Meeting Review: Advances from the GPCR Retreat

REFERENCES

• Yoon E J, Gerachshenko T, Spiegelberg B D, Alford S, Hamm H E. Gβ γ Interferes with Ca2 + -Dependent Binding of Synaptotagmin to the Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor (SNARE) Complex. Mol Pharmacol 2007; 72(5)1210–1219
   PubMedGoogle Scholar
• Chen S, Spiegelberg B D, Lin F, Dell E J, Hamm H E. Interaction of Gβ γ with RACK1 and other WD40 repeat proteins. J Mol Cell Cardiol 2004; 37(2)399–406
   PubMedGoogle Scholar
• Chen S, Lin F, Hamm H E. RACK1 binds to a signal transfer region of Gβ γ and inhibits phospholipase Cβ 2 activation. The Journal of Biological Chemistry 2005; 280(39)33445–33452
   PubMedGoogle Scholar
• Luttrell L M. Composition and function of G protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity. J Mol Neurosci 2005; 26(2–3)253–264
   PubMedGoogle Scholar
• Sato M, Blumer J B, Simon V, Lanier S M. Accessory proteins for G proteins: partners in signaling. Annu Rev Pharmacol Toxicol 2006; 46: 151–187
   PubMed Web of Science ®Google Scholar
• Blumer J B, Cismowski M J, Sato M, Lanier S M. AGS proteins: receptor-independent activators of G-protein signaling. Trends Pharmacol Sci 2005; 26(9)470–476
   PubMedGoogle Scholar
• Peregrin S, Jurado-Pueyo M, Campos P M, Sanz-Moreno V, Ruiz-Gomez A, Crespo P, Mayor F, Jr., Murga C. Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK. Curr Biol 2006; 16(20)2042–2047
   PubMedGoogle Scholar
• Zoudilova M, Kumar P, Ge L, Wang P, Bokoch G M, DeFea K A. β -arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. The Journal of Biological Chemistry 2007; 282(28)20634–20646
   PubMedGoogle Scholar
• Lavine N, Ethier N, Oak J N, Pei L, Liu F, Trieu P, Rebois R V, Bouvier M, Hebert T E, Van Tol H H. G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. The Journal of Biological Chemistry 2002; 277(48)46010–46019
   PubMedGoogle Scholar
• Beedle A M, McRory J E, Poirot O, Doering C J, Altier C, Barrere C, Hamid J, Nargeot J, Bourinet E, Zamponi G W. Agonist-independent modulation of N-type calcium channels by ORL1 receptors. Nature Neuroscience 2004; 7(2)118–125
   PubMedGoogle Scholar
• Rebois R V, Hebert T E. Protein complexes involved in heptahelical receptor-mediated signal transduction. Receptors Channels 2003; 9(3)169–194
   PubMedGoogle Scholar
• Jaen C, Doupnik C A. RGS3 and RGS4 differentially associate with G protein-coupled receptor-Kir3 channel signaling complexes revealing two modes of RGS modulation. Precoupling and collision coupling. The Journal of Biological Chemistry 2006; 281(45)34549–34560
   PubMedGoogle Scholar
• Rasmussen S G, Choi H J, Rosenbaum D M, Kobilka T S, Thian F S, Edwards P C, Burghammer M, Ratnala V R, Sanishvili R, Fischetti R F, Schertler G F, Weis W I, Kobilka B K. Crystal structure of the human β 2 adrenergic G-protein-coupled receptor. Nature 2007; 450(7168)383–387
   PubMed Web of Science ®Google Scholar
• Rosenbaum D M, Cherezov V, Hanson M A, Rasmussen S G, Thian F S, Kobilka T S, Choi H J, Yao X J, Weis W I, Stevens R C, Kobilka B K. GPCR engineering yields high-resolution structural insights into β 2-adrenergic receptor function. Science 2007; 318(5854)1266–1273
   PubMed Web of Science ®Google Scholar
• Cherezov V, Rosenbaum D M, Hanson M A, Rasmussen S G, Thian F S, Kobilka T S, Choi H J, Kuhn P, Weis W I, Kobilka B K, Stevens R C. High-resolution crystal structure of an engineered human β 2-adrenergic G protein-coupled receptor. Science 2007; 318(5854)1258–1265
   PubMed Web of Science ®Google Scholar
• Gautam D, Han S J, Hamdan F F, Jeon J, Li B, Li J H, Cui Y, Mears D, Lu H, Deng C, Heard T, Wess J. A critical role for β cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metabolism 2006; 3(6)449–461
   PubMed Web of Science ®Google Scholar
• Coward P, Wada H G, Falk M S, Chan S D, Meng F, Akil H, Conklin B R. Controlling signaling with a specifically designed Gi-coupled receptor. Proc Natl Acad Sci U SA 1998; 95(1)352–357
   PubMedGoogle Scholar
• Pauwels P J. Unravelling multiple ligand-activation binding sites using RASSL receptors. Trends Pharmacol Sci 2003; 24(10)504–507
   PubMedGoogle Scholar
• Eckhart A D, Ozaki T, Tevaearai H, Rockman H A, Koch W J. Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates β -adrenergic receptor signaling and increases resting blood pressure. Mol Pharmacol 2002; 61(4)749–758
   PubMed Web of Science ®Google Scholar
• Harris D M, Cohn H I, Pesant S, Zhou R H, Eckhart A D. Vascular Smooth Muscle Gq Signaling is Involved in High Blood Pressure in Both Induced Renal and Genetic Vascular Smooth Muscle-Derived Models of Hypertension. Am J Physiol Heart Circ Physiol 2007
   Google Scholar
• Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N, Luger T A, Hollenberg M D. Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 2005; 26(1)1–43
   PubMed Web of Science ®Google Scholar
• Cenac N, Andrews C N, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G, Beck P, Bunnett N W, Sharkey K A, Ferraz J G, Shaffer E, Vergnolle N. Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest 2007; 117(3)636–647
   PubMed Web of Science ®Google Scholar
• Fessart D, Simaan M, Zimmerman B, Comeau J, Hamdan F F, Wiseman P W, Bouvier M, Laporte S A. Src-dependent phosphorylation of β 2-adaptin dissociates the beta-arrestin-AP-2 complex. Journal of Cell Science 2007; 120: 1723–1732, (Pt 10)
   PubMed Web of Science ®Google Scholar
• Slessareva J E, Routt S M, Temple B, Bankaitis V A, Dohlman H G. Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein α subunit at the endosome. Cell 2006; 126(1)191–203
   PubMedGoogle Scholar
• Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson C D, Wang S, Eckhardt A E, Cowan C L, Spurney R F, Luttrell L M, Lefkowitz R J. Distinct β -arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. The Journal of Biological Chemistry 2006; 281(16)10856–10864
   PubMed Web of Science ®Google Scholar
• Gobeil F, Fortier A, Zhu T, Bossolasco M, Leduc M, Grandbois M, Heveker N, Bkaily G, Chemtob S, Barbaz D. G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm. Can J Physiol Pharmacol 2006; 84(3-4)287–297
   PubMedGoogle Scholar
• Boivin B, Chevalier D, Villeneuve L R, Rousseau E, Allen B G. Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes. The Journal of Biological Chemistry 2003; 278(31)29153–29163
   PubMedGoogle Scholar
• Boivin B, Lavoie C, Vaniotis G, Baragli A, Villeneuve L R, Ethier N, Trieu P, Allen B G, Hebert T E. Functional β -adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes. Cardiovasc Res 2006; 71(1)69–78
   PubMedGoogle Scholar
• Galandrin S, Oligny-Longpre G, Bouvier M. The evasive nature of drug efficacy: implications for drug discovery. Trends Pharmacol Sci 2007; 28(8)423–430
   PubMed Web of Science ®Google Scholar
• Galandrin S, Bouvier M. Distinct signaling profiles of β 1 and β 2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol 2006; 70(5)1575–1584
   PubMedGoogle Scholar
• Gales C, Van Durm J J, Schaak S, Pontier S, Percherancier Y, Audet M, Paris H, Bouvier M. Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes. Nat Struct Mol Biol 2006; 13(9)778–786
   PubMed Web of Science ®Google Scholar
• Dupre D J, Robitaille M, Ethier N, Villeneuve L R, Mamarbachi A M, Hebert T E. Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking. The Journal of Biological Chemistry 2006; 281(45)34561–34573
   PubMedGoogle Scholar
• Rebois R V, Robitaille M, Gales C, Dupre D J, Baragli A, Trieu P, Ethier N, Bouvier M, Hebert T E. Heterotrimeric G-proteins form stable complexes with adenylyl cyclase and Kir3. 1 channels in living cells. Journal of Cell Science 2006; 119: 2807–2818, (Pt 13)
   PubMed Web of Science ®Google Scholar
• Willardson B M, Howlett A C. Function of phosducin-like proteins in G protein signaling and chaperone-assisted protein folding. Cell Signal 2007; 19(12)2417–2427
   PubMedGoogle Scholar
• Dupre D J, Robitaille M, Richer M, Ethier N, Mamarbachi A M, Hebert T E. Dopamine receptor-interacting protein 78 acts as a molecular chaperone for Gγ subunits before assembly with Gβ. The Journal of Biological Chemistry 2007; 282(18)13703–13715
   PubMedGoogle Scholar