Antioxidant-rich Terminalia catappa fruit exerts antihypertensive effect via modulation of angiotensin-1-converting enzyme activity and H₂S/NO/cGMP signalling pathway in Wistar rats

References

• Adebayo, A.A., Oboh, G., and Ademosun, A.O., 2019. Almond-supplemented diet improves sexual functions beyond Phosphodiesterase-5 inhibition in diabetic male rats. Heliyon, 5 (12), e03035.
   PubMed Web of Science ®Google Scholar
• Adebayo, A.A., Oboh, G., and Ademosun, A.O., 2021. Effect of dietary inclusion of almond fruit on sexual behavior, arginase activity, pro-inflammatory, and oxidative stress markers in diabetic male rats. Journal of food biochemistry, 45 (3), e13269.
   PubMed Web of Science ®Google Scholar
• Adebayo, A.A., Oboh, G., and Ademosun, A.O., 2022. Nutraceutical potential of almond fruits in managing diabetes-related erectile dysfunction: Effect on Nrf-2 level and smooth muscle/collagen ratio. Andrologia, 54 (11), e14636.
   PubMed Web of Science ®Google Scholar
• Adefegha, S.A., 2018. Functional foods and nutraceuticals as dietary intervention in chronic diseases; novel perspectives for health promotion and disease prevention. Journal of dietary supplements, 15 (6), 977–1009.
   PubMedGoogle Scholar
• Agunloye, O.M., et al., 2019. Cardio-protective and antioxidant properties of caffeic acid and chlorogenic acid: Mechanistic role of angiotensin converting enzyme, cholinesterase and arginase activities in cyclosporine induced hypertensive rats. Biomedicine & pharmacotherapy = biomedecine & pharmacotherapie, 109, 450–458.
   PubMed Web of Science ®Google Scholar
• Ajibade, T., et al., 2022. Polyphenol-rich fraction of Terminalia catappa prevents chronic lead acetate induced oxidative stress and cardiorenal toxicities in rats. Clinical complementary medicine and pharmacology, 2 (2), 100032.
   Google Scholar
• Akinyemi, A.J., et al., 2015. Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats. Journal of functional foods, 17, 792–801.
   Web of Science ®Google Scholar
• Alcendor, R.R., et al., 2007. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circulation research, 100 (10), 1512–1521.
   PubMed Web of Science ®Google Scholar
• Alia, M., et al., 2003. Effect of grape antioxidant dietary fiber on the total antioxidant capacity and the activity of liver antioxidant enzymes in rat. Nutrition research, 23 (9), 1251–1267.
   Web of Science ®Google Scholar
• Al-Muzafar, H.M., and Amin, K.A., 2017. Efficacy of functional foods mixture in improving hypercholesterolemia, inflammatory and endothelial dysfunction biomarkers-induced by high cholesterol diet. Lipids in health and disease, 16 (1), 1–10.
   PubMedGoogle Scholar
• Asfaw Erku, D., and Basazn Mekuria, A., 2016. Prevalence and correlates of complementary and alternative medicine use among hypertensive patients in Gondar town, Ethiopia. Evidence-Based complementary and alternative medicine, 2016, 1–7.
   Web of Science ®Google Scholar
• Bidlingmeyer, B., Cohen, S., and Tarvin, T., 1984. Rapid analysis of amino acids using pre-column derivatization. Journal of chromatography, 336 (1), 93–104.
   PubMed Web of Science ®Google Scholar
• Bitok, E., and Sabaté, J., 2018. Nuts and cardiovascular disease. Progress in cardiovascular diseases, 61 (1), 33–37.
   PubMed Web of Science ®Google Scholar
• Blacher, J., et al., 2016. From epidemiological transition to modern cardiovascular epidemiology: hypertension in the 21st century. Lancet (London, England), 388 (10043), 530–532.
   PubMed Web of Science ®Google Scholar
• Boucher, J.L., Moali, C., and Tenu, J.P., 1999. Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization. Cellular and molecular life sciences: CMLS, 55 (8–9), 1015–1028.
   PubMed Web of Science ®Google Scholar
• Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical biochemistry, 72 (1-2), 248–254.
   PubMed Web of Science ®Google Scholar
• Brewster, U.C., Perazella, M.A., and Setaro, J.F., 2003. The renin-angiotensin-aldosterone system: cardiorenal effects and implications for renal and cardiovascular disease states. The American journal of the medical sciences, 326 (1), 15–24.
   PubMed Web of Science ®Google Scholar
• Cahill, P.A., and Redmond, E.M., 2016. Vascular endothelium–gatekeeper of vessel health. Atherosclerosis, 248, 97–109.
   PubMed Web of Science ®Google Scholar
• Chalimoniuk, M., et al., 2015. Endurance training upregulates the nitric oxide/soluble guanylyl cyclase/cyclic guanosine 3′, 5′-monophosphate pathway in the striatum, midbrain and cerebellum of male rats. Brain research, 1618, 29–40.
   PubMed Web of Science ®Google Scholar
• Chen, J.Y., et al., 2018. Nitric oxide bioavailability dysfunction involves in atherosclerosis. Biomedicine & pharmacotherapy = biomedecine & pharmacotherapie, 97, 423–428.
   PubMed Web of Science ®Google Scholar
• Chen, L., et al., 2023. Enhanced antihypertensive potential of fermented pomegranate juice: the contribution of phenolic compounds biotransformation and the resultant angiotensin-I-converting enzyme inhibition mechanism. Food chemistry, 404 (Pt B), 134745.
   PubMedGoogle Scholar
• Chyau, C.C., Ko, P.T., and Mau, J.L., 2006. Antioxidant properties of aqueous extracts from Terminalia catappa leaves. Lwt - food science and technology, 39 (10), 1099–1108.
   Web of Science ®Google Scholar
• Citi, V., et al., 2021. Role of hydrogen sulfide in endothelial dysfunction: Pathophysiology and therapeutic approaches. Journal of advanced research, 27, 99–113.
   PubMed Web of Science ®Google Scholar
• Claiborne, A., 1985. Catalase activity. In: R.A. Greenwald, ed. Handbook of methods for oxygen radical research. Boca Raton: CRC Press, 283–284.
   Google Scholar
• Cortés, B., et al., 2006. Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function. Journal of the American college of cardiology, 48 (8), 1666–1671.
   PubMed Web of Science ®Google Scholar
• Dada, F.A., et al., 2021. Evaluation of different almond (Terminalia catappa) extracts against oxidative stress induced by cyclosporine in brain and liver of rats. Journal of complementary & integrative medicine, 18 (4), 727–735.
   PubMedGoogle Scholar
• Daram, P., et al., 2021. Investigation of anti-inflammatory and anti-arthritic potentials of Terminalia catappa bark using in vitro assays and carrageenan-induced inflammation, complete Freund’s adjuvant induced arthritis model in rats. South african journal of botany, 141, 313–321.
   Web of Science ®Google Scholar
• De Giusti, V.C., Garciarena, C.D., and Aiello, E.A., 2009. Role of reactive oxygen species (ROS) in angiotensin II-induced stimulation of the cardiac Na+/HCO3− cotransport. Journal of molecular and cellular cardiology, 47 (5), 716–722.
   PubMed Web of Science ®Google Scholar
• Du, C., et al., 2019. Sulfhydrated sirtuin-1 increasing its deacetylation activity is an essential epigenetics mechanism of anti-atherogenesis by hydrogen sulfide. Antioxidants & redox signaling, 30 (2), 184–197.
   PubMed Web of Science ®Google Scholar
• Ezekian, J.E., and Hill, K.D., 2019. Management of pulmonary arterial hypertension in the pediatric patient. Current cardiology reports, 21 (12), 1–11.
   PubMed Web of Science ®Google Scholar
• Frankel, E. N., 1997. Nutritional benefits of flavonoids. In: Food factors for cancer prevention. Tokyo: Springer, 613–616.
   Google Scholar
• Fürstenau, C.R., et al., 2010. L-NAME-treatment alters ectonucleotidase activities in kidney membranes of rats. Life sciences, 87 (9-10), 325–332.
   PubMed Web of Science ®Google Scholar
• Ge, Y., et al., 2022. On-demand therapeutic delivery of hydrogen sulfide aided by biomolecules. Journal of controlled release: official journal of the controlled release society, 352, 586–599.
   PubMed Web of Science ®Google Scholar
• Gheibi, S., et al., 2018. Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension. Biochemical pharmacology, 149, 42–59.
   PubMed Web of Science ®Google Scholar
• Griendling, K.K., and Ushio-Fukai, M., 2000. Reactive oxygen species as mediators of angiotensin II signaling. Regulatory peptides, 91 (1-3), 21–27.
   PubMedGoogle Scholar
• Grover-Páez, F., and Zavalza-Gómez, A.B., 2009. Endothelial dysfunction and cardiovascular risk factors. Diabetes research and clinical practice, 84 (1), 1–10.
   PubMed Web of Science ®Google Scholar
• Hayashi, I., et al., 2007. High-throughput spectrophotometric assay of reactive oxygen species in serum. Mutation research, 631 (1), 55–61.
   PubMed Web of Science ®Google Scholar
• Iheagwam, F.N., et al., 2022. Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/streptozotocin-induced diabetic rats. Scientific reports, 12 (1), 1–15.
   PubMed Web of Science ®Google Scholar
• Incalza, M.A., et al., 2018. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vascular pharmacology, 100, 1–19.
   PubMed Web of Science ®Google Scholar
• Janporn, S., et al., 2015. Physicochemical properties of Terminalia catappa seed oil as a novel dietary lipid source. Journal of food and drug analysis, 23 (2), 201–209.
   PubMed Web of Science ®Google Scholar
• Johnson, F.K., et al., 2015. Arginase promotes endothelial dysfunction and hypertension in obese rats. Obesity (silver spring, Md.), 23 (2), 383–390.
   PubMed Web of Science ®Google Scholar
• Kagota, S., et al., 2006. Disturbances in nitric oxide/cyclic guanosine monophosphate system in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life sciences, 78 (11), 1187–1196.
   PubMed Web of Science ®Google Scholar
• Kovamees, O., et al., 2016. Arginase inhibition improves endothelial function in patients with familial hypercholesterolaemia irrespective of their cholesterol levels. Journal of internal medicine, 279 (5), 477–484.
   PubMed Web of Science ®Google Scholar
• Ladele, B., et al., 2016. Chemical composition and nutritional properties of Terminalia catappa L. oil and kernels from Benin. Comptes rendus chimie, 19 (7), 876–883.
   Web of Science ®Google Scholar
• Latorre, E., et al., 2018. Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2. Aging, 10 (7), 1666–1681.
   PubMedGoogle Scholar
• Lim, S.L., et al., 2015. Cardiac endothelium–myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fraction. European heart journal, 36 (31), 2050–2060.
   PubMed Web of Science ®Google Scholar
• Liwa, A., et al., 2017. Herbal and alternative medicine use in Tanzanian adults admitted with hypertension-related diseases: a mixed-methods study. International journal of hypertension, 2017, 1–9.
   Web of Science ®Google Scholar
• Mancardi, D., et al., 2009. Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide. Biochimica et biophysica acta, 1787 (7), 864–872.
   PubMed Web of Science ®Google Scholar
• Mau, J.L., Ko, P.T., and Chyau, C.C., 2003. Aroma characterization and antioxidant activity of supercritical carbon dioxide extracts from Terminalia catappa leaves. Food research international, 36 (1), 97–104.
   Web of Science ®Google Scholar
• Mazurakova, A., et al., 2022. Flavonoids exert potential in the management of hypertensive disorders in pregnancy. Pregnancy hypertension, 29, 72–85.
   PubMed Web of Science ®Google Scholar
• Ming, X.F., et al., 2012. Arginase II promotes macrophage inflammatory responses through mitochondrial reactive oxygen species, contributing to insulin resistance and atherogenesis. Journal of the American heart association, 1 (4), e000992.
   PubMed Web of Science ®Google Scholar
• Miranda, K.M., Espey, M.G., and Wink, D.A., 2001. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric oxide: biology and chemistry, 5 (1), 62–71.
   PubMed Web of Science ®Google Scholar
• Mullins, A.P., and Arjmandi, B.H., 2021. Health benefits of plant-based nutrition: focus on beans in cardiometabolic diseases. Nutrients, 13 (2), 519.
   PubMed Web of Science ®Google Scholar
• Nagate, T., et al., 2007. Diluted isoflurane as a suitable alternative for diethyl ether for rat anaesthesia in regular toxicology studies. The journal of veterinary medical science, 69 (11), 1137–1143.
   PubMed Web of Science ®Google Scholar
• Oboh, G., et al., 2017. In-vitro Inhibition of phosphodiesterase-5 and arginase activities in rat penile tissue by two Nigerian herbs (Hunteria umbellata and Anogeissus leiocarpus). Journal of basic and clinical physiology and pharmacology, 28 (4), 393–401.
   PubMedGoogle Scholar
• Oyeleye, S.I., et al., 2017. Phenolic profile and Enzyme Inhibitory activities of Almond (Terminalia catappa) leaf and Stem bark. International journal of food properties, 20 (sup3), S2810–S2821.
   Web of Science ®Google Scholar
• Padiya, R., et al., 2014. Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat. PloS one, 9 (5), e94228.
   PubMed Web of Science ®Google Scholar
• Paravicini, T.M., and Touyz, R.M., 2008. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes care, 31 (Supplement_2), S170–S180.
   PubMedGoogle Scholar
• Rodrigo, R., González, J., and Paoletto, F., 2011. The role of oxidative stress in the pathophysiology of hypertension. Hypertension research: official journal of the japanese society of hypertension, 34 (4), 431–440.
   PubMed Web of Science ®Google Scholar
• Salam, R., 2016. Expanding the definition of noncommunicable disease. Journal of social health and diabetes, 4 (2), 067–070.
   Google Scholar
• San, S.Y., Wan, J.M., and Louie, J.C.Y., 2022. Effect of plant-based functional foods for the protection against salt-induced endothelial dysfunction. Food science and human wellness, 11 (5), 1299–1305.
   Google Scholar
• Shodehinde, S.A., et al., 2017. Lasianthera africana leaves inhibit α-amylase, α-glucosidase, angiotensin-1-converting enzyme activities and Fe2+-induced oxidative damage in pancreas and kidney homogenates. Oriental pharmacy and experimental medicine, 17 (1), 41–49.
   Web of Science ®Google Scholar
• Suo, R., et al., 2013. Hydrogen sulfide prevents H2O2-induced senescence in human umbilical vein endothelial cells through SIRT1 activation. Molecular medicine reports, 7 (6), 1865–1870.
   PubMed Web of Science ®Google Scholar
• Tesfaye, S., Shifeta, M., and Hirigo, A.T., 2020. Pattern of cardiac diseases and co-existing morbidities among newly registered cardiac patients in an adult cardiac referral clinic of Hawassa University comprehensive specialized hospital, Southern-Ethiopia. Vascular health and risk management, 16, 379–387.
   PubMed Web of Science ®Google Scholar
• Tousoulis, D., et al., 2012. The role of nitric oxide on endothelial function. Current vascular pharmacology, 10 (1), 4–18.
   PubMed Web of Science ®Google Scholar
• Toyoda, K., and Ninomiya, T., 2014. Stroke and cerebrovascular diseases in patients with chronic kidney disease. The lancet. Neurology, 13 (8), 823–833.
   PubMed Web of Science ®Google Scholar
• Tucci, M., et al., 2022. Plant-Based Foods and Vascular Function: A Systematic Review of Dietary Intervention Trials in Older Subjects and Hypothesized Mechanisms of Action. Nutrients, 14 (13), 2615.
   PubMed Web of Science ®Google Scholar
• Vardi, Y., et al., 2002. Effects of sildenafil citrate (Viagra) on blood pressure in normotensive and hypertensive men. Urology, 59 (5), 747–752.
   PubMed Web of Science ®Google Scholar
• Wallace, J.L., and Wang, R., 2015. Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nature reviews. Drug discovery, 14 (5), 329–345.
   PubMed Web of Science ®Google Scholar
• World Health Organization, Public Health Agency of Canada, & Canada. Public Health Agency of Canada. 2005. Preventing chronic diseases: a vital investment. World Health Organization.
   Google Scholar
• Zhang, Y., et al., 2020. NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets. Nature reviews Cardiology, 17 (3), 170–194.
   PubMed Web of Science ®Google Scholar
• Zheng, M., et al., 2014. Hydrogen sulfide delays nicotinamide-induced premature senescence via upregulation of SIRT1 in human umbilical vein endothelial cells. Molecular and cellular biochemistry, 393 (1-2), 59–67.
   PubMed Web of Science ®Google Scholar
• Zulaikhah, S.T., 2017. The role of antioxidant to prevent free radicals in the body. Sains medika, 8 (1), 39–45.
   Google Scholar
• Zuo, J., and Jiang, Z., 2020. Melatonin attenuates hypertension and oxidative stress in a rat model of L-NAME-induced gestational hypertension. Vascular medicine (london, England), 25 (4), 295–301.
   PubMed Web of Science ®Google Scholar