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Original Article

A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms

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Pages 574-580 | Received 02 Aug 2016, Accepted 15 Sep 2016, Published online: 20 Oct 2016

References

  • Comhaire FH, Depypere HT. Hormones, herbal preparations and nutriceuticals for a better life after the menopause: part I. Climacteric 2015;18:358–63
  • Hill K. The demography of menopause. Maturitas 1996;23:113–27
  • Peng W, Sibbritt DW, Hickman L, Adams J. Association between use of self-prescribed complementary and alternative medicine and menopause-related symptoms: a cross-sectional study. Complement Ther Med 2015;23:666–73
  • Moilanen J, Aalto AM, Hemminki E, Aro AR, Raitanen J, Luoto R. Prevalence of menopause symptoms and their association with lifestyle among Finnish middle-aged women. Maturitas 2010;67:368–74
  • Gjelsvik B, Rosvold EO, Straand J, Dalen I, Hunskaar S. Symptom prevalence during menopause and factors associated with symptoms and menopausal age. Results from the Norwegian Hordaland Women's Cohort study. Maturitas 2011;70:383–90
  • Hess R, Thurston RC, Hays RD, et al. The impact of menopause on health-related quality of life: results from the STRIDE longitudinal study. Qual Life Res 2012;21:535–44
  • de Villiers TJ, Gass ML, Haines CJ, et al. Global Consensus Statement on menopausal hormone therapy. Climacteric 2013;16:203–4
  • Manson JE, Chlebowski RT, Stefanick ML, et al. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. JAMA 2013;310:1353–68
  • Sood R, Faubion SS, Kuhle CL, Thielen JM, Shuster LT. Prescribing menopausal hormone therapy: an evidence-based approach. Int J Womens Health 2014;6:47–57
  • Bakken K, Fournier A, Lund E, et al. Menopausal hormone therapy and breast cancer risk: impact of different treatments. The European Prospective Investigation into Cancer and Nutrition. Int J Cancer 2011;128:144–56
  • Gompel A, Santen RJ. Hormone therapy and breast cancer risk 10 years after the WHI. Climacteric 2012;15:241–9
  • Whayne TF, Jr, Mukherjee D. Women, the menopause, hormone replacement therapy and coronary heart disease. Curr Opin Cardiol 2015;30:432–8
  • Tsilidis KK, Allen NE, Key TJ, et al. Menopausal hormone therapy and risk of ovarian cancer in the European prospective investigation into cancer and nutrition. Cancer Causes Control 2011;22:1075–84
  • Shufelt CL, Merz CN, Prentice RL, et al. Hormone therapy dose, formulation, route of delivery, and risk of cardiovascular events in women: findings from the Women's Health Initiative Observational Study. Menopause 2014;21:260–6
  • Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321–33
  • Main C, Knight B, Moxham T, et al. Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database Syst Rev 2013;4:CD002229
  • Greiser CM, Greiser EM, Doren M. Menopausal hormone therapy and risk of ovarian cancer: systematic review and meta-analysis. Hum Reprod Update 2007;13:453–63
  • Burger HG, MacLennan AH, Huang KE, Castelo-Branco C. Evidence-based assessment of the impact of the WHI on women's health. Climacteric 2012;15:281–7
  • Peng W, Adams J, Sibbritt DW, Frawley JE. Critical review of complementary and alternative medicine use in menopause: focus on prevalence, motivation, decision-making, and communication. Menopause 2014;21:536–48
  • Borrelli F, Ernst E. Alternative and complementary therapies for the menopause. Maturitas 2010;66:333–43
  • Posadzki P, Lee MS, Moon TW, Choi TY, Park TY, Ernst E. Prevalence of complementary and alternative medicine (CAM) use by menopausal women: a systematic review of surveys. Maturitas 2013;75:34–43
  • Comhaire FH, Depypere HT. Hormones, herbal preparations and nutriceuticals for a better life after the menopause: part II. Climacteric 2015;18:364–71
  • Xia Y, Zhao Y, Ren M, et al. A randomized double-blind placebo-controlled trial of a Chinese herbal medicine preparation (Jiawei Qing'e Fang) for hot flashes and quality of life in perimenopausal women. Menopause 2012;19:234–44
  • Depypere HT, Comhaire FH. Herbal preparations for the menopause: beyond isoflavones and black cohosh. Maturitas 2014;77:191–4
  • Fu SF, Zhao YQ, Ren M, et al. A randomized, double-blind, placebo-controlled trial of Chinese herbal medicine granules for the treatment of menopausal symptoms by stages. Menopause 2016;23:311–23
  • von Studnitz FS, Eulenburg C, Mueck AO, Buhling KJ. The value of complementary and alternative medicine in the treatment of climacteric symptoms: results of a survey among German gynecologists. Complement Ther Med 2013;21:492–5
  • Liu J, Petersen NJ, Lee KF, et al. Application of temperature-correlated mobility theory for optimizing the MEKC separation of the main lignans from Schisandra Chinensis Fructus and its prescription Yuye Decoction. Electrophoresis 2014;35:2907–14
  • Yao Z, Liu XC, Gu YE. Schisandra chinensis Baill, a Chinese medicinal herb, alleviates high-fat-diet-inducing non-alcoholic steatohepatitis in rats. Afr J Tradit Complement Altern Med 2014;11:222–7
  • Chen J, Tian G. [Ecological investigation on Schisandra chinensis (Turcz.) Baill. of the Changbai Mountain]. Zhongguo Zhong Yao Za Zhi 1992;17:204–5, 55
  • Zhang L, Chen Z, Li X. [Seed germinative characteristics and embryo development of Schisandra chinensis (Turcz.) Bail]. Zhongguo Zhong Yao Za Zhi 1999;24:459–61, 510
  • Zhu M, Lin KF, Yeung RY, Li RC. Evaluation of the protective effects of Schisandra chinensis on Phase I drug metabolism using a CCl4 intoxication model. J Ethnopharmacol 1999;67:61–8
  • Lou Z, Zhang H, Gong C, et al. Analysis of lignans in Schisandra chinensis and rat plasma by high-performance liquid chromatography diode-array detection, time-of-flight mass spectrometry and quadrupole ion trap mass spectrometry. Rapid Commun Mass Spectrom 2009;23:831–42
  • Young Park J, Wook Yun J, Whan Choi Y, et al. Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability. Hypertens Res 2012;35:928–34
  • Kupperman HS, Blatt MH, Wiesbader H, Filler W. Comparative clinical evaluation of estrogenic preparations by the menopausal and amenorrheal indices. J Clin Endocrinol Metab 1953;13:688–703
  • Kupperman HS, Wetchler BB, Blatt MH. Contemporary therapy of the menopausal syndrome. J Am Med Assoc 1959;171:1627–37
  • Schneider HP, Heinemann LA, Rosemeier HP, Potthoff P, Behre HM. The Menopause Rating Scale (MRS): comparison with Kupperman index and quality-of-life scale SF-36. Climacteric 2000;3:50–8
  • Heinemann K, Assmann A, Mohner S, Schneider HP, Heinemann LA. [Reliability of the Menopause Rating Scale (MRS): Investigation in the German population]. Zentralbl Gynakol 2002;124:161–3
  • Schneider HP, Heinemann LA, Rosemeier HP, Potthoff P, Behre HM. The Menopause Rating Scale (MRS): reliability of scores of menopausal complaints. Climacteric 2000;3:59–64
  • Zhong S, Nie YC, Gan ZY, et al. Effects of Schisandra chinensis extracts on cough and pulmonary inflammation in a cough hypersensitivity guinea pig model induced by cigarette smoke exposure. J Ethnopharmacol 2015;165:73–82
  • Chun JN, Cho M, So I, Jeon JH. The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms. Fitoterapia 2014;97:224–33
  • Bae H, Kim R, Kim Y, et al. Effects of Schisandra chinensis Baillon (Schizandraceae) on lipopolysaccharide induced lung inflammation in mice. J Ethnopharmacol 2012;142:41–7
  • Lee SK, Kim SD, Lee HY, et al. alpha-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsis. Biochem Biophys Res Commun 2012;426:226–31
  • Lu Y, Chen DF. Analysis of Schisandra chinensis and Schisandra sphenanthera. J Chromatogr A 2009;1216:1980–90
  • Kim JE, Kim SG, Goo JS, et al. The alpha-iso-cubebenol compound isolated from Schisandra chinensis induces p53-independent pathway-mediated apoptosis in hepatocellular carcinoma cells. Oncol Rep 2012;28:1103–9
  • Oh SY, Kim YH, Bae DS, et al. Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Biosci Biotechnol Biochem 2010;74:285–91
  • Chen X, Zhang Y, Zu Y, Yang L. Chemical composition and antioxidant activity of the essential oil of Schisandra chinensis fruits. Nat Prod Res 2012;26:842–9
  • Cheng Z, Song H, Yang Y, Zhou H, Liu Y, Liu Z. Smashing tissue extraction of five lignans from the fruit of Schisandra chinensis. J Chromatogr Sci 2016;54:246–56
  • Chen Q, Wu YJ, Cheng NN, Li YL, Wang YM. [Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A]. Yao Xue Xue Bao 2010;45:1194–8
  • Hsieh MT, Wu CR, Wang WH, Lin LW. The ameliorating effect of the water layer of Fructus Schisandrae on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors. Pharmacol Res 2001;43:17–22
  • Hu D, Cao Y, He R, et al. Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Abeta1-42-induced memory impairment in mice. Oxid Med Cell Longev 2012;2012:721721
  • Song JX, Lin X, Wong RN, et al. Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells. Phytother Res 2011;25:435–43
  • Chan SW. Panax ginseng, Rhodiola rosea and Schisandra chinensis. Int J Food Sci Nutr 2012;63(Suppl 1):75–81
  • Hu D, Li C, Han N, et al. Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Abeta(1)(-)(4)(2)-induced memory impairment in mice. Planta Med 2012;78:1332–6
  • Lee SK, Kim SD, Kook M, et al. Therapeutic effects of alpha-iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, against sepsis. Biochem Biophys Res Commun 2012;427:547–52
  • Lee KP, Kang S, Park SJ, et al. Anti-allergic effect of alpha-cubebenoate isolated from Schisandra chinensis using in vivo and in vitro experiments. J Ethnopharmacol 2015;173:361–9
  • Hu D, Yang Z, Yao X, et al. Dibenzocyclooctadiene lignans from Schisandra chinensis and their inhibitory activity on NO production in lipopolysaccharide-activated microglia cells. Phytochemistry 2014;104:72–8
  • Liu CJ, Zhang SQ, Zhang JS, Liang Q, Li DS. Chemical composition and antioxidant activity of essential oil from berries of Schisandra chinensis (Turcz.) Baill. Nat Prod Res 2012;26:2199–203
  • Guo LY, Hung TM, Bae KH, et al. Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. Eur J Pharmacol 2008;591:293–9
  • Kang S, Lee KP, Park SJ, et al. Identification of a novel anti-inflammatory compound, alpha-cubebenoate from Schisandra chinensis. J Ethnopharmacol 2014;153:242–9
  • Kook M, Lee SK, Kim SD, et al. Anti-septic activity of alpha-cubebenoate isolated from Schisandra chinensis. BMB Rep 2015;48:336–41

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