Multiple Sclerosis, Sporadic Creutzfeldt–Jakob Disease and Bovine Spongiform Encephalopathy: Are they Autoimmune Diseases Evoked by Acinetobacter Microbes Showing Molecular Mimicry to Brain Antigens?

References

• Gibofsky A, Zabriskie JB. Rheumatic fever. In: Isenberg D, Maddison PJ, Woo P, Glass D, Breedveld FC (eds). Oxford Textbook of Rheumatology. Oxford: Oxford University Press, 2004, 669277.
   Google Scholar
• Wilson C, Ebringer A, Ahmadi K et al. Shared amino acid sequences between major histocompatibility complex class II glycoproteins, type XI collagen and Proteus mirabilis in rheumatoid arthritis. Ann Rheum Dis 1995; 54: 216–20.
   Google Scholar
• Ebringer A, Rashid T, Wilson C. Rheumatoid arthritis: proposal for the use of anti-microbial therapy in early cases. Scand J Rheumatol 2003; 32: 2–11.
   PubMed Web of Science ®Google Scholar
• Ebringer A, Rahsid T, Wilson C, Ptaszynska T, Fielder M. Ankylosing spondylitis, HLA-B27 and Klebsiella—an overview: proposal for early diagnosis and treatment. Curr Rheumatol Rev (in press).
   Google Scholar
• Schwimmbeck PL, Yu DTY, Oldstone MBA. Autoantibodies to HLA-B27 in the sera of HLA-B27 patients with ankylosing spondylitis and Reiter’s syndrome: molecular mimicry with Klebsiella pneumoniae as potential mechanism of autoimmune disease. J Exp Med 1987; 166: 173–81.
   PubMed Web of Science ®Google Scholar
• Fielder M, Pirt SJ, Tarpey I et al. Molecular mimicry and ankylosing spondylitis: possible role of a novel sequence in pullulanase of Klebsiella pneumoniae. FEBS 1995; 369: 243–8.
   Google Scholar
• Prusiner SB. Biology and genetics of prion diseases. Ann Rev Microbiol 1994; 48: 655–86.
   PubMed Web of Science ®Google Scholar
• Patterson PY. Experimental allergic encephalomyelitis and autoimmune disease. Adv Immunol 1966; 5: 131–208.
   PubMedGoogle Scholar
• Eylar EH, Caccam J, Jackson JJ et al. Experimental allergic encephalomyelitis: synthesis of disease- inducing site of the basic protein. Science 1970; 168: 1220–3.
   PubMedGoogle Scholar
• Ebringer A, Pirt SJ, Wilson C et al. Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens? Environ Health Perspect 1997; 105: 1172–4.
   Google Scholar
• Ebringer A, Hughes L, Rashid T, Wilson C. Acinetobacter immune responses in multiple sclerosis: etiopathogenetic role and its possible use as a diagnostic marker. Arch Neurol 2005; 62: 33–6.
   PubMedGoogle Scholar
• Tiwana H, Wilson C, Pirt J et al. Autoantibodies to brain components and antibodies to Acinetobacter calcoaceticus are present in bovine spongiform encephalopathy. Infect Immun 1999; 67: 6591–5.
   Google Scholar
• Wilson C, Hughes LE, Rashid T et al. Antibodies to Acinetobacter bacteria and bovine brain peptides, measured in bovine spongiform encephalopathy (BSE) in an attempt to develop an ante- mortem test. J Clin Lab Immunol 2003; 52: 23–40.
   Google Scholar
• Hughes LE, Bonell S, Natt RS et al. Antibody responses to Acinetobacter spp. and Pseudomonas aeruginosa in multiple sclerosis: prospects for diagnosis using the myelin-Acinetobacter- neurofilament antibody index. Clin Diagn Lab Immunol 2001; 8: 1181–8.
   Google Scholar
• Hughes L, Smith PA, Bonell S et al. Cross-reactivity between related sequences found in Acinetobacter sp., Pseudomonas aeruginosa, myelin basic protein and myelin oligodendrocyte glycoprotein in multiple sclerosis. J Neuroimmunol 2003; 144: 105–15.
   Google Scholar
• Allerberger F, Berger T, Reindl M et al. Anti-Acinetobacter and anti-neuronal antibodies in Austrian patients with multiple sclerosis and other neurological diseases. Ann Neurol (submitted).
   Google Scholar
• Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. Arthritis Rheum 1984; 27: 361–7.
   PubMed Web of Science ®Google Scholar
• Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315–24.
   PubMed Web of Science ®Google Scholar
• Poser CM, Paty DW, Scheinberg L et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13: 227–31.
   Google Scholar
• Khalafpour S, Ebringer A, Abuljadayel I et al. Antibodies to Klebsiella and Proteus micro- organisms in ankylosing spondylitis and rheumatoid arthritis patients measured by ELISA. Br J Rheumatol 1988; 27(Suppl.II): 86–9.
   Google Scholar
• Hafler DA. Multiple sclerosis. J Clin Invest 2004; 113: 788–94.
   PubMed Web of Science ®Google Scholar
• Landtblom AM, Riise T, Boiko A et al. Distribution of multiple sclerosis in Sweden based on mortality and disability compensation statistics. Neuroepidemiology 2002; 21: 167–79.
   Google Scholar
• Warren S, Warren KG, Svenson LW et al. Geographic and temporal distribution of mortality rates for multiple sclerosis in Canada, 1965–1994. Neuroepidemiology 2003; 22: 75–81.
   PubMedGoogle Scholar
• Cousens SN, Linsell L, Smith PG et al. Geographical distribution of variant CJD in the UK (excluding Northern Ireland). Lancet 1999; 353: 18–21.
   PubMedGoogle Scholar
• Rothwell PM, Charlton D. High incidence and prevalence of multiple sclerosis in south east Scotland: evidence of a genetic predisposition. J Neurol Neurosurg Psychiatr 1998; 64: 730–5.
   PubMed Web of Science ®Google Scholar
• Gilden DH. Viruses and multiple sclerosis. JAMA 2001; 286: 3127–9.
   PubMedGoogle Scholar
• Kulkarni AP, Kellaway LA, Lahiri DK et al. Neuroprotection from complement-mediated inflammatory damage. Ann NY Acad Sci 2004; 1035: 147–64.
   PubMed Web of Science ®Google Scholar
• Kovacs GG, Gasque P, Strobel T et al. Complement activation in human prion disease. Neurobiol Dis 2004; 15: 21–8.
   Google Scholar
• Ebringer A, Rashid T, Wilson C, Boden R, Thompson E. A possible link between multiple sclerosis and Creutzfeldt–Jakob disease based on clinical, genetic, pathological and immunological evidence involving Acinetobacter bacteria. Med Hypoth 2005; 64: 487–94.
   PubMedGoogle Scholar
• Gay D, Dick G, Upton G. Multiple sclerosis associated with sinusitis: case-controlled study in general practice. Lancet 1986; 1: 815–19.
   PubMed Web of Science ®Google Scholar
• Jones RL, Crowe P, Chavda SV et al. The incidence of sinusitis in patients with multiple sclerosis. Rhinology 1997; 35: 118–9.
   PubMedGoogle Scholar
• Casiano RR, Cohn S, Villasuso E et al. Comparison of antral tap with endoscopically directed nasal culture. Laryngoscope 2001; 111: 1333–7.
   Google Scholar
• Kirvan CA, Swedo SE, Heuser JS et al. Mimicry and autoantibody-mediated neuronal cell signalling in Sydenham chorea. Nat Med 2003; 9: 914–20.
   PubMed Web of Science ®Google Scholar
• Wilson C, Rashid T, Tiwana H et al. Cytotoxicity responses to peptide antigens in rheumatoid arthritis and ankylosing spondylitis. J Rheumatol 2003; 30: 972–8.
   Google Scholar