Combination antifungal therapy against Candida species: the new frontier-are we there yet?

References

• Kullberg BJ, Oude Lashof AML.Epidemiology of opportunistic invasive mycosesEuropean J Med Res2002; 7183–191
   PubMed Web of Science ®Google Scholar
• Pfaller MA, Diekema DJ.Role of sentinel surveillance of candidemia: trends in species distribution and antifungal susceptibilityJ Clin Microbiol2002; 403551–3557
   PubMed Web of Science ®Google Scholar
• Sobel JD, Vazquez JA.Contemporary Diagnosis and Management of Fungal InfectionsHandbooks in Health Care Co, Newton, PA 200365–122
   Google Scholar
• Sheehan DJ, Hitchcock CA, Sibley CM.Current and emerging azole antifungal agentsClin Microbiol Rev1999; 1240–79
   PubMed Web of Science ®Google Scholar
• Graybill JR.The echinocandins, first novel class of antifungal in two decades: will they live up to their promise?Int J Clin Pract2001; 55633–638
   PubMed Web of Science ®Google Scholar
• National Committee for Clinical and Laboratory Standards. Reference method for broth dilution antifungal susceptibility testing of yeast; approved standard. , NCCLS Document M27-A. Wayne, PA, 1997.
   Google Scholar
• Schoenknecht FD, Sabath LD, Thornsberry C.Susceptibility tests: Special testsManual of Clinical MicrobiologyEH LennetteASM Press, Washington, DC 19851000–1008
   Google Scholar
• Berenbaum MC.A method for testing for synergy with any number of agentsJ Infect Dis1978; 137122–130
   PubMed Web of Science ®Google Scholar
• Cosgrove RF, Beezer AE, Miles RJ.In vitro studies of amphotericin B in combination with the imidazole antifungal compounds clotrimazole and miconazoleJ infect Dis1978; 138681–685
   PubMed Web of Science ®Google Scholar
• Brajtburg JD, Kobayashi G, Medoff G, Kobayashi GS.Anti fungal action of amphotericin B in combination with other polyene or imidazole antibioticsJ Infect Dis1982; 146138–146
   PubMed Web of Science ®Google Scholar
• Petrou MA, Rogers TR.Interactions in vitro between polyenes and imidazoles against yeastsJ Antimicrob Chemother1991; 27491–506
   PubMed Web of Science ®Google Scholar
• van Etten EWM, van de Rhee NE, van Kampen KM, Bakker-Woudenbert IAJM.Effects of amphotericin b and fluconazole on the extracellular and intracellular growth of Candida albicansAntimicrob Agent Chemother1991; 352275–2281
   Google Scholar
• Martin E, Maier F, Bhakdi S.Antagonistic effects of fluconazole and 5-fluorocytosine on candidacidal action of amphotericin B in human serumAntimicrob Agent Chemother1994; 381331–1338
   PubMedGoogle Scholar
• Sud IJ, Feingold DS.Effect of ketoconazole on the fungicidal action of amphotericin B in Candida albicansAntimicrob Agents Chemother1983; 23185–187
   Google Scholar
• Scheven M, Schwegler F.Antagonistic interactions between azoles and amphotericin B with yeasts depend on azole lipophilia for special test conditions in vitroAntimicrob Agent Chemother1995; 391779–1783
   PubMed Web of Science ®Google Scholar
• Scheven M, Scheven ML.Interaction between azoles and amphotericin B in the treatment of candidiasisClin Infect Dis1995; 201079
   Google Scholar
• Vazquez JA, Arganoza MT, Vaishampayan JK, Akins RA.In-vitro interaction between amphotericin B and azoles in Candida albicansAntimicrob Agent Chemother1996; 402511–2516
   PubMed Web of Science ®Google Scholar
• Vazquez JA, Arganoza MT, Boikov D, et alStable Phenotypic resistance of Candida species to amphotericin B conferred by preexposure to subinhibitory levels of azolesJ Clin Microbiol1998; 362690–2695
   PubMed Web of Science ®Google Scholar
• Louie A, Kaw P, Banerjee P, et alImpact of the order of initiation of fluconazole and amphotericin b in sequential or combination therapy on killing of Candida albicans in vitro and in a rabbit model of endocarditis and pyelonephritisAntimicrob Agent Chemother2001; 45485–494
   PubMed Web of Science ®Google Scholar
• Polak AM.Determination de la synergie entre la 5-fluorocytosine et l'amphotericine B au mycoses de differentes modeles in vitro et in vivoBull Soc Franc Mycol Med1974; 3175–178
   Google Scholar
• Polak A, Scholer HJ.Combination of amphotericin B and flucytosineChemother1976; 6137–142
   Google Scholar
• Scalarone GM, Mikami Y, Kurita N, Yazawa K, Miyaji M.Comparative studies on the postantifungal effect produced by the synergistic interaction of flucytosine and amphotericin B on Candida albicansMycopathologia1992; 120133–138
   PubMed Web of Science ®Google Scholar
• Beggs WH, Sarosi GA, Andrewa FA.Synergistic action of amphotericin B and rifampin on Candida albicansAm Rev Respir Dis1974; 110671–673
   PubMed Web of Science ®Google Scholar
• Edwards JE, Jr, Morrison J, Henderson DK, Montgomerie JZ.Combined effect of amphotericin B and rifampin on Candida speciesAntimicrob Agent Chemother1980; 17484–487
   PubMedGoogle Scholar
• Schaumann RF, Shah PM.Effect of amphotericin b alone or in combination with rifampicin on phagocytosis of Candida species by human polymorphonuclear leukocytesMeth Find Exp Clin Pharma1992; 14753–758
   Google Scholar
• McCarthy PJ, Troke PF, Gull K.Mechanism of action of nikkomycin and the peptide transport system of Candida albicansJ Gen Microbiol1985; 131775–780
   PubMedGoogle Scholar
• Becker JM, Marcus S, Tallock J, et alUse of the chitin-synthesis inhibitor nikkomycin to treat disseminated candidiasis in miceJ Infect Dis1988; 15721221–21224
   Google Scholar
• Milewski S, Mignini F, Borowski E.Synergistic action of nikkomycin x/z with azole antifungals on Candida albicansJ Gen Microbiol1991; 1372155–2161
   PubMedGoogle Scholar
• Barchiesi F, Di Francesco LF, Scalise G.In vitro activities of terbinafine in combination with fluconazole and itraconazole against isolates of Candida albicans with reduced susceptibility to azolesAntimicrob Agent Chemother1997; 411812–1814
   PubMed Web of Science ®Google Scholar
• Barchiesi F, Di Francesco LF, Compagnucci P, et alIn-vitro interaction of terbinafine with amphotericin b. fluconazole and itraconazole against clinical isolates of Candida albicansJ Antimicrob Chemother1998; 4159–65
   PubMedGoogle Scholar
• Weig M, Muller FMC.Synergism of voriconazole and terbinafine against Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasisAntimicrob Agent Chemother2001; 45966–968
   PubMed Web of Science ®Google Scholar
• Perea S, Gonzalez G, Fothergill AW, Sutton DA, Rinaldi MG.In vitro activities of terbinafine in combination with fluconazole, itraconazole, voriconazole, and posaconazole against clinical isolates of Candida glabrata with decreased susceptibility to azolesJ Clin Microbiol2002; 40I831–1833
   Google Scholar
• Bachmann SP, Ramage G, Fothergill AW, , et al Combination of antifungal agents against Candida albicans biofilms in vitro 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, 2002; , San Diego, CA, Sep 27–30, abstract # M1813.
   Google Scholar
• Chin NX, Weitzman I, Della-Latta P. In vitro antifungal activity of fluvastatin, a cholesterol lowering agent, and synergy with fluconazole and itraconazole 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1996; , New Orleans, LA, Sept 18–20, abstract # E-049.
   Google Scholar
• Nakajima R, Kitamura A, Someya K, Tanaka M, Sato K.In vitro and in vivo antifungal activities of DU-6859a, a fluoroquinolone, in combination with amphotericin b and fluconazole against pathogenic fungiAntimicrob Agent Chemother1995; 391517–1521
   PubMed Web of Science ®Google Scholar
• Reiter B.The biological significance of lactoferrinInt J Tissue React1983; 587–96
   PubMedGoogle Scholar
• Kuipers ME, de Vries HG, Eikelbom MC, Meijer DKF, Swart PJ.Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolatesAntimicrob Agents Chemother1999; 432635–2641
   PubMed Web of Science ®Google Scholar
• Marchetti O, Moreillon P, Glauser MP, Bille J, Sanglard D.Potent synergism of the combination of fluconazole and cyclosporine in Candida albicanAntimicrob Agent Chemother2000; 442373–2381
   PubMed Web of Science ®Google Scholar
• Onyewu C, Blankenship JR, De. Poeta M, Heitman J.Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida kruseiAntimicrob Agent Chemother2003; 47956–964
   PubMed Web of Science ®Google Scholar
• Vitale RG, Rodero L, Afeltra J. In vitro synergistic activity of amlodipine in combination with fluconazole, itraconazole and terbinafine against clinical isolates of Candida albicans. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, 2002; , San Diego, CA, Sep 27–30, abstract # M-866.
   Google Scholar
• Andrade RA, Ostrosky-Zeichner L, Paetznick VL, Rodriguez JR, Chen E, Rex JH. Synergistic antifungal effect of fluconazole and CDR1/2 efflux pump inhibitors: Insights into the trailing growth phenomenon. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, 2002; , San Diego, CA, Sep 27–30, abstract # M-223.
   Google Scholar
• Grunstein M.Histone acetylation in chromatin structure and transcriptionNature1997; 389349–352
   PubMed Web of Science ®Google Scholar
• Sterner DE, Berger SL.Acetylation of histones and transcription-related factorsMicrobiol Mol Rev2000; 64435–459
   PubMed Web of Science ®Google Scholar
• Smith WL, Edlind TD.Histone deacetylase inhibitors enhance Candida albicans sensitivity to azole and related antifungals: correlation with reduction in CDR and ERG upregulationAntimicrob Agent Chemother2002; 463532–3539
   PubMed Web of Science ®Google Scholar
• Polak A, Scholer HJ, Wall M.Combination therapy of experimental candidiasis, cryptococcosis, and aspergillosis in miceChemother1982; 28461–479
   PubMedGoogle Scholar
• Polak A.Combination therapy of experimental candidiasis, cryptococcosis, aspergillosis and wangiellosis in miceChemother1987; 33381–395
   PubMed Web of Science ®Google Scholar
• Polak A.Antifungal combination therapy in localized candidosisMycoses1990; 33353–358
   Google Scholar
• Sugar AM, Hitchcock CA, Troke PF, Picard M.Combination therapy of murine invasive candidiasis with fluconazole and amphotericin BAntimicrob Agent Chemother1995; 39598–601
   PubMed Web of Science ®Google Scholar
• Sanati H, Ramos CF, Bayer AS, Ghannoum MA.Combination therapy with amphotericin B and fluconazole against invasive candidiasis in neutropenic-mouse and infective-endocarditis rabbit modelsAntimicrob Agent Chemother1997; 411345–1348
   PubMed Web of Science ®Google Scholar
• Sugar AM, Liu XP.Interactions of itraconazole with amphotericin B in the treatment of murine invasive candidiasisJ Infect Dis1998; 1771660–1663
   PubMed Web of Science ®Google Scholar
• Bocanegra R, Najvar LK, Hernandez S, Larsen RA, Graybill JR. In vivo combination of fluconazole and caspofungin against Candida albicans. 42nd Interscience Conference Antimicrobial Agents and Chemotherapy. 2002; , San Diego, CA, Sept 27–30, abstract # M-864.
   Google Scholar
• Cacciapuoti AF, Gurnani M, Halpern J, , et al. Combination treatment of posaconazole and amphotericin B against Candida albicans in a mouse systemic infection model. 42nd Interscience Conference Antimicrobial Agents and Chemotherapy. 2002; , San Diego, CA, Sept 27–30, abstract # M-415.
   Google Scholar
• Marchetti O, Entenza JM, Sanglard D, et alFluconazole plus cyclosporine: a fungicidal combination effective against experimental endocarditis due to Candida albicansAntimicrob Agent Chemother2000; 442932–2938
   PubMed Web of Science ®Google Scholar
• Brockmeyer NH, Hantschke D, Olbricht T, Hengge UA, Coos M.Comparative study of the therapy of Candida esophagitis in HIV-1 patients with fluconazole or amphotericin B and flucytosineMycoses1991; 3483–86
   Google Scholar
• Vazquez J, Lamarca A, Schwartz R, , et al. Management of fluconazole-refractory oropharyngeal Candidiasis using high dose terbinafine in patient with AIDS. 42nd Interscience Conference Antimicrobial Agents and Chemotherapy. 2000;, Toronto, Ontaria, Canada, abstract # 1418.
   Google Scholar
• Kujath P, Lerch K, Kochendorfer P, Boos C.Comparative study of the efficacy of fluconazole versus amphotericinB/flucytosine in surgical patients with systemic mycosesInfection1993; 21376–382
   PubMed Web of Science ®Google Scholar
• Abele-Norn M, Kopp A, Sternberg U, et alA randomized study comparing fluconazole with amphotericin B/5-flucytosine for the treatment of systemic Candida infections in intensive care patientsInfection1996; 24426–432
   Google Scholar
• Rex JH, Pappas PG, Karchmer AW, et alA randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconzole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjectsClin Infect Dis2003; 361221–1228
   PubMed Web of Science ®Google Scholar
• Sugar AM.Use of amphotericin B with azole antifungal drugs: what are we doing?Antimicrob Agent Chemother1995; 391907–1912
   PubMed Web of Science ®Google Scholar
• Rex JH, Walsh TJ, Sobel JD, et alPractice guidelines for the treatment of candidiasisClin Infect Dis2000; 30662–678
   PubMed Web of Science ®Google Scholar