Evidence for Use of Validated Sepsis Screening Tools in the Prehospital Population: A Scoping Review

References

• National Institute of General Medicine Sciences, National Institutes of Health. Sepsis; 2021 Sep 10 [accessed 2022 Jun 1]. https://www.nigms.nih.gov/education/fact-sheets/Pages/sepsis.aspx.
   Google Scholar
• Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Virulence. 2014;5(1):4–11. PMID: 24335434; PMCID: PMC3916382. doi:10.4161/viru.27372.
   PubMed Web of Science ®Google Scholar
• Collopy KT. What’s the point of point-of-care testing? HMP global learning network; 2014 Feb [accessed 2022 Jun 1]. https://www.hmpgloballearningnetwork.com/site/emsworld/article/11289724/whats-point-point-care-testing.
   Google Scholar
• Liu Y, Miller RG, Overstreet SE, Fowler RL. Improving outcomes in sepsis; 2021 Nov 16 [accessed 2022 Jun 1]. https://www.jems.com/patient-care/improving-outcomes-in-sepsis/.
   Google Scholar
• Wang HE, Weaver MD, Shapiro NI, Yealy DM. Opportunities for emergency medical services care of sepsis. Resuscitation. 2010;81(2):193–7. doi:10.1016/j.resuscitation.2009.11.008.
   PubMed Web of Science ®Google Scholar
• Groenewoudt M, Roest AA, Leijten FM, Stassen PM. Septic patients arriving with emergency medical services: a seriously ill population. Eur J Emerg Med. 2014;21(5):330–5. doi:10.1097/MEJ.0000000000000091.
   PubMed Web of Science ®Google Scholar
• Seymour CW, Band RA, Cooke CR, Mikkelsen ME, Hylton J, Rea TD, Goss CH, Gaieski DF. Out-of-hospital characteristics and care of patients with severe sepsis: a cohort study. J Crit Care. 2010;25(4):553–62. doi:10.1016/j.jcrc.2010.02.010.
   PubMed Web of Science ®Google Scholar
• Maciver M. Pre-hospital use of early warning scores to improve detection and outcomes of sepsis. Br J Community Nurs. 2021;26(3):122–9. doi:10.12968/bjcn.2021.26.3.122.
   PubMedGoogle Scholar
• McClelland H, Moxon A. Early identification and treatment of sepsis. Nursing Times; 2014 Jan 17 [accessed 2022 Jun 1]. https://www.nursingtimes.net/clinical-archive/infection-control/early-identification-and-treatment-of-sepsis-17-01-2014/.
   Google Scholar
• Seymour CW, Carlbom D, Engelberg RA, Larsen J, Bulger EM, Copass MK, Rea TD. Understanding of sepsis among emergency medical services: a survey study. J Emerg Med. 2012;42(6):666–77. doi:10.1016/j.jemermed.2011.06.013.
   PubMed Web of Science ®Google Scholar
• Fu L, Schwartz J, Moy A, Knaplund C, Kang MJ, Schnock KO, Garcia JP, Jia H, Dykes PC, Cato K, et al. Development and validation of early warning score system: a systematic literature review. J Biomed Inf. 2020;105:103410. doi:10.1016/j.jbi.2020.103410.
   PubMed Web of Science ®Google Scholar
• Fang A, Lim WT, Balakrishnan T. Early warning score validation methodologies and performance metrics: a systematic review. BMC Med Inform Decis Mak. 2020;20(1):111. doi:10.1186/s12911-020-01144-8.
   Web of Science ®Google Scholar
• Bone R, Balk R, Cerra F, Dellinger R, Fein A, Knaus W, Schein R, Sibbald W. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest. 1992;101(6):1644–55. doi:10.1378/chest.101.6.1644.
   PubMed Web of Science ®Google Scholar
• Arksey H, O'Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 2005;8(1):19–32. doi:10.1080/1364557032000119616.
   Google Scholar
• Lane DJ, Wunsch H, Saskin R, Cheskes S, Lin S, Morrison LJ, Scales DC. Screening strategies to identify sepsis in the prehospital setting: a validation study. CMAJ. 2020;192(10):E230–E239. doi:10.1503/cmaj.190966.
   PubMed Web of Science ®Google Scholar
• Jouffroy R, Tourtier JP, Philippe P, Bloch-Laine E, Bounes V, Gueye-Ngalgou P, Vivien B. Prehospital shock precautions on triage (PSPoT) score to assess in-hospital mortality for septic shock. Am J Emerg Med. 2021;44:230–4. doi:10.1016/j.ajem.2020.03.048.
   PubMed Web of Science ®Google Scholar
• Wallgren UK, Sjölin J, Järnbert-Pettersson H, Kurland L. Performance of NEWS2, RETTS, clinical judgement and the predict sepsis screening tools with respect to identification of sepsis among ambulance patients with suspected infection: a prospective cohort study. Scand J Trauma Resusc Emerg Med. 2021;29(1):114. doi:10.1186/s13049-021-00958-3.
   PubMed Web of Science ®Google Scholar
• Smyth MA, Brace-McDonnell SJ, Perkins GD. Identification of adults with sepsis in the prehospital environment: a systematic review. BMJ Open. 2016;6(8):e011218. doi:10.1136/bmjopen-2016-011218.
   PubMed Web of Science ®Google Scholar
• Williams TA, Tohira H, Finn J, Perkins GD, Ho KM. The ability of early warning scores (EWS) to detect critical illness in the prehospital setting: a systematic review. Resuscitation. 2016;102:35–43. doi:10.1016/j.resuscitation.2016.02.011.
   PubMed Web of Science ®Google Scholar
• Althunayyan SM, Alsofayan YM, Khan AA. Shock index and modified shock index as triage screening tools for sepsis. J Infect Public Health. 2019;12(6):822–6. doi:10.1016/j.jiph.2019.05.002.
   PubMed Web of Science ®Google Scholar
• Barbara P, Graziano C, Caputo W, Litvak I, Battinelli D, Hahn B. The quick sequential organ failure assessment (qSOFA) identifies patients in the out-of-hospital setting. Am J Emerg Med. 2018;36(6):1022–6. doi:10.1016/j.ajem.2018.01.073.
   PubMed Web of Science ®Google Scholar
• Bayer O, Schwarzkopf D, Stumme C, Stacke A, Hartog CS, Hohenstein C, Kabisch B, Reichel J, Reinhart K, Winning J. An early warning scoring system to identify septic patients in the prehospital setting: the PRESEP score. Acad Emerg Med. 2015;22(7):868–71. doi:10.1111/acem.12707.
   PubMed Web of Science ®Google Scholar
• Dorsett M, Kroll M, Smith CK, Asaro P, Liang SY, Moy HP. QSOFA has poor sensitivity for prehospital identification of severe sepsis and septic shock. Prehosp Emerg Care. 2017;21(4):489–97. doi:10.1080/10903127.2016.1274348.
   PubMed Web of Science ®Google Scholar
• Hunter CL, Silvestri S, Ralls G, Stone A, Walker A, Mangalat N, Papa L. Comparing quick sequential organ failure assessment to end-tidal carbon dioxide as mortality predictors in prehospital patients with suspected sepsis. WestJEM. 2018;19(3):446–51. doi:10.5811/westjem.2018.1.35607.
   Google Scholar
• Jouffroy R, Saade A, Carpentier A, Ellouze S, Philippe P, Idialisoa R, Carli P, Vivien B. Triage of septic patients using qSOFA criteria at the SAMU regulation: a retrospective analysis. Prehosp Emerg Care. 2018;22(1):84–90. doi:10.1080/10903127.2017.1347733.
   PubMed Web of Science ®Google Scholar
• Jouffroy R, Saade A, Ellouze S, Carpentier A, Michaloux M, Carli P, Vivien B. Prehospital triage of septic patients at the SAMU regulation: comparison of qSOFA, MRST, MEWS, and PRESEP scores. Am J Emerg Med. 2018;36(5):820–4. doi:10.1016/j.ajem.2017.10.030.
   PubMed Web of Science ®Google Scholar
• Jouffroy R, Pierre Tourtier J, Gueye P, Bloch-Laine E, Bounes V, Debaty G, Boularan J, Carli P, Vivien B. Prehospital shock index to assess 28-day mortality for septic shock. Am J Emerg Med. 2020;38(7):1352–6. doi:10.1016/j.ajem.2019.11.004.
   PubMed Web of Science ®Google Scholar
• Jouffroy R, Gilbert B, Tourtier JP, Bloch-Laine E, Ecollan P, Bounes V, Boularan J, Gueye-Ngalgou P, Vivien B. The prehospital SIGARC score to assess septic shock in-hospital, 30-day and 90-day mortality. Am J Emerg Med. 2021;46:355–60. doi:10.1016/j.ajem.2020.10.014.
   PubMed Web of Science ®Google Scholar
• Jouffroy R, Gilbert B, Thomas L, Bloch-Laine E, Ecollan P, Boularan J, Bounes V, Vivien B, Gueye-Ngalgou P. Association between prehospital shock index variation and 28-day mortality among patients with septic shock. BMC Emerg Med. 2022;22(1):87. doi:10.1186/s12873-022-00645-1.
   PubMed Web of Science ®Google Scholar
• Lane DJ, Lin S, Scales DC. Classification versus prediction of mortality risk using the SIRS and qSOFA scores in patients with infection transported by paramedics. Prehosp Emerg Care. 2020;24(2):282–9. doi:10.1080/10903127.2019.1624901.
   PubMed Web of Science ®Google Scholar
• Polito CC, Isakov A, Yancey AH, Wilson DK, Anderson BA, Bloom I, Martin GS, Sevransky JE. Prehospital recognition of severe sepsis: development and validation of a novel EMS screening tool. Am J Emerg Med. 2015;33(9):1119–25. doi:10.1016/j.ajem.2015.04.024.
   PubMed Web of Science ®Google Scholar
• Shu E, Tallman CI, Frye W, Boyajian JG, Farshidpour L, Young M, Campagne D. Pre-hospital qSOFA as a predictor of sepsis and mortality. Am J Emerg Med. 2019;37(7):1273–8. doi:10.1016/j.ajem.2018.09.025.
   PubMed Web of Science ®Google Scholar
• Silcock DJ, Corfield AR, Staines H, Rooney KD. Superior performance of national early warning score compared with quick sepsis-related organ failure assessment score in predicting adverse outcomes: a retrospective observational study of patients in the prehospital setting. Eur J Emerg Med. 2019;26(6):433–9. doi:10.1097/MEJ.0000000000000589.
   PubMed Web of Science ®Google Scholar
• Smyth MA, Gallacher D, Kimani PK, Ragoo M, Ward M, Perkins GD. Derivation and internal validation of the screening to enhance prehospital identification of sepsis (SEPSIS) score in adults on arrival at the emergency department. Scand J Trauma Resusc Emerg Med. 2019;27(1):67. doi:10.1186/s13049-019-0642-2.
   PubMedGoogle Scholar
• Tusgul S, Carron PN, Yersin B, Calandra T, Dami F. Low sensitivity of qSOFA, SIRS criteria and sepsis definition to identify infected patients at risk of complication in the prehospital setting at the emergency department triage. Scand J Trauma Resusc Emerg Med. 2017;25(1):108. doi:10.1186/s13049-017-0449-y.
   PubMed Web of Science ®Google Scholar
• Usul E, Korkut S, Kayipmaz AE, Halici A, Kavalci C. The role of the quick sequential organ failure assessment score (qSOFA) and modified early warning score (MEWS) in the pre-hospitalization prediction of sepsis prognosis. Am J Emerg Med. 2021;41:158–62. doi:10.1016/j.ajem.2020.09.049.
   PubMed Web of Science ®Google Scholar
• Wallgren UM, Castren M, Svensson AEV, Kurland L. Identification of adult septic patients in the prehospital setting: a comparison of two screening tools and clinical judgment. Eur J Emerg Med. 2014;21(4):260–5. doi:10.1016/j.ajem.2020.09.049.
   PubMed Web of Science ®Google Scholar
• Smith MEB, Chiovaro JC, O’Neil M, Kansagara D, Quinones A, Freeman F, Motu’apuaka M, Slatore CG. Early warning scores: a systematic review. Washington (DC): Department of Veterans Affairs; 2014. PMID: 25506953.
   Google Scholar
• National Highway Traffic Safety Administration. National EMS scope of practice model. 2007
   Google Scholar
• Title 202, Chapter 7, Regulation 701. Kentucky General Assembly; 2022. https://apps.legislature.ky.gov/law/kar/titles/202/007/701/.
   Google Scholar
• Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche J-D, Coopersmith CM, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10. doi:10.1001/jama.2016.0287.
   PubMed Web of Science ®Google Scholar
• Lee S, An W. New clinical criterion for septic shock: serum lactate level as new emerging vital sign. J Thorac Dis. 2016;8(7):1388–90. doi:10.21037/jtd.2016.05.55.
   PubMed Web of Science ®Google Scholar
• McGillicuddy D, Tang A, Cataldo L, Gusev J, Shapiro N. Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis. Intern Emerg Med. 2009;4(1):41–4. doi:10.1007/s11739-008-0153-z.
   PubMed Web of Science ®Google Scholar
• Hunter C, Silvestri S, Dean M, Falk J, Papa L. End-tidal carbon dioxide is associated with mortality and lactate in patients with suspected sepsis. Am J Emerg Med. 2013;31(1):64–71. doi:10.1016/j.ajem.2012.05.034.
   PubMed Web of Science ®Google Scholar
• Hunter C, Silvestri S, Ralls G, Stone A, Walker A, Papa L. A prehospital screening tool utilizing end-tidal carbon dioxide predicts sepsis and severe sepsis. Am J Emerg Med. 2016;34(5):813–9. doi:10.1016/j.ajem.2016.01.017.
   PubMed Web of Science ®Google Scholar
• Weiss S, Guerrero A, Root-Bowman C, Ernst A, Krumperman K, Femling J, Froman P. Sepsis alerts in EMS and the results of pre-hospital ETCO2. Am J Emerg Med. 2019;37(8):1505–9. doi:10.1016/j.ajem.2018.11.009.
   PubMed Web of Science ®Google Scholar
• Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, Moher D, Peters MDJ, Horsley T, Weeks L, et al. PRISMA extension for scoping reviews (PRISMA-SCR): checklist and explanation. Ann Intern Med. 2018;169(7):467–73. doi:10.7326/m18-0850.
   PubMed Web of Science ®Google Scholar