZE26.
   PubMed Web of Science ®Google Scholar
• Blicher B, Joshipura K, Eke P. (2005). Validation of self-reported periodontal disease: a systematic review. J Dent Res 84:881–90.
   PubMed Web of Science ®Google Scholar
• Califano JV. (2003). Position paper: periodontal diseases of children and adolescents. J Periodontol 74:1696–704. 7.
   PubMed Web of Science ®Google Scholar
• Chainani-Wu N. (2003). Safety and anti‑inflammatory activity of curcumin: a component of turmeric (Curcuma longa). J Altern Complement Med 9:161–8.
   PubMed Web of Science ®Google Scholar
• Chaturvedi TP. (2009). Uses of turmeric in dentistry: an update. Indian J Dent Res 20:107–9.
   PubMedGoogle Scholar
• Chen M, Li L, Wang Z, et al. (2019). High molecular weight hyaluronic acid regulates P. gingivalis–induced inflammation and migration in human gingival fibroblasts via MAPK and NF-kB signaling pathway. Arch Oral Biol 98:75–80.
   PubMed Web of Science ®Google Scholar
• Choi SJ, McClements DJ. (2020). Nanoemulsions as delivery systems for lipophilic nutraceuticals: strategies for improving their formulation, stability, functionality and bioavailability. Food Sci Biotechnol 29:149–68.
   PubMed Web of Science ®Google Scholar
• Çıkrıkçı S, Mozioglu E, Yılmaz H. (2008). Biological activity of curcuminoids isolated from Curcuma longa. Rec Nat Prod 2:19–24.
   Google Scholar
• Date AA, Desai N, Dixit R, Nagarsenker M. (2010). Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine 5:1595–616.
   PubMed Web of Science ®Google Scholar
• Erkan N, Tao Z, Rupasinghe HPV, et al. (2012). Antibacterial activities of essential oils extracted from leaves of Murraya koenigii by solvent-free microwave extraction and hydro-distillation. Nat Prod Commun 7:121–4.
   PubMed Web of Science ®Google Scholar
• Friedman PM, Mafong EA, Kauvar AN, Geronemus RG. (2002). Safety data of injectable nonanimal stabilized hyaluronic acid gel for soft tissue augmentation. Dermatol Surg 28:491–4.
   PubMed Web of Science ®Google Scholar
• Gao Y, Zhuang Z, Lu Y, et al. (2019). Curcumin mitigates neuro-inflammation by modulating microglia polarization through inhibiting TLR4 axis signaling pathway following experimental subarachnoid hemorrhage. Front Neurosci 13:1223.
   PubMed Web of Science ®Google Scholar
• Gift HC, Atchinson KA. (1995). Oral health, health and health related quality of life. Medical Care 33:557–77.
   Web of Science ®Google Scholar
• Goa KL, Benfield P. (1994). Hyaluronic acid. Drugs 47:536–66.
   PubMed Web of Science ®Google Scholar
• Gupta S, George M, Singhal M, et al. (2010). Leaves extract of murraya koenigii linn for anti-inflammatory and analgesic activity in animal models. J Adv Pharm Technol Res 1:68–77. Jan
   PubMedGoogle Scholar
• Hosny KM, Alhakamy NA, Sindi AM, et al. (2020). Coconut oil nanoemulsion loaded with a statin hypolipidemic drug for management of burns: formulation and in vivo evaluation. Pharmaceutics 12:1061.
   PubMed Web of Science ®Google Scholar
• Hosny KM, Khallaf RA, Asfour HZ, et al. (2021). Development and optimization of cinnamon oil nanoemulgel for enhancement of solubility and evaluation of antibacterial, antifungal and analgesic effects against oral microbiota. Pharmaceutics 13:1008.
   PubMed Web of Science ®Google Scholar
• Hosny KM, Sindi AM, Alkhalidi HM, et al. (2021). Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain. Drug Deliv 28:741–51.
   PubMed Web of Science ®Google Scholar
• Hosny K, Asfour H, Rizg W, et al. (2021). Formulation, optimization, and evaluation of oregano oil nanoemulsions for the treatment of infections due to oral microbiota. Int J Nanomedicine 16:5465–78.,.
   PubMed Web of Science ®Google Scholar
• Jain Y. (2013). Clinical evaluation of 0.2% hyaluronic acid containing gel in the treatment of gingivitis. Med J Dr. DY Patil Univ 6:416–20.
   Google Scholar
• Kahkhaie KR, Mirhosseini A, Aliabadi A, et al. (2019). Curcumin: a modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology 27:885–900.
   PubMed Web of Science ®Google Scholar
• Kaur S, Modi NH, Panda D, Roy N. (2010). Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ—a structural insight to unveil antibacterial activity of curcumin. Eur J Med Chem 45:4209–14.
   PubMed Web of Science ®Google Scholar
• Li Q, Sun J, Mohammadtursun N, et al. (2019). Curcumin inhibits cigarette smoke-induced inflammation via modulating the PPARgamma-NF-kappaB signaling pathway. Food Funct 10:7983–94.
   PubMed Web of Science ®Google Scholar
• Li X, Yin L, Ramage G, et al. (2019). Assessing the impact of curcumin on dual-species biofilms formed by Streptococcus mutans and Candida albicans. Microbiol Open 8:e937.
   Google Scholar
• Mahmoud EA, Bendas ER, Mohamed MI. (2010). Effect of formulation parameters on the preparation of superporous hydrogel self-nanoemulsifying drug delivery system (SNEDDS) of carvedilol. AAPS PharmSciTech 11:221–5.
   PubMed Web of Science ®Google Scholar
• Math MV, Balasubramaniam P. (2003). Curry leaves (Murraya koenigii Spreng) and halitosis. Br Med J 19:211.
   Google Scholar
• Medzhitov R, (2008). Origin and physiological roles of inflammation. Nature 4:428–35.
   Google Scholar
• Motterlini R, Foresti R, Bassi R, Green CJ. (2000). Curcumin, an antioxidant and anti‑inflammatory agent, induces heme oxygenase‑1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 28:1303–12.
   PubMed Web of Science ®Google Scholar
• Mudge E, Chan M, Venkataraman S, et al. (2016). Curcuminoids in turmeric roots and supplements: method optimization and validation. Food Anal Methods 9:1428–35.
   Web of Science ®Google Scholar
• Nguyen HA, Anderson CA, Miracle CM, Rifkin DE. (2017). The association between depression, perceived health status, and quality of life among individuals with chronic kidney disease: an analysis of the national health and nutrition examination survey 2011–2012. Nephron 136(2):127–35.
   Web of Science ®Google Scholar
• Nithya RJ, Gala VC, Chaaya SS. (2013). Inhibitory effects of plant extracts on multi-species dental biofilm formation-in vitro. Int J Pharma Bio Sci 4:487–95.
   Google Scholar
• Ouattara B, Simard RE, Holley RA, et al. (1997). Antibacterial activity of selected fatty acids and essential oils against six meat spoilage organisms. Int J Food Microbiol 37:155–62.
   PubMed Web of Science ®Google Scholar
• Oz M, Lozon Y, Sultan A, et al. (2015). Effects of monoterpenes on ion channels of excitable cells. Pharmacol Ther 152:83–97.
   PubMed Web of Science ®Google Scholar
• Patel VF, Liu F, Brown MB. (2011). Advances in oral transmucosal drug delivery. J Control Release 153:106–16.
   PubMed Web of Science ®Google Scholar
• Pavoni L, Perinelli DR, Bonacucina G, et al. (2020). An overview of micro- and nanoemulsions as vehicles for essential oils: formulation, preparation and stability. Nanomaterials (Basel) 10:135.
   PubMedGoogle Scholar
• Pinheiro LC, Tan X, Olshan AF, et al. (2017). Examining health-related quality of life patterns in women with breast cancer. Qual Life Res 26:1733–43.
   Google Scholar
• Rahimifard M, Maqbool F, Moeini-Nodeh S, et al. (2017). Targeting the TLR4 signaling pathway by polyphenols: a novel therapeutic strategy for neuroinflammation. Ageing Res Rev 36:11–9.
   PubMed Web of Science ®Google Scholar
• Rizg WY, Hosny KM, Elgebaly SS, et al. (2021). Preparation and optimization of garlic oil/apple cider vinegar nanoemulsion loaded with minoxidil to treat alopecia. Pharmaceutics 13:2150.
   PubMed Web of Science ®Google Scholar
• Salem HF, El-Menshawe SF, Khallaf RA, et al. (2020). A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension: optimization using Box-Benkhen design, in vitro and in vivo characterization. Drug Deliv Transl Res 10:227–40.
   PubMed Web of Science ®Google Scholar
• Salem HF, Nafady MM, Ewees MGE, et al. (2022). Rosuvastatin calcium-based novel nanocubic vesicles capped with silver nanoparticles-loaded hydrogel for wound healing management: optimization employing Box-Behnken design: in vitro and in vivo assessment. J Liposome Res 32:45–61.
   PubMed Web of Science ®Google Scholar
• Sapra B, Jain S, Tiwary AK. (2008). Percutaneous permeation enhancement by terpenes: mechanistic view. Aaps J 10:120–32.
   PubMed Web of Science ®Google Scholar
• Schwartzmann L. (2003). Quality of life related to health: conceptual aspects. Science Nurs 2:9–2.
   Google Scholar
• Sharifi S, Fathi N, Memar MY, et al. (2020). Anti-microbial activity of curcumin nanoformulations: new trends and future perspectives. Phytother Res 34:1926–46.
   PubMed Web of Science ®Google Scholar
• Sravani K, Suchetha A, Mundinamane DB, et al. (2015). Plant products in dental and periodontal disease: an overview. Int J Med Dent Sci 4:913–21.
   Google Scholar
• Sun H, Liu K, Liu W, et al. (2012). Development and characterization of a novel nanoemulsion drug-delivery system for potential application in oral delivery of protein drugs. Int J Nanomedicine 7:5529–43.
   PubMed Web of Science ®Google Scholar
• Tanaka T, Narazaki M, Kishimoto T. (2014). IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 6:a016295.
   PubMed Web of Science ®Google Scholar
• Teow SY, Liew K, Ali SA, et al. (2016). Antibacterial action of curcumin against Staphylococcus aureus: a brief review. J Trop Med 2016:2853045.
   PubMed Web of Science ®Google Scholar
• Toda S, Miyase T, Arich H. (1985). Natural antioxidants. Antioxidative compounds isolated from rhizome of Curcuma longa L. Chem Pharmacol Bul 33:1725–8.
   PubMed Web of Science ®Google Scholar
• Tyagi P, Singh M, Kumari H, et al. (2015). Bactericidal activity of curcumin is associated with damaging of bacterial membrane. PLoS ONE 10:e0121313.
   PubMed Web of Science ®Google Scholar
• Van der Velden U. (2006). The significance of supragingival plaque accumulation in periodontal disease. Int J Dent Hyg 4:11–4.
   PubMedGoogle Scholar
• WHOQoL Group. (1995). The World Health Organization quality of life assessment (WHOQoL): position paper from the World Health Organization. Soc Sci Med 41:1403–9.
   PubMed Web of Science ®Google Scholar
• Xiang J, Fang X, Li X. (2002). Transbuccal delivery of 2’,3’-dideoxycytidine: in vitro permeation study and histological investigation. Int J Pharm 231:57–66.
   PubMed Web of Science ®Google Scholar
• Yuan M, Niu J, Xiao Q, et al. (2022). Hyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacin. Drug Deliv 29:1232–42.
   PubMed Web of Science ®Google Scholar
• Yun DG, Lee DG. (2016). Antibacterial activity of curcumin via apoptosis-like response in Escherichia coli. Appl Microbiol Biotechnol 100:5505–14.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zheng Y, Luo Y, et al. (2019). Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-kappaB pathways in BV2 cells. Mol Immunol 116:29–37.
   PubMed Web of Science ®Google Scholar
• Zhu T, Chen Z, Chen G, et al. (2019). Curcumin attenuates asthmatic airway inflammation and mucus hypersecretion involving a PPARgamma-dependent NF-kappaB signaling pathway in vivo and in vitro. Mediators Inflamm 2019:4927430.
   PubMed Web of Science ®Google Scholar