The futile case of the aging ovary: is it mission impossible? A focused review

References

• Szafarowska M, Jerzak M. [Ovarian aging and infertility]. Ginekol Pol 2013;84:298–304
   PubMed Web of Science ®Google Scholar
• Toner JP, Philput CB, Jones GS, Muasker ST. Basal follicle-stimulating hormone level is a better predictor of in vitro fertilization performance than age. Fertil Steril 1991;55:784–91
   PubMed Web of Science ®Google Scholar
• Shapiro BS, Daneshman ST, Desai J, Garner FC, Aquirre M, Hudson C. The risk of embryo-endometrial asynchrony increases with maternal age after ovarian stimulation and in vitro fertilization. Reprod Biomed Online 2016;33:50–5
   PubMed Web of Science ®Google Scholar
• Practice Committee of the American Society for Reproductive Medicine (ASRM). Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril 2015;103:e9–17
   PubMed Web of Science ®Google Scholar
• Hipp H, Crawford S, Kawwass JF, et al. National trends and outcomes of autologous in vitro fertilization cycles among women aged 40 years and older. J Assist Reprod Genet 2017;34:885–94
   PubMed Web of Science ®Google Scholar
• Gleicher N, Kushnir VA, Albertini DF, Barad DH. Improvements in IVF in women of advanced age. J Endocrinol 2016;230:F1–6
   PubMed Web of Science ®Google Scholar
• Gleicher N, Kushnir VA, Weghofer A, Barad DH. The ‘graying’ of infertility services: an impending revolution nobody is ready for. Reprod Biol Endocrinol 2014;12:63
   PubMed Web of Science ®Google Scholar
• Cabry R, Merviel P, Hazout A, et al. Management of infertility in women over 40. Maturitas 2014;78:17–21
   PubMed Web of Science ®Google Scholar
• Gleicher N, Weghofer A, Barad DH. Defining ovarian reserve to better understand ovarian aging. Reprod Biol Endocrinol 2011;9:23
   PubMed Web of Science ®Google Scholar
• Wu YG, Barad DH, Kushnir VA, et al. Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval. J Endocrinol 2015;226:167–80
   PubMed Web of Science ®Google Scholar
• Pandian Z, McTavish AR, Aucoyy L, Hamilton MP, Bhattacharya S. Interventions for poor responders to controlled ovarian hyperstimulation in IVF. Cochrane Database Syst Rev 2010;(1):CD004379
   PubMed Web of Science ®Google Scholar
• Friedler S, Meltzer S, San- Ryss B, Robinson J, Lazer T, Libaty G. An upper limit of gonadotropin dose in patients undergoing ART should be advocated. Gynecol Endocrinol 2016;32:965–9
   PubMed Web of Science ®Google Scholar
• Baart EB, Martini E, Eijkemans MJ, et al. Milder ovarian stimulation for IVF reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Hum Reprod 2007;22:980–8
   PubMed Web of Science ®Google Scholar
• Song D, Shi Y, Zhong Y, Meng Q, Hou S, Li H. Efficiency of mild ovarian stimulation with clomiphene on poor ovarian responders during IVF\ICSI procedures: a meta-analysis. Eur J Obstet Gynecol Reprod Biol 2016;204:36–43
   PubMed Web of Science ®Google Scholar
• Gianaroli L, Magli MC, Cavallini G, et al. Predicting aneuploidy in human oocytes: key factors which affect the meiotic process. Hum Reprod 2010;25:2374–86
   PubMed Web of Science ®Google Scholar
• Baker VL, Brown MB, Luke B, Smith GW, Ireland JJ. Gonadotropin dose is negatively correlated with live birth rate: analysis of more than 650,000 assisted reproductive technology cycles. Fertil Steril 2015;104:1145–52
   PubMed Web of Science ®Google Scholar
• Yang R, Li H, Li R, Liu P, Qiao JA. comparison among different methods of letrozole combined with gonadotropins in an antagonist protocol and high-dose gonadotropin ovarian stimulation antagonist protocol in poor ovarian responders undergoing IVF. Arch Gynecol Obstet 2016;294:1091–7
   PubMed Web of Science ®Google Scholar
• Merviel P, Cabry-Goubet R, Lourdel E, et al. Comparative prospective study of 2 ovarian stimulation protocols in poor responders: effect on implantation rate and ongoing pregnancy rate. Reprod Health 2015;12:52
   PubMed Web of Science ®Google Scholar
• Jeve YB, Bhandari HM. Effective treatment protocol for poor ovarian response: a systematic review and meta-analysis. J Hum Reprod Sci 2016;9:70–81
   PubMedGoogle Scholar
• Xiao J, Chang S, Cheu S. The effectiveness of gonadotropin-releasing hormone antagonist in poor ovarian responders undergoing IVF. Fertil Steril 2013;100:1594–601
   PubMed Web of Science ®Google Scholar
• Polyzos NP, Devos M, Humaidan P, et al. Corifollitropin alfa followed by recombinant FSH in a GnRH antagonist protocol for poor ovarian responder patients: an observational pilot study. Fertil Steril 2013;99:422–6
   PubMed Web of Science ®Google Scholar
• Liondires MP, Escalpes M, Segaus JH, Scott RT Jr, Muller BT. Microdose follicular phase gonadotropin releasing hormone agonist compared with luteal phase agonist for ovarian stimulation in IVF. Fertil Steril 1999;72:1018–23
   PubMed Web of Science ®Google Scholar
• Toth TL, Awwad JT, Veech LL, Jones HW, Muasher SJ. Suppression and flare regimens of gonadotropin-releasing hormone agonist: use in women with different basal gonadotropin values in an IVF program. J Reprod Med Obstet Gynecol 1996;41:321–6
   Google Scholar
• Helher SG, Zelenik AJ, Ron GT. Independence of steroidogenic capacity and the luteinizing hormone receptor induction in developing granulosa cells. Endocrinology 1978;102:937–46
   PubMed Web of Science ®Google Scholar
• Hill MJ, Levenes ED, Levy G, et al. The use of recombinant luteinizing hormone in patients undergoing assisted reproductive techniques with advanced reproductive age: a systematic review and meta-analysis. Fertil Steril 2012;97:1108–14
   PubMed Web of Science ®Google Scholar
• Baerwald AR, Adams GP, Pierson RA. A new model for ovarian follicular development during the human menstrual cycle. Fertil Steril 2003;80:116–22
   PubMed Web of Science ®Google Scholar
• Yang DZ, Yang W, Li Y, He Z. Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction. J Assist Reprod Genet 2013;30:213–9
   PubMed Web of Science ®Google Scholar
• Kansal Kalra S, Ratcliffe S, Gracia CR, et al. Randomized controlled pilot trial of luteal phase recombinant FSH stimulation in poor responders. Reprod Biomed Online 2008;17:745–50
   PubMed Web of Science ®Google Scholar
• Kuang Y, Chen Q, Hong Q, et al. Double stimulations during the follicular and luteal phases of poor responders in IVF/ICSI programmes (Shanghai protocol). Reprod Biomed Online 2014;29:684–91
   PubMed Web of Science ®Google Scholar
• Zhang Q, Guo XM, Li Y. Implantation rates subsequent to the transfer of embryos produced at different phases during double stimulation of poor ovarian responders. Reprod Fertil Dev 2016;29:1178–83
   Web of Science ®Google Scholar
• Morgia F, Sbracia M, Schimberni M, et al. A controlled trial of natural cycle versus microdose GnRH analogue flare cycle in poor responders undergoing IVF. Fertil Steril 2004;81:1542–7
   PubMed Web of Science ®Google Scholar
• Reynolds KA, Omurtag KR, Jimenez PT, Rhee JS, Tuuli MG, Jungheim ES. Cycle cancellation and pregnancy after luteal estradiol priming in women defined as poor responders: a systematic review and meta-analysis. Hum Reprod 2013;28:2981–9
   PubMed Web of Science ®Google Scholar
• Cobo A, Garrido N, Crespo J, Jox A, Pellicer A. Accumulation of oocytes: a new strategy for managing low-responder patients. Reprod Biomed Online 2012;24:424–32
   PubMed Web of Science ®Google Scholar
• Allahbadia GN. Getting older women pregnant: contemporary thoughts. J Obstet Gynaecol India 2016;66:305–9
   PubMed Web of Science ®Google Scholar
• Tannus S, Son WY, Gilman A, Younes G, Shavit T, Dahan MH. The role of intracytoplasmic sperm injection in non-male factor infertility in advanced maternal age. Hum Reprod 2017;32:119–24
   PubMed Web of Science ®Google Scholar
• Li XL, Wang LI, Lei F, et al. The influence of different growth hormone addition protocols to poor ovarian responders on clinical outcomes in controlled ovary stimulation cycles. Medicine (Baltimore) 2017;96:1–8
   Web of Science ®Google Scholar
• Kloibianakis EM, Venetis CA, Diedrich K, Tarlotzis C, Griesinger G. Addition of growth hormone to gonadotropins in ovarian stimulation of poor responders treated by IVF: a systematic review and meta-analysis. Hum Reprod Update 2008;15:613–22
   Web of Science ®Google Scholar
• Nagels HE, Rishworth JR, Siristatides CS, Kroon B. Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. Cochrane Database Syst Rev 2015;(11):CD009749
   PubMed Web of Science ®Google Scholar
• Ethics Committee of the American Society for Reproductive Medicine. Oocyte or embryo donation to women of advanced reproductive age: an Ethics Committee opinion. Fertil Steril 2016;106:e3–7
   PubMed Web of Science ®Google Scholar
• Yeh JS, Steward RG, Dude AM, et al. Pregnancy rates in donor oocyte cycles compared to similar autologous in vitro fertilization cycles: an analysis of 26,457 fresh cycles from the Society for Assisted Reproductive Technology. Fertil Steril 2014;102:399–404
   PubMed Web of Science ®Google Scholar
• Zwerfel JE. Donor conception from the viewpoints of the child: positives, negatives and promoting the welfare of the child. Fertil Steril 2015;104:513–9
   PubMed Web of Science ®Google Scholar
• Rulli T. What is the value of three-parent IVF? Hastings Cent Rep 2016;46:38–47
   PubMed Web of Science ®Google Scholar
• Gollihue JL, Rabchevsky AG. Prospects for therapeutic mitochondrial transplantation. Mitochondrion 2017;35:70–9
   PubMed Web of Science ®Google Scholar
• Schatten H, Sun QY, Prather R. The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility. Reprod Biol Endocrinol 2014;12:111
   PubMed Web of Science ®Google Scholar
• Cohen J, Scott R, Alikani M, et al. Ooplasmic transfer in mature human oocytes. Mol Hum Reprod 1998;4:269–80
   PubMed Web of Science ®Google Scholar
• Yabuuchi A, Beyhan Z, Kagawa N, et al. Prevention of mitochondrial disease inheritance by assisted reproductive technologies: prospects and challenges. Biochim Biophys Acta 2012;1820:637–42
   PubMed Web of Science ®Google Scholar
• The Incredible, Surprising, Controversial, New Way to Make a Baby. 2016. Available from: http://www.ovascience.com/files/TIME_Magazine_May_2015.pdf
   Google Scholar
• Coghlan A, Exclusive: ‘3-parent’ baby method already used for infertility. New Sci 2016. Available from: https://www.newscientist.com/article/2108549-exclusive-3-parent-baby-method-already-used-for-infertility/
   Google Scholar
• Zhang J, Zhuang G, Zeng Y, et al. Pregnancy derived from human zygote pronuclear transfer in a patient who had arrested embryos after IVF. Reprod Biomed Online 2016;33:529–33
   PubMed Web of Science ®Google Scholar
• Virant-Klun I, Rozman P, Cvjeticanin B, et al. Parthenogenetic embryo-like structures in the human ovarian surface epithelium cell culture in postmenopausal women with no naturally present follicles and oocytes. Stem Cells Dev 2009;18:137–49
   PubMed Web of Science ®Google Scholar
• Hendriks S, Dancet EA, van Pelt AM, Hamer G, Repping S. Artificial gametes: a systematic review of biological progress towards clinical application. Hum Reprod Update 2015;21:285–96
   PubMed Web of Science ®Google Scholar