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Amyloid
The Journal of Protein Folding Disorders
Volume 30, 2023 - Issue 3
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Research Articles

The impact of Post-Transplant doxycycline in AL amyloidosis – updated results after Long-Term follow up

Nadine Abdallaha Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Angela Dispenzieria Division of Hematology, Mayo Clinic, Rochester, MN, USAORCID Iconhttps://orcid.org/0000-0001-8780-9512
ORCID Icon,
Eli Muchtara Division of Hematology, Mayo Clinic, Rochester, MN, USAORCID Iconhttps://orcid.org/0000-0003-2210-2174
ORCID Icon,
Francis K. Buadia Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Prashant Kapoora Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Martha Q. Lacya Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Yi L. Hwaa Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Amie Fondera Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Miriam A. Hobbsa Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Suzanne R. Haymana Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Nelson Leunga Division of Hematology, Mayo Clinic, Rochester, MN, USA;b Division of Nephrology, Mayo Clinic, Rochester, MN, USAORCID Iconhttps://orcid.org/0000-0002-5651-1411
ORCID Icon,
David Dinglia Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Ronald S. Goa Division of Hematology, Mayo Clinic, Rochester, MN, USAORCID Iconhttps://orcid.org/0000-0002-8284-3495
ORCID Icon,
Yi Lina Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Wilson I. Gonsalvesa Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Moritz Bindera Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Taxiarchis Kourelisa Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Rahma Warsamea Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Robert A. Kylea Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
S. Vincent Rajkumara Division of Hematology, Mayo Clinic, Rochester, MN, USA
,
Morie A. Gertza Division of Hematology, Mayo Clinic, Rochester, MN, USAORCID Iconhttps://orcid.org/0000-0002-3853-5196
ORCID Icon &
Shaji K. Kumara Division of Hematology, Mayo Clinic, Rochester, MN, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5392-9284
ORCID Icon show all
Pages 261-267 | Received 01 Aug 2022, Accepted 30 Nov 2022, Published online: 19 Dec 2022

References

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  • Shi J, Guan J, Jiang B, et al. Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. Proc Natl Acad Sci U S A. 2010;107(9):4188–4193.
  • Diomede L, Rognoni P, Lavatelli F, et al. A Caenorhabditis elegans–based assay recognizes immunoglobulin light chains causing heart amyloidosis. Blood. 2014;123(23):3543–3552.
  • Dispenzieri A, Gertz MA, Kyle RA, et al. Serum cardiac troponins and N-terminal pro-brain natriuretic peptide: a staging system for primary systemic amyloidosis. J Clin Oncol. 2004;22(18):3751–3757.
  • Szalat R, Sarosiek S, Havasi A, et al. Organ responses after highdose melphalan and stemcell transplantation in AL amyloidosis. Leukemia. 2021;35(3):916–919.
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  • Staron A, Burks EJ, Lee JC, et al. Assessment of minimal residual disease using multiparametric flow cytometry in patients with AL amyloidosis. Blood Adv. 2020;4(5):880–884.
  • Ward JE, Ren R, Toraldo G, et al. Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis. Blood. 2011;118(25):6610–6617.
  • Valero-Munoz M, Wilson RM, Breton-Romero R, et al. Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes. Int J Cardiol. 2020;321:133–136.
  • Kumar SK, Dispenzieri A, Lacy MQ, et al. Doxycycline used as post transplant antibacterial prophylaxis improves survival in patients with light chain amyloidosis undergoing autologous stem cell transplantation. Blood. 2012;120(21):3138–3138.
  • Blue BJ, Duncanson L, Hansen DK, et al. Impact of doxycycline on outcomes in AL amyloidosis. J Clin Oncol. 2020;38(15_suppl):e20568–e20568.
  • D'Souza A, Szabo A, Flynn KE, et al. Adjuvant doxycycline to enhance anti-amyloid effects: results from the dual phase 2 trial. EClinicalMedicine. 2020;23:100361.
  • Shen KN, Fu WJ, Wu Y, et al. Doxycycline combined with bortezomib-cyclophosphamide-dexamethasone chemotherapy for newly diagnosed cardiac light-chain amyloidosis: a multicenter randomized controlled trial. Circulation. 2022;145(1):8–17.
  • Wechalekar AD, Whelan C. Encouraging impact of doxycycline on early mortality in cardiac light chain (AL) amyloidosis. Blood Cancer J. 2017;7(3):e546-e546.
  • Gertz MA, Lacy MQ, Dispenzieri A, et al. Autologous stem cell transplant for immunoglobulin light chain amyloidosis: a status report. Leuk Lymphoma. 2010;51(12):2181–2187.
  • Comenzo RL, Reece D, Palladini G, et al. Consensus guidelines for the conduct and reporting of clinical trials in systemic light-chain amyloidosis. Leukemia. 2012;26(11):2317–2325.
  • A Trial of Doxycycline vs. Standard Supportive Therapy in Newly-diagnosed Cardiac AL Amyloidosis Patients Undergoing Bortezomib-based Therapy. https://clinicaltrials.gov/ct2/show/NCT03474458

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