Uterotropic effects of dietary equol administration in ovariectomized Sprague–Dawley rats

References

• Mahady G B, Parrot J, Lee C, Yun G S, Dan A. Botanical dietary supplement use in peri- and postmenopausal women. Menopause 2003; 10: 65–72
   PubMed Web of Science ®Google Scholar
• Wuttke W, Jarry H, Westphalen S, Christoffel V, Seidlova-Wuttke D. Phytoestrogens for hormone replacement therapy?. J Steroid Biochem Mol Biol 2002; 83: 133–147
   PubMed Web of Science ®Google Scholar
• Low Dog T. Menopause: a review of botanical dietary supplements. Am J Med 2005; 118(Suppl 12B)98–108
   PubMedGoogle Scholar
• Booth N L, Piersen C E, Banuvar S, Geller S E, Shulman L P, Farnsworth N R. Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review. Menopause 2006; 13: 251–264
   PubMed Web of Science ®Google Scholar
• Weiderpass E, Adami H O, Baron J A, et al. Risk of endometrial cancer following estrogen replacement with and without progestins. J Natl Cancer Inst 1999; 91: 1131–1137
   PubMed Web of Science ®Google Scholar
• Reed S D, Cushing-Haugen K L, Daling J R, Scholes D, Schwartz S M. Postmenopausal estrogen and progestogen therapy and the risk of uterine leiomyomas. Menopause 2004; 11: 214–222
   PubMed Web of Science ®Google Scholar
• Hale G E, Hughes C L, Robboy S J, Agarwal S K, Bievre M. A double-blind randomized study on the effects of red clover isoflavones on the endometrium. Menopause 2001; 8: 338–346
   PubMed Web of Science ®Google Scholar
• Nikander E, Rutanen E M, Nieminen P, Wahlstrom T, Ylikorkala O, Tiitinen A. Lack of effect of isoflavonoids on the vagina and endometrium in postmenopausal women. Fertil Steril 2005; 83: 137–142
   PubMed Web of Science ®Google Scholar
• Imhof M, Gocan A, Reithmayr F, et al. Effects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal women. Maturitas 2006; 55: 76–81
   PubMed Web of Science ®Google Scholar
• Unfer V, Casini M L, Costabile L, Mignosa M, Gerli S, Di Renzo G C. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004; 82: 145–148, quiz 265
   PubMed Web of Science ®Google Scholar
• Muthyala R S, Ju Y H, Sheng S, et al. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem 2004; 12: 1559–1567
   PubMed Web of Science ®Google Scholar
• Rowland I R, Wiseman H, Sanders T A, Adlercreutz H, Bowey E A. Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer 2000; 36: 27–32
   PubMed Web of Science ®Google Scholar
• Setchell K D, Brown N M, Desai P B, et al. Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes. J Nutr 2003; 133: 1027–1035
   PubMed Web of Science ®Google Scholar
• Morito K, Hirose T, Kinjo J, et al. Interaction of phytoestrogens with estrogen receptors alpha and beta. Biol Pharm Bull 2001; 24: 351–356
   PubMed Web of Science ®Google Scholar
• Setchell K D, Brown N M, Lydeking-Olsen E. The clinical importance of the metabolite equol – a clue to the effectiveness of soy and its isoflavones. J Nutr 2002; 132: 3577–3584
   PubMed Web of Science ®Google Scholar
• Heid C A, Stevens J, Livak K J, Williams P M. Real time quantitative PCR. Genome Res 1996; 6: 986–994
   PubMed Web of Science ®Google Scholar
• Rachon D, Vortherms T, Seidlova-Wuttke D, Wuttke W. Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats. Maturitas 2007; 57: 161–170
   PubMed Web of Science ®Google Scholar
• Rachon D, Vortherms T, Seidlova-Wuttke D, Wuttke W. Effects of dietary equol on body weight gain, intraabdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats. Menopause 2007; 14: 1–8
   PubMedGoogle Scholar
• Diel P, Schulz T, Smolnikar K, Strunck E, Vollmer G, Michna H. Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity. J Steroid Biochem Mol Biol 2000; 73: 1–10
   PubMed Web of Science ®Google Scholar
• Celis J E, Celis A. Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase. Proc Natl Acad Sci USA 1985; 82: 3262–3266
   PubMed Web of Science ®Google Scholar
• Kurki P, Vanderlaan M, Dolbeare F, Gray J, Tan E M. Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle. Exp Cell Res 1986; 166: 209–219
   PubMed Web of Science ®Google Scholar
• Schimmelpenning H, Eriksson E T, Franzen B, Zetterberg A, Auer G U. Prognostic value of the combined assessment of proliferating cell nuclear antigen immunostaining and nuclear DNA content in invasive human mammary carcinomas. Virchows Arch A Pathol Anat Histopathol 1993; 423: 273–279
   PubMedGoogle Scholar
• Dawson A E, Norton J A, Weinberg D S. Comparative assessment of proliferation and DNA content in breast carcinoma by image analysis and flow cytometry. Am J Pathol 1990; 136: 1115–1124
   PubMed Web of Science ®Google Scholar
• Battersby S, Anderson T J. Correlation of proliferative activity in breast tissue using PCNA/cyclin. Hum Pathol 1990; 21: 781
   PubMed Web of Science ®Google Scholar
• Martin L, Pollard J W, Fagg B. Oestriol, oestradiol-17beta and the proliferation and death of uterine cells. J Endocrinol 1976; 69: 103–115
   PubMedGoogle Scholar
• Quarmby V E, Korach K S. The influence of 17 beta-estradiol on patterns of cell division in the uterus. Endocrinology 1984; 114: 694–702
   PubMed Web of Science ®Google Scholar
• Lai M D, Lee L R, Cheng K S, Wing L Y. Expression of proliferating cell nuclear antigen in luminal epithelium during the growth and regression of rat uterus. J Endocrinol 2000; 166: 87–93
   PubMed Web of Science ®Google Scholar
• Diel P, Geis R B, Caldarelli A, et al. The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expression. Mol Cell Endocrinol 2004; 221: 21–32
   PubMed Web of Science ®Google Scholar
• Couse J F, Korach K S. Estrogen receptor null mice: what have we learned and where will they lead us?. Endocr Rev 1999; 20: 358–417
   PubMed Web of Science ®Google Scholar
• Adesanya O O, Zhou J, Samathanam C, Powell-Braxton L, Bondy C A. Insulin-like growth factor 1 is required for G2 progression in the estradiol-induced mitotic cycle. Proc Natl Acad Sci USA 1999; 96: 3287–3291
   PubMed Web of Science ®Google Scholar
• Sundstrom S A, Komm B S, Ponce-de-Leon H, Yi Z, Teuscher C, Lyttle C R. Estrogen regulation of tissue-specific expression of complement C3. J Biol Chem 1989; 264: 16941–16947
   PubMed Web of Science ®Google Scholar
• Harris H A, Katzenellenbogen J A, Katzenellenbogen B S. Characterization of the biological roles of the estrogen receptors, ERalpha and ERbeta, in estrogen target tissues in vivo through the use of an ERalpha-selective ligand. Endocrinology 2002; 143: 4172–4177
   PubMed Web of Science ®Google Scholar
• Heikaus S, Winterhager E, Traub O, Grummer R. Responsiveness of endometrial genes Connexin26, Connexin43, C3 and clusterin to primary estrogen, selective estrogen receptor modulators, phyto- and xenoestrogens. J Mol Endocrinol 2002; 29: 239–249
   PubMed Web of Science ®Google Scholar
• Hopert A C, Beyer A, Frank K, Strunck E, Wunsche W, Vollmer G. Characterization of estrogenicity of phytoestrogens in an endometrial-derived experimental model. Environ Health Perspect 1998; 106: 581–586
   PubMed Web of Science ®Google Scholar
• Wood C E, Appt S E, Clarkson T B, et al. Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biol Reprod 2006; 75: 477–486
   PubMed Web of Science ®Google Scholar
• Kraus W L, Katzenellenbogen B S. Regulation of progesterone receptor gene expression and growth in the rat uterus: modulation of estrogen actions by progesterone and sex steroid hormone antagonists. Endocrinology 1993; 132: 2371–2379
   PubMed Web of Science ®Google Scholar
• Kleinman D, Roberts C T, Jr, LeRoith D, Schally A V, Levy J, Sharoni Y. Regulation of endometrial cancer cell growth by insulin-like growth factors and the luteinizing hormone-releasing hormone antagonist SB-75. Regul Pept 1993; 48: 91–98
   PubMed Web of Science ®Google Scholar
• Strawn E Y, Jr, Novy M J, Burry K A, Bethea C L. Insulin-like growth factor I promotes leiomyoma cell growth in vitro. Am J Obstet Gynecol 1995; 172: 1837–1843, discussion 1843–4
   PubMed Web of Science ®Google Scholar
• Lurie S, Piper I, Woliovitch I, Glezerman M. Age-related prevalence of sonographically confirmed uterine myomas. J Obstet Gynaecol 2005; 25: 42–44
   PubMedGoogle Scholar
• Richter C P, Uhlenhuth E H. Comparison of the effects of gonadectomy of spontaneous activity of wild and domesticated Norway rats. Endocrinology 1954; 54: 311–322
   PubMed Web of Science ®Google Scholar
• Selvaraj V, Zakroczymski M A, Naaz A, et al. Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice. Biol Reprod 2004; 71: 966–972
   PubMed Web of Science ®Google Scholar
• Kaziro R, Kennedy J P, Cole E R, Southwell-Keely P T. The oestrogenicity of equol in sheep. J Endocrinol 1984; 103: 395–399
   PubMed Web of Science ®Google Scholar
• Tang B Y, Adams N R. Effect of equol on oestrogen receptors and on synthesis of DNA and protein in the immature rat uterus. J Endocrinol 1980; 85: 291–297
   PubMed Web of Science ®Google Scholar
• Arai Y, Uehara M, Sato Y, et al. Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. J Epidemiol 2000; 10: 127–135
   PubMedGoogle Scholar
• Faure E D, Chantre P, Mares P. Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 2002; 9: 329–334
   PubMed Web of Science ®Google Scholar
• Upmalis D H, Lobo R, Bradley L, Warren M, Cone F L, Lamia C A. Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 2000; 7: 236–242
   PubMed Web of Science ®Google Scholar
• Quella S K, Loprinzi C L, Barton D L, et al. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial. J Clin Oncol 2000; 18: 1068–1074
   PubMed Web of Science ®Google Scholar
• Davidson I W, Parker J C, Beliles R P. Biological basis for extrapolation across mammalian species. Regul Toxicol Pharmacol 1986; 6: 211–237
   PubMed Web of Science ®Google Scholar
• Vocci F, Farber T. Extrapolation of animal toxicity data to man. Regul Toxicol Pharmacol 1988; 8: 389–398
   PubMed Web of Science ®Google Scholar
• Setchell K D, Clerici C, Lephart E D, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr 2005; 81: 1072–1079
   PubMed Web of Science ®Google Scholar