Quetiapine Abuse Fourteen Years Later: Where Are We Now? A Systematic Review

References

• Aa, E., Helland, A., & Spigset, O. (2012). Kvetiapin kan ha misbrukspotensial [Quetiapine and the potential for abuse–Norwegian]. Tidsskrift for Den Norske Legeforening, 132(14), 1619–1620. doi:10.4045/tidsskr.11.1522
   PubMedGoogle Scholar
• Aggarwal, A., & Jiloha, R. C. (2008). Quetiapine induced myoclonus. Indian Journal of Medical Science, 62(10), 422–423.
   PubMedGoogle Scholar
• Altintoprak, A., Ünal, E., Bayrakçı, A., Gülseren, Ş., & Coşkunol, H. (2010). Ketiyapin bağımlılık mı yapıyor? (Does quetiapine have an addiction potential?). Anadolu Psikiyatri Dergisi, 11(1), 76–78.
   Google Scholar
• Anonymous. (2008). Abuse and diversion potential with quetiapine. Brown University Psychopharmacology Update, 19(10), 8.
   Google Scholar
• Anonymous. (2009). Antipsychotic drug being abused by addicts. Alcoholism & Drug Abuse Weekly, 21(28), 7.
   Google Scholar
• Anonymous. (2015). Quetiapine Abuse. Primary Care Drug Alerts, 36(7), 27–28.
   Google Scholar
• Anonymous. (2016). Quetiapine: Misuse and abuse. Prescrire Internationale, 25(169), 68.
   Google Scholar
• AstraZeneca Canada. (2017). Seroquel Product Monograph, March 2, 2017. Retrieved from https://www.astrazeneca.ca/content/dam/az-ca/downloads/productinformation/seroquel-xr-product-monograph-en.pdf
   Google Scholar
• Bastiaens, L., Galus, J., & Mazur, C. (2016). Abuse of gabapentin is associated with opioid addiction. Psychiatric Quarterly, 87(4), 763–767. doi:10.1007/s11126-016-9421-7
   PubMed Web of Science ®Google Scholar
• Blasio, A., Valenza, M., Iyer, M. R., Rice, K. C., Steardo, L., Hayashi, T., … Sabino, V. (2015). Sigma-1 receptor mediates acquisition of alcohol drinking and seeking behavior in alcohol-preferring rats. Behavioural Brain Research, 287, 315–322. doi:10.1016/j.bbr.2015.03.065
   PubMed Web of Science ®Google Scholar
• Bogart, G. T., & Ott, C. A. (2011). Abuse of second-generation antipsychotics: What prescribers need to know. Current Psychiatry, 10(5), 77–79.
   Google Scholar
• Boyer, P., Lecrubier, Y., Puech, A. J., Dewailly, J., & Aubin, F. (1995). Treatment of negative symptoms in schizophrenia with amisulpride. British Journal of Psychiatry, 166(1), 68–72. doi:10.1192/bjp.166.1.68
   PubMedGoogle Scholar
• Brett, J. (2015). Concerns about quetiapine. Australian Prescriber, 38(3), 95–97. doi:10.18773/austprescr.2015.032
   PubMed Web of Science ®Google Scholar
• Brutcher, R. E., & Nader, M. A. (2015). Effects of quetiapine treatment on cocaine self-administration and behavioral indices of sleep in adult rhesus monkeys. Psychopharmacology (Psychopharmacology), 232(2), 411–420. doi:10.1007/s00213-014-3672-5
   PubMed Web of Science ®Google Scholar
• Brutcher, R. E., Nader, S. H., & Nader, M. A. (2016). Evaluation of the reinforcing effect of quetiapine, alone and in combination with cocaine, in Rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics, 356(2), 244–250. doi:10.1124/jpet.115.228577
   PubMed Web of Science ®Google Scholar
• Caloro, M., Calabrò, G., de Pisa, E., Rosini, E., Kotzalidis, G. D., Lonati, D., … Girardi, P. (2018). Combined NMDA inhibitor use in a patient with multisubstance-induced psychotic disorder. Journal of Addiction Medicine, 12(3), 247–251. doi:10.1097/ADM.0000000000000390
   PubMed Web of Science ®Google Scholar
• Caniato, R. N., Gundabawady, A., Baune, B. T., & Alvarenga, M. E. (2009). Malingered psychotic symptoms and quetiapine abuse in a forensic setting. Journal of Forensic Psychiatry & Psychology, 20(6), 928–935. doi:10.1080/14789940903174196
   Web of Science ®Google Scholar
• Capece, J., & Pavlovsky, F. (2016). Tratamiento de la dependencia cannábica: Clínica, psicoterapia y evidencia [The treatment of cannabis dependence: Clinical work, psychotherapy and evidence–Spanish]. Vertex, XXVII, 469–473.
   PubMedGoogle Scholar
• Chen, C. Y., Shiah, I. S., Lee, W. K., Kuo, S. C., Huang, C. C., & Wang, T. Y. (2009). Dependence on quetiapine in combination with zolpidem and clonazepam in bipolar depression. Psychiatry and Clinical Neurosciences, 63(3), 427–428. doi:10.1111/j.1440-1819.2009.01953.x
   PubMed Web of Science ®Google Scholar
• Chiappini, S., & Schifano, F. (2018). Is there a potential of misuse for quetiapine?: Literature review and analysis of the European Medicines Agency/European Medicines Agency Adverse Drug Reactions' Database. Journal of Clinical Psychopharmacology, 38(1), 72–79.
   PubMed Web of Science ®Google Scholar
• Chouinard, G., Samaha, A. N., Chouinard, V. A., Peretti, C. S., Kanahara, N., Takase, M., & Iyo, M. (2017). Antipsychotic-induced dopamine supersensitivity psychosis: Pharmacology, criteria, and therapy. Psychotherapy and Psychosomatics, 86(4), 189–219. doi:10.1159/000477313
   PubMed Web of Science ®Google Scholar
• Cole, J. B., Stellpflug, S. J., Ellsworth, H., & Harris, C. R. (2012). Reversal of quetiapine-induced altered mental status with physostigmine: A case series. American Journal of Emergency Medicine, 30(6), 950–953.
   PubMed Web of Science ®Google Scholar
• Cornelis, C., Van Gastel, A., Dumont, G., Coppens, V., Sabbe, B., Morrens, M., & Van Den Eede, F. (2016). A case of dose escalation of quetiapine in persistent insomnia disorder. Acta Clinica Belgica, 14, 1–3. doi:10.1080/17843286.2016.1252546
   Google Scholar
• Crosby, K. M., Hausner, S., & Brahm, N. (2018). Consequences of undocumented medication use. Diabetes Spectrum : A Publication of the American Diabetes Association, 31(1), 96–98. doi:10.2337/ds16-0075
   PubMedGoogle Scholar
• Cross, A. J., Widzowski, D., Maciag, C., Zacco, A., Hudzik, T., Liu, J., … Wood, M. W. (2016). Quetiapine and its metabolite norquetiapine: Translation from in vitro pharmacology to in vivo efficacy in rodent models. British Journal of Pharmacology, 173(1), 155–166. doi:10.1111/bph.13346
   PubMed Web of Science ®Google Scholar
• Cubała, W. J., & Springer, J. (2014). Quetiapine abuse and dependence in psychiatric patients: A systematic review of 25 case reports in the literature. Journal of Substance Use, 19(5), 388–393. doi:10.3109/14659891.2013.810309
   Web of Science ®Google Scholar
• Datto, C., Berggren, L., Patel, J. B., & Eriksson, H. (2009). Self-reported sedation profile of immediate-release quetiapine fumarate compared with extended-release quetiapine fumarate during dose initiation: A randomized, double-blind, crossover study in healthy adult subjects. Clinical Therapeutics, 31(3), 492–502. doi:10.1016/j.clinthera.2009.03.002
   PubMed Web of Science ®Google Scholar
• Desarkar, P., Desarker, P., & Sinha, V. K. (2006). Quetiapine-induced acute dystonia and akathisia. Australian and New Zealand Journal of Psychiatry, 40(6–7), 607–608.
   PubMed Web of Science ®Google Scholar
• Dobbin, M. (2014). Pharmaceutical drug misuse in Australia. Australian Prescriber, 37(3), 79–81. doi:10.18773/austprescr.2014.033
   Google Scholar
• Erdoğan, S. (2010). Madde kullanım bozukluklarında ketiyapinin yeri, kötüye kullanım ve bağımlılık olasılığı: Bir gözden geçirme [Quetiapine in substance use disorders, abuse and dependence possibility: A review–Turkish]. Türk Psikiyatri Dergisi, 21(2), 167–175.
   PubMed Web of Science ®Google Scholar
• Evren, C., Karatepe, H. T., Aydın, A., Dalbudak, E., & Cakmak, D. (2009). Alkol/Madde bağımlılarında ketiyapinin etkisi ve kötüye kullanımı: Olgu serisi ve gözden geçirme [The effect of quetiapine on alcohol/drug dependents and its abuse: A case series and literature review–Turkish]. Klinik Psikofarmakoloji Bülteni, 19(2), 148–154.
   Google Scholar
• Figueroa, C., Brecher, M., Hamer-Maansson, J. E., & Winter, H. (2009). Pharmacokinetic profiles of extended release quetiapine fumarate compared with quetiapine immediate release. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(2), 199–204.
   PubMed Web of Science ®Google Scholar
• Fischer, B. A., & Boggs, D. L. (2010). The role of antihistaminic effects in the misuse of quetiapine: A case report and review of the literature. Neuroscience & Biobehavioral Reviews, 34(4), 555–558. doi:10.1016/j.neubiorev.2009.11.003
   PubMed Web of Science ®Google Scholar
• Flammia, D. D., Valouch, T., & Venuti, S. (2006). Tissue distribution of quetiapine in 20 cases in Virginia. Journal of Analytical Toxicology, 30(4), 287–292. doi:10.1093/jat/30.4.287
   PubMed Web of Science ®Google Scholar
• Fontanilla, D., Johannessen, M., Hajipour, A. R., Cozzi, N. V., Jackson, M. B., & Ruoho, A. E. (2009). The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science, 323(5916), 934–937. doi:10.1126/science.1166127
   PubMed Web of Science ®Google Scholar
• Fountain, J. S., & Slaughter, R. J. (2016). TOXINZ, the New Zealand Internet poisons information database: The first decade. Emergency Medicine Australasia, 28(3), 335–340. doi:10.1111/1742-6723.12594
   PubMed Web of Science ®Google Scholar
• Frauger, E., Pochard, L., Boucherie, Q., Giocanti, A., Chevallier, C., Daveluy, A., … Micallef, J, le Réseau français d’addictovigilance. (2017). Dispositif pharmacoépidémiologique de surveillance des substances psychoactives: Intérêts du programme national OPPIDUM du Réseau français d’addictovigilance [Surveillance system on drug abuse: Interest of the French national OPPIDUM program of French addictovigilance network–French]. Therapies, 72, 491–501. doi:10.1016/j.therap.2017.01.010
   PubMed Web of Science ®Google Scholar
• Galyuk, T. M., de Backer, G., de Jong, C. A., Beers, E., & Loonen, A. J. (2009). Misbruik van quetiapine. Twee verslaafde patiënten met een borderlinepersoonlijkheidsstoornis [Abuse of quetiapine. Two addicted patients with borderline personality disorder–Dutch]. Nederlands Tijdschrift Voor Geneeskunde, 153(14), 674–676.
   PubMedGoogle Scholar
• George, M., Haasz, M., Coronado, A., Salhanick, S., Korbel, L., & Kitzmiller, J. P. (2013). Acute dyskinesia, myoclonus, and akathisa (sic!) in an adolescent male abusing quetiapine via nasal insufflation: A case study. BMC Pediatrics, 13(1), 187.
   PubMedGoogle Scholar
• Gjerden, P., Bramness, J. G., Tvete, I. F., & Slørdal, L. (2017). The antipsychotic agent quetiapine is increasingly not used as such: Dispensed prescriptions in Norway 2004-2015. European Journal of Clinical Pharmacology, 73(9), 1173–1179. doi:10.1007/s00228-017-2281-8
   PubMed Web of Science ®Google Scholar
• Goldin, K. (1989). Cocaine or perhaps antihistamine abuse. Hospital Practice (Practice), 24, 14–16. doi:10.1080/21548331.1989.11703707
   PubMed Web of Science ®Google Scholar
• Grabowski, K. (2018). Quetiapine abuse and dependence: Is pharmacokinetics important? Acta Clinica Belgica, 73(2), 162. doi:10.1080/17843286.2017.1339964
   PubMed Web of Science ®Google Scholar
• Gugger, J. J., & Cassagnol, M. (2008). Low-dose quetiapine is not a benign sedative-hypnotic agent. American Journal on Addictions, 17(5), 454–455.
   PubMed Web of Science ®Google Scholar
• Guitart, X., Codony, X., & Monroy, X. (2004). Sigma receptors: Biology and therapeutic potential. Psychopharmacology (Psychopharmacology), 174(3), 301–319. doi:10.1007/s00213-004-1920-9
   PubMed Web of Science ®Google Scholar
• Hanley, M. J., & Kenna, G. A. (2008). Quetiapine: Treatment for substance abuse and drug of abuse. American Journal of Health-System Pharmacy, 65(7), 611–618. doi:10.2146/ajhp070112
   PubMed Web of Science ®Google Scholar
• Haridas, A., Kushon, D., Gurmu, S., & Oluwabusi, O. (2010). Smoking quetiapine: A “Maq Ball”? Primary Psychiatry, 17(9), 38–39.
   Google Scholar
• Haukka, J., Kriikku, P., Mariottini, C., Partonen, T., & Ojanperä, I. (2018). Non-medical use of psychoactive prescription drugs is associated with fatal poisoning. Addiction, 113(3), 464–472. doi:10.1111/add.14014
   PubMed Web of Science ®Google Scholar
• Hawkins, K. L., & Gidal, B. E. (2017). When adverse effects are seen as desirable: Abuse potential of the newer generation antiepileptic drugs. Epilepsy & Behavior, 77, 62–72. doi:10.1016/j.yebeh.2017.10.007
   PubMed Web of Science ®Google Scholar
• Heeren, N., & Farver, D. (2017). You abused what? Getting high with unique medications. South Dakota Medicine, 70(1), 38–39.
   PubMedGoogle Scholar
• Heilbronn, C. E., Lloyd, B., McElwee, P., Eade, A., & Lubman, D. I. (2012). Quetiapine-related harms are on the rise. Australian & New Zealand Journal of Psychiatry, 46(3), 279–280. doi:10.1177/0004867411432213
   PubMed Web of Science ®Google Scholar
• Heilbronn, C., Lloyd, B., McElwee, P., Eade, A., & Lubman, D. I. (2013). Trends in quetiapine use and non-fatal quetiapine-related ambulance attendances. Drug and Alcohol Review, 32(4), 405–411. doi:10.1111/dar.12028
   PubMed Web of Science ®Google Scholar
• Hussain, M. Z., Waheed, W., & Hussain, S. (2005). Intravenous quetiapine abuse. American Journal of Psychiatry, 162(9), 1755-a–1756. doi:10.1176/appi.ajp.162.9.1755-a
   Web of Science ®Google Scholar
• Huthwaite, M., Tucker, M., McBain, L., & Romans, S. (2018). Off label or on trend: A review of the use of quetiapine in New Zealand. The New Zealand Medical Journal, 131(1474), 45–50.
   PubMed Web of Science ®Google Scholar
• Ilyas, S., & Moncrieff, J. (2012). Trends in prescriptions and costs of drugs for mental disorders in England, 1998-2010. British Journal of Psychiatry, 200(5), 393–398. doi:10.1192/bjp.bp.111.104257
   PubMed Web of Science ®Google Scholar
• Inciardi, J. A., Surratt, H. L., Kurtz, S. P., & Cicero, T. J. (2007). Mechanisms of prescription drug diversion among drug-involved club- and street-based populations. Pain Medicine (Malden, Mass.), 8(2), 171–183. doi:10.1111/j.1526-4637.2006.00255.x
   PubMed Web of Science ®Google Scholar
• Indave, B. I., Minozzi, S., Pani, P. P., & Amato, L. (2016). Antipsychotic medications for cocaine dependence. Cochrane Database of Systematic Reviews, 3, CD006306.
   PubMedGoogle Scholar
• James, J. (2016). Dealing with drug-seeking behaviour. Australian Prescriber, 39(3), 96–100.
   PubMed Web of Science ®Google Scholar
• Jhaveri, K. D., & Webber, A. B. (2008). The Case | Triple acid-base disorder after drug abuse. Kidney International, 74(10), 1363–1364.
   PubMed Web of Science ®Google Scholar
• Kapur, S., & Seeman, P. (2000). Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action. Journal of Psychiatry and Neuroscience, 25(2), 161–166.
   PubMed Web of Science ®Google Scholar
• Kaya, H., Dilbaz, N., Okay, T., & Çeşmeci, U. (2009). Ketiyapin bağımlılık yapıyor mu? [Is quetiapine addictive?–Turkish]. Klinik Psikofarmakoloji Bülteni, 19(Suppl. 1), s32–s36.
   Google Scholar
• Keltner, N. L., & Vance, D. E. (2008). Biological perspectives. Incarcerated care and quetiapine abuse. Perspectives in Psychiatric Care, 44(3), 202–206. doi:10.1111/j.1744-6163.2008.00175.x
   PubMed Web of Science ®Google Scholar
• Kim, S., Lee, G., Kim, E., Jung, H., & Chang, J. (2017). Quetiapine misuse and abuse: Is it an atypical paradigm of drug seeking behavior?. Journal of Research in Pharmacy Practice, 6(1), 12–15. doi:10.4103/2279-042X.200987
   PubMed Web of Science ®Google Scholar
• Klein, L., Bangh, S., & Cole, J. B. (2017). Intentional recreational abuse of quetiapine compared to other second-generation antipsychotics. The Western Journal of Emergency Medicine, 18(2), 243–250.
   PubMed Web of Science ®Google Scholar
• Klein-Schwartz, W., Schwartz, E. K., & Anderson, B. D. (2014). Evaluation of quetiapine abuse and misuse reported to poison centers. Journal of Addiction Medicine, 8(3), 195–198. doi:10.1097/ADM.0000000000000020
   PubMed Web of Science ®Google Scholar
• Kolli, V., Mary, H., Garcia-Delgar, B., & Coffey, B. J. (2016). Quetiapine addiction in an adolescent. Journal of Child and Adolescent Psychopharmacology, 26(2), 174–176. doi:10.1089/cap.2016.29104.bjc
   PubMed Web of Science ®Google Scholar
• Kotagale, N. R., Mendhi, S. M., Aglawe, M. M., Umekar, M. J., & Taksande, B. G. (2013). Evidences for the involvement of sigma receptors in antidepressant like effect of quetiapine in mice. European Journal of Pharmacology, 702(1-3), 180–186. doi:10.1016/j.ejphar.2013.01.045
   PubMed Web of Science ®Google Scholar
• Kuroki, T., Nagao, N., & Nakahara, T. (2008). Neuropharmacology of second-generation antipsychotic drugs: A validity of the serotonin-dopamine hypothesis. Progress in Brain Research, 172, 199–212.
   PubMed Web of Science ®Google Scholar
• Lambe, J. (2013). Response to: 'quetiapine use: Science or clever marketing?' The Australian and New Zealand Journal of Psychiatry, 47(11), 1086doi:10.1177/0004867413495470
   PubMed Web of Science ®Google Scholar
• Lee, J., Pilgrim, J., Gerostamoulos, D., Robinson, J., & Wong, A. (2018). Increasing rates of quetiapine overdose, misuse, and mortality in Victoria, Australia. Drug and Alcohol Dependence, 187, 95–99. doi:10.1016/j.drugalcdep.2018.03.002
   PubMed Web of Science ®Google Scholar
• López-Muñoz, F., & Álamo, C. (2013). Active metabolites as antidepressant drugs: The role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders. Frontiers in Psychiatry, 4, 102. doi:10.3389/fpsyt.2013.00102
   PubMedGoogle Scholar
• Lu, L., Koya, E., Zhai, H., Hope, B. T., & Shaham, Y. (2006). Role of ERK in cocaine addiction. Trends in Neurosciences, 29(12), 695–703. doi:10.1016/j.tins.2006.10.005
   PubMed Web of Science ®Google Scholar
• Malekshahi, T., Tioleco, N., Ahmed, N., Campbell, A. N., & Haller, D. (2015). Misuse of atypical antipsychotics in conjunction with alcohol and other drugs of abuse. Journal of Substance Abuse Treatment, 48(1), 8–12. doi:10.1016/j.jsat.2014.07.006
   PubMed Web of Science ®Google Scholar
• Martinotti, G., Andreoli, S., Di Nicola, M., Di Giannantonio, M., Sarchiapone, M., & Janiri, L. (2008). Quetiapine decreases alcohol consumption, craving, and psychiatric symptoms in dually diagnosed alcoholics. Human Psychopharmacology: Clinical and Experimental, 23(5), 417–424. doi:10.1002/hup.944
   PubMed Web of Science ®Google Scholar
• Mattson, M. E., Albright, V. A., Yoon, J., & Council, C. L. (2015). Emergency department visits involving misuse and abuse of the antipsychotic quetiapine: Results from the Drug Abuse Warning Network (DAWN). Substance Abuse, 9, 39–46.
   PubMed Web of Science ®Google Scholar
• McKean, A., & Monasterio, E. (2012). Off-label use of atypical antipsychotics: Cause for concern? CNS Drugs, 26(5), 383–390. doi:10.2165/11632030-000000000-00000
   PubMed Web of Science ®Google Scholar
• McLarnon, M. E., Fulton, H. G., MacIsaac, C., & Barrett, S. P. (2012). Characteristics of quetiapine misuse among clients of a community-based methadone maintenance program. Journal of Clinical Psychopharmacology, 32(5), 721–723. doi:10.1097/JCP.0b013e3182670648
   PubMed Web of Science ®Google Scholar
• McLelland, A. E., Martin-Iverson, M. T., & Beninger, R. J. (2014). The effect of quetiapine (Seroquel™) on conditioned place preference and elevated plus maze tests in rats when administered alone and in combination with (+)-amphetamine. Psychopharmacology (Psychopharmacology), 231(22), 4349–4359. doi:10.1007/s00213-014-3578-2
   PubMed Web of Science ®Google Scholar
• Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G, PRISMA Group. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Journal of Clinical Epidemiology, 62(10), 1006–1012. doi:10.1016/j.jclinepi.2009.06.005
   PubMed Web of Science ®Google Scholar
• Monasterio, E., & McKean, A. (2011a). Off-label use of atypical antipsychotic medications in Canterbury, New Zealand. New Zealand Medical Journal, 124(1336), 24–29.
   PubMedGoogle Scholar
• Monasterio, E., & McKean, A. (2011b). Off-label prescribing of atypical antipsychotic medications. New Zealand Medical Journal, 124(1341), 80–82.
   PubMedGoogle Scholar
• Monasterio, E., & McKean, A. (2013a). Quetiapine use: Science or clever marketing? Australian & New Zealand Journal of Psychiatry, 47(1), 96–97. doi:10.1177/0004867412455234
   PubMed Web of Science ®Google Scholar
• Monasterio, E., & McKean, A. (2013b). Use of quetiapine in child and adolescent populations - response to letter from Dr Lambe. Australian & New Zealand Journal of Psychiatry, 47(11), 1084–1085. doi:10.1177/0004867413498274
   PubMed Web of Science ®Google Scholar
• Montebello, M. E., & Brett, J. (2017). Misuse and associated harms of quetiapine and other atypical antipsychotics. Current Topics in Behavioral Neurosciences, 34, 125–139.
   PubMedGoogle Scholar
• Morin, A. K. (2007). Possible intranasal quetiapine misuse. American Journal of Health-System Pharmacy, 64(7), 723–725. doi:10.2146/ajhp060226
   PubMed Web of Science ®Google Scholar
• Motta-Ochoa, R., Bertrand, K., Arruda, N., Jutras-Aswad, D., & Roy, É. (2017). I love having benzos after my coke shot”: The use of psychotropic medication among cocaine users in downtown Montreal. International Journal of Drug Policy, 49, 15–23. doi:10.1016/j.drugpo.2017.07.012
   PubMed Web of Science ®Google Scholar
• Murphy, D., Bailey, K., Stone, M., & Wirshing, W. C. (2008). Addictive potential of quetiapine. American Journal of Psychiatry, 165(7), 918. doi:10.1176/appi.ajp.2008.08020277
   PubMed Web of Science ®Google Scholar
• Nakao, S., Miyamoto, E., Masuzawa, M., Kambara, T., & Shingu, K. (2002). Ketamine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices is mediated not only via NMDA receptors but also via sigma receptors. Brain Research, 926(1–2), 191–196. doi:10.1016/S0006-8993(01)03338-8
   PubMed Web of Science ®Google Scholar
• Nord, M., Nyberg, S., Brogren, J., Jucaite, A., Halldin, C., & Farde, L. (2011). Comparison of D2 dopamine receptor occupancy after oral administration of quetiapine fumarate immediate-release and extended-release formulations in healthy subjects. The International Journal of Neuropsychopharmacology, 14(10), 1357–1366. doi:10.1017/S1461145711000514
   PubMed Web of Science ®Google Scholar
• Osborne, V., Davies, M., Layton, D., & Shakir, S. A. W. (2016). Utilisation of extended release quetiapine (Seroquel XL™): Results from an observational cohort study in England. European Psychiatry, 33, 61–67. doi:10.1016/j.eurpsy.2015.12.004
   PubMed Web of Science ®Google Scholar
• Oyemade, A. (2010). Seroquel misuse/abuse. Psychiatry (Edgmont (Pa. : Township)), 7(2), 15–16.
   PubMedGoogle Scholar
• Paparrigopoulos, T., Karaiskos, D., & Liappas, J. (2008). Quetiapine: Another drug with potential for misuse? A case report. Journal of Clinical Psychiatry, 69(1), 162–163.
   PubMed Web of Science ®Google Scholar
• Papoutsis, I., Katselou, M., Nikolaou, P., Dona, A., Spiliopoulou, C., & Athanaselis, S. (2017). A validated gas chromatography mass spectrometry method for the investigation of quetiapine-related deaths in Greece. European Journal of Forensic Sciences, 4(2), 1–10. doi:10.5455/ejfs.239625
   Google Scholar
• Pereira, A., Zhang, B., Malcolm, P., Sugiharto-Winarno, A., & Sundram, S. (2014). Quetiapine and aripiprazole signal differently to ERK, p90RSK and c-Fos in mouse frontal cortex and striatum: Role of the EGF receptor. BMC Neuroscience, 15(1), 30. doi:10.1186/1471-2202-15-30
   PubMedGoogle Scholar
• Peyrière, H., Diot, C., Eiden, C., & Petit, P, Réseau des Centres d’Addictovigilance. (2015). Potentiel d'abus et dépendence de la quétiapine [Abuse Liability of Quetiapine (Xeroquel®)–Article in French]. Thérapie, Aug 4. doi:10.2515/therapie/2015048
   Google Scholar
• Peyrière, H., Diot, C., Nogue, E., Verschave, M., Laure, M., Picot, M.-C., … Leglise, Y. (2017). Prevalence of antipsychotic-treated patients in a cohort of adult addicted patients. Journal of Clinical Psychopharmacology, 37(6), 669–674. doi:10.1097/JCP.0000000000000806
   PubMed Web of Science ®Google Scholar
• Pierre, J. M., Shnayder, I., Wirshing, D. A., & Wirshing, W. C. (2004). Intranasal quetiapine abuse. American Journal of Psychiatry, 161(9), 1718. doi:10.1176/appi.ajp.161.9.1718
   PubMed Web of Science ®Google Scholar
• Pilgrim, J. L., & Drummer, O. H. (2013). The toxicology and comorbidities of fatal cases involving quetiapine. Forensic Science, Medicine, and Pathology, 9(2), 170–176. doi:10.1007/s12024-012-9404-4
   PubMed Web of Science ®Google Scholar
• Pinkofsky, H. B., Hahn, A. M., Campbell, F. A., Rueda, J., Daley, D. C., & Douaihy, A. B. (2005). Reduction of opioid-withdrawal symptoms with quetiapine. The Journal of Clinical Psychiatry, 66(10), 1285–1288. doi:10.4088/JCP.v66n1011
   PubMed Web of Science ®Google Scholar
• Pinta, E. R., & Taylor, R. E. (2007). Quetiapine addiction? The American Journal of Psychiatry, 164(1), 174–175. doi:10.1176/ajp.2007.164.1.174
   PubMed Web of Science ®Google Scholar
• Piróg-Balcerzak, A., Habrat, B., & Mierzejewski, P. (2015). Niewłaściwe używanie i nadużywanie kwetiapiny [Misuse and abuse of quetiapine–English-Polish]. Psychiatria Polska, 49(1), 81–93. doi:10.12740/PP/32923
   PubMedGoogle Scholar
• Ramachandran, S., Chu, U. B., Mavlyutov, T. A., Pal, A., Pyne, S., & Ruoho, A. E. (2009). The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids. European Journal of Pharmacology, 609(1–3), 19–26. doi:10.1016/j.ejphar.2009.03.003
   PubMed Web of Science ®Google Scholar
• Reccoppa, L. (2011 Mar-Apr). Less abuse potential with XR formulation of quetiapine? The American Journal on Addictions, 20(2), 178. doi:10.1111/j.1521-0391.2010.00104.x
   PubMed Web of Science ®Google Scholar
• Rech, M. A., Donahey, E., Cappiello Dziedzic, J. M., Oh, L., & Greenhalgh, E. (2015). New drugs of abuse. Pharmacotherapy, 35(2), 189–197. doi:10.1002/phar.1522
   PubMed Web of Science ®Google Scholar
• Reddel, S. E., Bruno, R., Burns, L., Kirwan, A., Lokuge, K., & Dietze, P. (2014). Prevalence and associations of quetiapine fumarate misuse among an Australian national city sample of people who regularly inject drugs. Addiction, 109(2), 295–302. doi:10.1111/add.12395
   Web of Science ®Google Scholar
• Reeves, R. (2012). Guideline, education, and peer comparison to reduce prescriptions of benzodiazepines and low-dose quetiapine in prison. Journal of Correctional Health Care, 18(1), 45–52. doi:10.1177/1078345811421591
   PubMed Web of Science ®Google Scholar
• Reeves, R. R., & Brister, J. C. (2007). Additional evidence of the abuse potential of quetiapine. Southern Medical Journal, 100(8), 834–836. doi:10.1097/SMJ.0b013e3180f62d53
   PubMed Web of Science ®Google Scholar
• Reeves, R. R., & Burke, R. S. (2014). Abuse of combinations of gabapentin and quetiapine. Primary Care Companion of CNS Disorders, 16(5). doi:10.4088/PCC.14l01660
   PubMedGoogle Scholar
• Rizos, E., Douzenis, A., Gournellis, R., Christodoulou, C., & Lykouras, L. P. (2009). Tardive dyskinesia in a patient treated with quetiapine. The World Journal of Biological Psychiatry, 10(1), 54–57. doi:10.1080/15622970701362550
   PubMed Web of Science ®Google Scholar
• Sánchez, J. P. B., & Ellenbroek, B. A. (2017). Preclinical effects of antipsychotic drugs. Current Topics in Behavioral Neurosciences, 34, 1–16.
   PubMedGoogle Scholar
• Sansone, R. A., & Sansone, L. A. (2010). Is seroquel developing an illicit reputation for misuse/abuse? Psychiatry (Edgmont), 7(1), 13–16.
   Google Scholar
• Schifano, F., Chiappini, S., Corkery, J. M., & Guirguis, A. (2018). Abuse of prescription drugs in the context of novel psychoactive substances (NPS): A systematic review. Brain Sciences, 8(4), 73. doi:10.3390/brainsci8040073
   PubMed Web of Science ®Google Scholar
• Seshadri, M., Elsemary, A., Thalitaya, M. D., Chikodzore, L., & Nagalingam, P. (2017). Study on the prescribing patterns of antipsychotic medication in a rural England Community Mental Health Team. Psychiatria Danubina, 29(Suppl 3), 524–529.
   PubMedGoogle Scholar
• Shah, R., Grover, S., Maheshwari, U., Kate, N., & Malhotra, N. (2010). Acute akathisia with quetiapine: A case report and review of the literature. Indian Journal of Pharmacology, 42(6), 416–417.
   PubMed Web of Science ®Google Scholar
• Sharp, J. W. (1997). Phencyclidine (PCP) acts at sigma sites to induce c-fos gene expression. Brain Research, 758(1–2), 51–58. doi:10.1016/s0006-8993(97)00025-5
   PubMed Web of Science ®Google Scholar
• Srivastava, A., Patil, V., & Da Silva Pereira, Y. (2013). A case series of quetiapine addiction/dependence. German Journal of Psychiatry, 16(4), 152–155.
   Google Scholar
• Su, T. P., Weissman, A. D., & Yeh, S. Y. (1986). Endogenous ligands for sigma opioid receptors in the brain (“sigmaphin”): evidence from binding assays. Life Sciences, 38(24), 2199–2210.
   PubMed Web of Science ®Google Scholar
• Sun, W. L., Quizon, P. M., & Zhu, J. (2016). Molecular mechanism: ERK signaling, drug addiction, and behavioral effects. Progress in Molecular Biology and Translational Science, 137, 1–40.
   PubMed Web of Science ®Google Scholar
• Tamburello, A. C., Lieberman, J. A., Baum, R. M., & Reeves, R. (2012). Successful removal of quetiapine from a correctional formulary. Journal of the American Academy of Psychiatry and the Law, 40(4), 502–508.
   PubMed Web of Science ®Google Scholar
• Tauscher, J., Hussain, T., Agid, O., Verhoeff, N. P., Wilson, A. A., Houle, S., … Kapur, S. (2004). Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: Differentiation from other atypical antipsychotics. American Journal of Psychiatry, 161(9), 1620–1625. doi:10.1176/appi.ajp.161.9.1620
   PubMed Web of Science ®Google Scholar
• Tcheremissine, O. V. (2008). Is quetiapine a drug of abuse? Reexamining the issue of addiction. Expert Opinion on Drug Safety, 7(6), 739–748. doi:10.1517/14740330802496883
   PubMed Web of Science ®Google Scholar
• Vento, A. E., Schifano, F., Gentili, F., Pompei, F., Corkery, J. M., Kotzalidis, G. D., & Girardi, P. (2013). Bupropion perceived as a stimulant by two patients with a previous history of cocaine misuse. Annali Dell’Istituto Superiore di Sanità, 49(4), 402–405.
   PubMed Web of Science ®Google Scholar
• Waters, B. M., & Joshi, K. G. (2007). Intravenous quetiapine-cocaine use (“Q-ball”). The American Journal of Psychiatry, 164(1), 173–174. doi:10.1176/ajp.2007.164.1.173a
   PubMed Web of Science ®Google Scholar
• Yamamura, S., Ohoyama, K., Hamaguchi, T., Kashimoto, K., Nakagawa, M., Kanehara, S., … Okada, M. (2009). Effects of quetiapine on monoamine, GABA, and glutamate release in rat prefrontal cortex. Psychopharmacology (Berlin), 206(2), 243–258. doi:10.1007/s00213-009-1601-9
   PubMed Web of Science ®Google Scholar
• Yargic, I., & Caferov, C. (2011). Quetiapine dependence and withdrawal: a case report. Substance Abuse, 32(3), 168–169. doi:10.1080/08897077.2011.558448
   PubMed Web of Science ®Google Scholar
• Yasui, Y., & Su, T. P. (2016). Potential molecular mechanisms on the role of the sigma-1 receptor in the action of cocaine and methamphetamine. Journal of Drug and Alcohol Research, 5, 1. doi:10.4303/jdar/235970
   Google Scholar