Specific Interaction with Hepatocytes and Acute Toxicity of New Carrier Molecule Galactosyl-Polylysine

REFERENCES

• Akaike, T., M. Goto, A. Maeda, and T. Shinoda. 1993. A galactopyranosyl - substituted poly-e-L-lysine. Japan patent 236790, 22 September.
   Google Scholar
• Connors, T. A., R. Duncan, and R. J. Knox. 1995. The chemotherap y of colon cancer. Eur. J. Cancer 31:1373– 1378.
   Google Scholar
• Dragsten, P. R., D. B. Mitchell, G. Covert, and T. Baker. 1987. Drug delivery using vesicles targeted to the hepatic asialoglycoprotei n receptor. Biochim. Biophys. Acta 926:270– 279.
   PubMed Web of Science ®Google Scholar
• Duncan, R., R. P. Kopeckova, J. Strohalm, I. Hume, H. C. Cable, J. Pohl, B. Lloyd, and J. Kopecek. 1987. Anticancer agents coupled to N -(2- hydroxypropyl) methacrylamid e copolymers, I. Evaluation of daunomyci n and puromyci n conjugate s in vitro. Br. J. Cancer 55:165–174.
   PubMed Web of Science ®Google Scholar
• Duncan, R., P. Kopeckova, J. Strohalm, I. C. Hume, J. B. Lloyd, and J. Kopecek. 1988. Anticancer agents coupled to N -(2-hydroxypropyl) methacrylamide copolymers. II. Evaluation of daunomyci n conjugate s in vivo against L1210 leukemia. Br. J. Cancer 55:147–156.
   Google Scholar
• Duncan, R., L. W. Seymour, K. B. O’Hare, P. A. Flanagan, S. Wedge, I. C. Hume, Ulbrich, J. Strohalm, V. Subr, F. Spreafico, M. Grandi, M. Ripamonti, M. Farao, and A. Suarato. 1992. Preclinical evaluation of polymer-boun d doxorubicin. J. Control. Release 19:331–346.
   Google Scholar
• Fujita, T., M. Nishikawa, C. Tamaki, Y. Takakura, M. Hashida, and H. Sezaki. 1992. Targeted deliver y of human recombinan t superoxide dismutase by chemical modification with mono- and polysaccharid e derivatives. J. Phar- macol. Exp. Ther. 263:971– 978.
   PubMed Web of Science ®Google Scholar
• Goto, M., H. Yura, C. W. Chang, A. Kobayashi, T. Shinoda, A. Maeda, S. Kojima, K. Kobayashi, and T. Akaike. 1994. Lactose-carryin g polystyrene as a drug carrier: Investigatio n of body distributions to parenchyma l liver cells using 125 I-labelled lactose-carryin g polystyrene. J. Control. Release 28:223- 233.
   Google Scholar
• Hashida, M., R. Atumi, K. Nishida, S. Nakane, Y. Takakura, and H. Sezaki. 1990. Biliary Excretion of mitomycin C dextran conjugate s in relation to physic- ochemical characteristics of carrier dextran. J. Pharmacobio-Dyn. 13:441- 447.
   Google Scholar
• Hirabayashi, H., M. Nishikawa, Y. Takakura, and M. Hashida. 1996. Devel- opment and pharmacokinetic s of galactosylated poly-l-glutamic acid as a biodegradabl e carriers for liver-specific drug delivery. Pharm. Res. 13:880- 884.
   Google Scholar
• Kollen, W. J. W., P. Midoux, P. Erbacher, A. Yip, A. C. Roche, M. Monsigny, M. C. Glick, and T. F. Scanlin. 1996. Gluconoylated and glycosylated polylysines as vectors for gene transfer into cystic fibrosis airway epithelial cells. Hum. Gene Ther. 7:1577–1586.
   PubMed Web of Science ®Google Scholar
• Mahato, R. I., S. Takemura, K. Akamatsu, M. Nishikawa, Y. Takakura, and M. Hashida. 1997. Physicochemica l and disposition characteristics of anti- sense oligonucleotide s complexe d with glycosylate d poly (l-lysine). Biochem. Pharmacol. 53:887–895.
   PubMed Web of Science ®Google Scholar
• Midoux, P., C. Mendes, A. Legrand, J. Raimond, R. Mayer, M. Monsigny, and A. C. Roche. 1993. Specific gene transfer mediated by lactosylated poly-L- lysine into hepatom a cells. Nucleic Acids Res. 21:871–878.
   PubMed Web of Science ®Google Scholar
• Nishikawa, M., Y. Ohtsubo, J. Ohno, T. Fujita, Y. Koyama, F. Yamashita, M. Hashida, and H. Sezaki. 1992a. Pharmacokinetic s of receptor-mediate d hepatic uptake of glycosylated albumin in mice. Int. J. Pharm. 85:75- 85.
   PubMedGoogle Scholar
• Nishikawa, M., F. Yamashita, Y. Takakura, M. Hashida, and H. Sezaki. 1992b. Demonstration of the receptor-mediate d hepati c uptake of dextran in mice. J. Pharm. Pharmacol. 44:396–401.
   PubMed Web of Science ®Google Scholar
• Nishikawa, M., H. Hirabayashi, Y. Takakura, and M. Hashida. 1995. Design for cell-specific targeting of protein utilizing sugar-recognitio n mechanism: Effect of molecular weight of proteins on targeting efficiency. Pharm. Res. 12:209–214.
   PubMed Web of Science ®Google Scholar
• Ogawara, K., M. Nishikawa, Y. Takakura, and M. Hashida. 1998. Pharmaco- kinetic analysi s of hepatic uptake of galactosylate d bovine serum albumin in a perfused rat liver. J. Control. Release 50:309–317.
   Google Scholar
• Oka, A., M. D. Christensen, and P. H. Weigel. 1989. Hyperosmolarit y inhibits galactosyl receptor-mediate d but not fluid phase endocytosi s in isolated rat hepatocytes. J. Biol. Chem. 264:12016– 12024.
   PubMed Web of Science ®Google Scholar
• Rohlff, C., G. Holt, S. Courtney, and J. Trepel. 1997. Enhanced liver specific ac- tivity of a glycan-conjugate d 5-FU for the treatment of hepatocellula r cancer. Proc. Am. Assoc. Cancer Res. 38:104.
   Google Scholar
• Seglen, P. O. 1976. Preparation of isolated rat liver cells. Methods Cell Biol. 13:29–83.
   PubMedGoogle Scholar
• Shinoda, T., A. Maeda, S. Kagatani, Y. Konno, M. Goto, T. Sonobe, and T. Akaike. 1998. Specific interaction with hepatocytes, acute toxicity and drug release of new carrier molecul e galactosyl-poly-glutamate. J. Control. Release
   Google Scholar
• Takakura, Y., T. Fujita, H. Furitsu, M. Nishikawa, H. Sezaki, and M. Hashida. 1994. Pharmacokinetic s of succinylated proteins and dextran sulfate in mice: Implications for hepatic targeting of protein drugs by direct succinylatio n via scavenge r receptors. Int. J. Pharm. 105:19- 29.
   Google Scholar
• Takakura, Y., T. Fujita, M. Hashida, and H. Sezaki. 1990. Disposition charac- teristics of macromolecule s in tumor-bearin g mice. Pharm. Res. 7:339–346.
   PubMed Web of Science ®Google Scholar
• Toyama, H., K. Ito, Y. Komori, A. Sugioka, K. Shibata, S. Komai, T. Fujiwara, E. Ishikawa, K. Tomita, and N. Fujii. 1995. Evaluation of the residual functiona l reserve and the early regeneratio n after the hepatic resec- tion using asialoglycoprotei n receptor imaging agent. Kaku Igaku 32:323- 329.
   Google Scholar
• Trouet, A., M. Masquelier, R. Baurain, and D. C. D. Deprez. 1982. A cova- lent linkage between daunorubici n and proteins that is stable in serum and reversible by lysosoma l hydrolases, as required for a lysosomotropi c drug- carrier conjugate: In vitro and in vivo studies. Proc. Natl. Acad. Sci. USA 79:626–629.
   PubMed Web of Science ®Google Scholar
• Williamson, J., F. T. J. Scott, M. A. Hardman, and J. R. Brown. 1981. Try- panocidal activity of daunorubici n and related compounds. Nature 292:466- 467.
   Web of Science ®Google Scholar
• Wu, G. Y., and C. H. Wu. 1987. Receptor-mediate d in vitro gene transformation by a soluble DNA carrier system. J. Biol. Chem. 262:4429–4432.
   PubMed Web of Science ®Google Scholar