REFERENCES
- Robinson E S, Nutt D J, Jackson H C, Hudson A L. Antisense oligonucleotides in psychopharmacology and behaviour: Promises and pitfalls. J Psychopharmacol 1997; 11: 259–269
- Tilly G, Chapuis J, Vilette D, Laude H, Vilotte J L. Efficient and specific down-regulation of prion protein expression by RNAi. Biochem Biophys Res Commun 2003; 305: 548–551
- Xia X G, Zhou H, Zhou S, Yu Y, Wu R, Xu Z. An RNAi strategy for treatment of amyotrophic lateral sclerosis caused by mutant Cu, Zn superoxide dismutase. J Neurochem 2005; 92: 362–367
- Zhang Y, Zhang Y F, Bryant J, Charles A, Boado R J, Pardridge W M, Intravenous R NA. interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer. Clin Cancer Res 2004; 10: 3667–3677
- Robinson R. RNAi therapeutics: How likely, how soon?. PLoS Biol 2004; 2: e28
- Stevenson M. Therapeutic potential of RNA interference. N Engl J Med 2004; 351: 1772–1777
- Scacheri P C, Rozenblatt-Rosen O, Caplen N J, Wolfsberg T G, Umayam L, Lee J C, Hughes C M, Shanmugam K S, Bhattacharjee A, Meyerson M, Collins F S. Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci USA 2004; 101: 1892–1897
- Bitko V, Barik S. Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses. BMC Microbiol 2001; 1: 34–44
- Dillon C P, Sandy P, Nencioni A, Kissler S, Rubinson D A, Van Parijs L. RNAi as an experimental and therapeutic tool to study and regulate physiological and disease processes. Annu Rev Physiol 2005; 67: 147–173
- Fire A, Xu S, Montgomery M K, Kostas S A, Driver S E, Mello C C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806–811
- Davidson T J, Harel S, Arboleda V A, Prunell G F, Shelanski M L, Greene L A, Troy C M. Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation. Neurosci 2004; 24: 10040–10046
- Meister G, Tuschl T. Mechanisms of gene silencing by double-stranded RNA. Nature 2004; 431: 343–349
- Thakker D R, Hoyer D, Cryan J F. Interfering with the brain: use of RNA interference (RNAi) for understanding the pathophysiology of psychiatric and neurological disorders. Pharmacol Ther 2006; 109: 413–438
- Dorn G, Patel S, Wotherspoon G, Hemmings-Mieszczak M, Barclay J, Natt F J, Martin P, Bevan S, Fox A, Ganju P, Wishart W, Hall J. siRNA relieves chronic neuropathic pain. Nucleic Acids Res 2004; 32: e49
- Davies W. Knockdown not knockout. Drug Discovery Today 2005; 10: 157–158
- Thakker D R, Natt F, Hüsken D, Maier R, Müller M, van der Putten H, Hoyer D, Cryan J F. Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain using nonviral RNA interference. Proc Natl Acad Sci USA 2004; 101: 17270–17275
- Thakker D R, Natt F, van der Putten H, Maier R, Hoyer D, Cryan J F. siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain induces antidepressant-like effects. Mol Psychiatry 2005; 10: 782–789
- Hüsken D, Asselbergs F, Kinzel B, Natt F, Weiler J, Martin P, Haner R, Hall J. mRNA fusion constructs serve in a general cell-based assay to profile oligonucleotide activity. Nucleic Acids Res 2003; 31: e102
- Paxinos G, Franklin K BJ. The Mouse Brain in Stereotaxic Coordinates, 2nd ed. Academic Press, London 2001
- Mombereau C, Kaupmann K, Froestl W, Sansig G, van der Putten H, Cryan J F. Genetic and pharmacological evidence of a role for GABAB receptors in the modulation of anxiety-and antidepressant-like behavior. Neuropsychopharmacology 2004; 29: 1050–1062
- Cryan J F, Dalvi A, Jin S H, Hirsch B R, Lucki I, Thomas S A. Use of dopamine-β-hydroxylase-deficient mice to determine the role of norepinephrine in the mechanism of action of antidepressant drugs. J Pharmacol Exp Ther 2001; 298: 651–657
- Cryan J F, Mombereau C. In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry 2004; 9: 326–357
- Lucki I, Dalvi A, Mayorga A J. Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology 2001; 155: 315–322
- Holmes A, Yang R J, Murphy D L, Crawley J N. Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology 2002; 27: 914–923
- Bischoff S, Barhanin J, Bettler B, Mulle C, Heinemann S. Spatial distribution of kainate receptor subunit mRNA in the mouse basal ganglia and ventral mesencephalon. J Comp Neurol 1997; 379: 541–562
- Benmansour S, Cecchi M, Morilak D A, Gerhardt G A, Javors M A, Gould G G, Frazer A. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. J Neurosci 1999; 19: 10494–10501
- Hommel J D, Sears R M, Georgescu D, Simmons D L, Di Leone R J. Local gene knockdown in the brain using viral-mediated RNA interference. Nat Med 2003; 9: 1539–1544
- Van d en, Haute C, Eggermont K, Nuttin B, Debyser Z, Baekelandt V. Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain. Hum Gene Ther 2003; 14: 1799–1807
- Xia H, Mao Q, Eliason S L, Harper S Q, Martins I H, Orr H T, Paulson H L, Yang L, Kotin R M, Davidson B L. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med 2004; 10: 816–820
- Xia H, Mao Q, Paulson H L, Davidson B L. siRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol 2002; 20: 1006–1010
- Chao J, Nestler E J. Molecular neurobiology of drug addiction. Annu Rev Med 2004; 55: 113–132
- Lewis D A, Lieberman J A. Catching up on schizophrenia: natural history and neurobiology. Neuron 2000; 28: 325–334
- Millan M J. The neurobiology and control of anxious states. Prog Neurobiol 2003; 70: 83–244
- Nestler E J, Gould E, Manji H, Buncan M, Duman R S, Greshenfeld H K, Hen R, Koester S, Lederhendler I, Meaney M, Robbins T, Winsky L, Zalcman S. Preclinical models: status of basic research in depression. Biol Psychiatry 2002; 52: 503–528
- Sisodia S S, George-Hyslop St P H. γ-Secretase, Notch, Aβ and Alzheimer's disease: Where do the presenilins fit in?. Nat Rev Neurosci 2002; 3: 281–290
- Isacson R, Kull B, Salmi P, Wahlestedt C. Lack of efficacy of ‘naked’ small interfering RNA applied directly to rat brain. Acta Physiol Scand 2003; 179: 173–177
- Shishkina G T, Kalinina T S, Dygalo N N. Attenuation of α2A-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood. Neuroscience 2004; 129: 521–528
- Makimura H, Mizuno T M, Mastaitis J W, Agami R, Mobbs C V. Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci 2002; 3: 18
- Giros B, Jaber M, Jones S R, Wightman R M, Caron M G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 1996; 379: 606–612
- Thakker D R, Schmutz M, Maier R, Natt R, Hüsken D, van der Putten H, Flor P J, Hoyer D, Cryan J F. siRNA-induced knockdown of the group III metabotropic glutamate receptor mGluR7 in the adult mouse brain induces an anxiolytic-like response. Soc Neuroscience Abstr 2005; 678.10
- Thakker D R, Hoyer D, Schmutz M, Maier R, Natt F, Hüsken D, Sansig G, van der Putten H, Flor P J, Cryan J F. mGlur7 plays a key role in the modulation of anxiety behavior: Evidence from mGlur7-knockout mice and siRNA-induced knockdown in the adult mouse brain. Neuropharmacology 2005; 49: 275, (Suppl 1)
- Cryan J F, Mitsukawa K, Thakker D R, Mombereau C, Lötscher E, Uzunov D P, Natt F, Huesken D, Maier R, McAllister K, Hoyer D, van der Putten H, Flor P J. mGluR7: A novel therapeutic target for stress-related disorders. Neuropsychopharmacology 2005; 30: S31, (Suppl)