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Research Article

Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions

ORCID Icon, , , , &
Article: 2254530 | Received 28 Feb 2023, Accepted 26 Aug 2023, Published online: 05 Sep 2023

References

  • Abdel Hamid HM, Darwish ZE, Elsheikh SM, et al. (2021). Following cytotoxic nanoconjugates from injection to halting the cell cycle machinery and its therapeutic implications in oral cancer. BMC Cancer 21:1. doi: 10.1186/s12885-021-07849-x.
  • Ahmed IS, Elnahas OS, Assar NH, et al. (2020). Nanocrystals of fusidic acid for dual enhancement of dermal delivery and antibacterial activity: in vitro, ex vivo and in vivo evaluation. Pharmaceutics 12:199. doi: 10.3390/pharmaceutics12030199.
  • Ahmed MA, Abdelgawad WY, Gad MK, Mohamed MI. (2021). A novel approach for the treatment of oral ulcerative lesion using mucoadhesive proniosome gel. J Drug Delivery Sci Technol 63:102460. doi: 10.1016/j.jddst.2021.102460.
  • Alhallak M, Karpukhina N, Patel M. (2023). Triamcinolone acetonide release modelling from novel bilayer mucoadhesive films: an in vitro study. Dent Mater 39:595–19. doi: 10.1016/j.dental.2023.04.005.
  • Allam AN, Hamdallah SI, Abdallah OY. (2017). Chitosan-coated diacerein nanosuspensions as a platform for enhancing bioavailability and lowering side effects: preparation, characterization, and ex vivo/in vivo evaluation. Int J Nanomedicine 12:4733–45. doi: 10.2147/IJN.S139706.
  • Alqahtani WS, Almufareh NA, Al-Johani HA, et al. (2020). Oral and oropharyngeal cancers and possible risk factors across gulf cooperation council countries: a systematic review. World J Oncol 11:173–81. doi: 10.14740/wjon1283.
  • Alqalshy EM, Ibrahim AM, Abdel-Hafiz AA-S, et al. (2022). Effect of docosahexaenoic acid as a chemopreventive agent on experimentally induced hamster buccal pouch carcinogenesis. Cancer Treat Res Commun 31:100558. doi: 10.1016/j.ctarc.2022.100558.
  • Alshweiat A. (2020). Development and characterization of loratadine nanosystems for intranasal delivery using quality by design approach. PhD thesis, Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of pharmacy, University of Szeged. doi:10.14232/phd.10508.
  • Alshweiat A, Katona G, Csoka I, Ambrus R. (2018). Design and characterization of loratadine nanosuspension prepared by ultrasonic-assisted precipitation. Eur J Pharm Sci 122:94–104. doi: 10.1016/j.ejps.2018.06.010.
  • Andrade AO, Parente ME, Ares G. (2014). Screening of mucoadhesive vaginal gel formulations. Braz J Pharm Sci 50:931–41. doi: 10.1590/S1984-82502014000400029.
  • Atia NM, Hazzah HA, Gaafar PME, Abdallah OY. (2019). Diosmin nanocrystal-loaded wafers for treatment of diabetic ulcer: in vitro and in vivo evaluation. J Pharm Sci 108:1857–71. doi: 10.1016/j.xphs.2018.12.019.
  • Balasubramanian R, Kim SS, Lee J. (2018). Novel synergistic transparent k-carrageenan/xanthan gum/gellan gum hydrogel film: mechanical, thermal and water barrier properties. Int J Biol Macromol 118:561–8. doi: 10.1016/j.ijbiomac.2018.06.110.
  • Ball R, Bajaj P, Whitehead K. (2017). Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization. Int J Nanomedicine 12:305–15. Volume doi: 10.2147/ijn.s123062.
  • Bertram U, Bodmeier R. (2006). In situ gelling, bioadhesive nasal inserts for extended drug delivery: In vitro characterization of a new nasal dosage form. Eur J Pharm Sci 27:62–71. doi: 10.1016/j.ejps.2005.08.005.
  • Cazorla-Luna R, Martín-Illana A, Notario-Pérez F, et al. (2021). Naturally occurring polyelectrolytes and their use for the development of complex-based mucoadhesive drug delivery systems: an overview. Polymers 13:2241. doi: 10.3390/polym13142241.
  • Chavan DU, Marques SM, Bhide PJ, et al. (2020). Rapidly dissolving felodipine nanoparticle strips-formulation using design of experiment and characterisation. J Drug Delivery Sci Technol 60:102053. doi: 10.1016/j.jddst.2020.102053.
  • Chen Q, Dan H, Pan W, et al. (2021). Management of oral leukoplakia: a position paper of the Society of Oral Medicine, Chinese Stomatological Association. Oral Surg Oral Med Oral Pathol Oral Radiol 132:32–43. doi: 10.1016/j.oooo.2021.03.009.
  • Chhaparwal Y, M Pai K, Kamath M. s, et al. (2018). Efficacy and safety of tetrahydrocurcuminoid in the treatment of oral leukoplakia: a pilot study. Asian J Pharm Clin Res 11:194. doi: 10.22159/ajpcr.2018.v11i12.28107.
  • Council NR. (2010). Guide for the care and use of laboratory animals. https://grants.nih.gov/grants/olaw/guide-for-the-care-and-use-of-laboratory-animals.pdf
  • Elnaggar YS, Shehata EM, Galal S, Abdallah OY. (2017). Self-emulsifying preconcentrates of daidzein-phospholipid complex: design, in vitro and in vivo appraisal. Nanomedicine 12:893–910. doi: 10.2217/nnm-2016-0387.
  • Essawy MM, El-Sheikh SM, Raslan HS, et al. (2021). Function of gold nanoparticles in oral cancer beyond drug delivery: implications in cell apoptosis. Oral Dis 27:251–65. doi: 10.1111/odi.13551.
  • Farias S, Boateng JS. (2020). In vitro, ex vivo and in vivo evaluation of taste masked low dose acetylsalicylic acid loaded composite wafers as platforms for buccal administration in geriatric patients with dysphagia. Int J Pharm 589:119807. doi: 10.1016/j.ijpharm.2020.119807.
  • Farooq MA, Xu L, Aquib M, et al. (2020). Denatured food protein-coated nanosuspension: a promising approach for anticancer delivery of hydrophobic drug. J Mol Liq 303:112690. doi: 10.1016/j.molliq.2020.112690.
  • Freag MS, Saleh WM, Abdallah OY. (2018). Laminated chitosan-based composite sponges for transmucosal delivery of novel protamine-decorated tripterine phytosomes: ex-vivo mucopenetration and in-vivo pharmacokinetic assessments. Carbohydr Polym 188:108–20. doi: 10.1016/j.carbpol.2018.01.095.
  • Gangwar SK, Kumar A, Jose S, et al. (2022). Nuclear receptors in oral cancer-emerging players in tumorigenesis. Cancer Lett 536:215666. doi: 10.1016/j.canlet.2022.215666.
  • Gao F, Chen M, Yu J, et al. (2022). Tetrahydrocurcumin protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis. J Funct Foods 89:104957. doi: 10.1016/j.jff.2022.104957.
  • Ha J-M, Kang S-Y, Park C-W, et al. (2012). Effect of poloxamer on physicochemical properties of tacrolimus solid dispersion improving water solubility and dissolution rate. Journal of Pharmaceutical Investigation 42:171–6. doi: 10.1007/s40005-012-0025-4.
  • Habibi N, Bissonnette C, Pei P, et al. (2023). Mucopenetrating janus nanoparticles for field-coverage oral cancer chemoprevention. Pharm Res 40:749–64. doi: 10.1007/s11095-022-03465-x.
  • Hazzah HA, Farid RM, Nasra MMA, et al. (2015). Lyophilized sponges loaded with curcumin solid lipid nanoparticles for buccal delivery: development and characterization. Int J Pharm 492:248–57. doi: 10.1016/j.ijpharm.2015.06.022.
  • Jacob S, Nair AB, Shah J. (2020). Emerging role of nanosuspensions in drug delivery systems. Biomater Res 24:3. doi: 10.1186/s40824-020-0184-8.
  • Jain D, Athawale R, Bajaj A, et al. (2013). Studies on stabilization mechanism and stealth effect of poloxamer 188 onto PLGA nanoparticles. Colloids Surf B Biointerfaces 109:59–67. doi: 10.1016/j.colsurfb.2013.03.027.
  • Jongjitphisut N, Thitikornpong W, Wichitnithad W, et al. (2023). A stability-indicating assay for tetrahydrocurcumin-diglutaric acid and its applications to evaluate bioaccessibility in an in vitro digestive model. Molecules 28:1678. doi: 10.3390/molecules28041678.
  • Kalam MA, Iqbal M, Alshememry A, et al. (2022). Fabrication and characterization of tedizolid phosphate nanocrystals for topical ocular application: improved solubilization and in vitro drug release. Pharmaceutics 14:1328. doi: 10.3390/pharmaceutics14071328.
  • Kassem MAA, ElMeshad AN, Fares AR. (2015). Lyophilized sustained release mucoadhesive chitosan sponges for buccal buspirone hydrochloride delivery: formulation and in vitro evaluation. AAPS PharmSciTech 16:537–47. doi: 10.1208/s12249-014-0243-3.
  • Kéri O, Kocsis E, Nagy ZK, et al. (2018). Preparation of AL2O3 coated PVA and PVP nanofibers and AL2O3 nanotubes by electrospinning and atomic layer deposition. Rev Roum Chim 63:401–6.
  • Keshk AA, Elsayed NH, Zareh MM, et al. (2023). Kappa-carrageenan for benign preparation of CdSeNPs enhancing the electrochemical measurement of AC symmetric supercapacitor device based on neutral aqueous electrolyte. Int J Biol Macromol 234:123620. doi: 10.1016/j.ijbiomac.2023.123620.
  • Kianfar F, Ayensu I, Boateng JS. (2014). Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system. Drug Dev Ind Pharm 40:361–9. doi: 10.3109/03639045.2012.762655.
  • Kumar R, Siril PF. (2016). Preparation and characterization of polyvinyl alcohol stabilized griseofulvin nanoparticles. Mater Today: Proc 3:2261–7. doi: 10.1016/j.matpr.2016.04.135.
  • Lai C-S, Ho C-T, Pan M-H. (2020). The cancer chemopreventive and therapeutic potential of tetrahydrocurcumin. Biomolecules 10:831. doi: 10.3390/biom10060831.
  • Lai C-S, Wu J-C, Yu S-F, et al. (2011). Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis. Mol Nutr Food Res 55:1819–28. doi: 10.1002/mnfr.201100290.
  • Li Q, Chen F, Liu Y, et al. (2018). A novel albumin wrapped nanosuspension of meloxicam to improve inflammation-targeting effects. Int J Nanomedicine 13:4711–25. doi: 10.2147/ijn.s160714.
  • Lin H-W, Chen T-C, Yeh J-H, et al. (2022). Suppressive effect of tetrahydrocurcumin on pseudomonas aeruginosa lipopolysaccharide-induced inflammation by suppressing JAK/STAT and Nrf2/HO-1 pathways in microglial cells. Oxid Med Cell Longev 2022:4978556. doi: 10.1155/2022/4978556.
  • Liu M, Wen C, Pan S. (2021). Modulator effect of mangiferin on biochemical characterization in 7,12-dimethylbenz[a]anthracene induced oral cancer in experimental hamsters. Vet Med Sci 7:2015–25. doi: 10.1002/vms3.500.
  • Liu W, Zhang Z, Lin G, et al. (2017). Tetrahydrocurcumin is more effective than curcumin in inducing the apoptosis of H22 cells via regulation of a mitochondrial apoptosis pathway in ascites tumor-bearing mice. Food Funct 8:3120–9. doi: 10.1039/c7fo00484b.
  • Lopez-Vidal L, Real JP, Real DA, et al. (2022). Nanocrystal-based 3D-printed tablets: semi-solid extrusion using melting solidification printing process (MESO-PP) for oral administration of poorly soluble drugs. Int J Pharm 611:121311. doi: 10.1016/j.ijpharm.2021.121311.
  • Loron A, Gardrat C, Tabary N, et al. (2021). Tetrahydrocurcumin encapsulation in cyclodextrins for water solubility improvement: synthesis, characterization and antifungal activity as a new biofungicide. Carbohydrate Polymer Technologies and Applications 2:100113. doi: 10.1016/j.carpta.2021.100113.
  • Mahajan HD, Desmukh SB, Sisode NR, et al. (2023). Development and evaluation of oral nanosuspension of rosuvastatin. J Biomed Eng 40:24–34.
  • Mehanna M, Elgindy N, Mohyeldin S. (2016). The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity. Int J Nanomedicine 11:2209–22. doi: 10.2147/ijn.s94089.
  • Meng X, Lu Y, Gao Y, et al. (2021). Chitosan/alginate/hyaluronic acid polyelectrolyte composite sponges crosslinked with genipin for wound dressing application. Int J Biol Macromol 182:512–23. doi: 10.1016/j.ijbiomac.2021.04.044.
  • Miranda CA, Beretta EM, Ferreira LA, et al. (2023). Role of biotransformation in the diazinon-induced toxicity in HepG2 cells and antioxidant protection by tetrahydrocurcumin. Toxicol Rep 10:32–9. doi: 10.1016/j.toxrep.2022.12.005.
  • Mohamed MS, Abdelhafez WA, Zayed G, Samy AM. (2019). Optimization, in-vitro release and in-vivo evaluation of gliquidone nanoparticles. AAPS PharmSciTech 21:35. doi: 10.1208/s12249-019-1577-7.
  • Mohammed MF, Sadeq ZA, Salih OS. (2022). Formulation and evaluation of mucoadhesive buccal tablet of Anastrozole. J Adv Pharm Educ Res 12:38–44. doi: 10.51847/lEmpSyVsbx.
  • Momin M, Kurhade S, Khanekar P, Mhatre S. (2016). Novel biodegradable hydrogel sponge containing curcumin and honey for wound healing. J Wound Care 25:364–72. doi: 10.12968/jowc.2016.25.6.364.
  • Moustafa MA, El-Refaie WM, Elnaggar YSR, et al. (2023). Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer. Int J Biol Macromol 241:124528. doi: 10.1016/j.ijbiomac.2023.124528.
  • Nandini DB, Rao RS, Hosmani J, et al. (2020). Novel therapies in the management of oral cancer: an update. Dis Mon 66:101036. doi: 10.1016/j.disamonth.2020.101036.
  • Ossama M, Lamie C, Tarek M, et al. (2021). Management of recurrent aphthous ulcers exploiting polymer-based muco-adhesive sponges: in-vitro and in-vivo evaluation. Drug Deliv 28:87–99. doi: 10.1080/10717544.2020.1858999.
  • Ou J, Gao Y, Li H, et al. (2022). Application of 5-aminolevulinic acid-mediated waterlase-assisted photodynamic therapy in the treatment of oral leukoplakia. Sci Rep 12:9391. doi: 10.1038/s41598-022-13497-3.
  • Oyapero A, Oyapero O, Akinleye A. (2020). Burden of tobacco, kola nut and alcohol consumption and its association with periodontal disease, potentially malignant lesions and quality of life among bus drivers, Lagos State, Nigeria. Popul Med 2:1–9. doi: 10.18332/popmed/118726.
  • Panatarani C, Praseptiangga D, Widjanarko PI, et al. (2023). Synthesis, characterization, and performance of semi-refined kappa carrageenan-based film incorporating cassava starch. Membranes 13:100. doi: 10.3390/membranes13010100.
  • Pandey A, Chaturvedi M, Mishra S, et al. (2020). Reductive metabolites of curcumin and their therapeutic effects. Heliyon 6:e05469. doi: 10.1016/j.heliyon.2020.e05469.
  • Panich AM, Salti M, Prager O, et al. (2021). PVP-coated Gd-grafted nanodiamonds as a novel and potentially safer contrast agent for in vivo MRI. Magn Reson Med 86:935–42. doi: 10.1002/mrm.28762.
  • Paredes da Rocha N, de Souza A, Nishitani Yukuyama M, et al. (2023). Highly water-soluble dapsone nanocrystals: Towards innovative preparations for an undermined drug. Int J Pharm 630:122428. doi: 10.1016/j.ijpharm.2022.122428.
  • Patel J, Maji B, Moorthy NSHN, Maiti S. (2020). Xanthan gum derivatives: review of synthesis, properties and diverse applications. RSC Adv 10:27103–36. doi: 10.1039/d0ra04366d.
  • Peleg-Evron O, Davidovich-Pinhas M, Bianco-Peled H. (2023). Crosslinking konjac-glucomannan with kappa-carrageenan nanogels: a step toward the design of sacrificial materials. Int J Biol Macromol 227:654–63. doi: 10.1016/j.ijbiomac.2022.12.092.
  • Pérez Zamora CM, Michaluk AG, Chiappetta DA, Nuñez MB. (2022). Herbal buccal films with in vitro antibacterial and anti-inflammatory effects. Journal of Herbal Medicine 31:100527. doi: 10.1016/j.hermed.2021.100527.
  • Pınar SG, Oktay AN, Karaküçük AE, Çelebi N. (2023). Formulation strategies of nanosuspensions for various administration routes. Pharmaceutics 15:1520. doi: 10.3390/pharmaceutics15051520.
  • Pourfarzad A, Ahmadian Z, Habibi-Najafi MB. (2018). Interactions between polyols and wheat biopolymers in a bread model system fortified with inulin: a Fourier transform infrared study. Heliyon 4:e01017. doi: 10.1016/j.heliyon.2018.e01017.
  • Prasad R, Dalvi SV. (2020). Sonocrystallization: monitoring and controlling crystallization using ultrasound. Chem Eng Sci 226:115911. doi: 10.1016/j.ces.2020.115911.
  • Pukale SS, Mittal A, Chitkara D. (2021). Topical application of vitamin D3-loaded hybrid nanosystem to offset imiquimod-induced psoriasis. AAPS PharmSciTech 22:238. doi: 10.1208/s12249-021-02116-5.
  • Ravikumar R, Ganesh M, Senthil V, et al. (2018). Tetrahydro curcumin loaded PCL-PEG electrospun transdermal nanofiber patch: preparation, characterization, and in vitro diffusion evaluations. J Drug Delivery Sci Technol 44:342–8. doi: 10.1016/j.jddst.2018.01.016.
  • Roi A, Roi CI, Negruțiu ML, et al. (2020). The challenges of OSCC diagnosis: salivary cytokines as potential biomarkers. J Clin Med 9:2866. doi: 10.3390/jcm9092866.
  • Rosso A, Andretto V, Chevalier Y, et al. (2021). Nanocomposite sponges for enhancing intestinal residence time following oral administration. J Control Release 333:579–92. doi: 10.1016/j.jconrel.2021.04.004.
  • Rudhziah S, Apandi NAA, Subban RHY, Mohamed NS. (2019). Ionic conductivity of biopolymer electrolytes based on seaweed kappa-carrageenan. Sci Lett 12(2):45–52. doi: 10.18332/popmed/118726.
  • Said M, Haq B, Al Shehri D, et al. (2021). Modification of xanthan gum for a high-temperature and high-salinity reservoir. Polymers 13:4212. doi: 10.3390/polym13234212.
  • Saini K, Modgill N, Singh K, Kakkar V. (2022). Tetrahydrocurcumin lipid nanoparticle based gel promotes penetration into deeper skin layers and alleviates atopic dermatitis in 2,4-dinitrochlorobenzene (DNCB) Mouse Model. Nanomaterials (Basel) 12:636. doi: 10.3390/nano12040636.
  • Santos A M d, Meneguin AB, Fonseca-Santos B, et al. (2020). The role of stabilizers and mechanical processes on physico-chemical and anti-inflammatory properties of methotrexate nanosuspensions. J Drug Delivery Sci Technol 57:101638. doi: 10.1016/j.jddst.2020.101638.
  • Shahine Y, El-Aal SAA, Reda AM, et al. (2023). Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance. Inflammopharmacology 31:1341–59. doi: 10.1007/s10787-023-01198-w.
  • Shaji J, Balakrishnan G, Halim N, et al. (2022). Oral potentially malignant disorders: mini review. JOENTR 14:44–7. doi: 10.15406/joentr.2022.14.00504.
  • Shehata EMM, Gowayed MA, El-Ganainy SO, et al. (2022). Pectin coated nanostructured lipid carriers for targeted piperine delivery to hepatocellular carcinoma. Int J Pharm 619:121712. doi: 10.1016/j.ijpharm.2022.121712.
  • Shiledar RR, Tagalpallewar AA, Kokare CR. (2014). Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan. Carbohydr Polym 101:1234–42. doi: 10.1016/j.carbpol.2013.10.072.
  • Shin M, Izumi S, Nakane PK. (1995). Multilayer peroxidase-labeled antibody method: comparison with labeled streptavidin-biotin method, avidin-biotin-peroxidase complex method, and peroxidase-antiperoxidase method. J Clin Lab Anal 9:424–30. doi: 10.1002/jcla.1860090615.
  • Sokolova EV, Chusovitin EA, Barabanova AO, et al. (2013). Atomic force microscopy imaging of carrageenans from red algae of Gigartinaceae and Tichocarpaceae families. Carbohydr Polym 93:458–65. doi: 10.1016/j.carbpol.2012.12.026.
  • Song G, Lu H, Chen F, et al. (2018). Tetrahydrocurcumin‑induced autophagy via suppression of PI3K/Akt/mTOR in non‑small cell lung carcinoma cells. Mol Med Rep 17:5964–9. doi: 10.3892/mmr.2018.8600.
  • Soroushnia A, Ganji F, Vasheghani-Farahani E, Mobedi H. (2022). Effect of combined stabilizers on midazolam nanosuspension properties. Iran Polym J 31:215–22. doi: 10.1007/s13726-021-00981-2.
  • Tang X, Dong Q, Li J, et al. (2021). Anti-melanogenic mechanism of tetrahydrocurcumin and enhancing its topical delivery efficacy using a lecithin-based nanoemulsion. Pharmaceutics 13:1185. doi: 10.3390/pharmaceutics13081185.
  • Tang X, Zhang M, Zhang H, et al. (2021). Evaluation of the bioaccessibility of tetrahydrocurcumin-hyaluronic acid conjugate using in vitro and ex vivo models. Int J Biol Macromol 182:1322–30. doi: 10.1016/j.ijbiomac.2021.05.086.
  • Trivedi MK, Panda P, Sethi KK, et al. (2020). Solid and liquid state characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS, and NMR and its biological activities. J Pharm Anal 10:334–45. doi: 10.1016/j.jpha.2020.02.005.
  • Truong TH, Alcantara KP, Bulatao BPI, et al. (2022). Chitosan-coated nanostructured lipid carriers for transdermal delivery of tetrahydrocurcumin for breast cancer therapy. Carbohydr Polym 288:119401. doi: 10.1016/j.carbpol.2022.119401.
  • Tsai Y-Z, Tsai M-L, Hsu L-Y, et al. (2021). Tetrahydrocurcumin upregulates the adiponectin-adipor pathway and improves insulin signaling and pancreatic β-cell function in high-fat diet/streptozotocin-induced diabetic obese mice. Nutrients 13(12):4552. doi: 10.3390/nu13124552.
  • Vairaktaris E, Spyridonidou S, Papakosta V, et al. (2008). The hamster model of sequential oral oncogenesis. Oral Oncol 44:315–24. doi: 10.1016/j.oraloncology.2007.08.015.
  • Wang C, Wang M, Chen P, et al. (2022). Dasatinib nanoemulsion and nanocrystal for enhanced oral drug delivery. Pharmaceutics 14:197. doi: 10.3390/pharmaceutics14010197.
  • Wang H, Khor TO, Shu L, et al. (2012). Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem 12:1281–305. doi: 10.2174/187152012803833026.
  • Wang Q, Yang X, Gu X, et al. (2022). Celecoxib nanocrystal-loaded dissolving microneedles with highly efficient for osteoarthritis treatment. Int J Pharm 625:122108. doi: 10.1016/j.ijpharm.2022.122108.
  • Wang Y, Wang C, Zhao J, et al. (2017). A cost-effective method to prepare curcumin nanosuspensions with enhanced oral bioavailability. J Colloid Interface Sci 485:91–8. doi: 10.1016/j.jcis.2016.09.003.
  • Wu X, Liu Y, Li X, et al. (2010). Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method. Acta Biomater 6:1167–77. doi: 10.1016/j.actbio.2009.08.041.
  • Xu C, Xiong Q-W, Li Y, et al. (2022). Explore the multitarget mechanism of tetrahydrocurcumin preventing on UV-induced photoaging mouse skin. Heliyon 8:e09888. doi: 10.1016/j.heliyon.2022.e09888.
  • Yahoum MM, Toumi S, Tahraoui H, et al. (2023). Formulation and evaluation of xanthan gum microspheres for the sustained release of metformin hydrochloride. Micromachines 14:609. doi: 10.3390/mi14030609.
  • Yapijakis C, Kalogera S, Papakosta V, Vassiliou S. (2019). The hamster model of sequential oral carcinogenesis: an update. In Vivo 33:1751–5. doi: 10.21873/invivo.11665.
  • Yermak IM, Davydova VN, Kravchenko AO, et al. (2020). Mucoadhesive properties of sulphated polysaccharides carrageenans from red seaweed families Gigartinaceae and Tichocarpaceae. Int J Biol Macromol 142:634–42. doi: 10.1016/j.ijbiomac.2019.10.005.
  • Youssef JR, Boraie NA, Ibrahim HF, et al. (2021). Glibenclamide nanocrystal-loaded bioactive polymeric scaffolds for skin regeneration: in vitro characterization and preclinical evaluation. Pharmaceutics 13:1469. doi: 10.3390/pharmaceutics13091469.
  • Yoysungnoen B, Bhattarakosol P, Patumraj S, Changtam C. (2015). Effects of tetrahydrocurcumin on hypoxia-inducible factor-1α and vascular endothelial growth factor expression in cervical cancer cell-induced angiogenesis in nude mice. Biomed Res Int 2015:391748. doi: 10.1155/2015/391748.
  • Yu W, Liu X, Cai D, et al. (2023). Regional distributions of curcumin and tetrahydrocurcumin in the liver and small intestine of rats when orally co-administered with quercetin and paeoniflorin. Biopharm Drug Dispos 44:183–91. doi: 10.1002/bdd.2346.
  • Zhang X, Li Z, Gao J, et al. (2020). Preparation of nanocrystals for insoluble drugs by top-down nanotechnology with improved solubility and bioavailability. Molecules 25:1080. doi: 10.3390/molecules25051080.
  • Zhang Y, Liu Y, Zou J, et al. (2017). Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma. Oncotarget 8:91134–49. doi: 10.18632/oncotarget.19845.
  • Zhang Z, Zhang R, Chen L, McClements DJ. (2016). Encapsulation of lactase (β-galactosidase) into κ-carrageenan-based hydrogel beads: Impact of environmental conditions on enzyme activity. Food Chem 200:69–75. doi: 10.1016/j.foodchem.2016.01.014.
  • Zhao Y, Baeza JA, Koteswara Rao N, et al. (2014). Unsupported PVA- and PVP-stabilized Pd nanoparticles as catalyst for nitrite hydrogenation in aqueous phase. J Catal 318:162–9. doi: 10.1016/j.jcat.2014.07.011.
  • Zhao Y, Li Y, Du Q, et al. (2019). Shape memory histocompatible and biodegradable sponges for subcutaneous defect filling and repair: greatly reducing surgical incision. J Mater Chem B 7:5848–60. doi: 10.1039/c9tb00902g.
  • Zheng M, Lian F, Xiong Y, et al. (2019). The synthesis and characterization of a xanthan gum-acrylamide-trimethylolpropane triglycidyl ether hydrogel. Food Chem 272:574–9. doi: 10.1016/j.foodchem.2018.08.083.
  • Zhou Y, Fang Q, Niu B, et al. (2018). Comparative studies on amphotericin B nanosuspensions prepared by a high pressure homogenization method and an antisolvent precipitation method. Colloids Surf B Biointerfaces 172:372–9. doi: 10.1016/j.colsurfb.2018.08.016.
  • Zhu L, Xue Y, Feng J, et al. (2023). Tetrahydrocurcumin as a stable and highly active curcumin derivative: A review of synthesis, bioconversion, detection and application. Food Biosci 53:102591. doi: 10.1016/j.fbio.2023.102591.