Oral administration of Huanglian-Houpo herbal nanoemulsion loading multiple phytochemicals for ulcerative colitis therapy in mice

References

• A N, Kovooru L, Behera AK, Kumar KPP, Srivastava P. (2021). A critical review of synthesis procedures, applications and future potential of nanoemulsions. Adv Colloid Interface Sci 287:1.
   Web of Science ®Google Scholar
• Blasi P, Giovagnoli S, Schoubben A, Puglia C, Bonina F, Rossi C, Ricci M. (2011). Lipid nanoparticles for brain targeting I. Formulation optimization. Int J Pharm 419:287–14.
   PubMed Web of Science ®Google Scholar
• Ding YF, Sun T, Li S, Huang Q, Yue L, Zhu L, Wang R. (2020). Oral colon-targeted konjac glucomannan hydrogel constructed through noncovalent cross-linking by cucurbit[8]uril for ulcerative colitis therapy. ACS Appl Bio Mater 3:10–9.
   PubMedGoogle Scholar
• Dou YX, Zhou JT, Wang TT, Huang YF, Chen VP, Xie YL, Lin ZX, Gao JS, Su ZR, Zeng HF. (2018). Self-nanoemulsifying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis. Int J Nanomedicine 13:5887–907.
   PubMed Web of Science ®Google Scholar
• El-Naggar ME, Hussein J, El-sayed SM, Youssef AM, El Bana M, Latif YA, Medhat D. (2020). Protective effect of the functional yogurt based on Malva parviflora leaves extract nanoemulsion on acetic acid-induced ulcerative colitis in rats. J Mater Res Technol 9:14500–8.
   Google Scholar
• Galvão KCS, Vicente AA, Sobral PJA. (2018). Development, characterization, and stability of O/W pepper nanoemulsions produced by high-pressure homogenization. Food Bioprocess Technol 11:355–67.
   Web of Science ®Google Scholar
• Gao Q, Feng J, Liu W, Wen C, Wu Y, Liao Q, Zou L, Sui X, Xie T, Zhang J, Hu Y. (2022). Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment. Adv Drug Deliv Rev 188:114445.
   PubMed Web of Science ®Google Scholar
• Geremia A, Biancheri P, Allan P, Corazza GR, Di Sabatino A. (2014). Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev 13:3–10.
   PubMed Web of Science ®Google Scholar
• Ghazy OA, Fouad MT, Saleh HH, Kholif AE, Morsy TA. (2021). Ultrasound-assisted preparation of anise extract nanoemulsion and its bioactivity against different pathogenic bacteria. Food Chem 341:128259.
   PubMed Web of Science ®Google Scholar
• Harun SN, Nordin SA, Gani SSA, Shamsuddin AF, Basri M, Basri HB. (2018). Development of nanoemulsion for efficient brain parenteral delivery of cefuroxime: designs, characterizations, and pharmacokinetics. Int J Nanomedicine 13:2571–84.
   PubMed Web of Science ®Google Scholar
• He Y, Chen Z, Nie X, Wang D, Zhang Q, Peng T, Zhang C, Wu D, Zhang J. (2022). Recent advances in polysaccharides from edible and medicinal Polygonati rhizoma: From bench to market. Int J Biol Macromol 195:102–16.
   PubMed Web of Science ®Google Scholar
• Hsu HY, Chen BH. (2022). A comparative study on inhibition of breast cancer cells and tumors in mice by carotenoid extract and nanoemulsion prepared from sweet potato (Ipomoea batatas L.) peel. Pharmaceutics 14:980.
   PubMed Web of Science ®Google Scholar
• Jacob EM, Borah A, Pillai SC, Kumar DS. (2020). Inflammatory bowel disease: The emergence of new trends in lifestyle and nanomedicine as the modern tool for pharmacotherapy. Nanomaterials 10:2460.
   Web of Science ®Google Scholar
• Jain S, Jain AK, Pohekar M, Thanki K. (2013). Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: implications for drug-induced cardiotoxicity and nephrotoxicity. Free Radic Biol Med 65:117–30.
   PubMed Web of Science ®Google Scholar
• Jain S, Kumar N, Sharma R, Date T, Bhargavi N, Chaudhari D, Katiyar SS. (2023). Self-nanoemulsifying formulation for oral delivery of sildenafil: effect on physicochemical attributes and in vivo pharmacokinetics. Drug Deliv Transl Res 13:839–51.
   PubMed Web of Science ®Google Scholar
• Jing W, Dong S, Luo X, Liu J, Wei B, Du W, Yang L, Luo H, Wang Y, Wang S, Lu H. (2021). Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Pharmacol Res 164:105358.
   PubMed Web of Science ®Google Scholar
• Kali G, Knoll P, Bernkop-Schnurch A. (2022). Emerging technologies to increase gastrointestinal transit times of drug delivery systems. J Control Release 346:289–99.
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Siegmund B, Le Berre C, Wei SC, Ferrante M, Shen B, Bernstein CN, Danese S, Peyrin-Biroulet L, Hibi T. (2020). Ulcerative colitis. Nat Rev Dis Primers 6:74.
   PubMed Web of Science ®Google Scholar
• Kumbhar SA, Kokare CR, Shrivastava B, Gorain B, Choudhury H. (2020). Preparation, characterization, and optimization of asenapine maleate mucoadhesive nanoemulsion using Box-Behnken design: In vitro and in vivo studies for brain targeting. Int J Pharm 586:119499.
   PubMedGoogle Scholar
• Kwon M, Lim DY, Lee CH, Jeon JH, Choi MK, Song IS. (2020). Enhanced intestinal absorption and pharmacokinetic modulation of berberine and its metabolites through the inhibition of P-glycoprotein and intestinal metabolism in rats using a berberine mixed micelle formulation. Pharmaceutics 12:882.
   PubMed Web of Science ®Google Scholar
• Li C, Ai G, Wang Y, Lu Q, Luo C, Tan L, Lin G, Liu Y, Li Y, Zeng H, Chen J, Lin Z, Xian Y, Huang X, Xie J, Su Z. (2020). Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-kappaB pathway. Pharmacol Res 152:104603.
   PubMed Web of Science ®Google Scholar
• Li Q, Zhai W, Jiang Q, Huang R, Liu L, Dai J, Gong W, Du S, Wu Q. (2015). Curcumin-piperine mixtures in self-microemulsifying drug delivery system for ulcerative colitis therapy. Int J Pharm 490:22–31.
   PubMed Web of Science ®Google Scholar
• Liu C, Jiang Y, Liu G, Guo Z, Jin Q, Long D, Zhou W, Qian K, Zhao H, Liu K. (2022). PPARGC1A affects inflammatory responses in photodynamic therapy (PDT)-treated inflammatory bowel disease (IBD). Biochem Pharmacol 202:115119.
   PubMed Web of Science ®Google Scholar
• Liu Y, Li BG, Su YH, Zhao RX, Song P, Li H, Cui XH, Gao HM, Zhai RX, Fu XJ, Ren X. (2022). Potential activity of Traditional Chinese Medicine against Ulcerative colitis: A review. J Ethnopharmacol 289:115084.
   PubMed Web of Science ®Google Scholar
• Liu R, Luo C, Pang Z, Zhang J, Ruan S, Wu M, Wang L, Sun T, Li N, Han L, Shi JJ, Huang YY, Guo WS, Peng SJ, Zhou WH, Gao HL. (2023). Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment. Chin Chem Lett 34:107518.
   Web of Science ®Google Scholar
• Ma Y, Yang J, Zhang Y, Zheng C, Liang Z, Lu P, Song F, Wang Y, Zhang J. (2022). Development of a naringenin microemulsion as a prospective ophthalmic delivery system for the treatment of corneal neovascularization: in vitro and in vivo evaluation. Drug Deliv 29:111–27.
   PubMed Web of Science ®Google Scholar
• Moolakkadath T, Aqil M, Ahad A, Imam SS, Praveen A, Sultana Y, Mujeeb M. (2020). Preparation and optimization of fisetin loaded glycerol based soft nanovesicles by Box-Behnken design. Int J Pharm 578:119125.
   PubMed Web of Science ®Google Scholar
• Okoshi K, Uekusa Y, Narukawa Y, Kiuchi F. (2021). Solubility enhancement of berberine-baicalin complex by the constituents of Gardenia Fruit. J Nat Med 75:76–83.
   PubMed Web of Science ®Google Scholar
• Qushawy M, Mortagi Y, Alshaman R, Mokhtar HI, Hisham FA, Alattar A, Liang D, Enan ET, Eltrawy AH, Alamrani ZH, Alshmrani, SA, Zaitone, SA. (2022). Formulation and characterization of O/W nanoemulsions of hemp seed oil for protection from steatohepatitis: analysis of hepatic free fatty acids and oxidation markers. Pharmaceuticals 15:864.
   Web of Science ®Google Scholar
• Ravanfar R, Tamaddon AM, Niakousari M, Moein MR. (2016). Preservation of anthocyanins in solid lipid nanoparticles: Optimization of a microemulsion dilution method using the Placket-Burman and Box-Behnken designs. Food Chem 199:573–80.
   PubMed Web of Science ®Google Scholar
• Shen P, Zhang Z, He Y, Gu C, Zhu K, Li S, Li Y, Lu X, Liu J, Zhang N, Cao Y. (2018). Magnolol treatment attenuates dextran sulphate sodium-induced murine experimental colitis by regulating inflammation and mucosal damage. Life Sci 196:69–76.
   PubMed Web of Science ®Google Scholar
• Shi H, Zhao X, Gao J, Liu Z, Liu Z, Wang K, Jiang J. (2020). Acid-resistant ROS-responsive hyperbranched polythioether micelles for ulcerative colitis therapy. Chin Chem Lett 31:3102–6.
   Web of Science ®Google Scholar
• Singh Y, Meher JG, Raval K, Khan FA, Chaurasia M, Jain NK, Chourasia MK. (2017). Nanoemulsion: Concepts, development and applications in drug delivery. J Control Release 252:28–49.
   PubMed Web of Science ®Google Scholar
• Subongkot T, Ngawhirunpat T. (2017). Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid. Int J Nanomedicine 12:5585–99.
   PubMed Web of Science ®Google Scholar
• Sun M, Ban W, Ling H, Yu X, He Z, Jiang Q, Sun J. (2022). Emerging nanomedicine and prodrug delivery strategies for the treatment of inflammatory bowel disease. Chin Chem Lett 33:4449–60.
   Web of Science ®Google Scholar
• Sun T, Kwong CHT, Gao C, Wei J, Yue L, Zhang J, Ye RD, Wang R. (2020). Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine. Theranostics 10:10106–19.
   PubMed Web of Science ®Google Scholar
• Tripathi CB, Parashar P, Arya M, Singh M, Kanoujia J, Kaithwas G, Saraf SA. (2018). QbD-based development of alpha-linolenic acid potentiated nanoemulsion for targeted delivery of doxorubicin in DMBA-induced mammary gland carcinoma: in vitro and in vivo evaluation. Drug Deliv Transl Res 8:1313–34.
   PubMed Web of Science ®Google Scholar
• Usach I, Alaimo A, Fernandez J, Ambrosini A, Mocini S, Ochiuz L, Peris JE. (2021). Magnolol and honokiol: two natural compounds with similar chemical structure but different physicochemical and stability properties. Pharmaceutics 13:224.
   PubMed Web of Science ®Google Scholar
• Wang X, Gu H, Zhang H, Xian J, Li J, Fu C, Zhang C, Zhang J. (2021). Oral core-shell nanoparticles embedded in hydrogel microspheres for the efficient site-specific delivery of magnolol and enhanced antiulcerative colitis therapy. ACS Appl Mater Interfaces 13:33948–61.
   PubMed Web of Science ®Google Scholar
• Wang J, Wang L, Lou GH, Zeng HR, Hu J, Huang QW, Peng W, Yang XB. (2019). Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. Pharm Biol 57:193–225.
   PubMed Web of Science ®Google Scholar
• Wu Y, Li J, Zhong X, Shi J, Cheng Y, He C, Li J, Zou L, Fu C, Chen M, Zhang J, Gao H. (2022). A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy. Asian J Pharm Sci 17:206–18.
   PubMed Web of Science ®Google Scholar
• Wu Q, Wei D, Dong L, Liu Y, Ren C, Liu Q, Chen C, Chen J, Pei J. (2019). Variation in the microbial community contributes to the improvement of the main active compounds of Magnolia officinalis Rehd. et Wils in the process of sweating. Chin Med 14:45.
   PubMed Web of Science ®Google Scholar
• Xie L, Feng S, Zhang X, Zhao W, Feng J, Ma C, Wang R, Song W, Cheng J. (2021). Biological response profiling reveals the functional differences of main alkaloids in rhizoma coptidis. Molecules 26:7389.
   PubMed Web of Science ®Google Scholar
• Xie Q, Li H, Ma R, Ren M, Li Y, Li J, Chen H, Chen Z, Gong D, Wang J. (2022). Effect of Coptis chinensis franch and Magnolia officinalis on intestinal flora and intestinal barrier in a TNBS-induced ulcerative colitis rats model. Phytomedicine 97:153927.
   PubMed Web of Science ®Google Scholar
• Yang M, Yang C, Zhang Y, Yan X, Ma Y, Zhang Y, Cao Y, Xu Q, Tu K, Zhang M. (2022). An oral pH-activated “nano-bomb” carrier combined with berberine by regulating gene silencing and gut microbiota for site-specific treatment of ulcerative colitis. Biomater Sci 10:1053–67.
   PubMed Web of Science ®Google Scholar
• Yen CC, Chen YC, Wu MT, Wang CC, Wu YT. (2018). Nanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide. Int J Nanomedicine 13:669–80.
   PubMed Web of Science ®Google Scholar
• Zeng F, Wang D, Tian Y, Wang M, Liu R, Xia Z, Huang Y. (2021). Nanoemulsion for improving the oral bioavailability of hesperetin: formulation optimization and absorption mechanism. J Pharm Sci 110:2555–61.
   PubMed Web of Science ®Google Scholar
• Zhang C, Chen Z, He Y, Xian J, Luo R, Zheng C, Zhang J. (2021). Oral colon-targeting core-shell microparticles loading curcumin for enhanced ulcerative colitis alleviating efficacy. Chin Med 16:92.
   PubMed Web of Science ®Google Scholar
• Zhang C, Li J, Xiao M, Wang D, Qu Y, Zou L, Zheng C, Zhang J. (2022). Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy. Chin Chem Lett 33:4924–9.
   Web of Science ®Google Scholar
• Zhang C, Wang X, Xiao M, Ma J, Qu Y, Zou L, Zhang J. (2022). Nano-in-micro alginate/chitosan hydrogel via electrospray technology for orally curcumin delivery to effectively alleviate ulcerative colitis. Materials & Design 221:110894.
   Web of Science ®Google Scholar
• Zhang FL, Yin XJ, Yan YL, Wu QF. (2022). Pharmacokinetics and pharmacodynamics of Huanglian-Houpo decoction based on berberine hydrochloride and magnolol against H1N1 influenza virus. Eur J Drug Metab Pharmacokinet 47:57–67.
   PubMed Web of Science ®Google Scholar
• Zhang CL, Zhang S, He WX, Lu JL, Xu YJ, Yang JY, Liu D. (2017). Baicalin may alleviate inflammatory infiltration in dextran sodium sulfate-induced chronic ulcerative colitis via inhibiting IL-33 expression. Life Sci 186:125–32.
   PubMed Web of Science ®Google Scholar
• Zhang S, Zhao Y, Tan L, Wu S, Zhang Q, Zhao B, Li G. (2022). A novel berberine-glycyrrhizic acid complex formulation enhanced the prevention effect to doxorubicin-induced cardiotoxicity by pharmacokinetic modulation of berberine in rats. Front Pharmacol 13:891829.
   PubMed Web of Science ®Google Scholar
• Zhao L, Xiao HT, Mu HX, Huang T, Lin ZS, Zhong LLD, Zeng GZ, Fan BM, Lin CY, Bian ZX. (2017). Magnolol, a natural polyphenol, attenuates dextran sulfate sodium-induced colitis in mice. Molecules 22:1218.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Xu G, Ni Q, Wang Y, Gao Q, Zhang Y. (2022). Microemulsion delivery system improves cellular uptake of genipin and its protective effect against Abeta1-42-induced PC12 cell cytotoxicity. Pharmaceutics 14:617.
   PubMed Web of Science ®Google Scholar
• Zhong Y, Xiao Q, Li S, Chen L, Long J, Fang W, Yu F, Huang J, Zhao H, Liu D. (2022). Bupi Yichang Pill alleviates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the homeostasis of follicular helper T cells. Phytomedicine 100:154091.
   PubMed Web of Science ®Google Scholar
• Zhu P, He J, Huang S, Han L, Chang C, Zhang W. (2021). Encapsulation of resveratrol in zein-polyglycerol conjugate stabilized O/W nanoemulsions: Chemical stability, in vitro gastrointestinal digestion, and antioxidant activity. Lwt 149:112049.
   Web of Science ®Google Scholar
• Zoya I, He HS, Wang LT, Qi JP, Lu Y, Wu W. (2021). The intragastrointestinal fate of paclitaxel-loaded micelles: Implications on oral drug delivery. Chin Chem Lett 32:1545–9.
   Web of Science ®Google Scholar