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Review Article

Control of Peroxisome Proliferator-Activated Receptor Fate by the UbiquitinProteasome System

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Pages 679-692 | Published online: 10 Oct 2008

REFERENCES

  • Chawla A, Repa J J, Evans R M, Mangelsdorf D J. Nuclear receptors and lipid physiology: Opening the x-files. Science 2001; 294: 1866–1870
  • Aranda A, Pascual A. Nuclear hormone receptors and gene expression. Physiol Rev 2001; 81: 1269–1304
  • Gronemeyer H, Gustafsson J A, Laudet V. Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov 2004; 3: 950–964
  • Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: Nuclear control of metabolism. Endocr Rev 1999; 20: 649–688
  • Glass C K, Ogawa S. Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol 2006; 6: 44–55
  • Kersten S, Desvergne B, Wahli W. Roles of ppars in health and disease. Nature 2000; 405: 421–424
  • Nolte R T, Wisely G B, Westin S, Cobb J E, Lambert M H, Kurokawa R, Rosenfeld M G, Willson T M, Glass C K, Milburn M V. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 1998; 395: 137–143
  • Kliewer S A, Umesono K, Noonan D J, Heyman R A, Evans R M. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 1992; 358: 771–774
  • Lefebvre P, Chinetti G, Fruchart J C, Staels B. Sorting out the roles of PPARα in energy metabolism and vascular homeostasis. J Clin Invest 2006; 116: 571–580
  • Semple R K, Chatterjee V K, O'Rahilly S. PPARγ and human metabolic disease. J Clin Invest 2006; 116: 581–589
  • Tontonoz P, Hu E, Spiegelman B M. Stimulation of adipogenesis in fibroblasts by PPARγ 2, a lipid-activated transcription factor. Cell 1994; 79: 1147–1156
  • Ricote M, Li A C, Willson T M, Kelly C J, Glass C K. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 1998; 391: 79–82
  • Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K, Satoh S, Nakano R, Ishii C, Sugiyama T, Eto K, Tsubamoto Y, Okuno A, Murakami K, Sekihara H, Hasegawa G, Naito M, Toyoshima Y, Tanaka S, Shiota K, Kitamura T, Fujita T, Ezaki O, Aizawa S, Kadowaki T, et al. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999; 4: 597–609
  • Schwartz S, Raskin P, Fonseca V, Graveline J F. Effect of troglitazone in insulin-treated patients with type ii diabetes mellitus. Troglitazone and exogenous insulin study group. N Engl J Med 1998; 338: 861–866
  • Michalik L, Desvergne B, Wahli W. Peroxisome-proliferator-activated receptors and cancers: Complex stories. Nat Rev Cancer 2004; 4: 61–70
  • Tontonoz P, Singer S, Forman B M, Sarraf P, Fletcher J A, Fletcher C D, Brun R P, Mueller E, Altiok S, Oppenheim H, Evans R M, Spiegelman B M. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid x receptor. Proc Natl Acad Sci USA 1997; 94: 237–241
  • Sarraf P, Mueller E, Jones D, King F J, DeAngelo D J, Partridge J B, Holden S A, Chen L B, Singer S, Fletcher C, Spiegelman B M. Differentiation and reversal of malignant changes in colon cancer through PPARγ. Nat Med 1998; 4: 1046–1052
  • Sarraf P, Mueller E, Smith W M, Wright H M, Kum J B, Aaltonen L A, de la Chapelle A, Spiegelman B M, Eng C. Loss-of-function mutations in PPARγ associated with human colon cancer. Mol Cell 1999; 3: 799–804
  • Mueller E, Smith M, Sarraf P, Kroll T, Aiyer A, Kaufman D S, Oh W, Demetri G, Figg W D, Zhou X P, Eng C, Spiegelman B M, Kantoff P W. Effects of ligand activation of peroxisome proliferator-activated receptor γ in human prostate cancer. Proc Natl Acad Sci USA 2000; 97: 10990–10995
  • Kroll T G, Sarraf P, Pecciarini L, Chen C J, Mueller E, Spiegelman B M, Fletcher J A. Pax8-PPARγ 1 fusion oncogene in human thyroid carcinoma [corrected]. Science 2000; 289: 1357–1360
  • Lefebvre A M, Chen I, Desreumaux P, Najib J, Fruchart J C, Geboes K, Briggs M, Heyman R, Auwerx J. Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in c57bl/6j-apcmin/+ mice. Nat Med 1998; 4: 1053–1057
  • Kliewer S A, Forman B M, Blumberg B, Ong E S, Borgmeyer U, Mangelsdorf D J, Umesono K, Evans R M. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA 1994; 91: 7355–7359
  • Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W. Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α,-β, and-γ in the adult rat. Endocrinology 1996; 137: 354–366
  • Michalik L, Wahli W. Involvement of PPAR nuclear receptors in tissue injury and wound repair. J Clin Invest 2006; 116: 598–606
  • Barish G D, Narkar V A, Evans R M. PPARδ : A dagger in the heart of the metabolic syndrome. J Clin Invest 2006; 116: 590–597
  • He T C, Chan T A, Vogelstein B, Kinzler K W. Ppardelta is an apc-regulated target of nonsteroidal anti-inflammatory drugs. Cell 1999; 99: 335–345
  • Shao J, Sheng H, DuBois R N. Peroxisome proliferator-activated receptors modulate k-ras-mediated transformation of intestinal epithelial cells. Cancer Res 2002; 62: 3282–3288
  • Gupta R A, Tan J, Krause W F, Geraci M W, Willson T M, Dey S K, DuBois R N. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. Proc Natl Acad Sci USA 2000; 97: 13275–13280
  • Jarvis M C, Gray T J, Palmer C N. Both PPARγ and PPARδ influence sulindac sulfide-mediated p21waf1/cip1 upregulation in a human prostate epithelial cell line. Oncogene 2005; 24: 8211–8215
  • Gupta R A, Dubois R N. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer 2001; 1: 11–21
  • Park B H, Vogelstein B, Kinzler K W. Genetic disruption of ppardelta decreases the tumorigenicity of human colon cancer cells. Proc Natl Acad Sci USA 2001; 98: 2598–2603
  • Hatae T, Wada M, Yokoyama C, Shimonishi M, Tanabe T. Prostacyclin-dependent apoptosis mediated by PPARδ. J Biol Chem 2001; 276: 46260–46267
  • Ciechanover A, Orian A, Schwartz A L. Ubiquitin-mediated proteolysis: Biological regulation via destruction. Bioessays 2000; 22: 442–451
  • Koegl M, Hoppe T, Schlenker S, Ulrich H D, Mayer T U, Jentsch S. A novel ubiquitination factor, e4, is involved in multiubiquitin chain assembly. Cell 1999; 96: 635–644
  • Baek K H. Conjugation and deconjugation of ubiquitin regulating the destiny of proteins. Exp Mol Med 2003; 35: 1–7
  • Terrell J, Shih S, Dunn R, Hicke L. A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol Cell 1998; 1: 193–202
  • Dennis A P, Lonard D M, Nawaz Z, O'Malley B W. Inhibition of the 26s proteasome blocks progesterone receptor-dependent transcription through failed recruitment of rna polymerase ii. J Steroid Biochem Mol Biol 2005; 94: 337–346
  • Spence J, Gali R R, Dittmar G, Sherman F, Karin M, Finley D. Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain. Cell 2000; 102: 67–76
  • Goldknopf I L, Taylor C W, Baum R M, Yeoman L C, Olson M O, Prestayko A W, Busch H. Isolation and characterization of protein A24, a “histone-like” non-histone chromosomal protein. J Biol Chem 1975; 250: 7182–7187
  • Muratani M, Tansey W P. How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol 2003; 4: 192–201
  • Lee K B, Wang D, Lippard S J, Sharp P A. Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase ii in vitro. Proc Natl Acad Sci USA 2002; 99: 4239–4244
  • Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem 1998; 67: 425–479
  • Syvala H, Vienonen A, Zhuang Y H, Kivineva M, Ylikomi T, Tuohimaa P. Evidence for enhanced ubiquitin-mediated proteolysis of the chicken progesterone receptor by progesterone. Life Sci 1998; 63: 1505–1512
  • Alarid E T, Bakopoulos N, Solodin N. Proteasome-mediated proteolysis of estrogen receptor: A novel component in autologous down-regulation. Mol Endocrinol 1999; 13: 1522–1534
  • Dace A, Zhao L, Park K S, Furuno T, Takamura N, Nakanishi M, West B L, Hanover J A, Cheng S. Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors. Proc Natl Acad Sci USA 2000; 97: 8985–8990
  • Lonard D M, Nawaz Z, Smith C L, O'Malley B W. The 26S proteasome is required for estrogen receptor-α and coactivator turnover and for efficient estrogen receptor-α transactivation. Mol Cell 2000; 5: 939–948
  • Deroo B J, Archer T K. Proteasome inhibitors reduce luciferase and β-galactosidase activity in tissue culture cells. J Biol Chem 2002; 277: 20120–20123
  • Kopf E, Plassat J L, Vivat V, de The H, Chambon P, Rochette-Egly C. Dimerization with retinoid x receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors α and γ through the ubiquitin-proteasome pathway. J Biol Chem 2000; 275: 33280–33288
  • Rochette-Egly C. Dynamic combinatorial networks in nuclear receptor-mediated transcription. J Biol Chem 2005; 280: 32565–32568
  • Pickart C M. Targeting of substrates to the 26S proteasome. FASEB J 1997; 11: 1055–1066
  • Blanquart C, Barbier O, Fruchart J C, Staels B, Glineur C. Peroxisome proliferator-activated receptor alpha (PPARα) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes. J Biol Chem 2002; 277: 37254–37259
  • Hauser S, Adelmant G, Sarraf P, Wright H M, Mueller E, Spiegelman B M. Degradation of the peroxisome proliferator-activated receptor γ is linked to ligand-dependent activation. J Biol Chem 2000; 275: 18527–18533
  • Nawaz Z, Lonard D M, Smith C L, Lev-Lehman E, Tsai S Y, Tsai M J, O'Malley B W. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol Cell Biol 1999; 19: 1182–1189
  • Webster J C, Jewell C M, Bodwell J E, Munck A, Sar M, Cidlowski J A. Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein. J Biol Chem 1997; 272: 9287–9293
  • Hirotani M, Tsukamoto T, Bourdeaux J, Sadano H, Osumi T. Stabilization of peroxisome proliferator-activated receptor α by the ligand. Biochem Biophys Res Commun 2001; 288: 106–110
  • Dennis A P, Haq R U, Nawaz Z. Importance of the regulation of nuclear receptor degradation. Front Biosci 2001; 6: D954–959
  • Read L D, Snider C E, Miller J S, Greene G L, Katzenellenbogen B S. Ligand-modulated regulation of progesterone receptor messenger ribonucleic acid and protein in human breast cancer cell lines. Mol Endocrinol 1988; 2: 263–271
  • Zhu J, Gianni M, Kopf E, Honore N, Chelbi-Alix M, Koken M, Quignon F, Rochette-Egly C, de The H. Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARα) and oncogenic RARα fusion proteins. Proc Natl Acad Sci USA 1999; 96: 14807–14812
  • Li X Y, Boudjelal M, Xiao J H, Peng Z H, Asuru A, Kang S, Fisher G J, Voorhees J J. 1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin. Mol Endocrinol 1999; 13: 1686–1694
  • Yeap B B, Krueger R G, Leedman P J. Differential posttranscriptional regulation of androgen receptor gene expression by androgen in prostate and breast cancer cells. Endocrinology 1999; 140: 3282–3291
  • Perissi V, Aggarwal A, Glass C K, Rose D W, Rosenfeld M G. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 2004; 116: 511–526
  • Lipford J R, Deshaies R J. Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation. Nat Cell Biol 2003; 5: 845–850

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