Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?

Madhurima DasDepartment of Physiology & Biophysics, Boston University School of Medicine, Boston, MA, USA and

Christopher J. WilsonDepartment of Chemistry, Northeastern University, Boston, MA, USA

Xiaohu MeiDepartment of Physiology & Biophysics, Boston University School of Medicine, Boston, MA, USA and

Thomas WalesDepartment of Chemistry, Northeastern University, Boston, MA, USA

John R. EngenDepartment of Chemistry, Northeastern University, Boston, MA, USA

Olga GurskyDepartment of Physiology & Biophysics, Boston University School of Medicine, Boston, MA, USA and Correspondence[email protected]

References

Das M, Gursky O. Amyloid-forming properties of human apolipoproteins: sequence analyses and structural insights. Adv Exp Med Biol 2015;855:175–211.
PubMed Web of Science ®Google Scholar
Das M, Wilson CJ, Mei X, Wales TE, Engen JR, Gursky O. Structural stability and local dynamics in disease-causing mutants of human apolipoprotein A-I: What makes the protein amyloidogenic? J Mol Biol 2016;428:449–62.
PubMed Web of Science ®Google Scholar
Mei X, Atkinson D. Crystal structure of C-terminal truncated apolipoprotein A-I reveals the assembly of high density lipoprotein (HDL) by dimerization. J Biol Chem 2011;286:38570–82.
PubMed Web of Science ®Google Scholar
Das M, Mei X, Jayaraman S, Atkinson D, Gursky O. Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - A common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis. Febs J 2014;281:2525–42.
PubMed Web of Science ®Google Scholar

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?

References

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date