Slit Proteins, Potential Endogenous Modulators of Inflammation

References and suggested reading

• Ackerman SL, Kozak LP, Przyborski SA, Rund LA, Boyer BB, Knowles BB (1997). The mouse rostral cerebel-lar malformation gene encodes an UNC-5-like protein. Nature 386: 838–842.
   PubMedGoogle Scholar
• Alfano M, Schmidtmayerova H, Amella CA, Pushkarsky T, Bukrinsky M (1999). The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains. J Exp Med 190: 597–605.
   Google Scholar
• Aloisi F (1999). The role of microglia and astrocytes in CNS immune surveillance and i=unopathology. In: The functional role of glial cells in health and disease: dialogue between glia and neurons. Mastas R, Tsacopoulos M (eds). Kluver Academic/Plenum: New York, pp 123–133.
   Google Scholar
• Aloisi F, Ria F, Adorini L (2000a). Regulation of T-cell re-sponses by CNS antigen presenting cells: different roles for microglia and astrocytes. Immunol Today 21: 141–147.
   Google Scholar
• Aloisi F, Serafinin B, Adorinin L (2000b). Glia-T cell dia-logue. J Neuroimmunol 107: 111–117.
   Google Scholar
• Antel J (2000). Antigen and superantigen presentation in the human CNS. J Neuroimmunol 107: 118–123.
   Google Scholar
• Arai H, Charo IF (1996). Differential regulation of G-protein-mediated signaling by chemokine receptors. J Biol Chem 271: 21814–21819.
   PubMed Web of Science ®Google Scholar
• Arai H, Tsou CL, Charo IF (1997). Chemotaxis in a lympho-cyte cell line transfected with C-C chemokine receptor 2B: evidence that directed migration is mediated by bg dimers released by activation of Gai-coupled receptors. Proc Nati Acad Sci USA 94: 14495–14499.
   PubMedGoogle Scholar
• Arenzana-Seisdedos F, Virelizier JL, Rousset D, Clark-Lewis I, Loetscher P, Moser B, Baggiolini M (1996). HIV blocked by chemokine antagonist. Nature 383: 400.
   Google Scholar
• Asensio VC, Campbell IL (1999). Chemokines in the CNS: plurifunctional mediators in diverse states. Trends Neu-rosci 22: 504–512.
   PubMed Web of Science ®Google Scholar
• Bacon KB, Szabo MC, Yssel H, Bolen JB, Schall TJ (1996). RANTES induces tyrosine kinase activity of stably com-plexed p125FAK and ZAP-70 in human T cells. J Exp Med 184: 873–882.
   PubMed Web of Science ®Google Scholar
• Baggiolini M (1998). Chemokines and leukocyte traffic. Nature 392: 565–568.
   PubMed Web of Science ®Google Scholar
• Baggiolini M, Dahinder CA (1994). CC chemokines in aller-gic inflammation. Immunol Today 15: 127–133.
   PubMedGoogle Scholar
• Baggiolini M, Dewald B, Moser B (1997). Human chemokines: an update. Annu Rev Immunol 15: 675–705.
   PubMed Web of Science ®Google Scholar
• Baggiolini M, Moser B (1997). Blocking chemokine recep-tors. J Exp Med 186: 1189–1191.
   PubMed Web of Science ®Google Scholar
• Bajetto A, et al (2001). Chemokines and their receptors in the central nervous system. Front Neuroendocrinol 22: 147–184.
   PubMed Web of Science ®Google Scholar
• Barnes DA, Tse J, Kaufhold M, Owen M, Hesselgesser J, Strieter R, Horuk R, Perez HD (1998). Polyclonal anti-body directed against human RANTES ameliorates dis-ease in the Lewis rat adjuvant-induced arthritis model. J Clin Invest 101: 2910–2919.
   PubMed Web of Science ®Google Scholar
• Bashaw G, Goodman CS (1999). Chimeric axon guidance receptors: the cytoplasmic domains of Slit and Netrin receptors specify attraction versus repulsion. Cell 97: 917–926.
   Google Scholar
• Battye R, Stevens A, Jacobs JR (1999). Axon repulsion from the midline of the Drosophila CNS requires slit function. Development 126: 2475–2481.
   Google Scholar
• Becher B, Prat A, Antel JP (2000). Brain-immune con-nection: immuno-regulatory properties of CNS-resident cells. Glia 29: 293–304.
   PubMed Web of Science ®Google Scholar
• Berger EA, Murphy PM, Farber JM (1999). Chemokine re-ceptors as HIV coreceptors: roles in viral entry, tropism, and disease. Annu Rev Immunol 17: 657–700.
   PubMed Web of Science ®Google Scholar
• Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA (1996). The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382: 829–833.
   PubMed Web of Science ®Google Scholar
• Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR (1997). The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Nati Acad Sci USA 94: 1925–1930.
   Google Scholar
• Bokoch GM (1995). Chemoattractant signaling and leuko-cyte activation. Blood 86: 1649–1660.
   PubMed Web of Science ®Google Scholar
• Boring L, Gosling J, Cleary M, Charo IF (1998). Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394: 894–897.
   PubMed Web of Science ®Google Scholar
• Boshoff C, Endo Y, Collins PD, Takeuchi Y, Reeves JD, Schweickart VL, Siani MA, Sasaki T, Williams TJ, Gray PW, Moore PS, Chang Y, Weiss RA (1997). Angio-genic and HIV-inhibitory functions of KSHV-encoded chemokines. Science 278: 290–294.
   PubMed Web of Science ®Google Scholar
• Boyden S (1962). The chemotactic effect of mixtures of an-tibody and antigen on polymorphonuclear leukocytes. J Exp Med 115: 453–466.
   PubMed Web of Science ®Google Scholar
• Bradl M (1996). Immune control of the brain. In: Immunoneurology. Choffion M, Steinman L (eds). Springer-Verlag: New York, pp 153–167.
   Google Scholar
• Brose K, Bland KS, Wang KB, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T (1999). Evo-lutionary conservation of the repulsive axon guidance function of Slit proteins and of their interactions with Robo receptors. Cell 96: 795–806.
   PubMed Web of Science ®Google Scholar
• Cajal S, Ramon Y (1911). Histology of the nervous system. Translated by Swanson N, Swanson LW, 1995. Oxford University Press: New York.
   Google Scholar
• Chan SS, Zheng H, Su MW, Wilk R, Killeen MT, Hedgecock EM, Culotti JG (1996). UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87: 187–195.
   Google Scholar
• Chen H, He Z, Bagri A, Tessier-Lavigne M (1998). Semaphorin-neuropilin interactions underlying sympa-thetic axon responses to class III semaphorins. Neuron 21: 1283–1290.
   Google Scholar
• Chen M-Y, Insall RH, Devreotes PN (1996). Signaling through chemoattractant receptors in Dictyostelium. Trends Genet 12: 52–57.
   Google Scholar
• Chen S, Bacon L Li, Garcia GE, Xia Y, Lo D, Thompson DA, Siani MA, Yamamoto T, Harrison JK, Feng L (1998). In vivo inhibition of CC and CX3C chemokine-induced leukocyte infiltration and attenuation of glomeru-lonephritis in Wistar-Kyoto (WKY) rats by yMIP-II. J Exp Med 188: 193–198.
   PubMed Web of Science ®Google Scholar
• Cheng HJ, Flanagan JG (1994). Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell 79: 157–168.
   PubMed Web of Science ®Google Scholar
• Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J (1996). The beta-chemokine re-ceptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85: 1135–1148.
   PubMed Web of Science ®Google Scholar
• Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (1995). Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors pro-duced by CD8+ T cells. Science 270: 1811–1815.
   PubMed Web of Science ®Google Scholar
• Cyster JG (1999). Chemokines and cell migration in sec-ondary lymphoid organs. Science 286: 2098–2102.
   PubMed Web of Science ®Google Scholar
• Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR (1996). Identification of a major co-receptor for primary isolates of HIV-1. Nature 381: 661–666.
   PubMed Web of Science ®Google Scholar
• Devreotes PN, Zigmond SH (1988). Chemotaxis in eukary-otic cells: a focus on leukocytes and Dictyostelium. Ann Rev Cell Biol 4: 649–686.
   PubMedGoogle Scholar
• Dilloo D, Bacon K, Holden W, Zhong W, Burdach S, Zlotnik A, Brenner M (1996). Combined chemokine and cytokine gene transfer enhances antitumor immunity. Nat Med 2: 1090–1095.
   Google Scholar
• Djellas Y, Antonakis K, Le Breton GC (1998). A molecular mechanism for signaling between seven-transmembrane receptors: evidence for a redistribution of G proteins. Proc Nati Acad Sci USA 95: 10944–10948.
   PubMed Web of Science ®Google Scholar
• Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RWA (1996).
   Google Scholar
• Dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85: 1149-1158.
   Google Scholar
• Downey GP (1994). Mechanisms of leukocyte motility and chemotaxis. Curr Opin Immunol 6: 113–124.
   PubMed Web of Science ®Google Scholar
• Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA (1996). HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381: 667–673.
   PubMed Web of Science ®Google Scholar
• Duel TF, Keim PS, Farmer M, Heinrikson RL (1977). Amino acid sequence of human platelet factor 4. Proc Nati Acad Sci USA 74: 2256–2258.
   Google Scholar
• Feiner L, Koppel AM, Kobayashi H, Raper JA (1997). Se-creted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neu-rons in situ. Neuron 19: 539–545.
   Google Scholar
• Feng L, Chen S, Garcia GE, Xia Y, Siani MA, Botti P, Wilson CB, Harrison JK, Bacon KB (1999). Prevention of cres-centic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication [In Process Citation]. Kidney Int 56: 612–620.
   PubMed Web of Science ®Google Scholar
• Feng L, Xia Y, Yoshimura T, Wilson CB (1995). Mod-ulation of neutrophil influx in glomerulonephritis in the rat with anti-macrophage inflammatory protein-2 (MIP-2) antibody. J Clin Invest 95: 1009–1017.
   Google Scholar
• Feng Y, Broder CC, Kennedy PE, Berger EA (1996). HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272: 872–877.
   PubMed Web of Science ®Google Scholar
• Forster R, Kre=er E, Schubel A, Breitfeld D, Kleinschmidt A, Nerl C, Bernhardt G, Lipp M (1998). Intracel-lular and surface expression of the HIV-1 core-ceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation. J Immuno1160: 1522–1531.
   Google Scholar
• Forster R, Mattis AE, Kre=er E, Wolf E, Brem G, Lipp M (1996). A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87: 1037–1047.
   Google Scholar
• Frohman EM, et al (2001). Autonomic regulation of neu-roimmunological responses: implications for multiple sclerosis. J Clin Immunol 21: 61–73.
   Google Scholar
• Fujioka T, Kolson DL, Rostami AM (1999). Chemokines and peripheral nerve demyelination. J NeuroVirol 5: 27–31.
   Web of Science ®Google Scholar
• Furie MB, Randolph GJ (1995). Chemokines and tissue in-jury. Am J Pathol 146: 1287–1301.
   PubMed Web of Science ®Google Scholar
• Ganju RK, Brubaker SA, Meyer J, Dutt P, Yang Y, Qin S, Newman W, Groopman JE (1998). The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the trans-membrane G-protein-coupled CXCR-4 receptor and ac-tivates multiple signal transduction pathways. J Biol Chem 273: 23169–23175.
   PubMed Web of Science ®Google Scholar
• Garcia-Zepeda EA, Combadiere C, Rothenberg ME, Sarafi MN, Lavigne F, Hamid Q, Murphy PM, Luster AD (1996a). Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in al-lergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol 157: 5613–5626.
   PubMed Web of Science ®Google Scholar
• Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (1996b). Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med 2: 449–456.
   Google Scholar
• Gerszten RE, Mach F, Sauty A, Rosenzweig A, Luster AD (2000). Chemokines, leukocytes, and atherosclerosis. J Lab Clin Med 136: 87–92.
   PubMed Web of Science ®Google Scholar
• Giger RJ, Urquhart ER, Gillespie SKH, Levengood DV, Ginty DD, Kolodkin AL (1998). Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of recep-tor function and specificity. Neuron 21: 1079–1092.
   PubMed Web of Science ®Google Scholar
• Glabinski AR, Ransohoff RM (1999). Chemokines and chemokine receptors in CNS pathology. J NeuroVirol 5: 3–12.
   PubMed Web of Science ®Google Scholar
• Godiska R, Chantry D, Dietsch GN, Gray PW (1995). Chemokine expression in murine experimental allergic encephalomyelitis. J Neuroimmunol 58: 167–176.
   PubMed Web of Science ®Google Scholar
• Gong JH, Ratkay LG, Waterfield JD, Clark-Lewis I (1997). An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model. J Exp Med 186: 131–137.
   Google Scholar
• Gray GE, Leber SM, Sanes JR (1990). Migratory patterns of clonally related cells in the developing central nervous system. Experientia 46: 929–940.
   PubMedGoogle Scholar
• Gregory WA, Edmondson JC, Hatten ME, Mason CA (1988). Cytology and neuron-glial apposition of migrat-ing cerebellar granule cells in vitro. J Neurosci 8: 1728–1934.
   PubMed Web of Science ®Google Scholar
• Grimm MC, Pullman WE, Bennett GM, Sullivan PJ, Pavli P, Doe WF (1995). Direct evidence of monocyte recruit-ment to inflammatory bowel disease mucosa. J Gastroen-terol Hepatol 10: 387–395.
   PubMed Web of Science ®Google Scholar
• Gu L, Rutledge B, Fiorillo J, Ernst C, Grewal I, Flavell R, Gladue R, Rollins B (1997). In vivo properties of mono-cyte chemoattractant protein-1. J Leukoc Biol 62: 577–580.
   PubMed Web of Science ®Google Scholar
• Halks-Miller M, Hesselgesser J, Miko IJ, Horuk R (1997). Chemokine receptors in developing human brain. Methods Enzymol 288: 27–38.
   Google Scholar
• Harada A, Sekido N, Akahoshi T, Wada T, Mukaida N, Matsushima K (1994). Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukoc Biol 56: 559–564.
   PubMed Web of Science ®Google Scholar
• Harris H (1954). Role of chemotaxis in inflammation. Physiol Rev 34: 529–562.
   PubMed Web of Science ®Google Scholar
• Harrison JK, Jiang Y, Chen S, Xia Y, Maciejewski D, McNamara RK, Streit WJ, Salafranca MN, Adhikari S, Thompson DA, Botti P, Bacon KB, Feng L (1998). Role for neuronally derived fractalkine in mediating inter-actions between neurons and CX3CR1-expressing mi-croglia. Proc Nati Acad Sci USA 95: 10896–10901.
   Google Scholar
• Hatten ME (1999). Central nervous system neuronal migration. Ann Rev Neurosci 22: 511–539.
   PubMed Web of Science ®Google Scholar
• He Z, Tessier-Lavigne M (1997). Neuropilin is a receptor for the axonal chemorepellent semaphorin III. Cell 90: 739–751.
   PubMed Web of Science ®Google Scholar
• Hesselgesser J, Halks-Miller M, DelVecchio V, Peiper SC, Hoxie J, Kolson DL, Taub D, Horuk R (1997). CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Curr Biol 7: 112–121.
   PubMed Web of Science ®Google Scholar
• Hesselgesser J, Horuk R (1999). Chemokine and chemokine receptor expression in the central nervous system. J Neuro Viro/ 5: 13–26.
   PubMed Web of Science ®Google Scholar
• Hesselgesser J, Taub D, Baskar P, Greenberg M, Hoxie J, Kolson DL, Horuk R (1998). Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is me-diated by the chemokine receptor CXCR4. Curr Biol 8: 595–598.
   PubMed Web of Science ®Google Scholar
• Horuk R (1999). Chemokine receptors and HIV-1: the fusion of two major research fields. Immunol Today 20: 89–94.
   PubMedGoogle Scholar
• Horuk R, Martin AW, Wang Z, Schweitzer L, Gerassimides A, Guo H, Lu Z, Hesselgesser J, Perez HD, Kim J, Parker J, Hadley TJ, Peiper SC (1997). Expression of chemokine receptors by subsets of neurons in the central nervous system. J Immuno1158: 2882–2890.
   Google Scholar
• Hu H (1999). Chemorepulsion of neuronal migration by Slit2 in the developing mammalian forebrain. Neuron 23: 703–711.
   PubMed Web of Science ®Google Scholar
• Hvas J, McLean C, Justesen J, Kannourakis G, Steinman L, Oksenberg J, Bernard C (1997). Perivascular T-cells ex-press the proinflammatory chemokine RANTES mRNA in multiple sclerosis lesions. Scand J Immunol 46: 195–203.
   PubMed Web of Science ®Google Scholar
• Hwang SB (1990). Specific receptors of platelet-activating factor, receptor heterogeneity, and signal transduction mechanisms. J Lipid Mediat 2: 123–158.
   PubMedGoogle Scholar
• Igarashi M, Strittmatter SM, Vartanian T, Fishman MC (1993). G Protein mediation of signals that cause growth cone collapse. Science 259: 77–79.
   Google Scholar
• Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, Kakizaki M, Takagi S, Nomiyama H, Schall TJ, Yoshie 0 (1997). Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521–530.
   Google Scholar
• Izikson L, Klein RS, Luster AD, Weiner HL (2002). Targeting monocyte recruitment in CNS autoi=une disease. Clin Immunol 103: 125–131.
   Google Scholar
• Jung S, Littman DR (1999). Chemokine receptors in lym-phoid organ homeostasis. Curr Opin Immunol 11: 319–325.
   PubMedGoogle Scholar
• Karpus WJ (1999). Chemokine regulation of inflammatory-mediated nervous system diseases. J NeuroVirol 5: 1–2.
   PubMed Web of Science ®Google Scholar
• Karpus WJ, Lukacs NW, McRae BL, Strieter RM, Kunkel SL, Miller SD (1995). An important role for the chemokine macrophage inflammatory protein-1 alpha in the patho-genesis of the T cell-mediated autoi=une disease, ex-perimental autoimmune encephalomyelitis. J Immunol 155: 5003–5010.
   PubMed Web of Science ®Google Scholar
• Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M (1996). Deleted in Colorec-tal Cancer (DCC) encodes a netrin receptor. Cell 87: 175–185.
   Google Scholar
• Kennedy TE, Serafini T, de la Torre JR, Tessier-Lavigne M (1994). Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78: 425–435.
   Google Scholar
• Kidd T, Bland KS, Goodman CS (1999). Slit is the midline repellent for the robo receptor in Drosophila. Cell 96: 785–794.
   PubMed Web of Science ®Google Scholar
• Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (1998). Roundabout controls axon crossing of the CNS midline and defines a novel subfam-ily of evolutionarily conserved guidance receptors. Cell 92: 205–215.
   PubMed Web of Science ®Google Scholar
• Kindt RM, Lander AD (1995). Pertussis toxin specifically inhibits growth cone guidance by a mechanism inde-pendent of direct G protein inactivation. Neuron 15: 79–88.
   Google Scholar
• Kledal TN, Rosenkilde MM, Coulin F, Simmons G, Johnsen AH, Alouani S, Power CA, Luttichau HR, Gerstoft J, Clapham PR, Clark-Lewis I, Wells TNC, Schwartz TW (1997). A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 277: 1656–1659.
   PubMed Web of Science ®Google Scholar
• Klein PS, Fontana D, Knox B, Theibert A, Devreotes PA (1985). cAMP receptors controlling cell-cell interac-tions in the development of Dictyostelium. Cold Spring Harbor Symp Quant Biol 50: 787–799.
   PubMedGoogle Scholar
• Klein PS, Sun TJ, Saxe CL 3d, Kimmel AR, Johnson RL, Devreotes PN (1988). A chemoattractant recep-tor controls development in Dictyostelium discoideum. Science 241: 1467–1472.
   PubMed Web of Science ®Google Scholar
• Klein RS, Rubin JB, Gibson HD, DeHaan EN, Alvarez-Hernandez X, Segal RA, Luster AD (2001). SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. Devel-opment 128: 1971–1981.
   Google Scholar
• Koch AE, Kunkel SL, Harlow LA, Johnson B, Evanoff HL, Haines GK, Burdick MD, Pope RM, Strieter RM (1992a). Enhanced production of monocyte chemoat-tractant protein-1 in rheumatoid arthritis. J Clin Invest 90: 772–779.
   PubMed Web of Science ®Google Scholar
• Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM, Elner SG, Strieter RM (1992b). Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258: 1798–1801.
   PubMed Web of Science ®Google Scholar
• Kolodkin AL, Levengood DV, Rowe EG, Tai Y-T, Giger RJ, Ginty DD (1997). Neuropilin is a semaphorin III receptor. Cell 90: 753–762.
   Google Scholar
• Kondo T, Novick AC, Toma H, Fairchild RL (1996). In-duction of chemokine gene expression during allo-geneic skin graft rejection. Transplantation 61: 1750–1757.
   PubMedGoogle Scholar
• Kuang Y, Wu Y, Jiang H, Wu D (1996). Selective G protein coupling by C-C chemokine receptors. J Biol Chem 271: 3975–3978.
   Google Scholar
• Lassman H (1999). Lymphocyte trafficking in the central nervous system. In: From basic immunology to immune mediated demyelination. Martino G, Adorinin L (eds). Springer-Verlag: Milan, Italy.
   Google Scholar
• Lalani AS, Masters J, Zeng W, Barrett J, Pannu, Everett H, Arendt CW, MaFadden G (1999). Use of chemokine re-ceptors by poxviruses. Science 286: 1968–1971.
   Google Scholar
• Lauffenburger DA, Horwitz AF (1996). Cell migration: a physically integrated molecular process. Cell 84: 359–369.
   PubMed Web of Science ®Google Scholar
• Lawrence DA, Kim D (2000). Central/peripheral nervous system and immune responses. Toxicology 142: 189–201.
   PubMed Web of Science ®Google Scholar
• Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (1997). Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386: 833–838.
   Google Scholar
• Leung-Hagesteijn C, Spence AM, Stem BD, Zhou Y, Su MW, Hedgecock EM, Culotti JG (1992). UNC-5, a trans-membrane protein with immunoglobulin and throm-bospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell 71: 289–299.
   Google Scholar
• Li HS, Chen JH, Wu W, Fagaly T, Yuan WL, Zhou L, Dupuis S, Jiang Z, Nash W, Gick C, Omitz D, Wu JY, Rao Y (1999). Vertebrate Slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 96: 807–818.
   PubMedGoogle Scholar
• Locati M, Murphy PM (1999). Chemokines and chemokine receptors: biology and clinical relevance in inflamma-tion and AIDS. Annu Rev Med 50: 425–440.
   PubMed Web of Science ®Google Scholar
• Luster AD (1998). Chemokines-chemotactic cytokines that mediate inflammation. N Engl j Med 338: 436–445.
   PubMed Web of Science ®Google Scholar
• Luster AD (2001). Antichemokine immunotherapy for al-lergic diseases. Curr Opin Allergy Clin Immunol 1: 561–567.
   PubMedGoogle Scholar
• Luster AD (2002). The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol 14: 129–135.
   PubMed Web of Science ®Google Scholar
• Mackay CR (1996). Chemokine receptors and T cell chemo-taxis. J Exp Med 184: 799–802.
   PubMed Web of Science ®Google Scholar
• Mashikian MV, Ryan TC, Seman A, Brazer W, Center DM, Cruikshank WW (1999). Reciprocal desensitization of CCR5 and CD4 is mediated by IL-16 and macrophage-inflammatory protein-1 beta, respectively. J Immunol 163: 3123–3130.
   PubMed Web of Science ®Google Scholar
• McCluskey LP, Lampson LA. Local neurochemicals and site specific immune regulation in the CNS. J Neuro-pathol Exp Neurol 59: 177–187.
   Google Scholar
• McCutcheon M (1946). Chemotaxis in leukocytes. Physiol Rev 26: 319–336.
   PubMed Web of Science ®Google Scholar
• Melchers F, Rolink AG, Schaneil C (1999). The role of chemokines in regulating cell migration during humoral immune responses. Cell 99: 351–354.
   PubMed Web of Science ®Google Scholar
• Mellado M, Rodriguez-Frade JM, Vila-Coro AJ, de Ana AM, Martinez AC (1999). Chemokine control of HIV-1 infec-tion. Nature 400: 723–724.
   PubMed Web of Science ®Google Scholar
• Mennicken F, Maki R, de Souza EB, Quirion R (1999). Chemokines and chemokine receptors in the CNS: a pos-sible role in neuroinflammation and patterning. Trends Pharmacol Sci 20: 73–78.
   PubMed Web of Science ®Google Scholar
• Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, Miller RJ (1998). Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Natl Acad Sci USA 95: 14500–14505.
   PubMed Web of Science ®Google Scholar
• Meucci O, Fatatis A, Simen AA, Miller RJ (2000). Expres-sion of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Nati Acad Sci USA 97: 8075–8080.
   PubMed Web of Science ®Google Scholar
• Mitchison TJ, Cramer LP (1996). Actin-based cell motility and cell locomotion. Cell 84: 371–379.
   PubMed Web of Science ®Google Scholar
• Miyagishi R, Kikuchi S, Fukazawa T, Tashiro K (1995). Macrophage inflammatory protein-1a in the cere-brospinal fluid of patients with multiple sclerosis and other inflammatory neurological diseases. J Neurol Sci 129: 223–227.
   PubMed Web of Science ®Google Scholar
• Mohle R, Bautz F, Rafii S, Moore MA, Brugger W, Kanz L (1998). The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood 91: 4523–4530.
   Google Scholar
• Montell DJ (1999). The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development. Development 126: 3035–3046.
   PubMed Web of Science ®Google Scholar
• Moore BB, Arenberg DA, Addison CL, Keane MP, Strieter RM (1998). Tumor angiogenesis is regulated by CXC chemokines. J Lab Clin Med 132: 97–103.
   PubMedGoogle Scholar
• Mueller B (1999). Growth cone guidance: first steps towards a deeper understanding. Annu Rev Neurosci 22: 351–388.
   PubMed Web of Science ®Google Scholar
• Murphy PM (1994). The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol 12: 593–633.
   PubMed Web of Science ®Google Scholar
• Nelken NA, Coughlin SR, Gordon D, Wilcox JN (1991). Monocyte chemoattractant protein-1 in human athero-matous plaques. J Clin Invest 88: 1121–1127.
   PubMed Web of Science ®Google Scholar
• Nelson PJ, Krensky AM (1998). Chemokines, lymphocytes and viruses: what goes around, comes around. Curr Opin Immunol 10: 265–270.
   PubMed Web of Science ®Google Scholar
• Neptune ER, Bourne HR (1997). Receptors induce chemo-taxis by releasing the bg subunit of Gi, not by acti-vating Gq or Gs. Proc Nati Acad Sci USA 94: 14489–14494.
   PubMedGoogle Scholar
• Neptune ER, Iiri T, Bourne HR (1999). Gai is not required for chemotaxis mediated by Gi-coupled receptors. J Biol Chem 274: 2824–2828.
   PubMed Web of Science ®Google Scholar
• Nguyen Ba-Charvet KT, Brose K, Marillat V, Kidd T, Goodman CS, Tessier-Lavigne M, Sotelo C, Chétiotal A (1999). Slit2-mediated chemorepulsion and collapse of developing forebrain axons. Neuron 22: 463–473.
   Google Scholar
• Nieto M, Frade JM, Sancho D, Mellado M, Martinez AC, Sanchez-Madrid F (1997). Polarization of chemokine re-ceptors to the leading edge during lymphocyte chemo-taxis. J Exp Med 186: 153–158.
   PubMedGoogle Scholar
• Nusslein-Volhard C, Wieschaus E, Kluding H (1984). Mu-tations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux's Arch Dev Biol 193: 267–282.
   PubMedGoogle Scholar
• Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, Moser B (1996). The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382: 833–835.
   PubMed Web of Science ®Google Scholar
• Parent CA, Devreotes PN (1996). Molecular genetics of sig-nal transduction in Dictyostelium. Annu Rev Biochem 65: 411–440.
   PubMed Web of Science ®Google Scholar
• Parent CA, Devreotes PN (1999). A cell's sense of direction. Science 284: 765–770.
   PubMed Web of Science ®Google Scholar
• Pattison J, Nelson PJ, Huie P, von Leuttichar I, Farshid G, Sibley RK, Krensky AM (1994). RANTES chemokine ex-pression in cell-mediated transplant rejection of the kid-ney. Lancet 343: 209–211.
   PubMed Web of Science ®Google Scholar
• Pearlman AL, Faust PL, Hatten ME, Brunstrom JE (1998). New directions for neuronal migration. Curr Opin Neu-robiol 8: 45–54.
   Google Scholar
• Piischel AW (1999). Divergent properties of mouse netrins. Mech Dev 83: 65–75.
   Google Scholar
• Rakic P (1971a). Neuron-glia relationship during granule cell migration in developing cerebellar cortex. J Comp Neurol 141: 283–312.
   PubMed Web of Science ®Google Scholar
• Rakic P (1971b). Guidance of neurons migrating to the fetal monkey neocortex. Brain Res 33: 471–476.
   PubMed Web of Science ®Google Scholar
• Rakic P (1972). Mode of cell migration to the superficial layers of fetal monkey neocortex. J Comp Neurol 145: 61–84.
   PubMed Web of Science ®Google Scholar
• Rakic P (1988). Specification of cerebral cortical areas. Sci-ence 241: 170–176.
   PubMed Web of Science ®Google Scholar
• Rakic P (1990). Principles of neural cell migration. Experi-entia 46: 882–891.
   PubMedGoogle Scholar
• Rakic P (1995). Radial versus tangential migration of neu-ronal clones in the developing cerebral cortex. Proc Nati Acad Sci USA 92: 11323–11327.
   PubMed Web of Science ®Google Scholar
• Ramsey WS (1972). Analysis of individual leukocyte be-havior during chemotaxis. Exp Cell Res 70: 129–139.
   Google Scholar
• Ransohoff RM, Hamilton TA, Tani M, Stoler MH, Shick HE, Major JA, Estes ML, Thomas DM, Tuohy VK (1993). Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune en-cephalomyelitis. FASEB 17: 592–600.
   Google Scholar
• Raper JA, Tessier-Lavigne M (1999). Growth cones and axon pathfinding. In: Fundamentals of neuroscience. Zigmond M, et al (eds). Academic Press: New York, pp 519–546.
   Google Scholar
• Rice DS, Sheldon M, D'Arcangelo G, Nakajima K, Goldowitz D, Curran T (1998). Disabled-1 acts down-stream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Develop-ment 125: 3719–3729.
   PubMedGoogle Scholar
• Rio C, Rieff HI, Qi P, Corfas G (1997). Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron 19: 39–50.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Frade JM, Vila-Coro AJ, Martin A, Nieto M, Sanchez-Madrid F, Proudfoot AE, Wells TN, Martinez AC, Mellado M (1999). Similarities and differences in RANTES- and (A0P)-RANTES-triggered signals: impli-cations for chemotaxis. J Cell Biol 144: 755–765.
   PubMed Web of Science ®Google Scholar
• Rollins BJ (1997). Chemokines. Blood 90: 909–928.
   PubMed Web of Science ®Google Scholar
• Rothberg JM, Hartley DA, Walther Z, Artavanis-Tsakonas S (1988). Slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system. Cell 55: 1047–1059.
   Google Scholar
• Rothberg JM, Jacob JR, Goodman CS, Artavanis-Tsakonas S (1990). Slit: an extracellular protein necessary for the de-velopment of midline glia and commissural axon path-ways contains both EGF and LRR domains. Genes Dev 4: 2169–2187.
   PubMed Web of Science ®Google Scholar
• Sanchez-Madrid F, Angel del Pozo M (1999). Leukocyte polarization in cell migration and immune interactions. EMBO J18: 501–511.
   Google Scholar
• Schmidtrnayerova H, Sherry B, Bukrinsky M (1996). Chemokines and HIV replication. Nature 382: 767.
   Google Scholar
• Segerer S, Nelson PJ, Schlondorff D (2000). Chemokines, chemokine receptors, and renal disease: from basic sci-ence to pathophysiologic and therapeutic studies. J Am Soc Nephrol 11: 152–176.
   Google Scholar
• Servant G, Weiner OD, Neptune ER, Sedat JW, Bourne HR (1999). Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10: 1163–1178.
   Google Scholar
• Sharpe RJ, Byers HR, Scott CF, Bauer SI, Maione TE (1990). Growth inhibition of murine melanoma and hu-man colon carcinoma by recombinant human platelet factor 4. J Natl Cancer Inst 82: 848–853.
   PubMedGoogle Scholar
• Simmons G, Clapham PR, Picard L, Offord RE, Rosenkilde MM, Schwartz TW, Buser R, Wells TNC, Proudfoot AE (1997). Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antag-onist. Science 276: 276–279.
   PubMed Web of Science ®Google Scholar
• Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, Schooley K, Goodwin, RG (1997). Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors. Virology 236: 316–327.
   PubMedGoogle Scholar
• Smith DR, Polverini PJ, Kunkel SL, Orringer MB, Whyte RI, Burdick MD, Wilke CA, Strieter RM (1994). Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. J Exp Med 179: 1409–1415.
   PubMed Web of Science ®Google Scholar
• Springer TA (1994). Traffic signals for lymphocyte re-circulation and leukocyte emigration: the multistep paradigm. Cell 76: 301–314.
   PubMed Web of Science ®Google Scholar
• Streblow DN, Soderberg-Naucler C, Vieira J, Smith P, Wakabayashi E, Ruchti F, Mattison K, Altschuler Y, Nelson JA (1999). The human cytomegalovirus chemokine receptor U528 mediates vascular smooth muscle cell migration. Cell 99: 511–520.
   PubMed Web of Science ®Google Scholar
• Strieter RM, Polverini PJ, Arenberg DA, Walz A, Opdenakker G, Van Damme J, Kunkel SL (1995). Role of C-X-C chemokines as regulators of angiogenesis in lung cancer. JLeukoc Biol 57: 752–762.
   PubMed Web of Science ®Google Scholar
• Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, Kishimoto T, Nagasawa T (1998). The chemokine receptor CXCR4 is essential for vascular-ization of the gastrointestinal tract. Nature 393: 591–594.
   PubMed Web of Science ®Google Scholar
• Takahashi T, Fournier A, Nakamura F, Wang L-H, Murakami Y, Kalb RG, Fujisawa H, Strittrnatter SM (1999). Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 99: 59–69.
   PubMed Web of Science ®Google Scholar
• Tamagnone L, Artigiani S, Chen H, He Z, Ming G-1, Song H-J, Chedotal A, Winberg ML, Goodman CS, Poo M-M, Tessier-Lavigne M, Comoglio PM (1999). Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 99: 71–80.
   PubMed Web of Science ®Google Scholar
• Tessier-Lavigne M, Goodman CS (1996). The molecular bi-ology of axon guidance. Science 274: 1123–1133.
   PubMed Web of Science ®Google Scholar
• Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, NimpfJ, Hammer RE, Richardson JA, Herz J (1999). Reeler/Disabled-like disruption of neuronal mi-gration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97: 689–701.
   PubMed Web of Science ®Google Scholar
• Walsh C, Cepko C (1988). Clonally related cortical cells show several migration patterns. Science 241: 1342–1345.
   PubMedGoogle Scholar
• Walsh C, Cepko C (1990). Widespread dispersion of neu-ronal clones across functional regions of the cerebral cortex. Science 255: 434–440.
   Google Scholar
• Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M (1999a). Netrin-3, a mouse homolog of hu-man NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. J Neurosci 19: 4938–4947.
   Google Scholar
• Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, Henzel W, Tessier-Lavigne M (1999b). Purification of an axon elongation- and branch-promoting activity from brain identifies a mammalian Slit protein as a positive regula-tor of sensory axon growth. Cell 96: 771–784.
   Google Scholar
• Wang JM, Oppenheim JJ (1999). Interference with the sig-naling capacity of CC chemokine receptor 5 can com-promise its role as an HIV-1 entry coreceptor in primary T lymphocytes. J Exp Med 190: 591–595.
   Google Scholar
• Ward SG, Bacon K, Westwick J (1998). Chemokines and T lymphocytes: more than an attraction. Immunity 9: 1–11.
   PubMed Web of Science ®Google Scholar
• Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS (1998). Plexin A is a neuronal semaphorin receptor that con-trols axon guidance. Cell 95: 903–916.
   PubMed Web of Science ®Google Scholar
• Wong K, Ren X-R, Huang Y-Z, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong W-C, Rao Y (2001). Signal transduction in neuronal migra-tion: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 107: 209–221.
   PubMed Web of Science ®Google Scholar
• Wong K, Wu JY, Rao Y (2002a). Neuronal migration. In En-cyclopedia of life sciences. New York: Nature Publishing Group. In press.
   Google Scholar
• Wong K, Park H-T, Wu JY, Rao Y (2002b). Slit proteins: guid-ance cues for cells ranging from neurons to leukocytes. Curr Op Genet Dev 12: 583–591.
   PubMed Web of Science ®Google Scholar
• Wu JY, Feng L, Park HT, Havlioglu N, Wen L, Tang H, Bacon K, Jiang Z, Zhang X, Rao Y (2001). The neuronal re-pellent slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 410: 948–952.
   PubMed Web of Science ®Google Scholar
• Wu W, Wong K, Chen JH, Jiang ZH, Dupuis S, Wu JY, Rao Y (1999). Directional guidance of neuronal migration in the olfactory system by the secreted protein Slit. Nature 400: 331–336.
   PubMed Web of Science ®Google Scholar
• Xia MQ, Hyman BT (1999). Chemokines/chemokine recep-tors in the central nervous system and Alzheimer's dis-ease. J NeuroVirol 5: 32–41.
   PubMed Web of Science ®Google Scholar
• Yla-Herttuala S, Lipton BA, Rosenfeld ME, Sarkioja T, Yoshimura T, Leonard EJ, Witztum JL, Steinberg D (1991). Expression of monocyte chemoattractant pro-tein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc Natl Acad Sci USA 88: 5252–5256.
   PubMed Web of Science ®Google Scholar
• Yuan W, Zhou L, Chen J, Wu JY, Rao Y, Omitz D (1999). The mouse Slit family: secreted ligands for Robo ex-pressed in patterns that suggest a role in morphogenesis and axon guidance. Dev Biol 212: 290–306.
   Google Scholar
• Zallen JA, Yi BA, Bargmann CI (1998). The conserved im-munoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans. Cell 92: 217–227.
   Google Scholar
• Zhu Y, Li HS, Zhou L, Wu JY, Rao Y (1999). Cellular and molecular guidance of GABAergic neuronal migration from the striatum to the neocortex. Neuron 23: 473–485.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Yu T, Zhang X, Nagasawa T, Wu JY, Rao Y (2002). Role of the Chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nature Neurosci 5: 719–720.
   PubMedGoogle Scholar
• Zigmond SH (1974). Mechanisms of sensing chemical gra-dients by polymorphonuclear leukocytes. Nature 249: 450–452.
   Google Scholar
• Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR (1998). Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393: 595–599.
   PubMed Web of Science ®Google Scholar