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Review

Testosterone therapy for sexual dysfunction in postmenopausal women

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Pages 181-191 | Received 07 Apr 2007, Accepted 13 Dec 2007, Published online: 03 Jul 2009

References

  • Hutchinson K A. Androgens and sexuality. Am J Med 1995; 98: 111–15S
  • Dennerstein L, Dudley E, Burger H. Are changes in sexual functioning during midlife due to aging or menopause. Fertil Steril 2001; 76: 456–460
  • Sarrel P M. Sexuality and menopause. Obstet Gynecol 1990; 75: 26–30S
  • Longcope C. Adrenal and gonadal androgen secretion in normal females. Clin Endocrinol Metab 1986; 15: 213–228
  • Dunn J F, Nisula B C, Rodbard D. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 1981; 53: 58–68
  • Speroff L, Fritz M A. Clinical Gynecologic Endocrinology and Infertility7th edn. Lippincott Williams & Wilkins, Baltimore, MD 2004
  • Adashi E Y. The climacteric ovary as a functional gonadotropin-driven androgen producing gland. Fertil Steril 1994; 62: 20–27
  • Zumoff B, Strain G W, Miller L K, Rosner W. Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Metab 1995; 80: 1429–1430
  • McCoy N L, Davidson J M. A longitudinal study of the effects of menopause on sexuality. Maturitas 1985; 7: 203–210
  • Dennerstein L, Randolph J, Taffe J, Dudley E, Burger H. Hormones, mood, sexuality, and the menopausal transition. Fertil Steril 2002; 77: S42–S48
  • Davis S R, Davison S L, Donath S, Bell R. Relationships between circulating androgen levels and self reported sexual function in women. JAMA 2005; 294: 91–96
  • Taieb J, Mathian B, Millot F, et al. Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children. Clin Chem 2003; 49: 1381–1395
  • American Psychiatric Association. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders4th edn. American Psychiatric Association, Washington, DC 1994
  • Sarrel P M. Sexuality and menopause. Obstet Gynecol 1990; 75: 26–30S
  • Nathorst-Boos J, Wiklund I, Mattsson L A, et al. Is sexual life influenced by transdermal estrogen therapy? A double blind placebo controlled study in postmenopausal women. Acta Obstet Gynecol Scand 1993; 72: 656–660
  • Myers L S, Dixen J, Morrissette D, et al. Effects of estrogen, androgen, and progestin on sexual psychophysiology and behavior in postmenopausal women. J Clin Endocrinol Metab 1990; 70: 1124–1131
  • Nachtigall L E, Raju U, Banderjee S, Wan L, Levitz M. Serum estradiol-binding profiles in postmenopausal women undergoing three common estrogen replacement therapies: associations with sex hormone-binding globulin, estradiol, and estrone levels. Menopause 2000; 7: 243–250
  • Simon J, Klaiber E, Wiita B, Bowen A, Yang H M. Differential effects of estrogen-androgen and estrogen only therapy on vasomotor symptoms, gonadotropin secretion, and endogenous androgen bioavailability in postmenopausal women. Menopause 1999; 6: 138–146
  • Lobo R A, Rosen R C, Yang H W, et al. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 2003; 79: 1341–1352
  • Braunstein G D. Safety of testosterone treatment in postmenopausal women. Fertil Steril 2007; 88: 1–17
  • Sherwin B B, Gelfand M M, Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985; 47: 339–351
  • Burger H, Hailes J, Nelson J, Menelaus M. Effect of combined implants of estradiol and testosterone on libido in postmenopausal women. Br Med J (Clin Res Ed) 1987; 294: 936–937
  • Davis S R, McCloud P, Strauss B JG, Burger H G. Testosterone enhances estradiol's effect on postmenopausal bone density and sexuality. Maturitas 1995; 21: 227–236
  • Sarrel P, Dobay B, Wiita B. Estrogen and estrogen-androgen replacement in postmenopausal women dissatisfied with estrogen-only therapy: sexual behaviour and neuroendocrine responses. J Reprod Med 1998; 43: 847–856
  • Floter A, Nathorst-Boos J, Carlstrom K, von Schoultz B. Addition of testosterone to estrogen replacement therapy in oophorectomized women: effects on sexuality and well-being. Climacteric 2002; 5: 357–365
  • Shifren J L, Braunstein G D, Simon J A, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000; 343: 682–688
  • Buster J E, Kingsberg S A, Aguirre O, et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 2005; 105: 944–952
  • Simon J, Braunstein G, Nachtigall L, et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder: results of the Intimate SM 1 study. J Clin Endocrinol Metab 2005; 90: 5226–5233
  • Braunstein G D, Sundwall D A, Katz M, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med 2005; 165: 1582–1589
  • Cardozo L, Gibb D M, Tuck S M, et al. The effects of subcutaneous hormone implants during climacteric. Maturitas 1984; 5: 177–184
  • Dow M G, Hart D M, Forrest C A. Hormonal treatments of sexual unresponsiveness in postmenopausal women: a comparative study. Br J Obstet Gynaecol 1983; 90: 361–366
  • Montgomery J C, Appleby L, Brincat M, et al. Effect of oestrogen and testosterone implants on psychological disorders in the climacteric. Lancet 1987; 1: 297–299
  • Sherwin B B. Affective changes with estrogen and androgen replacement therapy in surgically menopausal women. J Affect Disord 1988; 14: 177–187
  • Sherwin B B, Gelfand M. Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause. Am J Obstet Gynecol 1985; 151: 153–160
  • Regestein Q, Friebely J, Shifren J, Schiff I. Neurophysiological effects of methyltestosterone in women using menopausal hormonal replacement. J Womens Health Gend Based Med 2001; 10: 671–676
  • Savvas M, Studd J W, Norman S, et al. Increase in bone mass after one year of percutaneous oestradiol and testosterone implants in post-menopausal women who have previously received long-term oral oestrogens. Br J Obstet Gynaecol 1992; 99: 757–760
  • Watts N B, Notelovitz M, Timmons M C, et al. Comparison of oral estrogens and estrogen plus androgen on bone mineral density, menopausal symptoms and lipid-lipoprotein profiles in surgical menopause. Obstet Gynecol 1995; 85: 529–537
  • Whitehead M. Progestins and androgens. Fertil Steril 1994; 62: 161–167S
  • Hickok L R, Toomey C, Speroff L. A comparison of esterified estrogens with and without methyltestosterone: effects on endometrial histology and serum lipoproteins in postmenopausal women. Obstet Gynecol 1993; 82: 919–924
  • Davis S R, Walker K Z, Strauss B J. Effects of estradiol with and without testosterone on body composition and relationships with lipids in post-menopausal women. Menopause 2000; 7: 395–401
  • Gambrell R D, Teran A Z. Changes in lipids and lipoproteins with long-term estrogen deficiency and hormone replacement therapy. Am J Obstet Gynecol 1991; 165: 307–315
  • Sherwin B B, Gelfand M M, Schucher R, Gabor J. Postmenopausal estrogen and androgen replacement and lipoprotein lipid concentrations. Am J Obstet Gynecol 1987; 156: 414–419
  • Worboys S, Kotsopoulos D, Teede H, McGrath B, Davis S R. Evidence that parenteral testosterone therapy may improve endothelium-dependent and -independent vasodilatation in postmenopausal women already receiving estrogen. J Clin Endocrinol Metab 2001; 86: 158–161
  • Barlow D H, Abdalla H I, Roberts A D, Al Azzawi F, Leggate I, Hart D M. Long-term hormone implant therapy: hormonal and clinical effects. Obstet Gynecol 1986; 67: 321–325
  • Somboonporn W, Davis S. National Health and Medical Research Council. Testosterone effects on the breast: implications for testosterone therapy for women. Endoc Rev 2004; 25: 374–388
  • Dimitrakis C, Jones R A, Liu A, Bondy C A. Breast cancer incidence in postmenopausal women using testosterone in addition to usual hormone therapy. Menopause 2004; 11: 531–535
  • Gelfand M M, Wiita B. Androgen and estrogen-androgen hormone replacement therapy: a review of the safety literature, 1941 to 1996. Clin Ther 1997; 19: 383–404
  • Labrie F. Drug insight: breast cancer and tissue-specific hormone replacement therapy. Nat Clin Pract Endocrinol Metab 2007; 3: 584–593
  • Dimitrakakis C, Zhou J, Wang J, et al. A physiologic role for testosterone in limiting estrogenic stimulation of the breast. Menopause 2003; 10: 292–298
  • Gammon M D, Thompson W D. Polycystic ovaries and the risk of breast cancer. Am J Epidemiol 1991; 134: 818–824
  • Tamimi R M, Hankinson S E, Chen W Y, Rosner B, Colditz G A. Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women. Arch Intern Med 2006; 166: 1483–1489
  • Davis S R, Guay A T, Shifren J L, Mazer N A. Endocrine aspects of female sexual dysfunction. J Sex Med 2004; 1: 82–86
  • North American Menopause Society. The role of testosterone therapy in postmenopausal women: position statement of the North American Menopause Society. Menopause 2005; 12: 496–511
  • Wierman M E, Basson R, Davis S R, et al. Androgen therapy in women: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2006; 91: 3697–3710
  • Buckler H M, Robertson W R, Wu F C. Which androgen replacement therapy for women. J Clin Endocrinol Metab 1998; 83: 3920–3924
  • Goldstat R, Briganti E, Tran J, Wolfe R, Davis S R. Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women. Menopause 2003; 10: 390–398

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