Iron loading in humans: A risk factor for enhanced morbidity and mortality

References

• McCord J. Effects of positive iron status at a cellular level. Nutr Rev 1996; 54: 85–8
   PubMed Web of Science ®Google Scholar
• Weinberg E. D. Microbial pathogens with impaired ability to acquire host iron. BioMetals 2000; 13: 85–9
   PubMed Web of Science ®Google Scholar
• Weinberg E. D. Iron withholding as a defense strategy. Anemia of chronic disease, G Weiss, V. R Gordeuk, C Hershko. Taylor & Francis, Boca Raton 2005; 255–80
   Google Scholar
• Raisz L. G. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 2005; 115: 3318–25
   PubMed Web of Science ®Google Scholar
• Weinberg E. D. Iron loading: a risk factor for osteoporosis. BioMetals 2006; 19: 633–5
   PubMed Web of Science ®Google Scholar
• Obejero‐Paz C., Yang T., Dong W. Q., Levy M. N., Brittenham G. M., Kuryshev Y. A., Brown A. M. Deferoxamine promotes survival and prevents electrocardiographic abnormalities in the gerbil model of iron‐overload cardiomyopathy. J Lab Clin Med 2003; 141: 121–30
   PubMed Web of Science ®Google Scholar
• Roth C., Pekrun A., Bartz M., Jarry H., Eber S., Lakomek M., et al. Short stature and failure of pubertal development in thalassemia major: evidence for hypothalamic neurosecretory dysfunction of growth hormone secretion and defective pituitary gonadotropin secretion. Eur J Pediatr 1997; 156: 777–83
   PubMed Web of Science ®Google Scholar
• Hakobyan N., Kazarian T., Jabbar A. A., Valentino L. A. Pathobiology of haemophilic synovitis I: overexpression of mdm 2 oncogene. Blood 2004; 104: 2060–64
   PubMed Web of Science ®Google Scholar
• Berkovitch M., Bistritzer T., Milone S. D., Perlman K., Kucharaczyk W., Olivieri N. F. Iron deposition in the anterior pituitary in homozygous beta‐thalassemia: MRI evaluation and correlation with gonadal function. J Pediatr Endocrinol Metab 2000; 13: 179–84
   PubMed Web of Science ®Google Scholar
• Weinberg E. D. The development of awareness of the carcinogenic hazard of inhaled iron. Oncol Res 1999; 11: 109–13
   PubMed Web of Science ®Google Scholar
• Zhang Q. I., Huang X. I. Induction of ferritin and lipid peroxidation by coal samples with different prevalence of coal workers' pneumoconiosis: the role of iron in the coals. Am J Industr Med 2002; 42: 171–9
   PubMed Web of Science ®Google Scholar
• Malecki E. A., Connor J. R. The case for iron chelation and/or antioxidant therapy in Alzheimer's disease. Drug Devel Res 2002; 56: 526–30
   Web of Science ®Google Scholar
• Weinberg E. D. Patho‐ecological implications of microbial acquisition of host iron. Rev Med Microbiol 1998; 9: 171–8
   Web of Science ®Google Scholar
• Dubois S., Kowdley K. V. Review article: targeted screening for hereditary haemochromatosis in high‐risk groups. Alimen Pharmacol Ther 2004; 20: 1–14
   PubMed Web of Science ®Google Scholar
• Weinberg E. D. The role of iron in protozoan and fungal infectious diseases. J Eukaryot Microbiol 1999; 46: 231–7
   PubMedGoogle Scholar
• Ghio A. J., Ford E. S., Kennedy T. P., Hoidal J. R. The association between serum ferritin and uric acid in humans. Free Radic Res 2005; 39: 337–42
   PubMed Web of Science ®Google Scholar
• Moyo V. M., Makunike R., Gangaidzo I. T., Gordeuk V. R., McLaren C. E., Khumalo H., Saungweme T., Rouault T., Kiire C. F. African iron overload and hepatocellular carcinoma. Eur J Haematol 1998; 60: 28–34
   PubMed Web of Science ®Google Scholar
• Hulet S. W., Powers S., Connor J. R. Distribution of transferrin and ferritin binding in normal and multiple sclerotic brains. J Neurol Sci 1999; 165: 48–55
   PubMed Web of Science ®Google Scholar
• Schumacher H. R., Straka P. C., Krikker M. A., Dudley A. T. The arthropathy of hemochromatosis. Ann NY Acad Sci 1988; 526: 224–33
   PubMed Web of Science ®Google Scholar
• Forge A., Schacht J. Aminoglycoside antibiotics. Audiol Neurootol 2000; 5: 3–22
   PubMed Web of Science ®Google Scholar
• Gregory A., Hayflick S. J. Neurodegeneration with brain iron accumulation. Folia Neuropathol 2005; 43: 286–96
   PubMed Web of Science ®Google Scholar
• DiBisceglie A. M., Bonkovsky H., Chopra S., Flamm S., Reddy R. K., Grace N., Killenberg P., Hunt C., Tamburro C., Tavill A. S., et al. Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: a multicentre, prospective, randomized, controlled trial. Hepatology 2000; 32: 135–8
   PubMed Web of Science ®Google Scholar
• Fargion S., Mattioli M., Fracanzani A. L., Sampietro M., Tavazzi D., Fociana P., Taioli E., Valenti L., Fiorelli G. Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis. Am J Gastroenterol 2001; 96: 2448–55
   PubMed Web of Science ®Google Scholar
• Hahn P., Milam A. H., Dunaief J. L. Maculas affected by age‐related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane. Arch Ophthalmol 2003; 121: 1099–105
   PubMedGoogle Scholar
• Richardson D. R. Friedreich's ataxia: iron chelators that target the mitochondrion as a therapeutic strategy?. Expert Opin Invest Drugs 2003; 12: 235–45
   PubMed Web of Science ®Google Scholar
• Reid D. W., Lam Q. T., Schneider H., Walters E. H. Airway iron and iron‐regulatory cytokines in cystic fibrosis. Eur Respir J 2004; 24: 286–91
   PubMed Web of Science ®Google Scholar
• Thompson K. J., Shoham S., Connor J. R. Iron and neurodegenerative disorders. Brain Res Bull 2001; 55: 155–64
   PubMed Web of Science ®Google Scholar
• Wang X‐S., Lee S., Simmons Z., Boyer P., Scott K., Liu W., Connor J. R. Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences. J Neurol Sci 2004; 227: 27–33
   PubMed Web of Science ®Google Scholar
• deValk B., Marx J. J. M. Iron, atherosclerosis, and ischemic heart disease. Arch Intern Med 1999; 159: 1542–8
   PubMedGoogle Scholar
• Nelson R. L. Iron and colorectal cancer risk. Nutr Rev 2001; 59: 140–8
   PubMed Web of Science ®Google Scholar
• Farrar G., Altmann P., Welch S., Wyschrij O., Ghoso B., Lejeune J., Corbett J., Prasher V., Blair J. A. Defective gallium‐transferrin binding in Alzheimer disease and Down syndrome: possible mechanism for accumulation of aluminum in brain. Lancet 1990; 335: 747–50
   PubMed Web of Science ®Google Scholar
• Ikeda M. Iron overload without the C282Y mutation in patients with epilepsy. J Neurol Neurosurg Psychiatr 2001; 70: 551–3
   PubMed Web of Science ®Google Scholar
• Piperno A., Trombini P., Gelosa M., Mauri V., Pecci V., Vergani A., Salvioni A., Mariani R., Mancia G. Increased serum ferritin is common in men with essential hypertension. J Hypertens 2002; 20: 1513–8
   PubMed Web of Science ®Google Scholar
• Rayman M. P., Barlis J., Evans R. W., Redman C. W. G., King L. J. Abnormal iron parameters in the pregnancy syndrome preeclampsia. Am J Obstet Gynecol 2002; 187: 412–8
   PubMed Web of Science ®Google Scholar
• Bonkovsky H. L., Barnard G. V. The porphyrias. Curr Treat Option Gastroenterol 2000; 3: 487–500
   PubMedGoogle Scholar
• Weinberg E. D. Iron, infection and sudden infant death. Med Hypoth 2001; 56: 731–4
   PubMed Web of Science ®Google Scholar
• Whitington P. F., Hibbard J. U. High‐dose immunoglobulin during pregnancy for recurrent neonatal haemochromatosis. Lancet 2004; 364: 1690–8
   PubMed Web of Science ®Google Scholar
• Bathum L., Christiansen L., Nybo H., Ranberg K. A., Gaist D., Jeune B., Peterson E., Vaupel J., Christensen K. Association of mutations in the hemochromatosis gene with shorter life expectancy. Arch Intern Med 2001; 161: 2441–4
   PubMedGoogle Scholar
• Weinberg E. D. Do some carriers of hemochromatosis gene mutations have higher than normal rates of disease and death?. BioMetals 2002; 15: 347–50
   PubMed Web of Science ®Google Scholar
• Mainous A. G III., Gill J. M., Carek P. J. Elevated serum transferrin saturation and mortality. Ann Fam Med 2004; 2: 133–8
   PubMed Web of Science ®Google Scholar
• Beutler E., Felitti V. J., Koziol J. A., Ho N. J., Gelbart T. Penetrance of 845 G‐A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet 2002; 359: 211–8
   PubMed Web of Science ®Google Scholar
• Wells B. J., Mainous A. G III., King D. A., Gill J. M., Carek P. J., Geesey M. E. The combined effect of transferrin saturation and low density lipoprotein on mortality. Fam Med 2004; 36: 324–9
   PubMed Web of Science ®Google Scholar
• Araujo J. A., Romano E. L. F., Brito B. E., Parthe V., Romano M., Bracho M., Montano B. F., Cardier J. Iron overload augments the development of atherosclerotic lesions in rabbits. Arterioscler Thromb Vasc Biol 1995; 15: 1172–80
   PubMed Web of Science ®Google Scholar
• Miller M., Hutchins G. M. Hemochromatosis, multiorgan hemosiderosis, and coronary artery disease. J Am Med Assoc 1994; 272: 231–3
   Web of Science ®Google Scholar
• Sullivan J. L., Weinberg E. D. Iron and the role of Chlamydia pneumoniae in heart disease. Emerging Infect Dis 1999; 5: 724–6
   PubMed Web of Science ®Google Scholar
• Keller J. N., Hanni K. B., Markesbery W. R. Oxidized low‐density lipoprotein induces neuronal death: implications for calcium, reactive oxygen species, and capsases. J Neurochem 1999; 72: 2601–9
   PubMed Web of Science ®Google Scholar
• Mainous A. G III., Eschenbach S. L., Wells B. J., Everett C. J., Gill J. M. Cholesterol, transferrin saturation, and the development of dementia and Alzheimer's disease: results from an 18‐year population‐based cohort. Fam Med 2005; 37: 36–42
   PubMed Web of Science ®Google Scholar
• Luce D., Bugel I., Goldberg P., Goldberg M., Salomon C., Billon‐Galland M‐A., Nicolau J., Quenel P., Fevotte J., Brochard P. Environmental exposure to tremolite and respiratory cancer in New Caledonia: a case‐control study. Am J Epidemiol 2000; 151: 259–65
   PubMed Web of Science ®Google Scholar
• Mandel S., Youdim M. B. H. Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free Rad Biol Med 2004; 37: 304–17
   PubMed Web of Science ®Google Scholar
• Fleming D. J., Tucker K. L., Jacques P. F., Dallal G. E., Wilson P. W. F., Wood R. J. Dietary factors associated with the risk of high iron stores in the elderly Framingham heart study cohort. Am J Clin Nutr 2002; 76: 1375–84
   PubMed Web of Science ®Google Scholar
• Meyers D. G., Jensen K. C., Menitove J. E. A historical cohort study of the effect of lowering body iron through blood donation on incident cardiac events. Transfusion 2002; 42: 1135–9
   PubMed Web of Science ®Google Scholar
• Kontoghiorghes G. J. New chelation therapies and emerging chelating drugs for the treatment of iron overload. Expert Opin Emerging Drugs 2006; 11: 1–5
   PubMedGoogle Scholar
• Von Bonsdorff L., Sahlstedt L., Ebeleing F., Ruutu T., Parkkinen J. Apotransferrin administration prevents growth of Staphyloccocus epidermis in serum of stem cell transplant patients by binding free iron. FEMS Immunol Med Microbiol 2003; 37: 45–51
   PubMedGoogle Scholar
• Sullivan J. L. Iron, plasma antioxidants, and the ‘oxygen radical disease of prematurity’. Am J Dis Child 1988; 142: 1341–4
   PubMedGoogle Scholar
• Weinberg E. D. Therapeutic potential of iron chelators in diseases associated with iron mismanagement. J Pharm Pharmacol 2006; 58: 575–84
   PubMed Web of Science ®Google Scholar