The Plasma Cysteine/Sulphate Ratio: A Possible Clinical Biomarker

References

• Houston JB, Levy G. Modification of drug biotransformation by vitamin C in man Nature 1975; 255: 78–9.
   Google Scholar
• Houston JB, Levy G. Drug biotransformation interactions in man VI: acetaminophen and ascorbic acid J Pharm Sci 1976; 65: 1218–21.
   Google Scholar
• Jakoby WB, Sekura RD, Lyon ES, Marcus CJ, Wang J-L. Sulfotransferases In: Jakoby WB (ed.).Enzymic Basis of Detoxication, Vol. II. New York: Academic Press, 1980.
   Google Scholar
• Littlewood J, Glover V, Sandler M. Platelet phenolsulphotransferase deficiency in dietary migraine Lancet 1982; 983–6.
   Google Scholar
• Tyce GM, Messick JM, Yaksh TL, Byer DE, Danielson DR, Rorie DK. Amine sulfate formation in the central nervous system Fed Proc 1986; 45: 2247–53.
   Google Scholar
• Murch SH, MacDonald TT, Walker-Smith JA, Levin M, Lionetti P, Klein NJ. Disruption of sulphated glycosaminoglycans in intestinal inflammation Lancet 1993; 341: 711–14.
   Google Scholar
• Waring RH, Klovrza LV. Sulphur metabolism in autism J Nutr Environ Med 2000; 10: 25–32.
   Google Scholar
• Whiteley P, Shattock P. Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention Expert Opin Ther Targets 2002; 6(2): 175–83.
   PubMedGoogle Scholar
• Harris RM, Waring RH. Dietary modulation of human platelet phenolsulphotransferase activity Xenobiotica 1996; 26: 1241–7.
   Google Scholar
• Gibb C, Glover V, Sandler M. Inhibition of phenolsulphotransferase P by certain food constituents Lancet 1986; 794.
   Google Scholar
• Mitchell SC, Waring RH, Haley CS, Idle JR, Smith RL. Genetic aspects of the polymodally distributed sulphoxidation of S-carboxymethyl-L-cysteine in man Br J Clin Pharmacol 1984; 18: 507–21.
   Google Scholar
• Waring RH, Mitchell SC, Shah RR, Idle JR, Smith RL. Polymorphic sulphoxidation of S-carboxymethyl-L-cysteine in man Biochem Pharmacol 1982; 31: 3151–4.
   PubMed Web of Science ®Google Scholar
• Scadding GK, Ayesh R, Brostoff J, Mitchell SC, Waring RH, Smith RL. Poor sulphoxidation ability in patients with food sensitivity Br Med J 1988; 297: 105–7.
   Google Scholar
• Heafield MT, Fearn S, Steventon GB, Waring RH, Williams AC, Sturman SG. Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson’s and Alzheimer’s disease Neurosci Lett 1990; 110: 216–20.
   Google Scholar
• Waring RH, Steventon GB, Sturman SG, Heafield MTE, Smith MCG, Williams AC. S-methylation in motorneuron disease and Parkinson’s disease Lancet 1989; 356–7.
   Google Scholar
• Alam Z, Coombes N, Waring RH, Williams AC, Steventon GB. Platelet sulphotransferase activity, plasma sulphate levels and sulphation capacity in patients with migraine and tension headache Cephalalgia 1997; 17(7): 761–4.
   Google Scholar
• Alberti A, Pirrone P, Elia M, Waring RH, Romano C. Sulphation deficit in ‘‘low-functioning’’ autistic children: a pilot study Biol Psychiatr 1999; 46: 420–4.
   Google Scholar
• Vantrappen G, Geboes K. Glycosaminoglycans and the gut Lancet 1993; 341: 730–1.
   PubMedGoogle Scholar
• McFadden SA. Phenotypic variation in xenobiotic metabolism and adverse environmental response: focus on sulfur-dependent detoxification pathways Toxicology 1996; 111: 43–65.
   Google Scholar
• Steventon GB, Heafield MTE, Waring RH, Williams AC, Sturman S, Green M. Metabolism of low-dose paracetamol in patients with chronic neurological disease Xenobiotica 1990; 20: 117–22.
   Google Scholar
• Pall HS, Williams AC, Waring R, Elias E. Motorneurone disease as manifestation of pesticide toxicity Lancet 1987; 685.
   Google Scholar
• Droge W, Breitkreutz R. Glutathione and immune function Proc Nutr Soc 2000; 59: 595–600.
   PubMed Web of Science ®Google Scholar
• Jariwalla RJ. Micro-nutrient imbalance in HIV infection and AIDS: relevance to pathogenesis and therapy J Nutr Environ Med 1995; 5: 297–306.
   Google Scholar
• Harakeh S, Jariwalla RJ. Comparative study of the anti-HIV activities of ascorbate and thiol- containing reducing agents in chronically HIV-infected cells Am J Clin Nutr 1991; 54: 1231S–5S.
   Google Scholar
• Kalebic T, Kinter A, Poli G, Anderson ME, Meister A, Fauci AS. Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine Proc Natl Acad Sci 1991; 88: 986–90.
   Google Scholar
• Breitkreutz R, Pittack N, Nebe CT et al. Improvement of immune functions in HIV infection by sulphur supplementation: two randomized trials J Mol Med 2000; 78: 55–62.
   Google Scholar
• Micke P, Beeh KM, Sclaak JF, Buhl R. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients Eur J Clin Invest 2001; 31(2): 171–8.
   Google Scholar
• Micke P, Beeh KM, Buhl R. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients Eur J Nutr 2002; 41: 12–18.
   Google Scholar
• Scozzafava A, Casini A, Supuran CT. Targeting cysteine residues of biomolecules: new approaches for the design of antiviral and anticancer drugs Curr Med Chem 2002; 9: 1167–85.
   Google Scholar
• Sokolov Y, Mirzabekov T, Martin DW, Lehrer RI, Kagan BL. Membrane channel formation by antimicrobial protegrins Biochim Biophys Acta 1999; 1420: 23–9.
   PubMed Web of Science ®Google Scholar
• Sprietsma JE. Cysteine, glutathione (GSH) and zinc and copper ions together are effective, natural, intracellular inhibitors of (AIDS) viruses Med Hypotheses 1999; 52(6): 529–38.
   Google Scholar
• Blaylock RL. Excitotoxins: The Taste that Kills. Santa Fe, New Mexico: Health Press, 1994.
   Google Scholar
• Parsons RB, Waring RH, Ramsden DB, Williams AC. In vitro effect of the cysteine metabolites homocysteic acid, homocysteine and cysteic acid upon human neuronal cell lines Neurotoxicology 1998; 19(4–5): 599–603.
   Google Scholar
• Csoma Z, Kharitonov SA, Balint B, Bush A, Wilson NM, Barnes PJ. Increased leukotrienes in exhaled breath condensate in childhood asthma Am J Respir Crit Care Med 2002; 166(10): 1345–9.
   Google Scholar
• Obshima N, Nagase H, Koshino T et al. A functional study on CysLT(1) receptors in human eosinophils Int Arch Allergy Immunol 2002; 129(1): 67–75.
   Google Scholar
• Arango P, Borish L, Frierson HF Jr, Kountakis SE. Cysteinyl leukotrienes in chronic hyperplastic rhinosinusitis Otolaryngol Head Neck Surg 2002; 127(6): 512–15.
   Google Scholar
• Fauler J, Thon A, Tsikas D, von der Hardt H, Frohlich JC. Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis Arthritis Rheum 1994; 37(1): 93–7.
   Google Scholar
• Pilkington AE, Waring RH. The determination of inorganic sulphate levels in biological fluids using HPLC techniques Med Sci Res 1988; 16: 35–6.
   Google Scholar
• Qusti S, Parsons RB, Abouglila KDH, Waring RH, Williams AC, Ramsden DB. Development of an in vitro model for cysteine dioxygenase expression in the brain Cell Biol Toxicol 2000; 16: 243–55.
   Google Scholar
• Wilkinson LJ, Waring RH. Cysteine dioxygenase: modulation of expression in human cell lines by cytokines and control of sulphate production Toxicol In Vitro 2002; 16(4): 481–3.
   Google Scholar
• Ovsyannikova IG, Reid KC, Jacobson RM, Oberg AL, Klee GG, Poland GA. Cytokine production patterns and antibody response to measles vaccine Vaccine 2003; 21(25–26): 3946–53.
   Google Scholar
• Linder MC. Nutrition and metabolism of fats In: Linder MC (ed.) Nutritional Biochemistry and Metabolism with Clinical Applications, 2nd edn. East Norwalk, Connecticut: Prentice-Hall International, 1991: 51–85.
   Google Scholar
• Chandrasekar B, Fernandes G. Decreased pro-inflammatory cytokines and increased antioxidant enzyme gene expression by omega-3 lipids in murine lupus nephritis Biochem Biophys Res Commun 1994; 200: 893–8.
   Google Scholar
• Fritsche KL, Anderson M, Feng C. Consumption of eicosapentaenoic acid and docosahexaenoic acid impair murine interleukin-12 and interferon-gamma J Infect Dis 2000; 182 (Suppl. 1): S54–61.
   Google Scholar
• Mantzioris E, Cleland LG, Gibson RA, Neumann MA, Demasi M, James MJ. Biochemical effects of a diet containing foods enriched with n-3 fatty acids Am J Clin Nutr 2000; 72(1): 42–8.
   Google Scholar
• Das UN. Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how? Prostaglandins Leukot Essent Fatty Acids 2000; 63(6): 351–62.
   PubMed Web of Science ®Google Scholar
• Kremer JM, Bigauoette J, Michalek AV et al. Effects of manipulation of dietary fatty acids on clinical manifestations of rheumatoid arthritis Lancet 1985: 184–7.
   Google Scholar
• Van der Tempel H, Tulleken JE, Limburg PC, Muskiet FAJ, Van Rijswijk MH. Effects of fish oil supplementation in rheumatoid arthritis Ann Rheum Dis 1990; 49: 76–80.
   PubMed Web of Science ®Google Scholar
• Moss M. Purines, alcohol and boron in the diets of people with chronic digestive problems J Nutr Environ Med 2001; 11: 23–32.
   Google Scholar
• Pinto J, Huang YP, McConnell RJ, Rivlin RS. Increased urinary riboflavin excretion resulting from boric acid ingestion J Lab Clin Med 1978; 92(1): 126–34.
   Google Scholar
• Pinto JT, Rivlin RS. Drugs that promote renal excretion of riboflavin Drug–Nutr Interact 1987; 5: 143–51.
   PubMedGoogle Scholar
• Pfeiffer CC. Mental and Elemental Nutrients New Canaan, Connecticut: Keats Publishing, 1975.
   Google Scholar
• Ryan ET, Calderwood SB. Cholera vaccines Clin Infect Dis 2000; 31(2): 561–5.
   Google Scholar
• Adachi JA, D’Alessio FR, Ericsson CD. Reactive arthritis associated with typhoid vaccination in travelers: report of two cases with negative HLA-B27 J Travel Med 2000; 7(1): 35–6.
   Google Scholar
• Makani S, Gollapudi S, Yel L, Chiplunkar S, Gupta S. Biochemical and molecular basis of thimerosol-induced apoptosis in T cells: a major role of mitochondrial pathway Genes Immun 2002; 3(5): 270–8.
   Google Scholar
• Hertog MGL, Hollman PCH, Katan MJ. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands J Agric Food Chem 1992; 40: 2379–83.
   Google Scholar
• Hertog MGL, Hollman PCH, Van de Putte B. Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices J Agric Food Chem 1993; 41: 1242–6.
   Web of Science ®Google Scholar
• Montedoro G, Servili M, Baldioli M, Miniati E. Simple and hydrolyzable phenolic compounds in virgin olive oil. 2. Initial characterization of the hydrolyzable fraction J Agric Food Chem 1992; 40: 1577–80.
   Web of Science ®Google Scholar
• Strong FM. Pressor amines in foods In: Toxicants Occurring Naturally in Foods. Food Protection Committee, Food and Nutrition Board, National Academy of Sciences, National Research Council. Publication 1354. Washington DC, 1966.
   Google Scholar
• Joneja JV. Dietary Management of Food Allergies and Intolerances. A Comprehensive Guide. Vancouver: JA Hall Publications, 1998.
   Google Scholar