1,427
Views
4
CrossRef citations to date
0
Altmetric
Hematology

Healthcare resource use and direct costs in severe aplastic anemia (SAA) patients before and after treatment with eltrombopag

, , , &
Pages 243-251 | Received 30 Jul 2019, Accepted 09 Oct 2019, Published online: 20 Nov 2019

References

  • National Heart, Lung, and Blood Institute (NHLBI). What is aplastic anemia. [cited 2018 Aug 31]. Available from https://www.nhlbi.nih.gov/node/80148.
  • Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood. 2006;108(8):2509–2519.
  • Townsley DM, Desmond R, Dunbar CE, et al. Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes. Int J Hematol. 2013;98(1):48–55.
  • Pickard AS, Huynh L, Ivanova JI, et al. Value of transfusion independence in severe aplastic anemia from patients’ perspectives – a discrete choice experiment. J Patient Rep Outcomes. 2018;2(1):13.
  • Camitta BM, Rappeport JM, Parkman R, et al. Selection of patients for bone marrow transplantation in severe aplastic anemia. Blood. 1975;45(3):355–363.
  • Kumar R, Bonfim C, George B. Hematopoietic cell transplantation for aplastic anemia. Curr Opin Hematol. 2017;24(6):509–514.
  • Passweg JR, Marsh JC. Aplastic anemia: first-line treatment by immunosuppression and sibling marrow transplantation. Hematology Am Soc Hematol Educ Program. 2010;2010(1):36–42.
  • Chiu V, Weitz IC, Hermel DJ. Tacrolimus is effective immunosuppressive therapy in aplastic anemia. Blood. 2017;130(Suppl 1):1183. [cited 2019 Sep 17]. Available from http://www.bloodjournal.org/content/130/Suppl_1/1183
  • de Latour RP, Huynh L, Ivanova JI, et al. A retrospective chart review to assess burden of illness among patients with severe aplastic anemia with insufficient response to immunosuppressive therapy. 2017 (Abstract no. 678). 59th American Society of Hematology (ASH) Annual Meeting & Exposition, Atlanta, December 9–12.
  • Montane E, Ibanez L, Vidal X, et al. Epidemiology of aplastic anemia: a prospective multicenter study. Haematologica. 2008;93(4):518–523.
  • Bacigalupo A, Hows J, Gluckman E, et al. Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party. Br J Haematol. 1988;70(2):177–182.
  • Killick SB, Bown N, Cavenagh J, et al. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol. 2016;172(2):187–207.
  • Peslak SA, Olson T, Babushok DV. Diagnosis and treatment of aplastic anemia. Curr Treat Options Oncol. 2017;18(12):70.
  • Desmond R, Townsley DM, Dumitriu B, et al. Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug. Blood. 2014;123(12):1818–1825.
  • Olnes MJ, Scheinberg P, Calvo KR, et al. Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med. 2012;367(1):11–19.
  • Townsley DM, Scheinberg P, Winkler T, et al. Eltrombopag added to standard immunosuppression for aplastic anemia. N Engl J Med. 2017;376(16):1540–1550.
  • Joshi S, Rose MJ, Stanek JR, et al. A comparison of resource utilization, cost and mortality in children treated for severe aplastic anemia. Blood. 2016;128(22):2333.
  • PROMACTA® (eltrombopag) tablets, for oral use. Package insert. Novartis Pharmaceuticals Corporation. East Hanover, New Jersey. 2018.
  • Cai B, Said Q, Li X, et al. Healthcare costs and resource utilization in patients with severe aplastic anemia in the US. J Med Econ. 2019;22(10):1055–1062.
  • Tremblay G, Said Q, Cai B, et al. Comparing costs and consequences of eltrombopag plus IST versus IST alone for first-line treatment in severe aplastic anemia: results from a responder analysis. Blood. 2018;132(Supplement 1):1041.
  • IBM Watson Health. Putting Research Data Into Your Hands with the MarketScan Databases. [cited 2018 Oct 15]. Available from http://truvenhealth.com/Markets/Life-Sciences/Products/Data-Tools/MarketScan-Databases.
  • Hansen L. Truven Health Analystics. The MarketScan® Databases for Life Sciences Researchers. 2016.
  • MarketScan® Research [database on the Internet]. Ann Arbor, MI: Truven Health Analytics; 2018. [cited 2018 Oct 13]. http://marketscan.truvenhealth.com/marketscanportal/
  • Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45(6):613–619.
  • United States Department of Labor. Bureau of Labor Statistics. Consumer Price Index. [cited 2019 Feb 15]. Available from https://www.bls.gov/cpi/latest-numbers.htm
  • Broder MS, Quock TP, Chang E, et al. The cost of hematopoietic stem-cell transplantation in the United States. Am Health Drug Benefits. 2017;10(7):366–374.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.