107
Views
15
CrossRef citations to date
0
Altmetric
Original Article

Effects of the addition of methyltestosterone to combined hormone therapy with estrogens and progestogens on sexual energy and on orgasm in postmenopausal women

, , , , &
Pages 17-25 | Received 22 Jan 2007, Accepted 08 Aug 2007, Published online: 03 Jul 2009

References

  • Penteado S RL, Fonseca A M, Bagnoli V R, Assis J S, Pinotti J A. Sexuality in healthy postmenopausal women. Climacteric 2003; 6: 321–329
  • Semmens J P, Wagner G. Estrogen deprivation and vaginal function in post-menopausal women. JAMA 1982; 248: 445–448
  • Burger H G, Hailles J, Menelaus M, Nelson J, Hudson B, Balasz N. The management of persistent menopausal symptoms with oestradiol testosterone implants: clinical, lipid and hormonal results. Maturitas 1984; 6: 351–358
  • Sarrel P, Dobay B, Wiita B. Estrogen and estrogen-androgen replacement in postmenopausal women dissatisfied with estrogen-alone therapy. J Reprod Med 1998; 43: 847–856
  • Lobo R A, Rosen C R, Yang H M, Block B A, Van Der Hoop R G. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 2003; 79: 1341–1352
  • de Paula F J, Soares J M, Jr, Haidar M A, Lima G R, Baracat E C. The benefits of androgens combined with hormone replacement therapy regarding to patients with postmenopausal sexual symptoms. Maturitas 2007; 56: 69–77
  • Gelfand M M, Ferenczy A, Bergeron C. Endometrial response to estrogen-androgen stimulation. Menopause Evaluation, Treatment and Health Concerns, C B Hamond, F B Haseltine, I Seniff. Alan R. Liss, New York 1989; 29–40
  • Sherwin B B. The impact of different doses of estrogen and progestin on mood and sexual behavior in postmenopausal women. J Clin Endocrinol Metab 1991; 172: 336–343
  • Dennerstein L, Burrows G D, Wood C, Hyman G. Hormones and sexuality: effects of estrogen and progestogen. Obstet Gynecol 1980; 56: 316–322
  • Warnock J B, Bundren J C, Morris D W. Female hypoactive sexual desire disorder due to androgen deficiency: clinical and psychometric issues. Psychopharmacol Bull 1997; 33: 761–766
  • Redmond G P. Hormones and sexual function. Int J Fertil Womens Med 1999; 44: 193–197
  • Hoeger K M, Guzick D S. The use of androgens in menopause. Clin Obstet Gynecol 1999; 42: 883–894
  • Dobs A S, Nguyen T, Pace C, Roberts C P. Differential effects of oral estrogen versus oral estrogen–androgen replacement therapy on body composition in postmenopausal women. J Clin Endocrinol Metab 2002; 87: 1509–1516
  • Gelfand M M, Wiita B. Androgen and estrogen–androgen hormone replacement therapy: a review of the safety literature, 1941–1996. Clin Ther 1997; 19: 383–404
  • Sands R, Studd J. Exogenous androgens in postmenopausal women. Am J Med 1995; 98: 76–79S
  • Rako S. Testosterone deficiency: a key factor in the increased cardiovascular risk to women following hysterectomy or with natural aging?. J Womens Health 1998; 7: 825–829
  • Sherwin B B, Gelfand M M. The role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosom Med 1987; 49: 397–409
  • Sherwin B B. Changes in sexual behavior as a function of plasma sex steroid levels in post-menopausal women. Maturitas 1985; 7: 225–233
  • Sherwin B B, Gelfand M M, Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985; 47: 339–351
  • Bancroft J, Sherwin B B, Alexander G M, Davidson D W, Walker A. Oral contraceptives, androgens, and the sexuality of young women. II. The role of androgens. Arch Sex Behav 1991; 20: 121–135
  • Mathur R S, Landgrebe S C, Moody L O, Semmens J P, Williamson H O. The effect of estrogen treatment on plasma concentrations of steroid hormones, gonadotropins, prolactin and sex hormone-binding globulin in post-menopausal women. Maturitas 1985; 7: 129–133
  • Anastasiadis A G, Davis A R, Salomon L, Burchardt M, Shabsigh R. Hormonal factors in female sexual dysfunction. Curr Opin Urol 2002; 12: 503–507
  • Bancroft J, Davidson D W, Warner P, et al. Androgens and sexual behaviour in women using oral contraceptives. Clin Endocrinol (Oxf) 1980; 12: 327–340
  • Davis A R, Castano P M. Oral contraceptives and libido in women. Annu Rev Sex Res 2004; 15: 297–320
  • Nathorst-Boos J, Hammar M. Effect on sexual life: a comparison between tibolone and a continuous estradiol-norethisterone acetate regimen. Maturitas 1997; 26: 15–20
  • Matson S C, Henderson K A, McGrath G J. Physical findings and symptoms of depot medroxyprogesterone acetate use in adolescent females. J Pediatr Adolesc Gynecol 1997; 10: 18–23
  • Fraser I, Dennerstein G. Depo-Provera use in an Australian metropolitan practice. Med J Aust 1994; 160: 553–556
  • Heber K. Medroxyprogesterone acetate as an injectable contraceptive. Aust Fam Physician 1988; 17: 199–201
  • Kuppermann M, Varner R E, Summitt Jr R L, et al. Effect of hysterectomy vs medical treatment on health-related quality of life and sexual functioning: the medicine or surgery (Ms) randomized trial. JAMA 2004; 291: 1447–1455
  • Sarrel P M. Sexuality and menopause. Obstet Gynecol 1990; 75: 26–30
  • Birrell S N, Butler L M, Harris J M, Buchanan G, Tilley W D. Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancer. FASEB J 2007; 21: 2285–2293
  • Gelfand M M. Sexuality among older women. J Women's Health Gender Based Med 2000; 9: 15–20

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.