117
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Effect of Divalent Cations on Pore Formation and Degradation of Poly(D,L-lactide-co-glycolide)

, &
Pages 563-572 | Received 19 Jan 2007, Accepted 01 May 2007, Published online: 07 Oct 2008

REFERENCES

  • Sinha V.R., Trehan A. Biodegradable microspheres for protein delivery. J. Control. Release 2003; 90: 261–280
  • Reslow M., Jönsson M., Laakso T. Sustained-release of human growth hormone from PLG-coated starch microspheres. Drug Deliv. Syst. Sci. 2002; 2(4)103–109
  • Sansdrap P., Moës A.J. In vitro evaluation of the hydrolytic degradation of dispersed and aggregated poly(DL-lactide-co-glycolide) microspheres. J. Control. Release 1997; 43: 47–58
  • Webber W.L., Lago F., Thanos C., Mathiowitz E. Characterization of soluble, salt-loaded, degradable PLGA films and their release of tetracycline. J. Biomed. Mater. Res. 1998; 41: 18–29
  • Batycky R.P., Hanes J., Langer R., Edwards D.A. A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. J. Pharm. Sci. 1997; 86(12)1464–1476
  • Zhu G., Schwendeman S.P. Stabilization of proteins encapsulated in cylindrical poly(lactide-co-glycolide) implants: Mechanism of stabilization by basic additives. Pharm. Res. 2000; 17(3)351–357
  • Shenderova A., Burke T.G., Schwendeman S.P. The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins. Pharm. Res. 1999; 16(2)241–248
  • Tracy M.A., Ward K.L, Firouzabadian L., Wang Y., Dong N., Qian R., Zhang Y. Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro. Biomaterials 1999; 20: 1057–1062
  • Johnson OL, Cleland JL, Jung Lee H., Charnis M., Duenas E., Jaworowicz W., Shepard D., Shahzamani A., Jones AJS, Putney SD. A month-long effect from a single injection of microencapsulated human growth hormone. Nat. Med. 1996; 2(7)795–799
  • Bilati U., Allemann E., Doelker E. Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles. Eur. J. Pharm. Biopharm. 2005; 59: 375–388
  • Takenaga M., Yamaguchi Y., Kitagawa A., Ogawa Y., Kawai S., Mizushima Y., Igarashi R. Optimum formulation for sustained-release insulin. Int. J. Pharm. 2004; 271: 85–94
  • Carino G.P., Jacob J.S., Mathiowitz E. Nanosphere based oral insulin delivery. J. Control. Release 2000; 65: 261–269
  • Lam X.M., Duenas E.T., Daugherty A.L., Levin N., Cleland J.L. Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes. J. Control. Release 2000; 67: 281–292
  • Takada S., Yamagata Y., Misaki M., Taira K., Kurokawa T. Sustained release of human growth hormone from microcapsules prepared by a solvent evaporation technique. J. Control. Release 2003; 88: 229–242
  • Johnson O.L., Jaworowicz W., Cleland J.L., Bailey L., Charnis M., Duenas E., Wu C., Shepard D., Magil S., Last T., Jones A.J.S., Putney S.D. The stabilization and encapsulation of human growth hormone into biodegradable microspheres. Pharm. Res. 1997; 14(6)730–735
  • Gappa H., Baudys M., Koh J.J, Kim S.W., Bae Y.H. The effect of zinc-crystallized glucagon-like peptide-1 on insulin secretion of macroencapsulated pancreatic islets. Tissue Eng. 2001; 7: 35–44
  • Choi S., Baudys M., Kim S.W. Control of blood glucose by novel GLP-1 delivery using biodegradable triblock copolymer of PLGA-PEG-PLGA in type 2 diabetic rats. Pharm. Res. 2004; 21: 827–831
  • Zhang Y., Zale S., Sawyer L., Bernstein H. Effects of metal salts on poly(dl-lactide-co-glycolide) polymer hydrolysis. J. Biomed. Mater. Res. 1997; 34: 531–538
  • Zhu G., Mallery S.R., Schwendeman S.P. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide). Nat. Biotechnol. 2000; 18: 52–56
  • Pratt L., Chu C., Auer J., Kim J., Zollweg JA, Chu CC. The effect of ionic electrolytes on hydrolytic degradation of biodegradable polymer: mechanical and thermodynamic properties and molecular modeling. J. Polymer Sci. Part A: Polymer Chem. 1993; 31: 1759–1769
  • Shah SS, Cha Y., Pitt CG. J. Control. Release. Poly(glycolic acid-co-dl-lactic acid): diffusion or degradation controlled drug delivery? 1992; 18: 261–270
  • Reich G. In vitro degradation kinetics of PLA/PLGA microspheres and films: The role played by buffer salts. Proceed. Int'l. Symp. Control. Release Bioact. Mater. 1997; 24: 175–176
  • Yamagata Y., Misaki M., Kurokawa T., Taira K., Takada S. Preparation of a copoly (dl-lactic/glycolic acid)-zinc oxide complex and its utilization to microcapsules containing recombinant human growth hormone. Int. J. Pharm. 2003; 251: 133–141
  • Shakweh M., Besnard M., Nicolas V., Fattal E. Poly (lactide-co-glycolide) particles of different physicochemical properties and their uptake by peyer's patches in mice. Eur. J. Pharm. Biopharm. 2005; 61: 1–13
  • Lee S.C., Oh J.T., Jang M.H., Chung S.I. Quantitative analysis of polyvinyl alcohol on the surface of poly(d,l-lactide-co-glycolide) microparticles prepared by solvent evaporation method: effect of particle size and PVA concentration. J. Control. Release 1999; 59: 123–132
  • Boury F., Marchais H., Proust J.E., Benoit J.P. Bovine serum albumin release from poly(α-hydroxy acid) microspheres: Effects of polymer molecular weight and surface properties. J. Control. Release 1997; 45: 75–86
  • Vander A., Sherman J., Luciano D. Human Physiology–The Mechanisms of Body Function; 7th. The McGraw-Hill Companies, Inc, New York 1998; 375
  • Fu K., Pack D.W., Klibanov A.M., Langer R. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm. Res. 2000; 17(1)100–106
  • Fredenberg S., Reslow M., Axelsson A. Measurement of protein diffusion through poly(D, L-lactide-co-glycolide). Pharm. Dev. Technol. 2004; 10(2)299–307
  • Ishihara T., Izumo N., Higaki M., Shimada E., Hagi T., Mine L., Ogawa Y., Mizushima Y. Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its relase profile. J. Control. Release 2005; 105: 68–76
  • Lowry TH, Shueller Richardson K. Mechanism and Theory in Organic Chemistry. Harper & Row, New York 1981; 281–287
  • Badri Viswanathan N., Patil SS, Pandit JK, Lele AK, Kulkarni MG, Mashelkar RA. Morphological changes in degrading PLGA and P(dl)LA microspheres: implications for the design of controlled release systems. J. Microencapsul. 2001; 18(6)783–800
  • Li S., McCarthy S. Further investigations on the hydrolytic degradation of poly (dl-lactide). Biomaterials 1999; 20: 35–44
  • Li S. Hydrolytic degradation characteristics of aliphatic polyesters derived from lactic and glycolic acids. J. Biomed. Mater. Res. 1999; 48: 342–353
  • Blasi P., D'souza S.S., Selmin F., DeLuca P.P. J. Control. Release. Plasticizing effect of water on poly(lactide-co-glycolide) 2005; 108: 1–9
  • Park T.G. Degradation of poly(lactic-co-glycolic acid) microspheres: Effect of copolymer composition. Biomaterials 1999; 16(15)1123–1130
  • Friess W., Schlapp M. Release mechanisms from gentamicin loaded poly(lactic-co-glycolic acid) (PLGA) microparticles. J. Pharm. Sci. 2002; 91(3)845–855
  • Yamaguchi Y., Takenaga M., Kitagawa A., Ogawa Y., Mizushima Y., Igarashi R. Insulin-loaded biodegradable PLGA microcapsules: Initial burst release controlled by hydrophilic additives. J. Control. Release 2002; 81: 235–249
  • Wang J., Wang B.M., Schwendeman S.P. Characterization of the initial burst release of a model peptide from poly(D, L-lactide-co-glycolide) microspheres. J. Control. Release 2002; 82: 289–307

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.