Vitamin D Supplementation As a Potential therapeutic Mediator in Asthma: Does Dose Really Matter? a Critical Review of the Literature

References

• Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31:143–178.
   PubMed Web of Science ®Google Scholar
• Korn S, Hubner M, Jung M, et al. Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res. 2013;14:25.
   PubMed Web of Science ®Google Scholar
• Yao TC, Tu YL, Chang SW, et al. Prediction of allergies in Taiwanese Children Study G. Serum 25-hydroxyvitamin D levels in relation to lung function and exhaled nitric oxide in children. J Pediatr. 2014;165:1098–1103.e1.
   PubMedGoogle Scholar
• Confino-Cohen R, Brufman I, Goldberg A, et al. Vitamin D, asthma prevalence and asthma exacerbations: a large adult population-based study. Allergy. 2014;69:1673–1680.
   PubMed Web of Science ®Google Scholar
• Kerley CP, Elnazir B, Faul J, et al. Vitamin D as an adjunctive therapy in asthma. Part 2: a review of human studies. Pulm Pharmacol Ther. 2015;32:75–92.
   PubMed Web of Science ®Google Scholar
• Salas NM, Luo L, Harkins MS. Vitamin D deficiency and adult asthma exacerbations. J Asthma. 2014;51:950–955.
   PubMed Web of Science ®Google Scholar
• Montero-Arias F, Sedó-Mejía G, Ramos-Esquivel A. Vitamin D insufficiency and asthma severity in adults from Costa Rica. Allergy Asthma Immunol Res. 2013;5:283–288.
   PubMed Web of Science ®Google Scholar
• Ji J, Hemminki K, Sundquist K, et al. Seasonal and regional variations of asthma and association with osteoporosis: possible role of vitamin D in asthma. J Asthma. 2010;47:1045–1048.
   PubMed Web of Science ®Google Scholar
• Joseph CL, Ownby DR, Peterson EL, et al. Racial differences in physiologic parameters related to asthma among middle-class children. Chest. 2000;117:1336–1344.
   PubMed Web of Science ®Google Scholar
• Tsai CL, Delclos GL, Huang JS, et al. Age-related differences in asthma outcomes in the United States, 1988-2006. Ann Allergy Asthma Immunol. 2013;110:240–246,246 e1.
   PubMed Web of Science ®Google Scholar
• McCollum E, Simmonds N, Becker J, et al. An experimental demonstration of the existence of a vitamin which promotes calcium deposition. J Biol Chem. 1922;53:293–298.
   PubMedGoogle Scholar
• Heaton TB. On the vitamin D. Biochem J. 1922;16:800–808.
   PubMedGoogle Scholar
• Niruban SJ, Alagiakrishnan K, Beach J, et al. Association between vitamin D and respiratory outcomes in Canadian adolescents and adults. J Asthma. 2015;52:653–661.
   PubMed Web of Science ®Google Scholar
• Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 2005;26:662–687.
   PubMed Web of Science ®Google Scholar
• Griffin MD, Lutz W, Phan VA, et al. Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc Natl Acad Sci USA. 2001;98:6800–6805.
   PubMed Web of Science ®Google Scholar
• Bosse Y, Lemire M, Poon AH, et al. Asthma and genes encoding components of the vitamin D pathway. Respir Res. 2009;10:98.
   PubMed Web of Science ®Google Scholar
• Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer. 2007;7:684–700.
   PubMed Web of Science ®Google Scholar
• Munns CF, Simm PJ, Rodda CP, et al. Incidence of vitamin D deficiency rickets among Australian children: an Australian Paediatric Surveillance Unit study. Med J Aust. 2012;196:466–468.
   PubMed Web of Science ®Google Scholar
• Carraro S, Giordano G, Reniero F, et al. Asthma severity in childhood and metabolomic profiling of breath condensate. Allergy. 2013;68:110–117.
   PubMed Web of Science ®Google Scholar
• Uysalol M, Uysalol EP, Yilmaz Y, et al. Serum level of vitamin D and trace elements in children with recurrent wheezing: a cross-sectional study. BMC Pediatr. 2014;14:270.
   PubMed Web of Science ®Google Scholar
• Bener A, Ehlayel MS, Tulic MK, et al. Vitamin D deficiency as a strong predictor of asthma in children. Int Arch Allergy Immunol. 2012;157:168–175.
   PubMed Web of Science ®Google Scholar
• Cassim R, Russell MA, Lodge CJ, et al. The role of circulating 25 hydroxyvitamin D in asthma: a systematic review. Allergy. 2015;70:339–354.
   PubMed Web of Science ®Google Scholar
• Castro M, King TS, Kunselman SJ, National Heart L, Blood Institute's A, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014;311:2083–2091.
   PubMed Web of Science ®Google Scholar
• Martineau AR, MacLaughlin BD, Hooper RL, et al. Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs). Thorax. 2015;70:451–457.
   PubMed Web of Science ®Google Scholar
• Bar Yoseph R, Livnat G, Schnapp Z, et al. The effect of vitamin D on airway reactivity and inflammation in asthmatic children: a double-blind placebo-controlled trial. Pediatr Pulmonol. 2015;50:747–753.
   PubMed Web of Science ®Google Scholar
• Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91:1255–1260.
   PubMed Web of Science ®Google Scholar
• Yadav M, Mittal K. Effect of vitamin D supplementation on moderate to severe bronchial asthma. Indian J Pediatr. 2014;81:650–654.
   PubMed Web of Science ®Google Scholar
• Arshi S, Fallahpour M, Nabavi M, et al. The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma. Ann Allergy Asthma Immunol. 2014;113:404–409.
   PubMed Web of Science ®Google Scholar
• Powe CE, Karumanchi SA, Thadhani R. Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med. 2014;370:880–881.
   PubMedGoogle Scholar
• Hollis BW, Wagner CL, Drezner MK, et al. Circulating vitamin D3 and 25-hydroxyvitamin D in humans: an important tool to define adequate nutritional vitamin D status. J Steroid Biochem Mol Biol. 2007;103:631–634.
   PubMed Web of Science ®Google Scholar
• Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:53–58.
   PubMed Web of Science ®Google Scholar
• Vieth R. Why the minimum desirable serum 25-hydroxyvitamin D level should be 75 nmol/L (30 ng/ml). Best Pract Res Clin Endocrinol Metab. 2011;25:681–691.
   PubMed Web of Science ®Google Scholar
• Heaney RP, Holick MF. Why the IOM recommendations for vitamin D are deficient. J Bone Miner Res. 2011;26:455–457.
   PubMed Web of Science ®Google Scholar
• Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–1930.
   PubMed Web of Science ®Google Scholar
• Majak P, Jerzyńska J, Smejda K, et al. Correlation of vitamin D with Foxp3 induction and steroid-sparing effect of immunotherapy in asthmatic children. Ann Allergy Asthma Immunol. 2012;109:329–335.
   PubMed Web of Science ®Google Scholar
• Lewis E, Fernandez C, Nella A, et al. Relationship of 25-hydroxyvitamin D and asthma control in children. Ann Allergy Asthma Immunol. 2012;108:281–282.
   PubMed Web of Science ®Google Scholar
• Majak P, Olszowiec-Chlebna M, Smejda K, et al. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol. 2011;127:1294–1296.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Leung DY, Richers BN, et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012;188:2127–2135.
   PubMed Web of Science ®Google Scholar
• D'Ambrosio D, Cippitelli M, Cocciolo MG, et al. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest. 1998;101:252–262.
   PubMed Web of Science ®Google Scholar
• Adorini L, Penna G, Giarratana N, et al. Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases. J Cell Biochem. 2003;88:227–233.
   PubMed Web of Science ®Google Scholar
• Agrawal T, Gupta GK, Agrawal DK. Calcitriol decreases expression of importin alpha3 and attenuates RelA translocation in human bronchial smooth muscle cells. J Clin Immunol. 2012;32:1093–1103.
   PubMed Web of Science ®Google Scholar
• Song Y, Qi H, Wu C. Effect of 1,25-(OH)2D3 (a vitamin D analogue) on passively sensitized human airway smooth muscle cells. Respirology. 2007;12:486–494.
   PubMed Web of Science ®Google Scholar
• Mann EH, Chambers ES, Pfeffer PE, et al. Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Ann NY Acad Sci. 2014;1317:57–69.
   PubMed Web of Science ®Google Scholar
• Yim S, Dhawan P, Ragunath C, et al. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3). J Cyst Fibros. 2007;6:403–410.
   PubMed Web of Science ®Google Scholar
• Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J. 2001;15:2579–2585.
   PubMed Web of Science ®Google Scholar
• Wjst M, Altmuller J, Braig C, et al. A genome-wide linkage scan for 25-OH-D(3) and 1,25-(OH)2-D3 serum levels in asthma families. J Steroid Biochem Mol Biol. 2007;103:799–802.
   PubMed Web of Science ®Google Scholar
• Chin KY, Ima-Nirwana S, Wan Ngah WZ. Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men. Aging Male. 2015;18:175–179.
   PubMed Web of Science ®Google Scholar
• Canguven O, Talib RA, El Ansari W, et al. Vitamin D treatment improves levels of sexual hormones, metabolic parameters and erectile function in middle-aged vitamin D deficient men. Aging Male. 2017;20:9.
   PubMed Web of Science ®Google Scholar
• Park SG, Yeo JK, Cho DY, et al. Impact of metabolic status on the association of serum vitamin D with hypogonadism and lower urinary tract symptoms/benign prostatic hyperplasia. Aging Male. 2018;21:55–59.
   PubMed Web of Science ®Google Scholar
• Culha MG, Atalay HA, Canat HL, et al. The relationship between erectile dysfunction severity, mean platelet volume and vitamin D levels. Aging Male. 2018;1–6. DOI:10.1080/13685538.2018.1459544
   PubMedGoogle Scholar
• Basat S, Sivritepe R, Ortaboz D, et al. The relationship between vitamin D level and erectile dysfunction in patients with type 2 diabetes mellitus. Aging Male. 2018;21:111–115.
   PubMed Web of Science ®Google Scholar
• Canguven O, Albayrak S. Do low testosterone levels contribute to the pathogenesis of asthma? Med Hypotheses. 2011;76:585–588.
   PubMed Web of Science ®Google Scholar
• Montano LM, Espinoza J, Flores-Soto E, et al. Androgens are bronchoactive drugs that act by relaxing airway smooth muscle and preventing bronchospasm. J Endocrinol. 2014;222:1–13.
   PubMed Web of Science ®Google Scholar
• Proal AD, Albert PJ, Marshall TG. Dysregulation of the vitamin D nuclear receptor may contribute to the higher prevalence of some autoimmune diseases in women. Ann NY Acad Sci. 2009;1173:252–259.
   PubMed Web of Science ®Google Scholar
• Marshall TG. Vitamin D discovery outpaces FDA decision making. Bioessays. 2008;30:173–182.
   PubMed Web of Science ®Google Scholar
• Nguyen M, Trubert CL, Rizk-Rabin M, et al. 1,25-Dihydroxyvitamin D3 and fetal lung maturation: immunogold detection of VDR expression in pneumocytes type II cells and effect on fructose 1,6 bisphosphatase. J Steroid Biochem Mol Biol. 2004;89–90:93–97.
   PubMed Web of Science ®Google Scholar
• Britt RD Jr, Faksh A, Vogel ER, et al. Vitamin D attenuates cytokine-induced remodeling in human fetal airway smooth muscle cells. J Cell Physiol. 2015;230:1189–1198.
   PubMed Web of Science ®Google Scholar
• Masoli M, Fabian D, Holt S, et al. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004;59:469–478.
   PubMed Web of Science ®Google Scholar
• Mirzakhani H, Al-Garawi A, Weiss ST, et al. Vitamin D and the development of allergic disease: how important is it? Clin Exp Allergy. 2015;45:114–125.
   PubMed Web of Science ®Google Scholar
• Rajabbik MH, Lotfi T, Alkhaled L, et al. Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies. Allergy Asthma Clin Immunol. 2014;10:31.
   PubMed Web of Science ®Google Scholar
• Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009;19:73–78.
   PubMed Web of Science ®Google Scholar
• Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84:18–28.
   PubMed Web of Science ®Google Scholar
• Araki T, Holick MF, Alfonso BD, et al. Vitamin D intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States. J Clin Endocrinol Metab. 2011;96:3603–3608.
   PubMed Web of Science ®Google Scholar
• Kara C, Gunindi F, Ustyol A, et al. Vitamin D intoxication due to an erroneously manufactured dietary supplement in seven children. Pediatrics. 2014;133:e240–e244.
   PubMed Web of Science ®Google Scholar
• Petrovic SL, Engel G, Haugland RP, et al. Characterization of beta-adrenergic receptor subtypes in androgen-induced mouse kidney hypertrophy using a new high-affinity ligand, [125I] iodocyanopindolol. Biochim Biophys Acta 1983;756:286–296.
   PubMedGoogle Scholar
• Osman M. Therapeutic implications of sex differences in asthma and atopy. Arch Dis Child. 2003;88:587–590.
   PubMed Web of Science ®Google Scholar