Advanced search
Publication Cover
Amyloid
The Journal of Protein Folding Disorders
Volume 12, 2005 - Issue 4
Submit an article Journal homepage
196
Views
39
CrossRef citations to date
0
Altmetric
Original

Quantitative serum free light chain assay in the diagnostic evaluation of AL amyloidosis

Harun Akar Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
,
David C. Seldin Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Stem Cell Transplant Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
,
Barbarajean Magnani Department of Laboratory Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
,
Carl O'Hara Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Laboratory Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Pathology at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
,
John L. Berk Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
,
Christopher Schoonmaker Boston University School of Public Health, Boston, MA, 02118, USA
,
Howard Cabral Boston University School of Public Health, Boston, MA, 02118, USA
,
Laura M. Dember Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
,
Vaishali Sanchorawala Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Stem Cell Transplant Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
,
Lawreen H. Connors Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Biochemistry at Boston University School of Medicine, Boston, MA, 02118, USA
,
Rodney H. Falk Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
&
Dr Martha Skinner Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USACorrespondence[email protected]
 show all
Pages 210-215 | Published online: 06 Jul 2009

References

  • Glenner G G, Terry W, Harada M, Isersky C, Page D. Amyloid fibril proteins: proof of homology with immunoglobulin light chains by sequence analyses. Science 1971; 172: 1150–1151
  • Falk R H, Comenzo R, Skinner M L. The systemic amyloidoses. New Engl J Med 1997; 337: 898–909
  • Kyle R A, Gertz M A. Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Seminars in Hem 1995; 32: 45–59
  • Sanchorawala V, Wright D G, Seldin D C, Dember L, Finn K, Falk R H, Berk J, Quillen K, Skinner M. An overview of the use of high-dose mephalan with autologous stem cell transplantation for the treatment of AL amyloidosis. Bone Marrow Transplant 2001; 28: 637–642
  • Skinner M, Sanchorawala V, Seldin D C, Dember L, Falk R H, Berk J, Anderson J J, O'Hara C, Finn K, Libbey C A, et al. Survival and clinical response to treatment with high-dose melphalan and autologous stem-cell transplantation in patients with AL amyloidosis: an 8-year study. Ann Intern Med 2004; 140: 85–93
  • Seldin D C, Anderson J J, Sanchorawala V, Malek K, Wright D G, Quillen K, Finn K T, Jerk J L, Dember L M, et al. Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation. Blood 2004; 104: 1888–1893
  • Dispenzieri A, Kyle R A, Lacy M Q, Therneau T M, Larson D R, Plevak M F, Rajkumar S V, Fonseca R, Greipp P R, Witzig T E, et al. Superior survival in primary systemic amyloidosis patients undergoing peripheral blood stem cell transplant: a case control study. Blood 2004; 103: 3960–3963
  • Drayson M, Tang L X, Drew R, Mead G P, Carr-Smith H D, Bradwell A A. Serum free light chain measurements for identifying and monitoring patients with nonsecretory myeloma. Blood 2001; 97: 2900–2902
  • Bradwell A R, Carr-Smith H D, Mead G P, Tang L X, Showell P J, Drayson M T, Drew R. Highly sensitive, automated immunoasay for immunoglobulin free light chains in serum and urine. Clin Chem 2001; 47: 673–680
  • Katzmann J A, Clark R J, Abraham R S, Bryant S, Lymp J F, Bradwell A R, Kyle R A. Serum reference intervals and diagnostic ranges for free kappa and lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem 2002; 48: 1437–1444
  • Abraham R S, Clark R J, Bryant S C, Lymp J F, Larson T, Kyle R A, Katzmann J A. Correlation of serum immunoglobulin free light chain quantification with urinary Bence Jones protein in light chain myeloma. Clin Chem 2002; 48: 655–657
  • Swan N, Skinner M, O'Hara C J. Bone marrow core biopsy specimens in AL(primary) amyloidosis. A morphologic and immunohistochemical study of 100 cases. Am J Clin Pathol 2003; 120: 610–616
  • Bradwell A A. Serum free light chain analysis. 2nd ed. The Binding Site Inc, San Diego 2004; 97–106
  • Abraham R S, Katzmann J A, Clark R J, Bradwell A R, Kyle R A, Gertz M A. Quantitative analysis of serum free light chains: a new marker for the diagnostic evaluation of primary systemic amyloidosis. Am J Clin Pathol 2003; 119: 274–278
  • Lachmann H J, Gallimore R, Gillmore J D, Carr-Smith H D, Bradwell A R, Pepys M B, Hawkins P N. Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy. Br J Haematol 2003; 122: 78–84

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.