175
Views
18
CrossRef citations to date
0
Altmetric
Research Article

Opsin Oligomerization in a Heterologous Cell System

, , &
Pages 505-526 | Published online: 10 Oct 2008

REFERENCES

  • Milligan G, Ramsay D, Pascal G, Carrillo J J. GPCR dimerisation. Life Sci 2003; 74: 181–188
  • Park P S, Filipek S, Wells J W, Palczewski K. Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry 2004; 43: 15643–15656
  • White J H, Wise A, Main M J, Green A, Fraser N J, Disney G H, Barnes A A, Emson P, Foord S M, Marshall F H. Heterodimerization is required for the formation of a functional GABAB receptor. Nature 1998; 396: 679–682
  • Terrillon S, Bouvier M. Roles of G-protein-coupled receptor dimerization. EMBO Rep 2004; 5: 30–34
  • Milligan G. G protein-coupled receptor dimerization: function and ligand pharmacology. Mol Pharmacol 2004; 66: 1–7
  • Chabre M, le Maire M. Monomeric G-protein-coupled receptor as a functional unit. Biochemistry 2005; 44: 9395–9403
  • Fotiadis D, Liang Y, Filipek S, Saperstein D A, Engel A, Palczewski K, The G. protein-coupled receptor rhodopsin in the native membrane. FEBS Lett 2004; 564: 281–288
  • Liang Y, Fotiadis D, Filipek S, Saperstein D A, Palczewski K, Engel A. Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem 2003; 278: 21655–21662
  • Law P Y, Erickson-Herbrandson L J, Zha Q Q, Solberg J, Chu J, Sarre A, Loh H H. Heterodimerization of μ-and δ-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions. J Biol Chem 2005; 280: 11152–11164
  • Pfeiffer M, Kirscht S, Stumm R, Koch T, Wu D, Laugsch M, Schroder H, Hollt V, Schulz S. Heterodimerization of substance P and μ-opioid receptors regulates receptor trafficking and resensitization. J Biol Chem 2003; 278: 51630–51637
  • Pfeiffer M, Koch T, Schroder H, Laugsch M, Hollt V, Schulz S. Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization. J Biol Chem 2002; 277: 19762–19772
  • Rocheville M, Lange D C, Kumar U, Patel S C, Patel R C, Patel Y C. Receptors for dopamine and somatostatin: Formation of hetero-oligomers with enhanced functional activity. Science 2000; 288: 154–157
  • Ayoub M A, Couturier C, Lucas-Meunier E, Angers S, Fossier P, Bouvier M, Jockers R. Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J Biol Chem 2002; 277: 21522–21528
  • Mercier J F, Salahpour A, Angers S, Breit A, Bouvier M. Quantitative assessment of β1-and β2-adrenergic receptor homo-and heterodimerization by bioluminescence resonance energy transfer. J Biol Chem 2002; 277: 44925–44931
  • Breit A, Lagace M, Bouvier M. Hetero-oligomerization between β2-and β 3-adrenergic receptors generates a β-adrenergic signaling unit with distinct functional properties. J Biol Chem 2004; 279: 28756–28765
  • Jordan B A, Devi L A. G-protein-coupled receptor heterodimerization modulates receptor function. Nature 1999; 399: 697–700
  • Wall M A, Coleman D E, Lee E, Iniguez-Lluhi J A, Posner B A, Gilman A G, Sprang S R. The structure of the G protein heterotrimer Giα 1β1γ2. Cell 1995; 83: 1047–1058
  • Lambright D G, Sondek J, Bohm A, Skiba N P, Hamm H E, Sigler P B. The 2.0 å crystal structure of a heterotrimeric G protein. Nature 1996; 379: 311–319
  • Palczewski K, Kumasaka T, Hori T, Behnke C A, Motoshima H, Fox B A, Le Trong I, Teller D C, Okada T, Stenkamp R E, Yamamoto M, Miyano M. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 2000; 289: 739–745
  • Baneres J L, Parello J. Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein. J Mol Biol 2003; 329: 815–829
  • Bulenger S, Marullo S, Bouvier M. Emerging role of homo-and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol Sci 2005; 26: 131–137
  • Kroeger K M, Hanyaloglu A C, Seeber R M, Miles L E, Eidne K A. Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer. J Biol Chem 2001; 276: 12736–12743
  • Yoshioka K, Saitoh O, Nakata H. Agonist-promoted heteromeric oligomerization between adenosine A1 and P2Y1 receptors in living cells. FEBS Lett 2002; 523: 147–151
  • Berglund M M, Schober D A, Esterman M A, Gehlert D R, Neuropeptide Y. Y4 receptor homodimers dissociate upon agonist stimulation. J Pharmacol Exp Ther 2003; 307: 1120–1126
  • Heding A. Use of the BRET 7TM receptor/β-arrestin assay in drug discovery and screening. Expert Rev Mol Diagn 2004; 4: 403–411
  • Pfleger K D, Eidne K A. Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells. Biochem J 2005; 385: 625–637
  • George S R, O'Dowd B F, Lee S P. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov 2002; 1: 808–820
  • AbdAlla S, Lother H, el Massiery A, Quitterer U. Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness. Nat Med 2001; 7: 1003–1009
  • Zhu W Z, Chakir K, Zhang S, Yang D, Lavoie C, Bouvier M, Hebert T E, Lakatta E G, Cheng H, Xiao R P. Heterodimerization of β1-and β2-adrenergic receptor subtypes optimizes β adrenergic modulation of cardiac contractility. Circ Res 2005; 97: 244–251
  • Angers S, Salahpour A, Joly E, Hilairet S, Chelsky D, Dennis M, Bouvier M. Detection of β 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci USA 2000; 97: 3684–3689
  • Veatch W, Stryer L. The dimeric nature of the gramicidin A transmembrane channel: Conductance and fluorescence energy transfer studies of hybrid channels. J Mol Biol 1977; 113: 89–102
  • Vrecl M, Jorgensen R, Pogacnik A, Heding A. Development of a BRET2 screening assay using β-arrestin 2 mutants. J Biomol Screen 2004; 9: 322–333
  • Samama P, Cotecchia S, Costa T, Lefkowitz R J. A mutation-induced activated state of the β 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem 1993; 268: 4625–4636
  • Nakahara T, Maruko T, Sakamoto K, Ishii K. Influence of receptor number on the cAMP response to forskolin in Chinese hamster ovary cells transfected with human β2-adrenoceptor. Biol Pharm Bull 2004; 27: 239–241
  • Ayoub M A, Levoye A, Delagrange P, Jockers R. Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers. Mol Pharmacol 2004; 66: 312–321
  • Suda K, Filipek S, Palczewski K, Engel A, Fotiadis D. The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Mol Membr Biol 2004; 21: 435–446
  • Liang Y, Fotiadis D, Maeda T, Maeda A, Modzelewska A, Filipek S, Saperstein D A, Engel A, Palczewski K. Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem 2004; 279: 48189–48196
  • Breitwieser G E. G protein-coupled receptor oligomerization: Implications for G protein activation and cell signaling. Circ Res 2004; 94: 17–27
  • Gomes I, Jordan B A, Gupta A, Trapaidze N, Nagy V, Devi L A. Heterodimerization of μ and δ opioid receptors: a role in opiate synergy. J Neurosci 2000; 20: 1–5
  • Margeta-Mitrovic M, Jan Y N, Jan L Y. Function of GB1 and GB2 subunits in G protein coupling of GABAB receptors. Proc Natl Acad Sci USA 2001; 98: 14649–14654
  • Duthey B, Caudron S, Perroy J, Bettler B, Fagni L, Pin J P, Prezeau L. A single subunit (GB2) is required for G-protein activation by the heterodimeric GABAB receptor. J Biol Chem 2002; 277: 3236–3241
  • Osuga Y, Hayashi M, Kudo M, Conti M, Kobilka B, Hsueh A J. Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation. J Biol Chem 1997; 272: 25006–25012
  • Ji I, Lee C, Song Y, Conn P M, Ji T H. Cis-and trans-activation of hormone receptors: The LH receptor. Mol Endocrinol 2002; 16: 1299–1308
  • Lee C, Ji I, Ryu K, Song Y, Conn P M, Ji T H. Two defective heterozygous luteinizing hormone receptors can rescue hormone action. J Biol Chem 2002; 277: 15795–15800
  • Carrillo J J, Pediani J, Milligan G. Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins. J Biol Chem 2003; 278: 42578–42587
  • Holst B, Brandt E, Bach A, Heding A, Schwartz T W. Non-peptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol Endocrinol 2005; 19: 2400–2411

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.