Design and evaluation of in situ gel eye drops containing nanoparticles of Gemifloxacin Mesylate

References

• Abbas MN, Khan SA, Sadozai SK, et al. (2022). Nanoparticles loaded thermoresponsive in situ gel for ocular antibiotic delivery against bacterial keratitis. Polymers 14:1.
   Web of Science ®Google Scholar
• Almeida H, Amaral MH, Lobão P, et al. (2014a). Applications of polymeric and lipid nanoparticles in ophthalmic pharmaceutical formulations: present and future considerations. J Pharm Pharm Sci 17:278–11.
   PubMed Web of Science ®Google Scholar
• Almeida H, Amaral MH, Lobão P, Lobo JMS. (2014b). In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations. Drug Discov Today 19:400–12.
   PubMed Web of Science ®Google Scholar
• Almeida H, Amaral MH, Lobão P, Sousa Lobo JM. (2013). Applications of oloxamers in ophthalmic pharmaceutical formulations: an overview. Expert Opin Drug Deliv 10:1223–37.
   PubMed Web of Science ®Google Scholar
• Bodratti AM, Alexandridis P. (2018). Formulation of poloxamers for drug delivery. JFB 9:11–24.
   Google Scholar
• Bohrey S, Chourasiya V, Pandey A. (2016). Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study. Nano Converg 3:3–7.
   PubMed Web of Science ®Google Scholar
• Destruel PL, Zeng N, Brignole-Baudouin F, et al. (2020). In situ gelling ophthalmic drug delivery system for the optimization of diagnostic and preoperative mydriasis: in vitro drug release, cytotoxicity and mydriasis pharmacodynamics. Pharmaceutics 12:360–19.
   PubMed Web of Science ®Google Scholar
• Destruel PL, Zeng N, Maury M, et al. (2017). In vitro and in vivo evaluation of in situ gelling systems for sustained topical ophthalmic delivery: state of the art and beyond. Drug Discov Today 22:638–51.
   PubMed Web of Science ®Google Scholar
• Garala K, Joshi P, Shah M, et al. (2013). Formulation and evaluation of periodontal in situ gel. Int J Pharm Investig 3:29–41.
   PubMedGoogle Scholar
• Gouda AA, Amin AS, El-Sheikh R, Yousef AG. (2014). Spectrophotometric determination of gemifloxacin mesylate, moxifloxacin hydrochloride, and enrofloxacin in pharmaceutical formulations using Acid dyes. J Anal Methods Chem 2014:286379.
   PubMed Web of Science ®Google Scholar
• Hamed R, Kamal A, Zaid Alkilani A. Zaid Alkilani (2020). A gelation and rheological characterization of carbopol® in simulated gastrointestinal fluid of variable chemical properties. Pakistan Journal of Pharmaceutical Sciences 33:923–8.
   PubMed Web of Science ®Google Scholar
• Hani U, Osmani RAM, Alqahtani A, et al. (2021). 23 full factorial design for formulation and evaluation of floating oral in situ gelling system of piroxicam. J Pharm Innov 16:528–536.
   Web of Science ®Google Scholar
• Hani U, Rahamathulla M, Osmani RAM, et al. (2022). Development and characterization of oral raft forming in situ gelling system of neratinib anticancer drug using 32 factorial design. Polymers 14:2520.
   PubMed Web of Science ®Google Scholar
• Imam SS, Abbas Bukhari SN, Ahmad J, et al. (2018). Formulation and optimization of levofloxacin loaded chitosan nanoparticle for ocular delivery: in-vitro characterization, ocular tolerance and antibacterial activity. Int J Biol Macromol 108:650–9.,
   PubMed Web of Science ®Google Scholar
• Kirchhof S, Goepferich AM, Brandl FP. (2015). Hydrogels in ophthalmic applications. Eur J Pharm Biopharm 95:227–38.
   PubMed Web of Science ®Google Scholar
• Pandey M, Choudhury H, Aziz ABA, et al. (2021). Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research. Polymers 13:1340–62.
   PubMed Web of Science ®Google Scholar
• Paradkar MU, Parmar M. (2017). Formulation development and evaluation of natamycin niosomal in-situ gel for ophthalmic drug delivery. Undefined 39:113–22.
   Google Scholar
• Rahamathulla M, Hani U, Alqahtani A, et al. (2021a). 23 factorial design and optimization of effervescent floating matrix tablet of neratinib. J Pharm Innov 102788:2–9.
   Google Scholar
• Rahamathulla M, Saisivam S, Alshetaili A, et al. (2021b). Design and evaluation of losartan potassium effervescent floating matrix tablets: in vivo X-ray imaging and pharmacokinetic studies in albino rabbits. Polymers 13:3476.
   PubMed Web of Science ®Google Scholar
• Rajalakshmi R, Padmaja C, Radhika N, et al. (2013). Formulation and assessment of GM ocular In situ gelling system. Int Res J Pharm 4:33–8.
   Google Scholar
• Scoper SV. (2008). Review of third-and fourth-generation fluoroquinolones in ophthalmology: in-vitro and in-vivo efficacy. Adv Ther 25:979–94.
   PubMed Web of Science ®Google Scholar
• Shubhra QTH, Tóth J, Gyenis J, Feczkó T. (2014). Poloxamers for surface modification of hydrophobic drug carriers and their effects on drug delivery. Polym. Rev 54:112–38.
   Web of Science ®Google Scholar
• Silva MM, Calado R, Marto J, et al. (2017). D. Chitosan nanoparticles as a mucoadhesive drug delivery system for ocular administration. Mar Drugs 15, 370:2–16.
   Web of Science ®Google Scholar
• Tagalpallewar A, Rai P, Polshettiwar S, et al. (2021). Formulation, optimization and evaluation of ion triggered ophthalmic in situ gel. Pharm Res Int 33:58–77.
   Google Scholar
• Wang K, Han Z. (2017). Injectable hydrogels for ophthalmic applications. J Control Release 268:212–24.
   PubMed Web of Science ®Google Scholar
• Wu Y, Liu Y, Li X, et al. (2019). Research progress of in-situ gelling ophthalmic drug delivery system. Asian J Pharm Sci 14:1–15.
   PubMed Web of Science ®Google Scholar
• Wu Y, Yang W, Wang C, et al. (2005). Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate. Int J Pharm 295:235–245.
   PubMed Web of Science ®Google Scholar
• Youssef A, Dudhipala N, Majumdar S. (2020). Ciprofloxacin loaded ­nanostructured lipid carriers incorporated into in-situ gels to improve management of bacterial endophthalmitis. Pharmaceutics 12, 572:1–11.
   Web of Science ®Google Scholar