Progesterone: the forgotten hormone in men?

References

• Thornton JW, Need E, Crews D. Resurrecting the ancestral steroid receptor: ancient origin of estrogen signalling. Science 2003;301:1714–7
   PubMed Web of Science ®Google Scholar
• Thornton JW. Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. PNAS 2001;98:5671–6
   PubMed Web of Science ®Google Scholar
• Mc Lachlan JA. Environmental signalling: what embryos and evolution teach us about endocrine disrupting chemicals. Endocr Rev 2001;22:319–41
   PubMed Web of Science ®Google Scholar
• Kravitz HM, Haywood TW, Kelly J, Liles S, Cavanaugh JL. Medroxyprogesterone and paraphiles: do testosterone levels matter? Bull Am Acad Psychiatry Law 1996;24:73–83
   PubMedGoogle Scholar
• Zumpe D, Clancy AN, Michael RP. Progester- one decreases mating and estradiol uptake in preoptic areas of male monkeys. Physiol Behav 2001;74:603–12
   PubMed Web of Science ®Google Scholar
• El-Hefnawy T, Huhtaniemi IT. Progesterone and testicular function. Aging Male 1999;2:240–5
   Google Scholar
• Shackleton C, Malunowicz E. Apparent preg- nene hydroxylation deficiency (APDH): seeking the parentage of an orphan metabolome. Steroids 2003;68:707–17
   PubMed Web of Science ®Google Scholar
• Nadjafi-Triebsch C, Huell M, Burki D, Rohr UD. Progesterone increase under DHEA-sub- stitution in males. Maturitas 2003;45:231–5
   PubMed Web of Science ®Google Scholar
• Naville D, Keeney DS, Jenkin G, Murry BA, Head JR, Mason JI. Regulation of expression of male-specific rat liver microsomal 3 beta-hydro- xysteroid dehydrogenase. Mol Endocrinol 1991;5:1090–100
   PubMedGoogle Scholar
• Liang JH, Sankai T, Yoshida T, Cho F, Yoshikawa Y. Localization of testosterone and 3beta-hydroxysteroid dehydrogenase/delta5-del- ta4-isomerase in cynomolgus monkey (Macaca fascicularis) testes. J Med Primatol 1998;27:10–4
   PubMed Web of Science ®Google Scholar
• Pelletier G, Li S, Luu-The V, Tremblay Y, Belanger A, Labrie F. Immunoelectron micro- scopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydro- xysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads. J Endocrinol 2001;171:373–83
   PubMed Web of Science ®Google Scholar
• Burtis CA, Ashwood RE, eds. Tietz Textbook of Clinical Chemistry. Philadelphia: WB Saunders Co, 1999
   Google Scholar
• Zumoff B, Miller L, Levin J, et al. Follicular- phase serum progesterone levels of nonsmoking women do not differ from the levels of nonsmoking men. Steroids 1990;55:557–9
   PubMed Web of Science ®Google Scholar
• Muneyyirci-Delale O, Dalloul M, Nacharaju VL, Altura BM, Altura BT. Serum ionized magnesium and calcium and sex hormones in healthy young men: importance of serum progesterone level. Fertil Steril 1999;72:817–22
   PubMed Web of Science ®Google Scholar
• Gro¨schl M, Rauh M, Do¨ rr H-J. Circadian rhythm of salivary cortisol, 17a-hydroxy proges- terone, and progesterone in healthy children. Clin Chem 2003;49:1688–91
   PubMed Web of Science ®Google Scholar
• Genazzani AR, Petraglia F, Bernardi F, et al. Circulating levels of allopregnanolone in hu- mans: gender, age, and endocrine influences. J Clin Endocrinol Metab 1998;83:2099–103
   PubMed Web of Science ®Google Scholar
• Be´langer A, Candas B, Dupont A, et al. Changes in serum concentrations of conjugated and unconjugated steroids in 40–80-year-old men. J Clin Endocrinol Metab 1994;79:1086–90
   PubMed Web of Science ®Google Scholar
• Winkelmann BR, Ma¨rz W, Boehm BO, et al. on behalf of the LURIC study group. Rationale and design of the LURIC study – a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. Pharmacogenomics 2001;2(Suppl 1):S1–73
   Google Scholar
• Martin RM, Lin CJ, Costa EMF, et al. P450c17 deficiency in Brazilian patients: biochemical diagnosis through progesterone levels confirmed by CYP17 genotyping. J Clin Endocrinol Metab 2003;88:5739–6
   PubMed Web of Science ®Google Scholar
• McGowan EM, Weinberger RP, Graham JD, et al. Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels. J Molec Endocrinol 2003;31:241–53
   PubMed Web of Science ®Google Scholar
• McGowan EM, Saad S, Bendall LJ, Bradstock KF, Clarke CL. Effect of progesterone receptor A predominance on breast cancer cell migration into bone marrow fibroblasts. Breast Canc Res Treatm 2004;83:211–20
   PubMed Web of Science ®Google Scholar
• Arnett-Mansfield RL, deFazo A, Wain GV, et al. Relative expression of progesterone receptors A and B in endometrioid cancers of the endome- trium. Cancer Res 2001;61:4576–82
   PubMed Web of Science ®Google Scholar
• Conneely OM, Jericevic BM. Progesterone regulation of reproductive function through functionally distinct progesterone receptor iso- forms. Rev Endocr Metab Disorders 2002;3:201–9
   PubMedGoogle Scholar
• Takimoto GS, Tung L, Abdel-Hafiz H, et al. Functional properties of the N-terminal region of progesterone receptors and their mechanistic relationship to structure. J Steroid Biochem Molec Biol 2003;85:209–19
   PubMed Web of Science ®Google Scholar
• Conneely OM, Mulac-Jericevic B, Lydon JP. Progesterone-dependent regulation of female reproductive activity by two distinct progester- one receptor isoforms. Steroids 2003;68:771–8
   PubMed Web of Science ®Google Scholar
• Haseroth K, Christ M, Falkenstein E, Wehling M. Aldosterone- and progesterone-membrane- binding proteins: new concepts of nongenomic steroid action. Curr Protein Peptide Sci 2000;1:385–401
   PubMed Web of Science ®Google Scholar
• Falkenstein E, Heck M, Gerdes D, et al. Specific progesterone binding to a membrane protein and related nongenomic effects on Ca2+ -fluxes in sperm. Endocrinology 1999;140:5999–6002
   PubMed Web of Science ®Google Scholar
• Falkenstein E, Tillmann H-C, Christ M, Feuring M, Wehling M. Multiple actions of steroid hormones – a focus on rapid, nongenomic effects. Pharmacol Rev 2000;52:513–55
   PubMed Web of Science ®Google Scholar
• Samadi A, Carlson CG, Gueorguiev A, Cen- edella RJ. Rapid, non-genomic actions of progesterone and estradiol on steady-state cal- cium and resting calcium influx in lens epithelial cells. Pfu¨gers Arch-Eur J Physiol 2002;444:700–9
   PubMed Web of Science ®Google Scholar
• Zhu Y, Rice CD, Pang Y, Pace M, Thomas P. Cloning expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. PNAS 2003;100:2231–6
   PubMed Web of Science ®Google Scholar
• Zhu Y, Bond J, Thomas P. Identification, classification, and partial characterization of genes in humans and other vertebrates homo- logous to a fish membrane progestin receptor. PNAS 2003;100:2237–42
   PubMed Web of Science ®Google Scholar
• De Vivo I, Hankinson SE, Colditz GA, Hunter DJ. A functional polymorphism in the proges- terone receptor gene is associated with an increase in breast cancer risk. Cancer Res 2003;63:5236–8
   PubMed Web of Science ®Google Scholar
• Beagley KW, Gockel CM. Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone. FEMS Immunol Med Microbiol 2003;38:13–22
   PubMed Web of Science ®Google Scholar
• Suzuki T, Murry BA, Darnel AD, Sasano H. Progesterone metabolism in human leukemic monoblast U937 cells. Endocr J 2002;49:539–46
   PubMed Web of Science ®Google Scholar
• Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J. Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. PNAS 2003;100:868–73
   PubMed Web of Science ®Google Scholar
• Hubler TR, Denny WB, Valentine DL, Cheung-Flynn J, Smith DF, Scammell JG. The FK506-binding immunophilin FKBP51 is tran- scriptionally regulated by progestin and attenuates progestin responsiveness. Endocrinology 2003;2380–7
   Google Scholar
• Pedersen SB, Kristensen K, Richelsen B. Anti- glucocorticoid effects of progesterone in vivo on rat adipose tissue metabolism. Steroids 2003;68:543–50
   PubMed Web of Science ®Google Scholar
• Honer C, Nam K, Fink C, et al. Glucocorticoid receptor antagonism by cyproterone acetate and RU 486. Molec Pharmacol 2003;63:1012–20
   PubMed Web of Science ®Google Scholar
• Allolio B, Oremus M, Reincke M, et al. High- dose progesterone infusion in healthy males: evidence against antiglucocorticoid activity of progesterone. Eur J Endocrinol 1995;133:696–700
   PubMed Web of Science ®Google Scholar
• Ishibashi H, Suzuki T, Suzuki S, et al. Sex steroid hormone recptors in human thymoma. J Clin Endocrinol Metab 2003;88:2309–17
   PubMed Web of Science ®Google Scholar
• Baldi E, Luconi M, Bonaccorsi L, Forti G. Signal transduction pathways in human spermatozoa. J Reprod Immunol 2002;53:121–31
   PubMed Web of Science ®Google Scholar
• Kirkman-Brown JC, Punt EL, Barratt CL, Publicover SJ. Zona pellucida and progester- one-induced Ca2+ signaling and acrosome reaction in human spermatozoa. J Androl 2002; 23:306–15
   PubMedGoogle Scholar
• The´rien I, Manjunath P. Effect of progesterone on bovine sperm capacitation and acrosome reaction. Biol Reprod 2003;69:1408–15
   PubMed Web of Science ®Google Scholar
• Foresta C, Rossato M, Mioni R, Zorzi M. Progesterone induces capacitation in human spermatozoa. Andrologia 1992;24:33–5
   PubMed Web of Science ®Google Scholar
• Uhler ML, Leung A, Chan SY, Wang C. Direct effects of progesterone and antiprogesterone in human sperm hyperactivated motility and acro- some reaction. Fertil Steril 1992;58:1191–8
   PubMed Web of Science ®Google Scholar
• Emiliozi C, Cordonier H, Guerin JF, Ciapa B, Benchaib M, Fenichel P. Effects of progesterone on human spermatozoa prepared for in-vitro fertilization. Int J Androl 1996;19:39–47
   PubMedGoogle Scholar
• Osman RA, Andria ML, Jones AD, Meizel S. Steroid induced exocytosis: the human sperm acrosome reaction. Biochem Biophys Res Commun 1989;160:828–33
   PubMed Web of Science ®Google Scholar
• Meizel S, Turner KO. Progesterone acts at the plasma membrane of human sperm. Mol Cell Endocrinol 1991;77:R1–5
   PubMed Web of Science ®Google Scholar
• Lindahl PE. Effects of some steroid hormones on head-to-head association in bovine spermatozoa. Exp Cell Res 1978;111:73–81
   PubMed Web of Science ®Google Scholar
• Thomas P, Meizel S. Phosphatidylinositol-4,5- bisphosphate hydrolysis in human sperm stimu- lated with follicular fluid or progesterone is dependent upon Ca2 + influx. Biochem J 1989; 264:539–46
   PubMed Web of Science ®Google Scholar
• Blackmore PF, Beebe SJ, Danforth DR, Alex- ander N. Progesterone and 17alpha-hydroxy- progesterone. Novel stimulators of calcium influx in human sperm. J Biol Chem 1990;265:1376–80
   PubMed Web of Science ®Google Scholar
• Gonza´lez-Martine´z MT, Bonilla-Herna´ndez M, Guzma´n-Grenfell AM. Stimulation of voltage- dependent calcium channels during capacitation and by progesterone in human sperm. Arch Biochem Biophys 2002;408:205 – 10
   Google Scholar
• Harper CV, Kirkman-Brown JC, Barrrat CLR, Publicover SJ. Encoding of progesterone stimu- lus intensity by intracellular [Ca2+] ([Ca2 +]i) in human spermatozoa. Biochem J 2003;372:407–17
   PubMed Web of Science ®Google Scholar
• Blackmore PF, Neulen J, Lattanzio F, Beebe SJ. Cell surface-binding sites for progesterone mediated calcium uptake in human sperm. J Biol Chem 1991;266:18655–9
   PubMed Web of Science ®Google Scholar
• Luconi M, Bonaccorsi L, Maggi M, et al. Identification and characterization of functional nongenomic progesterone receptors on human sperm membrane. J Clin Endocrinol Metab 1998; 83:877 – 85
   Web of Science ®Google Scholar
• Pietrobon EO, De Los A` ngeles Monclus, Alberdi AJ, Forne´s MW. Progesterone receptor availability in mouse spermatozoa during epidi- dymal transit and capacitation: Ligand blot detection of progesterone-binding protein. J Androl 2003;24:612–20
   PubMedGoogle Scholar
• Francavilla F, Romano R, Pandolfi C, et al. Evaluation of the effect of 17aOH-progesterone and 17ß-oestradiol on human sperm ability to fuse with oocytes: comparison and possible interference with the effect of progesterone. Int J Androl 2003;26:342–7
   PubMedGoogle Scholar
• Bahamondes L, Nascimento JAA, Munuce MJ, Fazano F, Fau´ ndes A. The in vitro effect of levonorgestrel on the acrosome reaction of human spermatozoa from fertile men. Contra- ception 2003;68:55–9
   PubMed Web of Science ®Google Scholar
• Martinez G, Zayas H, Ducolomb Y, Garcia GA, Betancourt M, Castro I. Effect of norethisterone and its A-ring reduced metabolites on the acrosome reaction in porcine spermatozoa. Andrologia 2002;34:296–300
   PubMed Web of Science ®Google Scholar
• Falsetti C, Baldi E, Krausz C, Casano R, Failli P, Forti G. Decreased responsiveness to progester- one of spermatozoa in oligozoospermic patients. J Androl 1993;14:17–22
   PubMedGoogle Scholar
• Oehninger S, Blackmore P, Morshedi M, Sueldo C, Acosta AA, Alexander NJ. Defective calcium influx and acrosome reaction (spontaneous and progesterone-induced) in spermatozoa of infer- tile men with severe teratozoospermia. Fertil Steril 1994;61:349–54
   PubMed Web of Science ®Google Scholar
• Tesarik J, Mendoza C. Defective function of a nongenomic progesterone receptor as a sole sperm anomaly in infertile patients. Fertil Steril 1992;56:793–7
   Google Scholar
• Brady BM, Anderson RA, Kinniburgh D, Baird DT. Demonstration of progesterone receptor- mediated gonadotrophin suppression in the hu- man male. Clin Endocrinol 2003;58:506–12
   PubMed Web of Science ®Google Scholar
• Anderson RA, Baird DT. Male contraception. Endocr Rev 2002;23:735–62
   PubMed Web of Science ®Google Scholar
• Wang C, Swerdloff RS. Male contraception. Best Practice & Res Clin Obstet Gynaecol 2002;16:193–203
   PubMed Web of Science ®Google Scholar
• Meriggiola MC, Constantino A, Cerpolini S, et al. Testosterone undecanoate maintains sperma- togenic suppression induced by cyproterone acetate plus testosterone undecanoate in normal men. J Clin Endocrinol Metab 2003;88:5818–26
   PubMed Web of Science ®Google Scholar
• Nieschlag E, Zitzmann M, Kamischke A. Use of progestins in male contraception. Steroids 2003; 68:965–72
   PubMed Web of Science ®Google Scholar
• Kamischke A, Nieschlag E. Progress towards hormonal male contraception. TRENDS Phar- macol Sci 2004;25:49–57
   PubMed Web of Science ®Google Scholar
• McLachlan RI, Robertson DM, Pruysers E, et al. Relationship between serum gonadotropins and spermatogenic suppression in men undergoing steroidal contraceptive treatment. J Clin Endocri- nol Metab 2004;89:142–9
   PubMed Web of Science ®Google Scholar
• Zirkin B, Chen H. Regulation of Leydig cell steroidogenic function during aging. Biol Reprod 2000;63:977–81
   PubMed Web of Science ®Google Scholar
• Luo L, Chen H, Zirkin BR. Leydig cell aging: steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme. J Androl 2001;22:149–56
   PubMedGoogle Scholar
• Chen H, Irizarry RA, Luo L, Zirkin BR. Leydig cell gene expression: effects of age and caloric restriction. Exp Gerontol 2004;39:31–43
   PubMed Web of Science ®Google Scholar
• Paust HJ, Wessels J, Ivell R, Mukhopadhyay AK. The expression of the RLF/INSL3 gene is reduced in Leydig cells of the aging rat testis. Exp Gerontol 2002;37:1461–7
   PubMed Web of Science ®Google Scholar
• Gruenewald DA, Hess DL, Wilkinson CW, Matsumoto AM. Excessive testicular progester- one secretion in aged male Fischer 344 rats: a potential cause of age-related gonadotropin suppression and confounding variable in aging studies. J Gerontol Biol Sci 1992;47:B164–70
   Google Scholar
• El-Hefnawy T, Huhtaniemi I. Progesterone can participate in down-regulation of the luteinizing hormone receptor gene expression and function in cultured murine Leydig cells. Mol Cell Endocrinol 1998;137:127–38
   PubMed Web of Science ®Google Scholar
• El-Hefnawy T, Manna PR, Luconi M, Baldi E, Slotte JP, Huhtaniemi I. Progesterone action in a murine Leydig tumor cell line (mLTC-1), possibly through a nonclassical receptor type. Endocrinology 2000;141:247–55
   PubMed Web of Science ®Google Scholar
• Schwarzenbach H, Manna PR, Stocco DM, Chakrabarti G, Mukhopadhyay AK. Stimulatory effect of progesterone on the expression of steroidogenic acute regulatory protein in MA10 Leydig cells. Biol Reprod 2003;68:1054–63
   PubMed Web of Science ®Google Scholar
• Schwarzenbach H, Chakrabarti G, Paust HJ, Mukhopadhyay AK. Gonadotropin-mediated regulation of the murine VEGF expression in MA-10 Leydig cells. J Androl 2004;25:128–39
   PubMedGoogle Scholar
• Rossato M, Nogara A, Merico M, Ferlin A, Foresta C. Identification of functional binding sites for progesterone in rat Leydig cell mem- brane. Steroids 1999;64:168–75
   PubMed Web of Science ®Google Scholar
• Oettel M. The endocrine pharmacology of testosterone therapy in men. Naturwissenschaften 2004;91:6676
   Google Scholar
• Pirke KM, Sintermann R, Vogt HJ. Testoster- one and testosterone precursors in the spermatic vein and in the testicular tissue of old men. Reduced oxygen supply may explain the relative increase of testicular progesterone and 17 alpha- hydroxyprogesterone content and production in old age. Gerontology 1980;26:221–30
   PubMed Web of Science ®Google Scholar
• Saez JM. Leydig cells: endocrine, paracrine, and autocrine regulation. Endocr Rev 1994;15:574– 626
   Google Scholar
• Bonkhoff H, Fixemer T, Hunsicker I, Rember- ger K. Estrogen receptor expression in prostate cancer and premalignant prostatic lesions. Am J Pathol 1999;155:641–7
   PubMed Web of Science ®Google Scholar
• Ha¨rko¨nen P, To¨ rn S, Kurkela R, et al. Sex hormone metabolism in prostate cancer cells during transition to an androgen-independent state. J Clin Endocrinol Metab 2003;88:705–12
   PubMed Web of Science ®Google Scholar
• Bonkhoff H, Fixemer T, Hunsicker I, Rember- ger K. Progesterone receptor expression in human prostate cancer: correlation with tumor progression. Prostate 2001;48:285–91
   PubMed Web of Science ®Google Scholar
• Kumar VL, Wadhwa SN, Kumar V, Farooq A. Androgen, estrogen, and progesterone receptor contents and serum hormone profiles in patients with benign hypertrophy and carcinoma of the prostate. J Surg Oncol 1990;44:122–8
   PubMed Web of Science ®Google Scholar
• Mobbs BG, Johnson IE, Liu Y. Quantitation of cytosolic and nuclear estrogen and progesterone receptor in benign, untreated, and treated malignant human prostatic tissue by radioligand binding and enzyme-immunoassays. Prostate 1990;16:235–44
   PubMed Web of Science ®Google Scholar
• Brolin J, Skoog L, Ekman P. Immunohisto- chemistry and biochemistry in detection of androgen, progesterone, and estrogen receptors in benign and malignant human prostatic tissue. Prostate 1992;20:281–95
   PubMed Web of Science ®Google Scholar
• Hiramatsu M, Maehara I, Orikasa S, Sasano H. Immunolocalization of oestrogen and progester- one receptors in prostatic hyperplasia and carcinoma. Histopathology 1996;28:163–8
   PubMed Web of Science ®Google Scholar
• Ito Y, Kurosawa I, Yamanaka H, Koya A, Imai K, Kasaku N, Shida K. The mechanism of antiandrogenic action of chlormadinone acetate (CMA). Hinyouka Kiyo 1977;68:537–52
   Google Scholar
• Takezawa Y, Fukori N, Yamanaka H, Mieda M, Honma S, Kushitani M, Hamataki N. Effect of the new steroidal antiandrogen TZP-4238 on hormone-induced canine prostatic hyperplasia. Prostate 1992;21:315–29
   PubMed Web of Science ®Google Scholar
• Takezawa Y, Ito K, Suzuki K, Fukabori N, Yamanaka H, Mieda M, Kamataki N, Kushitani M. Effect of a new steroidal antiandrogen, TZP- 4238, on spontaneously developed canine benign prostatic hyperplasia. Prostate 1995;27:321–8
   PubMed Web of Science ®Google Scholar
• Harada M, Kinoshita Y, Moriyama M, Kondo I, Nakahashi M, Kumagai H, Sasaki K, Hosaka M. Histological evaluation of benign prostatic hy- perplasia treated by long-term administration of chlormadinone acetate (CMA). Prostate 1994;25:147–55
   PubMed Web of Science ®Google Scholar
• Suzuki T, Ito K, Kurosawa K, Yamanaka H. Expression and degradation of rat androgen receptor following castration. Analysis by Wes- tern blot and immunohistochemistry. Tohoku J Exp Med 1997;183:159–66
   PubMed Web of Science ®Google Scholar
• Murakoshi M, Ikeda R, Tagawa M, Fukui N. Immunohistochemical studies of the effect of chlormadinone acetate on prostatic hyperplasia. Acta Histochem Cytochem 2002;35:353–9
   Web of Science ®Google Scholar
• Tassinari D, Fochessati F, Panzini I, Poggi B, Sartori S, Ravaiali A. Rapid progression of advanced ‘‘hormone resistant’’ prostate cancer during palliative treatment with progestins for cancer cachexia. J Pain Symptom Management 2003;25:481–4
   PubMed Web of Science ®Google Scholar
• Eid MA, Lewis RW, Kumar MV. Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor a-related apoptosis-inducing ligand (TRAIL). Mol Canc Ther 2002;1:831–40
   PubMed Web of Science ®Google Scholar
• Song L-N, Coghland M, Gelman EP. Antian- drogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor. Molec Endocrinol 2004;18:70–85
   PubMedGoogle Scholar
• Inoue T, Akahira JI, Suzuki T, Darnel AD, Kaneko C, Takahashi K, Hatori M, Shirane R, Kumabe T, Kurokowa Y, Satomi S, Sasano H. Progesterone production and actions in the human central nervous system and neurogenic tumors. J Clin Endocrinol Metab 2002;87:5325–31
   PubMed Web of Science ®Google Scholar
• Inoue T, Sasano H. Possible effects of progester- one on human central nervous system and neurogenic tumors. J Endocrinol Invest 2004;27:76–9
   PubMed Web of Science ®Google Scholar
• Konstantinidou AE, Korkolopoulo P, Mahera H, et al. Hormone receptors in non-malignant meningiomas correlate with apoptosis, cell proliferation and recurrence-free survival. Histo- pathology 2003;43:280–90
   Google Scholar
• Gruber T, Dare AO, Balos LL, Lele S, Fenster- maker RA. Multiple meningiomas arising during long-term therapy with the progesterone agonist megestrol acetate. J Neurosurg 2004;100:328–31
   PubMed Web of Science ®Google Scholar
• McLaughlin ME, Jacks T. Progesterone receptor expression in neurofibromas. Cancer Res 2003; 63:752–5
   PubMed Web of Science ®Google Scholar
• Oduwole OO, Ma¨kinen JM, Isomaa VV, Karttunen TJ, Vihko PT. Sex steroid metabolism in human gastric mucosa: 17ß-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues. Anticancer Res 2003;23:3889–98
   PubMed Web of Science ®Google Scholar
• Pfaffl MW, Lange IG, Meyer HHD. The gastrointestinal tract as target of steroid hormone action: quantification of steroid receptor mRNA expression (AR,ERa, ERß and PR) in 10 bovine gastrointestinal tract compartments by kinetic RT-PCR. J Steroid Biochem Molec Biol 2003;84:159–66
   PubMed Web of Science ®Google Scholar
• Wu CW, Chi CW, Hsieh MC, et al. Serum progesterone in patients with gastric adenocarci- noma before and after gastrectomy. Cancer 1998; 83:445–8
   PubMed Web of Science ®Google Scholar
• Baulieu EE. Neurosteroids: a new function in the brain. Biol Cell 1991;71:3–10
   PubMed Web of Science ®Google Scholar
• Tsutsui K, Sakamoto H, Ukena K. Biosynthesis and action of neurosteroids in the cerebellar Purkinje neuron. J Steroid Biochem Mol Biol 2003; 85:311–21
   PubMed Web of Science ®Google Scholar
• Baulieu E-E. ‘‘New’’ active steroids and an unforeseen mechanism of action. CR Acad Sci Paris, Sciences de la vie 2000;323:513–8
   PubMed Web of Science ®Google Scholar
• Baulieu E-E, Schumacher M. Progesterone as a neurosteroid, with special reference to the effect of progesterone on myelination. Hum Reprod 2000;15(Suppl 1):1–13
   Google Scholar
• Matsui D, Sakari M, Sato T, et al. Transcrip- tional regulation of the mouse steroid 5a- reductase type II gene by progesterone in brain. Nucl Acids Res 2002;30:1387–93
   PubMed Web of Science ®Google Scholar
• Sinchak K, Mills RH, Tao L, LaPolt P, Lu JKH, Micevych P. Estrogen induces de novo proges- terone synthesis in astrocytes. Dev Neurosci 2003; 25:343–8
   PubMed Web of Science ®Google Scholar
• Giachino C, Galbiati M, Fasolo A, Peretto P, Melcangi RC. Effects of progesterone deriva- tives, dihydroprogesterone and tetrahydropro- gesterone, on the subependymal layer of the adult rat. J Neurobiol 2004;58:493–502
   PubMedGoogle Scholar
• Genazzani AR, Stomati M, Morittu A, et al. Progesterone, progestagens and the central nervous system. Hum Reprod 2000;15(Suppl 1): 14–27
   Google Scholar
• Blaustein JD. Minireview: Neuronal steroid hormone receptors: They’re not just for hormones anymore. Endocrinology 2004;145:1075–81
   PubMed Web of Science ®Google Scholar
• Melcangi RC, Magnaghi V, Galbiati M, Martini L. Formation and effects of neuroactive steroids in the central and peripheral nervous system. Int Rev Neurobiol 2001;46:145–76
   PubMed Web of Science ®Google Scholar
• Sullivan SD, Moenter SM. Neurosteroids alter g-aminobutyric acid postsynaptic currents in gonadotropin-releasing hormone neurons: a possible mechanism for direct steroidal control. Endocrinology 2003;144:4366–75
   PubMed Web of Science ®Google Scholar
• Flood JF, Morley JE, Roberts E. Memory- enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci USA 1992;89:1567–71
   PubMed Web of Science ®Google Scholar
• Meyer DA, Carta M, Partridge LD, Covey DF, Valenzuela CF. Neurosteroids enhance sponta- neous glutamate release in hippocampal neurons. J Biol Chem 2002;277:28725–32
   PubMed Web of Science ®Google Scholar
• Barton D, Loprinzi C, Quella S, Sloan J, Pruthi S, Novotny P. Depomedroxyprogesterone acet- ate for hot flashes. J Pain Symptom Management 2002;24:603–7
   PubMed Web of Science ®Google Scholar
• Reyna-Neyra A, Camacho-Arroyo I, Ferrera P, Arias C. Estradiol and progesterone modify microtubule associated protein 2 content in the rast hippocampus. Brain Res Bull 2002;58:607–12
   PubMed Web of Science ®Google Scholar
• Cervantes M, Gonza´lez-Vidal MD, Ruelas R, Escobar A, Moral´ı G. Neuroprotective effects of progesterone on damage elicited by acute global cerebral ischemia in neurons of the caudate nucleus. Arch Med Res 2002;33:6–14
   PubMed Web of Science ®Google Scholar
• Shear DA, Galani R, Hoffman SW, Stein DG. Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury. Exp Neurol 2002;178:59–67
   PubMed Web of Science ®Google Scholar
• Pajovic SB, Saicic ZS, Spasic, MB, Petrovic VM. The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats. Physiol Res 2003;52:189–94
   PubMed Web of Science ®Google Scholar
• Goss CW, Hoffman SW, Stein DG. Behavioral effects and anatomic correlates after brain injury: a progesterone dose–response study. Pharmacol Biochem Behav 2003;76:231–42
   PubMed Web of Science ®Google Scholar
• Djebali M, Hoffman SW, Stein DG. Allopreg- nanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex. Neuroscience 2004;123:349–59
   PubMed Web of Science ®Google Scholar
• Deniselle MCG, Costa JJL, Gonzalez SL, et al. Basis of progesterone protection in spinal cord neurodegeneration. J Steroid Biochem Mol Biol 2003;83:199–209
   Web of Science ®Google Scholar
• Belelli D, Herd MB. The contraceptive agent Provera enhances GABAA receptor-mediated inhibitory neurotransmission in the rat hippo- campus: evidence for endogenous neurosteroids? J Neurosci 2003;23:10013–20
   PubMed Web of Science ®Google Scholar
• Garcia-Segura LM, McCarthy MM. Mini-re- view: Role of glia in neuroendocrine function. Endocrinology 2004;145:1082–6
   PubMed Web of Science ®Google Scholar
• Melcangi RC, Azcoitia I, Ballabio M, et al. Neuroactive steroids influence peripheral myeli- nation: a promising opportunity for preventing or treating age-dependent dysfunctions of per- ipheral nerves. Prog Neurobiol 2003;71:57–66
   PubMed Web of Science ®Google Scholar
• Azcoitia I, Leonelli E, Magnaghi V, Veiga S, Gracia-Segura LM, Melcangi RC. Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats. Beurobiol Aging 2003;24:853–60
   PubMed Web of Science ®Google Scholar
• Martini L, Magnaghi V, Melcangi RC. Actions of progesterone and its 5a-reduced metabolites on the major proteins of the myelin of the peripheral nervous system. Steroids 2003;68:825–9
   PubMed Web of Science ®Google Scholar
• Melcangi RC, Ballabio M, Cavarretta I, et al. Effects of neuroactive steroids on myelin of peripheral nervous system. J Steroid Biochem Mol Biol 2003;85:323–7
   PubMed Web of Science ®Google Scholar
• Ibanez C, Shields SA, El-Etr M, Baulieu E-E, Schumacher M, Franklin RJM. Systemic pro- gesterone administration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demye- lination in male rats. Neuropathol Appl Neurobiol 2004;30:80–9
   PubMed Web of Science ®Google Scholar
• Sereda MW, Meyer zur Ho¨ rste G, Suter U, Uzma N, Nave K-A. Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A). Nature Med 2003;9:1533–7
   PubMed Web of Science ®Google Scholar
• Wolkowitz OM, Reus VI. Editorial: Neuro- transmitters, neurosteroids and neurotrophins: new models of the pathophysiology and treat- ment of depression. World J Biol Psychiatry 2002;4:98–102
   Web of Science ®Google Scholar
• Von Broekhoven F, Verkes RJ. Neurosteroids in depression: a review. Psychopharmacology 2003; 165:97–110
   PubMed Web of Science ®Google Scholar
• Rupprecht R. Neuroactive steroids: mechanisms of action and neuropsychopharmacological prop- erties. Psychneuroendocrinology 2003;28:139–68
   PubMed Web of Science ®Google Scholar
• Selye H. The antagonism between anesthetic steroid hormones and pentylenetetrazol (metra- zol). J Lab Clin Med 1942;27:1051–3
   Google Scholar
• Ciriza I, Azcoitia I, Garcia-Segura LM. Reduced progesterone metabolites protect rat hippocam- pal neurones from kainic acid excitotoxicity in vivo. J Neuroendocrinol 2004;16:58–63
   PubMed Web of Science ®Google Scholar
• Persad V, Wong CGT, Cortez MA, Wang YT, Snead OC. Hormonal regulation of atypical absence seizures. Ann Neurol 2004;55:353–61
   PubMed Web of Science ®Google Scholar
• Herzog AG, Frye CA. Seizure exacerbation associated with inhibition of progesterone meta- bolism. Ann Neurol 2003;53:390–1
   PubMed Web of Science ®Google Scholar
• Van Luijtelaar G, Budziszewska B, Tetich M, Lason W. Finasteride inhibits the progesterone- induced spike-wave discharges in a genetic model of absence epilepsy. Pharmacol Biochem Behav 2003;75:889–94
   PubMed Web of Science ®Google Scholar
• Borowicz KK, Luszczki J, Swiader M, Kleinrok Z, Czuczwar SJ. Influence of sexual hormone antagonists on the anticonvulsant action of conventional antiepileptic drugs against electri- cally- and pentylenetetrazol-induced seizures in mice. Eur Neuropsychopharmacol 2004;14:77–85
   PubMed Web of Science ®Google Scholar
• Canonaco M, Facciolo RM, Alo R. Neuroactive steroid mechanisms and GABA type A receptor subunit assembly in hypothalamic and extrahy- pothalamic regions. Int Rev Cytol 2002;214:63– 101
   Google Scholar
• Schumacher M, Weill-Engerer S, Liere P, et al. Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Progress Neurobiol 2003;71:3–29
   PubMed Web of Science ®Google Scholar
• Soederpalm AHV, Lindsey S, Purdy RH, Hauger R, de Wot H. Administration of progesterone produces mild sedative-like effects in men and women. Psychoneuroendocrinology 2004;29:339–54
   PubMed Web of Science ®Google Scholar
• Friess E, Tagaya H, Trachsel L, Holsboer F, Rupprecht R. Progesterone-induced changes in sleep in male subjects. Am J Physiol (Endocrinol Metab) 1997;35:E885–91
   Google Scholar
• Gro¨n G, Friess E, Herpers M, Rupprecht R. Assessment of cognitive performance after pro- gesterone administration in healthy male volunteers. Neuropsychobiology 1997;35:147–51
   Google Scholar
• Wiedemann K, Seier F, Hirschmann M, Lauer C, Holsboer F. Sleep endocrine effects of megestrol acetate and mifepristone, a mixed glucocorticoid- and progesterone-receptor an- tagonist. Neuropsychopharmacology 1994;10S:Part 2, 21 S
   Google Scholar
• Witt DM, Gao G, Caldwell JD. Testosterone and sexual experience alter levels of plasma membrane binding sites for progesterone in the male rat brain. Horm Metab Res 2003;35:69–75
   PubMed Web of Science ®Google Scholar
• Shirai M, Yamanaka M, Shiina H, Igawa M, et al. Downregulation of androgen, estrogen and progesterone receptor genes and protein is involved in aging-related erectile dysfunction. Int J Impotence Res 2003;15:391–6
   PubMed Web of Science ®Google Scholar
• Hasselbach KA. Ein Beitrag zur Respiration Physiologia der Gravidita¨t. Skand Arch Physiol 1912;27:1–12
   Google Scholar
• Hasselbach KA, Gammeltoft SA. Die neutrali- ta¨tsregulation des graviden Organismus. Biochem J 1915;68:206–4
   Google Scholar
• Griffith FR Jr, Pucker GW, Brownell KA, Klein JD, Carmer ME. Studies in human physiology, alveolar air and blood gas capacity. Am J Physiol 1929;89:449–70
   Google Scholar
• Waddell BJ, O’Leary PC. Distribution and metabolism of topically applied progesterone in a rat model. J Steroid Biochem Mol Biol 2002;80:449–55
   PubMed Web of Science ®Google Scholar
• Gonza´lez-Arenas A, Villamar-Cruz O, Guerra- Araiza C, Camacho-Arroyo I. Regulation of progesterone receptor isoforms expression by sex steroids in the rat lung. J Steroid Biochem Mol Biol 2003;85:25–31
   PubMed Web of Science ®Google Scholar
• Beyer C, Ku¨ ppers E, Karolczak M, Trotter A. Ontogenetic expression of estrogen and proges- terone receptors in the mouse lung. Biol Neonate 2003;84:59–63
   PubMedGoogle Scholar
• Saaresranta T, Polo O. Hormones and breathing. Chest 2002;122:2165–82
   PubMed Web of Science ®Google Scholar
• Weisberg J, Wanger J, Olson J, et al. Megestro- lacetate stimulates weight gain and ventilation in underweight COPD patients. Chest 2002;121:1070–8
   PubMed Web of Science ®Google Scholar
• Vos PJE, Folgering HTM, de Boo TM, Lem- mens WJGM, van Herwaarden CLA. Effects of chlormadinone acetate, acetazolamide and oxy- gen on awake and asleep gas exchange in patients with chronic pulmonary disease (COPD). Eur Respir J 1994;7:850–5
   PubMed Web of Science ®Google Scholar
• Wagenaar M, Vos PJ, Heijdra YF, Teppemar LJ, Folgering HTM. Combined treatment with azetazolamide and medroxyprogesterone in chronic obstructive pulmonary disease patients. Eur Respir J 2002;20:1130–7
   PubMed Web of Science ®Google Scholar
• Brunette MG, Leclerc M. Renal action of progesterone: effect on calcium reabsorption. Mol Cell Endocrinol 2002;194:183–90
   PubMed Web of Science ®Google Scholar
• Quinkler M, Bumke-Vogt C, Meyer B, Ba¨hr V, Oelkers W, Diederich S. The human kidney is a progesterone-metabolizing and androgen-pro- ducing organ. J Clin Endocrinol Metab 2003;88:2803–9
   PubMed Web of Science ®Google Scholar
• Zitzmann M, Junker R, Kamischke A, Nieschlag E. Contraceptive steroids influence the hemo- static activation state in healthy men. J Androl 2002;23:503–11
   PubMedGoogle Scholar
• Molinari C, Battaglia A, Grossini E, Mary DASG, Surico N, Vacca G. Effect of progester- one on peripheral blood flow in prepubertal female anaesthetized pigs. J Vasc Res 2001;38:569–77
   PubMed Web of Science ®Google Scholar
• Welter BH, Hansen EL, Saner KJ, Wei Y, Price TM. Membrane-bound progesterone receptor expression in human aortic endothelial cells. J Histochem Cytochem 2003;51:1049–55
   PubMed Web of Science ®Google Scholar
• Simoncini T, Mannella P, Fornari L, Carusa A, Varone G, Genazzani AR. In vitro effects of progesterone and progestins on vascular cells. Steroids 2003;68:831–6
   PubMed Web of Science ®Google Scholar
• Lee W-S, Liu C-W, Juan S-H, Liang Y-C, Ho P-Y, Lee L-H. Molecular mechanism of pro- gesterone-induced antiproliferation in rat aortic smooth muscle cells. Endocrinology 2003;144:2785–90
   PubMed Web of Science ®Google Scholar
• Monjo M, Rodr´ıguez AM, Palou A, Roca P. Direct effects of testosterone, 17ß-estradiol, and progesterone on adrenergic regulation in cul- tured brown adipocytes: potentialmechanism for gender-dependent thermogenesis. Endocrinology 2003;144:4923–30
   PubMed Web of Science ®Google Scholar
• Rodr´ıguez AM, Monjo M, Roca P, Palou A. Opposite actions of testosterone and progester- one on UCP1 mRNA expression in cultured brown adipocytes. Cell Mol Life Sci 2002;59:1714–23
   PubMed Web of Science ®Google Scholar
• Von Roenn JH. Randomized trials of megestrol acetate for AIDS-associated anorexia and cachex- ia. Oncology 1994;51(Suppl 1):19–24
   Google Scholar
• Yeh S-S, Wu S-Y, Lee T-P, et al. Improvement in quality-of-life measures and stimulation of weight gain after treatment with megestrol acetate oral suspension in geriatric cachexia: results of a double-blind, placebo-controlled study. J Am Geriatr Soc 2000;48:485–92
   PubMed Web of Science ®Google Scholar
• Tom´ıska M, Tom´ıskova M, Salajka F, Adam Z, Vorl´ıcek J. Palliative treatment of cancer anor- exia with oral suspension of megestrol acetate. Neoplasma 2003;50:227–33
   PubMed Web of Science ®Google Scholar
• Lambert CP, Sullivan DH, Freeling SA, Lind- quist DM, Evans WJ. Effects of testosterone replacement and/or resistance exercise on the composition of megestrol acetate stimulated weight gain in elderly men: a randomized controlled trial. J Clin Endocrinol Metab 2002;87:2100–6
   PubMed Web of Science ®Google Scholar
• Leinung MC, Liporace R, Miller CH. Induction of adrenal suppression by megestrol acetate in patients with AIDS. Ann Intern Med 1995;122:843–5
   PubMed Web of Science ®Google Scholar
• Lortholary O, Christeff N, Casassus P, et al. Hypothalamo-pituitary-adrenal function in hu- man immunodeficiency virus-infected men. J Clin Endocrinol Metab 1996;81:791–6
   PubMed Web of Science ®Google Scholar
• Shirayama Y, Hashimoto K, Suzuki Y, Higuchi T. Correlation of plasma neurosteroid levels to the severity of negative symptoms in male patients with schizophrenia. Schizophrenia Res 2002;58:69–74
   PubMed Web of Science ®Google Scholar