543
Views
11
CrossRef citations to date
0
Altmetric
Original Articles

Relationship of Cannabis Use Disorder and Irritable Bowel Syndrome (IBS): An Analysis of 6.8 Million Hospitalizations in the United States

, , &

References

  • Abrams, D. I. (2018). The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report. European Journal of Internal Medicine, 49, 7–11. doi:10.1016/j.ejim.2018.01.003
  • Aizpurua-Olaizola, O., Soydaner, U., Öztürk, E., Schibano, D., Simsir, Y., Navarro, P., … Usobiaga, A. (2016). Evolution of the Cannabinoid and terpene content during the growth of cannabis sativa plants from different chemotypes. Journal of Natural Products, 79(2), 324–331. doi:10.1021/acs.jnatprod.5b00949
  • Andrews, E. B., Eaton, S. C., Hollis, K. A., Hopkins, J. S., Ameen, V., Hamm, L. R., … Mangel, A. W. (2005). Prevalence and demographics of irritable bowel syndrome: Results from a large web-based survey. Alimentary Pharmacology and Therapeutics, 22(10), 935–942. doi:10.1111/j.1365-2036.2005.02671.x
  • Atakan, Z. (2012). Cannabis, a complex plant: Different compounds and different effects on individuals. Therapeutic Advances in Psychopharmacology, 2(6), 241–254. doi:10.1177/2045125312457586
  • Bandelow, B., Baldwin, D., Abelli, M., Bolea-Alamanac, B., Bourin, M., Chamberlain, S. R., … Riederer, P. (2017). Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition. The World Journal of Biological Psychiatry, 18(3), 162–214. doi:10.1080/15622975.2016.1190867
  • Bennett, E. J., Tennant, C. C., Piesse, C., Badcock, C. A., & Kellow, J. E. (1998). Level of chronic life stress predicts clinical outcome in irritable bowel syndrome. Gut, 43(2), 256–261. doi:10.1136/gut.43.2.256
  • Camilleri, M. (2018). Cannabinoids and gastrointestinal motility: Pharmacology, clinical effects, and potential therapeutics in humans. Neurogastroenterology & Motility, 30(9), e13370. doi:10.1111/nmo.13370
  • Canavan, C., West, J., & Card, T. (2014). The epidemiology of irritable bowel syndrome. Clinical Epidemiology, 6, 71–80. doi:10.2147/CLEP.S40245
  • Chang, L., Sundaresh, S., Elliott, J., Anton, PA., Baldi, P., Licudine, A., … Mayer, EA. (2009). Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterology & Motility, 21(2), 149–159. doi:10.1111/j.1365-2982.2008.01171.x
  • Choung, R. S., Locke, G. R., 3rd, Zinsmeister, A. R., Schleck, C. D., & Talley, N. J. (2009). Psychosocial distress and somatic symptoms in community subjects with irritable bowel syndrome: A psychological component is the rule. The American Journal of Gastroenterology, 104(7), 1772–1779. doi:10.1038/ajg.2009.239
  • Dickhaus, B., Mayer, E. A., Firooz, N., Stains, J., Conde, F., Olivas, T. I., … Naliboff, B. D. (2003). Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress. The American Journal of Gastroenterology, 98(1), 135–143. doi:10.1111/j.1572-0241.2003.07156.x
  • Fadgyas-Stanculete, M., Buga, A. M., Popa-Wagner, A., & Dumitrascu, D. L. (2014). The relationship between irritable bowel syndrome and psychiatric disorders: From molecular changes to clinical manifestations. Journal of Molecular Psychiatry, 2(1), 4. doi:10.1186/2049-9256-2-4
  • Fifi, A. C., Axelrod, C. H., Chakraborty, P., & Saps, M. (2018). Herbs and spices in the treatment of functional gastrointestinal disorders: A review of clinical trials. Nutrients, 10(11), 1715. doi:10.3390/nu1011
  • Ford, A. C., Lacy, B. E., & Talley, N. J. (2017). Irritable Bowel Syndrome. New England Journal of Medicine, 376(26), 2566–2578. doi:10.1056/NEJMra1607547
  • Geeraerts, B., Vandenberghe, J., Van Oudenhove, L., Gregory, L. J., Aziz, Q., DuPont, P., … Tack, J. (2005). Influence of experimentally induced anxiety on gastric sensorimotor function in humans. Gastroenterology, 129(5), 1437–1444. doi:10.1053/j.gastro.2005.08.020
  • Gomez Alvarez, D. F., Morales Vargas, J. G., Rojas Medina, L. M., Mujica Oviedo, S. C., Camacho Lopez, P. A., & Rueda Jaimes, G. E. (2009). Prevalence of irritable bowel syndrome and associated factors according to the Rome III diagnostic criteria in a general population in Colombia]. Gastroenterología y Hepatología, 32(6), 395–400. [ doi:10.1016/j.gastrohep.2009.01.177
  • Goyal, H., Singla, U., Gupta, U., & May, E. (2017). Role of cannabis in digestive disorders. European Journal of Gastroenterology & Hepatology, 29(2), 135–143. doi:10.1097/MEG.0000000000000779
  • Grodzinsky, E., Hallert, C., Faresjo, T., Bergfors, E., & Faresjo, A. O. (2012). Could gastrointestinal disorders differ in two close but divergent social environments? International Journal of Health Geographics, 11(1), 5. doi:0.1186/1476-072X-11-5 doi:10.1186/1476-072X-11-5
  • Gros, D. F., Antony, M. M., McCabe, R. E., & Swinson, R. P. (2009). Frequency and severity of the symptoms of irritable bowel syndrome across the anxiety disorders and depression. Journal of Anxiety Disorders, 23(2), 290–296. doi:10.1016/j.janxdis.2008.08.004
  • Gwee, K. A. (2005). Irritable bowel syndrome in developing countries–a disorder of civilization or colonization? Neurogastroenterology and Motility, 17(3), 317–324. doi:10.1111/j.1365-2982.2005.00627.x
  • NIS description of data elements. (2018). Accessed: April 15, 2019: https://www.hcup-us.ahrq.gov/db/nation/nis/nisdde.jsp
  • Hornby, P. J., & Prouty, S. M. (2004). Involvement of cannabinoid receptors in gut motility and visceral perception. British Journal of Pharmacology, 141(8), 1335–1345. doi:10.1038/sj.bjp.0705783
  • Izzo, A. A., & Sharkey, K. A. (2010). Cannabinoids and the gut: New developments and emerging concepts. Pharmacology & Therapeutics, 126(1), 21–38. doi:10.1016/j.pharmthera.2009.12.005
  • Jerndal, P., Ringström, G., Agerforz, P., Karpefors, M., Akkermans, L. M., Bayati, A., & Simrén, M. (2010). Gastrointestinal-specific anxiety: An important factor for severity of GI symptoms and quality of life in IBS. Neurogastroenterology & Motility, 22(6), 646–e179. doi:10.1111/j.1365-2982.2010.01493.x
  • Katsinelos, P., Lazaraki, G., Kountouras, J., Paroutoglou, G., Oikonomidou, I., Mimidis, K., … Chatzimavroudis, G. (2009). Prevalence, bowel habit subtypes and medical care-seeking behaviour of patients with irritable bowel syndrome in Northern Greece. European Journal of Gastroenterology & Hepatology, 21(2), 183–189. doi:10.1097/MEG.0b013e328312eb97
  • Khalsa, J. H., & Bunt, G. (2019). Cannabidiol as medicine: Are we there? Paper Presented at the American Society of Addiction Medicine 50th Annual Conference, Orlando, FL.
  • Klooker, T. K., Leliefeld, K. E., Van Den Wijngaard, R. M., & Boeckxstaens, G. E. (2011). The cannabinoid receptor agonist delta-9-tetrahydrocannabinol does not affect visceral sensitivity to rectal distension in healthy volunteers and IBS patients. Neurogastroenterology & Motility, 23(1), 30–35. e32. doi:10.1111/j.1365-2982.2010.01587.x
  • Koloski, N. A., Talley, N. J., & Boyce, P. M. (2003). Does psychological distress modulate functional gastrointestinal symptoms and health care seeking? A prospective, community Cohort study. The American Journal of Gastroenterology, 98(4), 789–797. doi:10.1111/j.1572-0241.2003.07388.x
  • Locke, G. R., 3rd, Yawn, B. P., Wollan, P. C., Melton, L. J., 3rd, Lydick, E., & Talley, N. J. (2004). Incidence of a clinical diagnosis of the irritable bowel syndrome in a United States population. Alimentary Pharmacology and Therapeutics, 19(9), 1025–1031. doi:10.1111/j.1365-2036.2004.01938.x
  • Lovell, R. M., & Ford, A. C. (2012). Global prevalence of and risk factors for irritable bowel syndrome: A meta-analysis. Clinical Gastroenterology and Hepatology, 10(7), 712–721.e714. doi:10.1016/j.cgh.2012.02.029
  • Lyubashina, O. A. (2004). Possible mechanisms of involvement of the amygdaloid complex in the control of gastric motor function. Neuroscience and Behavioral Physiology, 34(4), 379–388. doi:10.1023/B:NEAB.0000018750.65372.18
  • Manseau, M. W., Rajparia, A., Joseph, A., Azarchi, S., Goff, D., Satodiya, R., & Lewis, C. F. (2017). Clinical characteristics of synthetic cannabinoid use in a large urban psychiatric emergency setting. Substance Use & Misuse, 52(6), 822–825. doi:10.1080/10826084.2016.1263663
  • Massa, F., Storr, M., & Lutz, B. (2005). The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract. Journal of Molecular Medicine, 83(12), 944–954. doi:10.1007/s00109-005-0698-5
  • Meier, R., Beglinger, C., Dederding, J. P., Meyer-Wyss, B., Fumagalli, M., Rowedder, A., … Brignoli, R. (1995). Influence of age, gender, hormonal status and smoking habits on colonic transit time. Neurogastroenterology & Motility, 7(4), 235–238. doi:10.1111/j.1365-2982.1995.tb00231.x
  • Meleine, M., & Matricon, J. (2014). Gender-related differences in irritable bowel syndrome: Potential mechanisms of sex hormones. World Journal of Gastroenterology, 20(22), 6725–6743. doi:10.3748/wjg.v20.i22.6725
  • Mitra, D., Davis, K. L., & Baran, R. W. (2011). All-cause health care charges among managed care patients with constipation and comorbid irritable bowel syndrome. Postgraduate Medicine, 123(3), 122–132. doi:10.3810/pgm.2011.05.2290
  • Myers, B., & Greenwood-Van Meerveld, B. (2009). Role of anxiety in the pathophysiology of irritable bowel syndrome: Importance of the amygdala. Front Neurosci, 3, 47. doi:10.3389/neuro.21.002.2009
  • Nam, S. Y., Kim, B. C., Ryu, K. H., & Park, B. J. (2010). Prevalence and risk factors of irritable bowel syndrome in healthy screenee undergoing colonoscopy and laboratory tests. Journal of Neurogastroenterology and Motility, 16(1), 47–51. doi:10.5056/jnm.2010.16.1.47
  • NIS Description of Data Elements. Healthcare Cost and Utilization Project (HCUP). (2017). Retrieved from https://www.hcup-us.ahrq.gov/db/nation/nis/nisdde.jsp
  • Osborn, L. A., Lauritsen, K. J., Cross, N., Davis, A. K., Rosenberg, H., Bonadio, F., & Lang, B. (2015). Self-medication of somatic and psychiatric conditions using botanical marijuana. Journal of Psychoactive Drugs, 47(5), 345–350. doi:10.1080/02791072.2015.1096433
  • Pan, G., Lu, S., Ke, M., Han, S., Guo, H., & Fang, X. (2000). Epidemiologic study of the irritable bowel syndrome in Beijing: Stratified randomized study by cluster sampling. Chinese Medical Journal, 113(1), 35–39.
  • Patel, R. S., Katta, S. R., Patel, R., Ravat, V., Gudipalli, R., Patel, V., & Patel, J. (2018). Cannabis use disorder in young adults with acute myocardial infarction: Trend inpatient study from 2010 to 2014 in the United States. Cureus, 10(8), e3241. doi:10.7759/cureus.3241
  • Pellissier, S., & Bonaz, B. (2017). The place of stress and emotions in the irritable Bowel Syndrome. Vitamins and Hormones, 103, 327–354. doi:10.1016/bs.vh.2016.09.005
  • Posserud, I., Syrous, A., Lindstrom, L., Tack, J., Abrahamsson, H., & Simren, M. (2007). Altered rectal perception in irritable bowel syndrome is associated with symptom severity. Gastroenterology, 133(4), 1113–1123. doi:10.1053/j.gastro.2007.07.024
  • Rausch, T., Beglinger, C., Alam, N., Gyr, K., & Meier, R. (1998). Effect of transdermal application of nicotine on colonic transit in healthy nonsmoking volunteers. Neurogastroenterology & Motility, 10(3), 263–270. doi:10.1046/j.1365-2982.1998.00105.x
  • Sałaga, M., Abalo, R., & Fichna, J. (2017). Cannabis and cannabinoids and the effects on gastrointestinal function: An overview Handbook of Cannabis and Related Pathologies, Biology. Pharmacology, Diagnosis, and Treatment, 471–480. Retrieved from https://www.semanticscholar.org/paper/Cannabis-and-Cannabinoids-and-the-Effects-on-An-Sa%C5%82aga-Abalo/1be1b14d940c6be3d991283c71019cb0507ff948
  • Simren, M., Abrahamsson, H., Svedlund, J., & Bjornsson, E. S. (2001). Quality of life in patients with irritable bowel syndrome seen in referral centers versus primary care: The impact of gender and predominant bowel pattern. Scandinavian Journal of Gastroenterology, 36(5), 545–552. doi:10.1080/003655201750153476
  • Talley, N. J., Phillips, S. F., Bruce, B., Twomey, C. K., Zinsmeister, A. R., & Melton, L. J. 3rd. (1990). Relation among personality and symptoms in nonulcer dyspepsia and the irritable bowel syndrome. Gastroenterology, 99(2), 327–333. doi:10.1016/0016-5085(90)91012-U
  • Videlock, E. J., Adeyemo, M., Licudine, A., Hirano, M., Ohning, G., Mayer, M., … Chang, L. (2009). Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndrome. Gastroenterology, 137(6), 1954–1962. doi:10.1053/j.gastro.2009.08.058
  • Wong, B. S., Camilleri, M., Busciglio, I., Carlson, P., Szarka, L. A., Burton, D., & Zinsmeister, A. R. (2011). Pharmacogenetic trial of a cannabinoid agonist shows reduced fasting colonic motility in patients with nonconstipated irritable bowel syndrome. Gastroenterology, 141(5), 1638–1647. e1631-1637. doi:10.1053/j.gastro.2011.07.036
  • Yuece, B., Sibaev, A., Broedl, UC., Marsicano, G., Göke, B., Lutz, B., … Storr, M. (2007). Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex. Neurogastroenterology & Motility, 19(9), 744–753. doi:10.1111/j.1365-2982.2007.00975.x

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.