Calcitonin-loaded octamaleimic acid–silsesquioxane nanoparticles in hydrogel scaffold support osteoinductivity in bone regeneration

References

• Agrawal K, Singh G, Puri D, Prakash S. 2011. Synthesis and characterization of hydroxyapatite powder by sol-gel method for biomedical application. JMMCE. 10(08):727–734.
   Google Scholar
• Ahmadipour S, Varshosaz J, Hashemibeni B, Safaeian L, Manshaei M. 2020. Polyhedral oligomeric silsesquioxane/platelets rich plasma/gelrite-based hydrogel scaffold for bone tissue engineering. Curr Pharm Des. 26(26):3147–3160.
   PubMed Web of Science ®Google Scholar
• Aminian M, Nabatchian F, Vaisi-Raygani A, Torabi M. 2013. Mechanism of Coomassie Brilliant Blue G-250 binding to cetyltrimethylammonium bromide: an interference with the Bradford assay. Anal Biochem. 434(2):287–291.
   PubMed Web of Science ®Google Scholar
• Bahrambeigi V, Salehi R, Hashemibeni B, Esfandiari E. 2012. Transcriptomic comparison of osteopontin, osteocalcin and core binding factor 1 genes between human adipose derived differentiated osteoblasts and native osteoblasts. Adv Biomed Res. 1:8.
   PubMedGoogle Scholar
• Bai X, Gao M, Syed S, Zhuang J, Xu X, Zhang XQ. 2018. Bioactive hydrogels for bone regeneration. Bioact Mater. 3(4):401–417.
   PubMed Web of Science ®Google Scholar
• Bradford M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254.
   PubMed Web of Science ®Google Scholar
• Breimer LH, Macintyre I, Zaidi M. 1988. Peptides from the calcitonin genes: molecular genetics, structure and function. Biochem J. 255(2):377–390.
   PubMed Web of Science ®Google Scholar
• Cancedda R, Dozin B, Giannoni P, Quarto R. 2003. Tissue engineering and cell therapy of cartilage and bone. Matrix Biol. 22(1):81–91.
   PubMed Web of Science ®Google Scholar
• Chen Y, Huang Z, Li X, Li S, Zhou Z, Zhang Y, Feng Q. l, Yu B. 2012. In vitro biocompatibility and osteoblast differentiation of an injectable chitosan/nano-hydroxyapatite/collagen scaffold. J Nanomater. 2012:1–6. Article ID
   Web of Science ®Google Scholar
• Costa L, Silva-Correia J, Oliveira JM, Reis RL. 2018. Gellan gum-based hydrogels for osteochondral repair. Adv Exp Med Biol. 1058:281–304.
   PubMed Web of Science ®Google Scholar
• Crivello OJ, Lara PE, Oliveira-Filho RM, Menecheli-Josd A. 1996. Effect of calcitonin on bone healing. J Craniomaxillofac Surg. 24:11–132.
   Google Scholar
• Douglas TEL, Wlodarczyk M, Pamula E, Declercq HA, de Mulder ELW, Bucko MM, Balcaen L, Vanhaecke F, Cornelissen R, Dubruel P, et al. 2014. Enzymatic mineralization of gellan gum hydrogel for bone tissue-engineering applications and its enhancement by polydopamine. J Tissue Eng Regen Med. 8(11):906–18.
   PubMed Web of Science ®Google Scholar
• Edri R, Gal I, Noor N, Harel T, Fleischer S, Adadi N, Green O, Shabat D, Heller L, Shapira A, et al. 2019. Personalized hydrogels for engineering diverse fully autologous tissue implants. Adv Mater. 31(1):1803895.,
   PubMed Web of Science ®Google Scholar
• Fan M, Ma Y, Tan H, Jia Y, Zou S, Guo S, Zhao M, Huang H, Ling Z, Chen Y, et al. 2017. Covalent and injectable chitosan-chondroitin sulfate hydrogels embedded with chitosan microspheres for drug delivery and tissue engineering. Mater Sci Eng C Mater Biol Appl. 71:67–74.
   PubMed Web of Science ®Google Scholar
• Georgiou CD, Grintzalis K, Zervoudakis G, Papapostolou I. 2008. Mechanism of Coomassie brilliant blue G-250 binding to proteins: a hydrophobic assay for nanogram quantities of proteins. Anal Bioanal Chem. 391(1):391–403.
   PubMed Web of Science ®Google Scholar
• Gera S, Pooladanda V, Godugu C, Challa VS, Wankar J, Dodoala S, Sampathi S. 2020. Rutin nanosuspension for potential management of osteoporosis: effect of particle size reduction on oral bioavailability, in vitro and in vivo activity. Pharm Dev Technol. 25(8):971–988.
   PubMed Web of Science ®Google Scholar
• Ghasemiyeh P, Mohammadi-Samani S. 2019. Hydrogels as drug delivery systems; pros and cons. Trends Pharm Sci. 5:7–24.
   Google Scholar
• Hoang QQ, Sicheri F, Howard AJ, Yang DSC. 2003. Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature. 425(6961):977–980.
   PubMed Web of Science ®Google Scholar
• Hunter GK, Hauschka PV, Poole RA, Rosenberg LC, Goldberg HA. 1996. Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. Biochem J. 317(1):59–64.
   PubMedGoogle Scholar
• Issa JP, Defino HL, Sebald W, Coutinho‐Netto J, Iyomasa MM, Shimano AC, Bentley MV, Pitol DL. 2012. Biological evaluation of the bone healing process after application of two potentially osteogenic proteins: an animal experimental model. Gerodontology. 29(4):258–264.
   PubMed Web of Science ®Google Scholar
• John Ł, Malik M, Janeta M, Szafert S. 2017. First step towards a model system of the drug delivery network based on amide-POSS nanocarriers. RSC Adv. 7(14):8394–401.
   Web of Science ®Google Scholar
• Kamel R, El-Wakil NA, Abdelkhalek AA, Elkasabgy NA. 2020. Nanofibrillated cellulose/cyclodextrin based 3D scaffolds loaded with raloxifene hydrochloride for bone regeneration. Int J Biol Macromol. 156:704–716.
   PubMed Web of Science ®Google Scholar
• Kamble S, Varamini P, Müllner M, Pelras T, Rohanizadeh R. 2020. Bisphosphonate-functionalized micelles for targeted delivery of curcumin to metastatic bone cancer. Pharm Dev Technol. 25(9):1118–1126.
   PubMed Web of Science ®Google Scholar
• Kolambkar Y, Dupont K, Boerckel J, Huebsch N, Mooney D, Hutmacher D, Guldberg R. 2011. An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects. Biomaterials. 32(1):65–74.
   PubMed Web of Science ®Google Scholar
• Lamprecht A, Yamamoto H, Takeuchi H, Kawashima Y. 2004. pH-sensitive microsphere delivery increases oral bioavailability of calcitonin. J Control Release. 98(1):1–9.
   PubMed Web of Science ®Google Scholar
• Lazić S, Zec S, Miljević N, Milonjić S. 2001. The effect of temperature on the properties of hydroxyapatite precipitated from calcium hydroxide and phosphoric acid. Thermochim Acta. 374(1):13–22.
   Web of Science ®Google Scholar
• LeBaron RG, Athanasiou KA. 2000. Ex vivo synthesis of articular cartilage. Biomaterials. 21(24):2575–2587.
   PubMed Web of Science ®Google Scholar
• Lopez-Heredia MA, Łapa A, Mendes AC, Balcaen L, Samal SK, Chai F, Van der Voort P, Stevens CV, Parakhonskiy BV, Chronakis IS, et al. 2017. Bioinspired, biomimetic, double-enzymatic mineralization of hydrogels for bone regeneration with calcium carbonate. Mater Lett. 190:13–6.
   Web of Science ®Google Scholar
• Li X, Feng Q, Cui F. 2006. In vitro degradation of porous nano-hydroxyapatite/collagen/PLLA scaffold reinforced by chitin fibres. Mater Sci Eng C. 26(4):716–20.
   Google Scholar
• Li W, Huang A, Zhong Y, Huang L, Yang J, Zhou C, Zhou L, Zhang Y, Fu G. 2020. Laminin-modified gellan gum hydrogels loaded with the nerve growth factor to enhance the proliferation and differentiation of neuronal stem cells. RSC Adv. 10(29):17114–22.
   Web of Science ®Google Scholar
• Lin CW, Huang YF, Kannan AM. 2007. Semi-interpenetrating network based on cross-linked poly(vinyl alcohol) and poly(styrene sulfonic acid-co-maleic anhydride) as proton exchange fuel cell membranes. J Power Sources. 164(2):449–456.
   Web of Science ®Google Scholar
• Lv Y, He H, Qi J, Lu Y, Zhao W, Dong X, Wu W. 2018. Visual validation of the measurement of entrapment efficiency of drug nanocarriers. Int J Pharm. 547(1-2):395–403.
   PubMed Web of Science ®Google Scholar
• Macintyre I, Zaidi M, Milet C. 1987. Hormonal regulation of extracellular calcium. In: Baker P.F. (Ed.), Handbook of Experimental Pharmacology, Calcium in Drug Action. Berlin: Springer-Verlag, 83:p. 411.
   Google Scholar
• McKee MD, Nanci A. 1996. Osteopontin: An interfacial extracellular matrix protein in mineralized tissues. Connect Tissue Res. 35(1-4):197–205.
   PubMed Web of Science ®Google Scholar
• Moxon SR, Smith AM. 2016. Controlling the rheology of gellan gum hydrogels in cell culture conditions. Int J Biol Macromol. 84:79–86.
   PubMed Web of Science ®Google Scholar
• Mizuno M, Kuboki Y. 2001. Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen. J Biochem. 129(1):133–8.
   PubMed Web of Science ®Google Scholar
• Posadowska U, Brzychczy-Włoch M, Drożdż A, Krok-Borkowicz M, Włodarczyk-Biegun M, Dobrzyński P, Chrzanowski W, Pamuła E. 2016. Injectable hybrid delivery system composed of gellan gum, nanoparticles and gentamicin for the localized treatment of bone infections. Expert Opin Drug Deliv. 13(5):613–20.
   PubMed Web of Science ®Google Scholar
• Rao LG, Heersche JNM, Marchuk LL, Sturtridge W. 1981. Immunohistochemical demonstration of calcitonin binding to specific cell types in fixed rat bone tissue. Endocrinology. 108(5):1972–81.
   PubMed Web of Science ®Google Scholar
• Ren B, Chen X, Du S, Ma Y, Chen H, Yuan G, Li J, Xiong D, Tan H, Ling Z, et al. 2018. Injectable polysaccharide hydrogel embedded with hydroxyapatite and calcium carbonate for drug delivery and bone tissue engineering. Int J Biol Macromol. 118(Pt A):1257–66.
   PubMedGoogle Scholar
• Romberg RW, Werness PG, Riggs BL, Mann KG. 1986. Inhibition of hydroxyapatite crystal growth by bone-specific and other calcium-binding proteins. Biochemistry. 25(5):1176–80.
   PubMed Web of Science ®Google Scholar
• Sadeghi D, Nazarian H, Marouf N, Karim-Aghalou F, Nojehdehyan H, Vahid Dastjerdi E. 2013. Alkaline phosphatase activity of osteoblast cells on three-dimensional chitosan gelatin/hydroxyapatite composite scaffolds. J Dent Sch. 30:203–209.
   Google Scholar
• Sani F, Mehdipour F, Talaei-Khozani T, Sani M, Razban V. 2017. Fabrication of platelet-rich plasma/silica scaffolds for bone tissue engineering. Bioinsp Biomim Nanobiomater. 7:74–81.
   Web of Science ®Google Scholar
• Sassioto MC, Inouye CM, Aydos RD, Figueiredo AS. 2006. Bone repair in rats treated with sodic diclofenac and calcitonin. Acta Cir Bras. 21(suppl 4):40–4.
   PubMedGoogle Scholar
• Shahbazi MA, Almeida PV, Mäkilä E, Correia A, Ferreira MP, Kaasalainen M, Salonen J, Hirvonen J, Santos HA. 2014. Poly(methyl vinyl ether-alt-maleic acid)-functionalized porous silicon nanoparticles for enhanced stability and cellular internalization. Macromol Rapid Commun. 35(6):624–9.
   PubMed Web of Science ®Google Scholar
• Shannon RD. 1976. Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides. Acta Cryst A. 32(5):751–67.
   Web of Science ®Google Scholar
• Shin H, Olsen BD, Khademhosseini A. 2014. Gellan gum microgel-reinforced cell-laden gelatin hydrogels. J Mater Chem B. 2(17):2508–16.
   PubMed Web of Science ®Google Scholar
• Silvent J, Nassif N, Helary C, Azaïs T, Sire JY, Guille MM. 2013. Collagen osteoid-like model allows kinetic gene expression studies of non-collagenous proteins in relation with mineral development to understand bone biomineralization. PLoS One. 8(2):e57344.doi: 10.1371/journal.pone.0057344.
   PubMed Web of Science ®Google Scholar
• Sinswat P, Tengamnuay P. 2003. Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl-and dimethyl-β-cyclodextrins. Int J Pharm. 257(1-2):15–22.
   PubMed Web of Science ®Google Scholar
• Sondergaard BC, Wulf H, Henriksen K, Schaller S, Oestergaard S, Qvist P, Tankó LB, Bagger YZ, Christiansen C, Karsdal MA. 2006. Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes. Osteoarthritis Cartilage. 14(8):759–68.
   PubMed Web of Science ®Google Scholar
• Sobierajska E, Konopka M, Janaszewska A, Piorecka K, Blauz A, Klajnert-Maculewicz B, Stanczyk M, Stanczyk W. 2017. Unusual enhancement of doxorubicin activity on co-delivery with polyhedral oligomeric silsesquioxane (POSS). Materials. 10(5):559.
   Web of Science ®Google Scholar
• Tan H, Fan M, Ma Y, Qiu J, Li X, Yan J. 2014. Injectable gel scaffold based on biopolymer microspheres via an enzymatic reaction. Adv Healthc Mater. 3(11):1769–1775.
   PubMed Web of Science ®Google Scholar
• Torres-Lugo M, Peppas NA. 2000. Transmucosal delivery systems for calcitonin: a review. Biomaterials. 21(12):1191–6.
   PubMed Web of Science ®Google Scholar
• Tørring O, Bucht E, Sjöstedt U, Sjöberg HE. Sjoberg 1991. Salmon calcitonin treatment by nasal spray in primary hyperparathyroidism. Bone. 12(5):311–316.
   PubMed Web of Science ®Google Scholar
• Tsukamoto Y, Fukutani S, Mori M. 1992. Hydroxyapatite-induced alkaline phosphatase activity of human pulp fibroblasts. J Mater Sci: Mater Med. 3(3):180–3.
   Web of Science ®Google Scholar
• Ubios AM, Jares Furno G, Guglielmotti MB. 1991. Effect of calcitonin on alveolar wound healing. J Oral Pathol Med. 20(7):322–4.
   PubMed Web of Science ®Google Scholar
• Varshosaz J, Minaiyan M, Forghanian M. 2014. Prolonged hypocalcemic effect by pulmonary delivery of calcitonin loaded poly(methyl vinyl ether maleic acid) bioadhesive nanoparticles. Biomed Res Int. 2014:932615.
   PubMed Web of Science ®Google Scholar
• Wafaa KA, Hassouni MK. 2014. The influence of local administration of calcitonin and alendronate on bone formation marker (osteocalcin) in critical size defect. IJARESM. 2:2455–6211.
   Google Scholar
• Wafaa KA, Mohammed KH. 2014. The influence of local administration of calcitonin and alendronate on bone formation marker (osteocalcin) in critical size defect: an experimental study in sheep. IJARESM.
   Google Scholar
• Wang Y, Zhang S, Zeng X, Ma LL, Khor KA, Qian M. 2008. Initial attachment of osteoblastic cells onto sol-gel derived fluoridated hydroxyapatite coatings . J Biomed Mater Res A. 84(3):769–76.
   PubMedGoogle Scholar
• Yan J, Miao Y, Tan H, Zhou T, Ling Z, Chen Y, Xing X, Hu X. 2016. Injectable alginate/hydroxyapatite gel scaffold combined with gelatin microspheres for drug delivery and bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 63:274–84.
   PubMed Web of Science ®Google Scholar
• Yong-Hee L, Patrick J. 2000. Oral delivery of salmon calcitonin. Adv Drug Deliv Rev. 42:225–238.
   PubMed Web of Science ®Google Scholar
• Yun J-H, Han S-H, Choi S-H, Lee M-H, Lee S-J, Song SU, Oh N. 2014. Effects of bone marrow-derived mesenchymal stem cells and platelet-rich plasma on bone regeneration for osseointegration of dental implants: preliminary study in canine three-wall intrabony defects. J Biomed Mater Res B Appl Biomater. 102(5):1021–30.
   PubMed Web of Science ®Google Scholar
• Zaidi M, Breimer LH, Macintyre I. 1987. Biology of peptides from the calcitonin genes. Q J Exp Physiol. 72(4):371–408.
   PubMedGoogle Scholar
• Zor T, Selinger Z. 1996. Linearization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies. Anal Biochem. 236(2):302–308.
   PubMed Web of Science ®Google Scholar
• Zhao X, Ma R, Yang M, Yang H, Jin P, Li Z, Fan Y, Du A, Cao X. 2017. Fabrication of POSS-coated CdTe quantum dots sensitized solar cells with enhanced photovoltaic properties. J Alloys Compd. 726:593–600.
   Web of Science ®Google Scholar