The Future of Substance Abuse Now: Relationships among Adolescent Use of Vaping Devices, Marijuana, and Synthetic Cannabinoids

References

• Abush, H., Ghose, S., Van Enkevort, E. A., Clementz, B. A., Pearlson, G. D., Sweeney, J. A., Keshavan, M. S., Tamminga, C. A., & Ivleva, E. I. (2018). Associations between adolescent cannabis use and brain structure in psychosis. Psychiatry Research. Neuroimaging, 276, 53–64. https://doi.org/10.1016/j.pscychresns.2018.03.008
   PubMed Web of Science ®Google Scholar
• American Association of Poison Control Centers. (2017, November 28). American Association of Poison Control Centers publishes 34th annual report of the National Poison Data System: Calls to Poison Control show upward trend in medical severity; Poison Control increasingly utilized by health care providers [Press release]. Retrieved September 15, 2020 from https://piper.filecamp.com/uniq/XJqwjSDMu0IHRLo8.pdf
   Google Scholar
• Anonymous. (2016). eCig DMT: A Comprehensive Guide. Retrieved November 18, 2020 from https://www.reddit.com/r/DMT/comments/4ut5zw/ecig_dmt_a_comprehensive_ guide/
   Google Scholar
• Anonymous. (2014). Shroomery: Magic mushrooms demystified. How to consume DMT powder? Retrieved September 15, 2020 from https://www.shroomery.org/forums/showflat.php/Number/21031079
   Google Scholar
• Anonymous. (2017). DMT- The E-Cig Experience. Retrieved September 15, 2020 from https://steemit.com/psychedelics/@arconite/dmt-the-e-cig-experience
   Google Scholar
• Armenian, P., Darracq, M., Gevorkyan, J., Clark, S., Kaye, B., & Brandehoff, N. P. (2018). Intoxication from the novel synthetic cannabinoids AB-PINACA and ADB-PINACA: A case series and review of the literature. Neuropharmacology, 134(Pt A), 82–91. https://doi.org/10.1016/j.neuropharm.2017.10.017
   PubMed Web of Science ®Google Scholar
• Azagba, S. (2018). E-cigarette use, dual use of e-cigarettes and tobacco cigarettes, and frequency of cannabis use among high school students. Addictive Behaviors, 79, 166–170. https://doi.org/10.1016/j.addbeh.2017.12.028
   PubMed Web of Science ®Google Scholar
• Bentivegna, K., Atuegwu, N. C., Oncken, C., DiFranza, J. R., & Mortensen, E. M. (2020). Electronic cigarettes associated with incident and polysubstance use among youth. Journal of Adolescent Health, 2020, 1–7. https://doi.org/10.1016/j.jadohealth.2020.05.026
   Google Scholar
• Blanco, C., Hasin, D. S., Wall, M. M., Flórez-Salamanca, L., Hoertel, N., Wang, S., Kerridge, B. T., & Olfson, M. (2016). Cannabis use and risk of psychiatric disorders: Prospective evidence from a U.S. National longitudinal study. JAMA Psychiatry, 73(4), 388–395. https://doi.org/10.1001/jamapsychiatry.2015.3229
   PubMed Web of Science ®Google Scholar
• Blum, K., Febo, M., Smith, D. E., Roy, A. K., Demetrovics, Z., Cronjé, F. J., Femino, J., Agan, G., Fratantonio, J. L., Pandey, S. C., Badgaiyan, R. D., & Gold, M. S. (2015). Neurogenetic and epigenetic correlates of adolescent predisposition to and risk for addictive behaviors as a function of prefrontal cortex dysregulation. Journal of Child and Adolescent Psychopharmacology, 25(4), 286–292. https://doi.org/10.1089/cap.2014.0146
   PubMed Web of Science ®Google Scholar
• Blundell, M., Dargan, P., & Wood, D. (2018). A cloud on the horizon-a survey into the use of electronic vaping devices for recreational drug and new psychoactive substance (NPS) administration. QJM : Monthly Journal of the Association of Physicians, 111(1), 9–14. https://doi.org/10.1093/qjmed/hcx178
   PubMed Web of Science ®Google Scholar
• Brents, L. K., & Prather, P. L. (2014). The K2/spice phenomenon: Emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products. Drug Metabolism Reviews, 46(1), 72–85. https://doi.org/10.3109/03602532.2013.839700
   PubMed Web of Science ®Google Scholar
• Broman, C. L., Li, X., & Reckase, M. D. (2008). Family structure and mediators of adolescent drug use. Journal of Family Issues, 29, 1625–1649. https://doi.org/10.1177/0192513X08322776
   Web of Science ®Google Scholar
• Buser, G. L., Gerona, R. R., Horowitz, B. Z., Vian, K. P., Troxell, M. L., Hendrickson, R. G., Houghton, D. C., Rozansky, D., Su, S. W., & Leman, R. F. (2014). Acute kidney injury associated with smoking synthetic cannabinoid. Clinical Toxicology (Philadelphia, Pa.).), 52(7), 664–673. https://doi.org/10.3109/15563650.2014.932365
   PubMed Web of Science ®Google Scholar
• Camenga, D. R., Kong, G., Cavallo, D. A., Liss, A., Hyland, A., Delmerico, J., Cummings, K. M., & Krishnan-Sarin, S. (2014). Alternate tobacco product and drug use among adolescents who use electronic cigarettes, cigarettes only, and never smokers. The Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine, 55(4), 588–591. https://doi.org/10.1016/j.jadohealth.2014.06.016
   PubMed Web of Science ®Google Scholar
• Cassidy, R. N., Meisel, M. K., DiGuiseppi, G., Balestrieri, S., & Barnett, N. P. (2018). Initiation of vaporizing cannabis: Individual and social network predictors in a longitudinal study of young adults. Drug and Alcohol Dependence, 188, 334–349. https://doi.org/10.1016/j.drugalcdep.2018.04.014
   PubMed Web of Science ®Google Scholar
• Caudevilla, F., Ventura, M., Fornís, I., Barratt, M. J., Vidal, C., Lladanosa, C. G., Quintana, P., Muñoz, A., & Calzada, N. (2016). Results of an international drug testing service for cryptomarket users. The International Journal on Drug Policy, 35, 38–41. https://doi.org/10.1016/j.drugpo.2016.04.017
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. (2020). Outbreak of lung injury associated with the use of e-cigarette, or vaping, products. Retrieved September 15, 2020 from https://www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html
   Google Scholar
• Clayton, H. B., Lowry, R., Ashley, C., Wolkin, A., & Grant, A. M. (2017). Health risk behaviors with synthetic cannabinoids versus marijuana. Pediatrics, 139(4), e20162675. https://doi.org/10.1542/peds.2016-2675
   PubMed Web of Science ®Google Scholar
• Cranford, J. A., Bohnert, K. M., Perron, B. E., Bourque, C., & Ilgen, M. (2016). Prevalence and correlates of "vaping" as a route of cannabis administration in medical cannabis patients. Drug and Alcohol Dependence, 169, 41–47. https://doi.org/10.1016/j.drugalcdep.2016.10.008
   PubMed Web of Science ®Google Scholar
• Cunliffe, J., Decary-Hetu, D., & Pollak, T. A. (2019). Nonmedical prescription psychiatric drug use and the darknet: A cryptomarket analysis. The International Journal on Drug Policy, 73, 263–272. https://doi.org/10.1016/j.drugpo.2019.01.016
   PubMed Web of Science ®Google Scholar
• Curran, K. A., Burk, T., Pitt, P. D., & Middleman, A. B. (2018). Trends and substance use associations with e-cigarette use in US adolescents. Clinical Pediatrics, 57(10), 1191–1198. https://doi.org/10.1177/0009922818769405
   PubMed Web of Science ®Google Scholar
• Dai, H., & Hao, J. (2017). Electronic cigarette and marijuana use among youth in the United States. Addictive Behaviors, 66, 48–54. https://doi.org/10.1016/j.addbeh.2016.11.005
   PubMed Web of Science ®Google Scholar
• Drope, J., Cahn, Z., Kennedy, R., Liber, A. C., Stoklosa, M., Henson, R., Douglas, C. E., & Drope, J. (2017). Key issues surrounding the health impacts of electronic nicotine delivery systems (ENDS) and other sources of nicotine. CA: A Cancer Journal for Clinicians, 67(6), 449–471. https://doi.org/10.3322/caac.21413
   PubMed Web of Science ®Google Scholar
• Drug Enforcement Administration. (2014, December). Marijuana concentrates. Retrieved September 15, 2020 from https://www.dea.gov/sites/default/files/resource-center/Publications/marijuana-concentrates.pdf
   Google Scholar
• Drug Enforcement Administration. (2017). Drugs of abuse: A DEA resource guide 2017 edition. Retrieved September 15, 2020 from https://www.dea.gov/sites/default/files/drug_of_abuse.pdf
   Google Scholar
• Drug Enforcement Administration. (2020). Fentanyl used in vape pens. Retrieved September 15, 2020 from https://www.dea.gov/sites/default/files/2020-09/Fentanyl%20Used%20in%20Vape%20Pens__PRB%20FINAL.pdf?fbclid=IwAR2egfp56LrUYXGRHQMXE2zbAviz3BCKL6BpU8QmFrYk1Kb-IUJA44Tg9ho
   Google Scholar
• Ershad, M., Dela Cruz, M., Mostafa, A., Khalid, M. M., Arnold, R., & Hamilton, R. (2020). Heroin adulterated with the novel synthetic cannabinoid, 5F-MDMB-PINACA: A case series. Clinical Practice and Cases in Emergency Medicine, 4(2), 121–125. https://doi.org/10.5811/cpcem.2020.2.45060
   PubMedGoogle Scholar
• Evans-Polce, R. J., Veliz, P. T., Boyd, C. J., & McCabe, S. E. (2020). E-cigarette and cigarette use among U.S. adolescents: Longitudinal associations with marijuana use and perceptions. American Journal of Preventive Medicine, 58(6), 854–857. https://doi.org/10.1016/j.amepre.2020.01.013
   PubMed Web of Science ®Google Scholar
• Ferrari, M. F., Raizada, M. K., & Fior-Chadi, D. R. (2008). Differential regulation of the renin-angiotensin system by nicotine in WKY and SHR glia. Journal of Molecular Neuroscience: Mn, 35(2), 151–160. https://doi.org/10.1007/s12031-007-9025-7
   PubMed Web of Science ®Google Scholar
• Foundation for a Drug-Free World. (2020). Synthetic marijuana: A short history. Retrieved September 15, 2020 from http://www.drugfreeworld.org/drugfacts/synthetic/synthetic-marijuana-short-history.html
   Google Scholar
• Gaiha, S. M., Cheng, J., & Halpern-Felsher, B. (2020). Association between youth smoking, electronic cigarette use, and COVID-19. The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, 67(4), 519–523. https://doi.org/10.1016/j.jadohealth.2020.07.002
   PubMed Web of Science ®Google Scholar
• Gautier, S., Kinouani, S., & Raherison, C. (2017). Do electronic cigarettes increase the risk of smoking among adolescents and young adults? Santé Publique, 29(3), 333–340. https://doi.org/10.3917/spub.173.0333
   PubMed Web of Science ®Google Scholar
• Giroud, C., de Cesare, M., Berthet, A., Varlet, V., Concha-Lozano, N., & Favrat, B. (2015). E-cigarettes: A review of new trends in cannabis use. International Journal of Environmental Research and Public Health, 12(8), 9988–10008. https://doi.org/10.3390/ijerph120809988
   PubMed Web of Science ®Google Scholar
• Goniewicz, M. L., Gupta, R., Lee, Y. H., Reinhardt, S., Kim, S., Kim, B., Kosmider, L., & Sobczak, A. (2015). Nicotine levels in electronic cigarette refill solutions: A comparative analysis of products from the U.S., Korea, and Poland. The International Journal on Drug Policy, 26(6), 583–588. https://doi.org/10.1016/j.drugpo.2015.01.020
   PubMed Web of Science ®Google Scholar
• Grana, R., Benowitz, N., & Glantz, S. A. (2014). E-cigarettes: A scientific review. Circulation, 129(19), 1972–1986. https://doi.org/10.1161/CIRCULATIONAHA.114.007667
   PubMed Web of Science ®Google Scholar
• Greenhill, R. (2018, August 30). Why some meth and dmt users are using vapes? Retrieved September 15, 2020 from https://www.vice.com/en_us/article/a3qbyj/why-some-meth-and-dmt-users-are-using-vapes
   Google Scholar
• Hampton, T. (2014). Experts call for research plus regulation of e-cigarettes. JAMA, 311(2), 123–124. https://doi.org/10.1001/jama.2013.285292
   PubMed Web of Science ®Google Scholar
• Hoyte, C. O., Jacob, J., Monte, A. A., Al-Jumaan, M., Bronstein, A. C., & Heard, K. J. (2012). A characterization of synthetic cannabinoid exposures reported to the National Poison Data System in 2010. Annals of Emergency Medicine, 60(4), 435–438. https://doi.org/10.1016/j.annemergmed.2012.03.007
   PubMed Web of Science ®Google Scholar
• Johnson, S. B., Blum, R. W., & Giedd, J. N. (2009). Adolescent maturity and the brain: The promise and pitfalls of neuroscience research in adolescent health policy. The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, 45(3), 216–221. https://doi.org/10.1016/j.jadohealth.2009.05.016
   PubMed Web of Science ®Google Scholar
• Johnston, L. D., Miech, R. A., O'Malley, P. M., Bachman, J. G., S Schulenberg, J. E., & Patrick, M. E. (2018). Monitoring the future national survey results on drug use: 1975-2017: Overview, key findings on adolescent drug use. Institute for Social Research, The University of Michigan.
   Google Scholar
• Johnston, L. D., Miech, R. A., O'Malley, P. M., Bachman, J. G., S Schulenberg, J. E., & Patrick, M. E. (2019). Monitoring the future national survey results on drug use: 1975-2018: Overview, key findings on adolescent drug use. Institute for Social Research, The University of Michigan.
   Google Scholar
• Johnston, L. D., Miech, R. A., O'Malley, P. M., Bachman, J. G., S Schulenberg, J. E., & Patrick, M. E. (2020). Monitoring the future national survey results on drug use: 1975-2019: Overview, key findings on adolescent drug use. Institute for Social Research, The University of Michigan.
   Google Scholar
• Johnston, L. D., O'Malley, P. M., Miech, R. A., Bachman, J. G., & Schulenberg, J. E. (2015). Monitoring the Future national survey results on drug use, 1975-2014: Overview, key findings on adolescent drug use. Institute for Social Research, The University of Michigan.
   Google Scholar
• Johnston, L. D., O'Malley, P. M., Miech, R. A., Bachman, J. G., & Schulenberg, J. E. (2016). Monitoring the future national survey results on drug use, 1975-2015: Overview, key findings on adolescent drug use. Institute for Social Research, The University of Michigan.
   Google Scholar
• Johnston, L. D., O'Malley, P. M., Miech, R. A., Bachman, J. G., & Schulenberg, J. E. (2017). Monitoring the future national survey results on drug use: 1975-2016: Overview, key findings on adolescent drug use. Institute for Social Research, The University of Michigan.
   Google Scholar
• Kenne, D. R., Fischbein, R. L., Tan, A. S., & Banks, M. (2017). The use of substances other than nicotine in electronic cigarettes among college students. Substance Abuse: Research and Treatment, 11, 1178221817733736 https://doi.org/10.1177/1178221817733736
   Web of Science ®Google Scholar
• Knapp, A. A., Lee, D. C., Borodovsky, J. T., Auty, S. G., Gabrielli, J., & Budney, A. J. (2018). Emerging trends in cannabis administration among adolescent cannabis users. Journal of Adolescent Health, 64(4), 1–7. https://doi.org/10.1016/j.jadohealth.2018.07.012
   Web of Science ®Google Scholar
• Kristjansson, A. L., Mann, M. J., & Sigfusdottir, I. D. (2015). Licit and illicit substance use by adolescent e-cigarette users compared with conventional cigarette smokers, dual users, and nonusers. Journal of Adolescent Health, 57(5), 562–564. https://doi.org/10.1016/j.jadohealth.2015.07.014
   PubMed Web of Science ®Google Scholar
• Kristjansson, A. L., Mann, M. J., & Smith, M. L. (2017). Prevalence of substance use among middle school-aged e-cigarette users compared with cigarette smokers, nonusers, and dual users: Implications for primary prevention. Substance Abuse, 38(4), 473–476. https://doi.org/10.1080/08897077.2017.1343218
   PubMed Web of Science ®Google Scholar
• Kuba, K., Imai, Y., & Penninger, J. M. (2006). Angiotensin-converting enzyme 2 in lung diseases. Current Opinion in Pharmacology, 6(3), 271–276. https://doi.org/10.1016/j.coph.2006.03.001
   PubMed Web of Science ®Google Scholar
• Kutner, M. H., Nachtsheim, C. J., Neter, J., & Li, W. (2013). Applied linear statistical models (5th ed.). McGraw-Hill Higher Education.
   Google Scholar
• Lam, R. P. K., Tang, M. H. Y., Leung, S. C., Chong, Y. K., Tsui, M. S. H., & Mak, T. W. L. (2017). Supraventricular tachycardia and acute confusion following ingestion of e-cigarette fluid containing AB-FUBINACA and ADB-FUBINACA: A case report with quantitative analysis of serum drug concentrations. Clinical Toxicology (Philadelphia, Pa.).), 55(7), 662–667. https://doi.org/10.1080/15563650.2017.1307385
   PubMed Web of Science ®Google Scholar
• Lanz, C., Mattsson, J., Soydaner, U., & Brenneisen, R. (2016). Medicinal cannabis: In vitro validation of vaporizers for the smoke-free inhalation of cannabis. PLOS One, 11(1), e0147286. https://doi.org/10.1371/journal.pone.0147286
   PubMed Web of Science ®Google Scholar
• Lanza, S. T., Russell, M. A., & Braymiller, J. L. (2017). Emergence of electronic cigarette use in US adolescents and the link to traditional cigarette use. Addictive Behaviors, 67, 38–43. https://doi.org/10.1016/j.addbeh.2016.12.003
   PubMed Web of Science ®Google Scholar
• Lessard, J., Henrie, J., Livingston, J. A., Leonard, K. E., Colder, C. R., & Eiden, R. D. (2014). Correlates of ever having used electronic cigarettes among older adolescent children of alcoholic fathers. Nicotine & Tobacco Research, 16(12), 1656–16560. https://doi.org/10.1093/ntr/ntu148
   PubMed Web of Science ®Google Scholar
• Li, H., Bu, Q., Chen, B., Shao, X., Hu, Z., Deng, P., Lv, L., Deng, Y., Zhu, R., Li, Y., Zhang, B., Hou, J., Du, C., Zhao, Q., Fu, D., Zhao, Y., & Cen, X. (2014). Mechanisms of metabonomic for a gateway drug: Nicotine priming enhances behavioral response to cocaine with modification in energy metabolism and neurotransmitter level. PLOS One, 9(1), e87040. https://doi.org/10.1371/journal.pone.0087040
   PubMed Web of Science ®Google Scholar
• Lozano, P., Barrientos-Gutierrez, I., Arillo-Santillan, E., Morello, P., Mejia, R., Sargent, J. D., & Thrasher, J. F. (2017). A longitudinal study of electronic cigarette use and onset of conventional cigarette smoking and marijuana use among Mexican adolescents. Drug Alcohol Depend, 180, 427–430. https://doi.org/10.1016/j.drugalcdep.2017.09.001
   PubMed Web of Science ®Google Scholar
• Luethi, D., & Liechti, M. E. (2020). Designer drugs: Mechanism of action and adverse effects. Archives of Toxicology, 94(4), 1085–1133. https://doi.org/10.1007/s00204-020-02693-7
   PubMed Web of Science ®Google Scholar
• Marynak, K. L., Gammon, D. G., Rogers, T., Coats, E. M., Singh, T., & King, B. A. (2017). Sales of nicotine-containing electronic cigarette products: United States, 2015. American Journal of Public Health, 107(5), 702–705. https://doi.org/10.2105/AJPH.2017.303660
   PubMed Web of Science ®Google Scholar
• McCabe, S. E., West, B. T., Veliz, P., & Boyd, C. J. (2017). E-cigarette use, cigarette smoking, dual use, and problem behaviors among U.S. Adolescents: Results from a national survey. The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, 61(2), 155–162. https://doi.org/10.1016/j.jadohealth.2017.02.004
   PubMed Web of Science ®Google Scholar
• Meier, M. H., Caspi, A., Ambler, A., Harrington, HLee., Houts, R., Keefe, R. S. E., McDonald, K., Ward, A., Poulton, R., & Moffitt, T. E. (2012). Persistent cannabis users show neuropsychological decline from childhood to midlife. Proceedings of the National Academy of Sciences of the United States of America, 109(40), E2657–E2664. https://doi.org/10.1073/pnas.1206820109
   PubMed Web of Science ®Google Scholar
• Meshack, A., Peters, R. J., Lin, M., Hill, M., Abughosh, S., Essien, E. J., & Savage, C. (2013). The beliefs of teenage male cannabinoid users: A qualitative study. American Journal of Health Studies, 28(3), 109–113.
   Google Scholar
• Monitoring the Future. (2020). Monitoring the future: A continuing study of American youth. Retrieved September 15, 2020 from http://www.monitoringthefuture.org/
   Google Scholar
• Münster-Müller, S., Matzenbach, I., Knepper, T., Zimmermann, R., & Pütz, M. (2020). Profiling of synthesis-related impurities of the synthetic cannabinoid Cumyl-5F-PINACA in seized samples of e-liquids via multivariate analysis of UHPLC-MSn data. Drug Testing and Analysis, 12(1), 119–126. https://doi.org/10.1002/dta.2673
   PubMed Web of Science ®Google Scholar
• Nikitin, D., Timberlake, D. S., & Williams, R. S. (2016). Is the e-liquid industry regulating itself? A look at e-liquid Internet vendors in the United States. Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco, 18(10), 1967–1972. https://doi.org/10.1093/ntr/ntw091
   PubMed Web of Science ®Google Scholar
• Oakes, J. M., Fuchs, R. M., Gardner, J. D., Lazartigues, E., & Yue, X. (2018). Nicotine and the renin-angiotensin system. Am J Physiol Regul Ingegr Comp Physiol, 315, 895–906. https://doi.org/10.1152/ajpregu.00099.2018
   PubMed Web of Science ®Google Scholar
• Olfson, M., Wall, M. M., Liu, S. M., & Blanco, C. (2018). Cannabis use and risk of prescription opioid use disorder in the United States. The American Journal of Psychiatry, 175(1), 47–53. https://doi.org/10.1176/appi.ajp.2017.17040413
   PubMed Web of Science ®Google Scholar
• Peace, M. R., Smith, M. E., & Poklis, J. L. (2020). The analysis of commercially available natural products recommended for use in electronic cigarettes. Rapid Communications in Mass Spectrometry, 34(11), 1–3. https://doi.org/10.1002/rcm.8771
   Web of Science ®Google Scholar
• Pentz, M. A., Shin, H., Riggs, N., Unger, J. B., Collison, K. L., & Chou, C. P. (2015). Parent, peer, and executive function relationships to early adolescent e-cigarette use: A substance use pathway? Addictive Behaviors, 42, 73–78. https://doi.org/10.1016/j.addbeh.2014.10.040
   PubMed Web of Science ®Google Scholar
• Pepper, J. K., MacMonegle, A. J., & Nonnemaker, J. M. (2019). Adolescents' use of basic, intermediate, and advanced device types for vaping. Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco, 21(1), 55–62. https://doi.org/10.1093/ntr/ntx279
   PubMed Web of Science ®Google Scholar
• Poklis, J. L., Mulder, H. A., & Peace, M. R. (2019). The unexpected identification of the cannabimimetic, 5F-ADB, and dextromethorphan in commercially available cannabidiol e-liquids. Forensic Science International, 294, e25–27. https://doi.org/10.1016/j.forsciint.2018.10.019
   PubMed Web of Science ®Google Scholar
• Pope, H. G., Gruber, A. J., Hudson, J. I., Cohane, G., Huestis, M. A., & Yurgelun-Todd, D. (2003). Early-onset cannabis use and cognitive deficits: What is the nature of the association? Drug and Alcohol Dependence, 69(3), 303–310. https://doi.org/10.1016/S0376-8716(02)00334-4
   PubMed Web of Science ®Google Scholar
• Ramamurthi, D., Chau, C., & Jackler, R. K. (2019). Juul and other stealth vaporisers: Hiding the habit from parents and teachers. Tobacco Control, 28(6), 610–617. https://doi.org/10.1136/tobaccocontrol-2018-054455
   Web of Science ®Google Scholar
• Renard, J., Rushlow, W. J., & Laviolette, S. R. (2016). What can rats tell us about adolescent cannabis exposure? Insights from preclinical research. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie, 61(6), 328–334. https://doi.org/10.1177/0706743716645288
   PubMed Web of Science ®Google Scholar
• Rettner, R. (2017, February 7). Synthetic marijuana linked to seizures, psychosis and death. Huffington Post. Retrieved September 15, 2020 from https://www.huffingtonpost.com/entry/synthetic-marijuana-linked-to-seizures-psychosis-and-death_us_5899f9d6e4b0406131395f53
   Google Scholar
• Robertson, L., Hoek, J., Blank, M. L., Richards, R., Ling, P., & Popova, L. (2019). Dual use of electronic nicotine delivery systems (ENDS) and smoked tobacco: A qualitative analysis. Tobacco Control, 28(1), 13–19. https://doi.org/10.1136/tobaccocontrol-2017-054070
   PubMed Web of Science ®Google Scholar
• Romer, D., & Moreno, M. (2017). Digital media and risks for adolescent substance abuse and problematic gambling. Pediatrics, 140(Suppl 2), S102–S106. https://doi.org/10.1542/peds.2016-1758L
   PubMedGoogle Scholar
• Schmidt, L., Reidmohr, A., Harwell, T. S., & Helgerson, S. D. (2014). Prevalence and reasons for initiating use of electronic cigarettes among adults in Montana, 2013. Preventing Chronic Disease, 11, E204. https://doi.org/10.5888/pcd11.140283
   PubMed Web of Science ®Google Scholar
• Segal-Gavish, H., Gazit, N., Barhum, Y., Ben-Zur, T., Taler, M., Hornfeld, S. H., Gil-Ad, I., Weizman, A., Slutsky, I., Niwa, M., Kamiya, A., Sawa, A., Offen, D., & Barzilay, R. (2017). Bdnf overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction. Human Molecular Genetics, 26(13), 2462–2471. https://doi.org/10.1093/hmg/ddx139
   PubMed Web of Science ®Google Scholar
• Sutherland, R., Allsop, S., & Peacock, A. (2020). New psychoactive substances in Australia: Patterns and characteristics of use, adverse effects, and interventions to reduce harm. Current Opinion in Psychiatry, 33(4), 343–351. https://doi.org/10.1097/YCO.0000000000000606
   PubMed Web of Science ®Google Scholar
• Tamba, B. I., Stanciu, G. D., Uritu, C. M., Rezus, E., Stefanescu, R., Mihai, C. T., Luca, A., Rusu-Zota, G., Leon-Constantin, M., Cojocaru, E., Gafton, B., & Alexa-Stratulat, T. (2020). Challenges and opportunities in preclinical research of synthetic cannabinoids for pain therapy. Medicina ( Medicina), 56(1), 22–24. https://doi.org/10.3390/medicina56010024
   Web of Science ®Google Scholar
• Taylor, M., Collin, S. M., Munafò, M. R., MacLeod, J., Hickman, M., & Heron, J. (2017). Patterns of cannabis use during adolescence and their association with harmful substance use behaviour: Findings from a uk birth cohort. Journal of Epidemiology and Community Health, 71(8), 764–770. https://doi.org/10.1136/jech-2016-208503
   PubMed Web of Science ®Google Scholar
• Temple, J. R., Shorey, R. C., Lu, Y., Torres, E., Stuart, G. L., & Le, V. D. (2017). E-cigarette use of young adults motivations and associations with combustible cigarette alcohol, marijuana, and other illicit drugs. The American Journal on Addictions, 26(4), 343–348. https://doi.org/10.1111/ajad.12530
   PubMed Web of Science ®Google Scholar
• Tournebize, J., Gibaja, V., & Kahn, J. P. (2017). Acute effects of synthetic cannabinoids: Update 2015. Substance Abuse, 38(3), 344–366. https://doi.org/10.1080/08897077.2016.1219438
   PubMed Web of Science ®Google Scholar
• U.S. Food and Drug Administration. (2018, July 19). Statement from FDA warning about significant health risks of contaminated illegal synthetic cannabinoid products that are being encountered by FDA. Retrieved September 15, 2020 from https://www.fda.gov/news-events/press-announcements/statement-fda-warning-about-significant-health-risks-contaminated-illegal-synthetic-cannabinoid
   Google Scholar
• U.S. Food and Drug Administration. (2019, September 25). FDA regulation of electronic nicotine delivery systems and investigation of vaping illnesses. Retrieved September 15, 2020 from https://www.fda.gov/news-events/congressional-testimony/fda-regulation-electronic-nicotine-delivery-systems-and-investigation-vaping-illnesses-9,252,019
   Google Scholar
• U.S. Food and Drug Administration. (2020a, May 1). FDA launches new campaign: “The Real Cost” youth e-cigarette prevention campaign. Retrieved September 15, 2020 from https://www.fda.gov/tobacco-products/youth-and-tobacco/fda-launches-new-campaign-real-cost-youth-e-cigarette-prevention-campaign
   Google Scholar
• U.S. Food and Drug Administration. (2020b, September 17). Vaporizers, e-cigarettes, and other electronic nicotine delivery systems. Retrieved October 20, 2020 from https://www.fda.gov/tobacco-products/products-ingredients-components/vaporizers-e-cigarettes-and-other-electronic-nicotine-delivery-systems-ends
   Google Scholar
• Unger, J. B., Soto, D. W., & Leventhal, A. (2016). E-cigarette use and subsequent cigarette and marijuana use among Hispanic young adults. Drug and Alcohol Dependence, 163, 261–264. doi: 10.1016/j.drugalcdep.2016.04.027 https://doi.org/10.1016/j.drugalcdep.2016.04.027
   PubMed Web of Science ®Google Scholar
• United Nations Office on Drugs and Crime. (2018). April 2018- United States: Severe bleeding after synthetic cannabinoid use linked to a possible contamination. Retrieved September 15, 2020 from https://www.unodc.org/LSS/announcement/Details/b73d6954-3790-43d5-aa44-39926d19f672
   Google Scholar
• United Nations Office on Drugs and Crime. (2019). 5 Cannabis and Hallucinogens-World Drug Report 2020. Retrieved September 15, 2020 from https://wdr.unodc.org/wdr2019/prelaunch/WDR19_Booklet_5_CANNABIS_HALLUCINOGENS.pdf
   Google Scholar
• United Nations Office on Drugs and Crime. (2020a). March 2019-UNODC laboratory: Current NPS threats, a new publication, presents highlights from the UNODC toxicology portal. Retrieved September 15, 2020 from https://www.unodc.org/LSS/Announcement/Details/0bd37fbb-112a-4210-a52c-a0279483ae5d
   Google Scholar
• United Nations Office on Drugs and Crime. (2020b). Use. Global use estimate. Regional use estimates. National use estimates. National treatment data estimates. Internet surveys on the use of new psychoactive substances. Retrieved September 15, 2020 from https://www.unodc.org/LSS/Page/NPS/Use
   Google Scholar
• Varlet, V. (2016). Drug Vaping: From the Dangers of Misuse to New Therapeutic Devices. Toxics, 4(4), 1-16. https://doi.org/10.3390/toxics4040029
   PubMed Web of Science ®Google Scholar
• Warren, K. E., Tay, S., & Wen, L. S. (2017). The role of public health in combatting synthetic cannabinoid use in adolescents. The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, 60(5), 483–486. https://doi.org/10.1016/j.jadohealth.2017.02.015
   PubMed Web of Science ®Google Scholar
• Weaver, M. F., Hopper, J. A., & Gunderson, E. W. (2015). Designer drugs 2015: Assessment and management. Addiction Science & Clinical Practice, 10, 8–19. https://doi.org/10.1186/s13722-015-0024-7
   PubMed Web of Science ®Google Scholar
• Westling, E., Rusby, J. C., Crowley, R., & Light, J. M. (2017). Electronic cigarette use by youth: Prevalence, correlates, and use trajectories from middle to high school. The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, 60(6), 660–666. https://doi.org/10.1016/j.jadohealth.2016.12.019
   PubMed Web of Science ®Google Scholar
• Whelan, A. (2018). Drug overdose toll rises in Philadelphia as heroin prized for ‘purity’ turns out to be contaminated. The Philadelphia Inquirer. Retrieved November 18, 2020 from https://www.inquirer.com/philly/health/addiction/drug-overdose-toll-rises-in-philadelphia-as-heroin-prized-for-purity-turns-out-to-be-contaminated-20180724.html
   Google Scholar
• Whelan, A & Schaefer, M. A. (2018). Philly overdose drug may have contained toxic designer drug. The Philadelphia Inquirer. Retrieved November 18, 2020 from https://www.inquirer.com/philly/health/heroin-contamination-philadelphia-synthetic-cannabinoid-cfsre-20180726.html
   Google Scholar
• Williams, R. (2020). Cannabis as a gateway drug for opioid use disorder. The Journal of Law, Medicine & Ethics : A Journal of the American Society of Law, Medicine & Ethics, 48(2), 268–274. https://doi.org/10.1177/1073110520935338
   PubMed Web of Science ®Google Scholar
• World Health Organization. (2020a, July 10). Heated tobacco products: Information sheet-2nd edition. Retrieved October 20, 2020 from https://www.who.int/publications/i/item/WHO-HEP-HPR-2020.2
   Google Scholar
• World Health Organization. (2020b). WHO Coronavirus Disease (COVID-19) dashboard. Retrieved October 20, 2020 from https://covid19.who.int/
   Google Scholar
• Worob, A., & Wenthur, C. (2019). Dark classics in chemical neuroscience: Synthetic cannabinoids (Spice/K2). ACS Chemical Neuroscience, December 4, 1-12. doi:https://doi.org/10.1021/acschemneuro.9b00586
   Google Scholar
• Wu, Y. (2020). Compensation of ACE2 function for possible clinical management of 2019-nCoV-induced acute lung injury. Virol Sin, 35(3), 256-258. doi.org/https://doi.org/ https://doi.org/10.1007/s12250-020-00205-6.
   Google Scholar
• Zare, S., Nemati, M., & Zheng, Y. (2018). A systematic review of consumer preference for e-cigarette attributes: Flavor, nicotine strength, and type. PLoS One, 13(3), e0194145–18. https://doi.org/10.1371/journal.pone.0194145
   PubMed Web of Science ®Google Scholar
• Zhang, Z., Zheng, X., Zeng, D. D., & Leischow, S. J. (2016). Tracking dabbing using search query surveillance: A case study in the United States. Journal of Medical Internet Research, 18(9), e252. https://doi.org/10.2196/jmir.5802
   PubMed Web of Science ®Google Scholar
• Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., Chen, H.-D., Chen, J., Luo, Y., Guo, H., Jiang, R.-D., Liu, M.-Q., Chen, Y., Shen, X.-R., Wang, X., … Shi, Z.-L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–289. https://doi.org/10.1038/s41586-020-2012-7
   PubMed Web of Science ®Google Scholar
• Zuckermann, A. M. E., Gohari, M. R., de Groh, M., Jiang, Y., & Leatherdale, S. T. (2019). Factors associated with cannabis use change in youth: Evidence from the compass study. Addictive Behaviors, 90, 158–163. doi: 10.1016/j.addbeh.2
   PubMed Web of Science ®Google Scholar