Similarities and differences between insulin and IGF-I: Structures, receptors, and signalling pathways

References

• Abbott A M, Bueno R, Pedrini M T, Murray J M, Smith R J. Insulin-like growth factor I receptor gene structure. J Biol Chem 1992; 267: 10759–1063
   PubMed Web of Science ®Google Scholar
• Accili D, Drago J, Lee E J, Johnson M D, Cool M H, Salvatore P, Asico L D, Jose P A, Taylor S I, Westphal H. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genetics 1996; 12: 106–109
   PubMed Web of Science ®Google Scholar
• Alarcon C, Morales A V, Pimentel B, Serna J, de Pablo F. (Pro)insulin and insulin-like growth factor I complementary expression and roles in early development. Comp Biochem Physiol B Biochem Mol Biol 1998; 121: 13–17
   PubMed Web of Science ®Google Scholar
• Baker J, Liu J-P, Robertson E J, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993; 75: 73–82
   PubMed Web of Science ®Google Scholar
• Baxter R C. Insulin-like growth factor-binding proteins: interactions with IGFs and intrinsic bioactivities. Am J Physiol 2000; 278: 967–976
   PubMed Web of Science ®Google Scholar
• Bayne M L, Applebaum J, Underwood D, Chicchi G G, Green B G, Hayes N S, Cascieri M A. The C region of the human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor. J Biol Chem 1989; 264: 11004–11011
   PubMed Web of Science ®Google Scholar
• Bendall S C, Stewart M H, Menendez P, George D, Vijayaragavan K, Werbowetski-Ogilvie T, Ramos-Mejia V, Rouleau A, Yang J, Bosse M, et al. IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature 2007; 448: 1015–1023
   PubMed Web of Science ®Google Scholar
• Bentov I, Werner H. IGF, IGF receptor and overgrowth syndromes. Pediatr Endocrinol Rev 2004; 1: 352–360
   PubMedGoogle Scholar
• Bentov I, Werner H. Insulin-like growth factor-I. Handbook of Biologically Active Peptides, A Kastin. Elsevier Press, San Diego 2006; 1385–1392
   Google Scholar
• Christofori G, Naik P, Hanahan D. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature 1994; 369: 414–418
   PubMed Web of Science ®Google Scholar
• DeChiara T M, Efstratiadis A, Robertson E J. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 1990; 345: 78–80
   PubMed Web of Science ®Google Scholar
• Denley A, Brierley G V, Carroll J M, Lindenberg A, Booker G W, Cosgrove L, Wallace J C, Forbes B E, Roberts C T, Jr. Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain. Endocrinology 2006; 147: 1029–1036
   PubMed Web of Science ®Google Scholar
• Dupont J, LeRoith D. Insulin and insulin-like growth factor-I receptors: similarities and differences in signal transduction. Hormone Research 2001; 55(Suppl. 2)22–26
   PubMedGoogle Scholar
• Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Qu J, Masiarz F, Kan Y W, Goldfine I D, Roth R A, Rutter W J. The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell 1985; 40: 747–758
   PubMed Web of Science ®Google Scholar
• Florini J R, Ewton D Z. Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-I. J Biol Chem 1990; 265: 13435–13437
   PubMed Web of Science ®Google Scholar
• Frasca F, Pandini G, Scalia R, Sciacca L, Mineo R, Constantino A, Goldfine I D, Belfiore A, Vigneri R. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol 1999; 19: 3278–3288
   PubMed Web of Science ®Google Scholar
• Grill C J, Cohick W S. Insulin-like growth factor binding protein-3 mediates IGF-I action in a bovine mammary epithelial cell line independent of an IGF interaction. J Cell Physiol 2000; 183: 273–283
   PubMed Web of Science ®Google Scholar
• Guler H P, Zapf J, Froesch E R. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. New England J Med 1987; 317: 137–140
   PubMed Web of Science ®Google Scholar
• Holly J, Perks C. The role of insulin-like growth factor binding proteins. Neuroendocrinology 2006; 83: 154–160
   PubMed Web of Science ®Google Scholar
• Jacobs S, Kull F C, Jr, Cuatrecasas P. Monensin blocks the maturation of receptors for insulin and somatomedin C: identification of receptor precursors. Proc Natl Acad Sci USA 1983; 80: 1228–1232
   PubMed Web of Science ®Google Scholar
• Kjeldsen T, Andersen A S, Wiberg F C, Rasmussen J S, Schaffer L, Balschmidt P, Moller K B, Moller N PH. The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site. Proc Natl Acad Sci USA 1991; 88: 4404–4408
   PubMed Web of Science ®Google Scholar
• Klammt J, Garten A, Barnikol-Oettler A, Beck-Sickinger A G, Kiess W. Comparative analysis of the signalling capabilities of the insulin receptor-related receptor. Biochem Biophys Res Comm 2005; 327: 557–564
   PubMed Web of Science ®Google Scholar
• Laviola L, Giorgino F, Chow J C, Baquero J A, Hansen H, Ooi J, Zhu J, Riedel H, Smith R J. The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts. J Biol Chem 1997; 99: 830–837
   Google Scholar
• Leboulleux S, Gaston V, Boulle N, Le Bouc Y, Gicquel C. Loss of heterozygosity at the mannose-6-phosphate/insulin-like growth factor 2 receptor locus: a frequent but late event in adrenocortical tumorigenesis. Eur J Endocrinol 2001; 144: 163–168
   PubMed Web of Science ®Google Scholar
• LeRoith D, Bondy C, Yakar S, Liu J-L, Butler A. The Somatomedin hypothesis: 2001. Endocrine Rev 2001; 22: 53–74
   PubMed Web of Science ®Google Scholar
• LeRoith D, Werner H, Beitner-Johnson D, Roberts C T, Jr. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocrine Rev 1995; 16: 143–163
   PubMed Web of Science ®Google Scholar
• Liu J-P, Baker J, Perkins A S, Robertson E J, Estratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993; 75: 59–72
   PubMed Web of Science ®Google Scholar
• Lu K, Campisi J. Ras proteins are essential and selective for the action of insulin-like growth factor 1 late in the G1 phase of the cell cycle in BALB/c murine fibroblasts. Proc Natl Acad Sci USA 1992; 89: 3889–3893
   PubMed Web of Science ®Google Scholar
• Macaulay V M. Insulin-like growth factors and cancer. Br J Cancer 1992; 65: 311–320
   PubMed Web of Science ®Google Scholar
• Mastick C C, Brady M J, Printen J A, Ribon V, Saltiel A R. Spatial determinants of specificity in insulin action. Mol Cell Biochem 1998; 182: 65–71
   PubMed Web of Science ®Google Scholar
• Morgan D O, Edman J C, Standring D N, Fried V A, Smith M C, Roth R A, Rutter W J. Insulin-like growth factor II receptor as a multifunctional binding protein. Nature 1987; 329: 301–307
   PubMed Web of Science ®Google Scholar
• Morrione A, Valentinis B, Xu S, Yumet G, Louvi A, Efstratiadis A, Baserga R. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc Natl Acad Sci USA 1997; 94: 3777–3782
   PubMed Web of Science ®Google Scholar
• Moschos S J, Mantzoros C S. The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology 2002; 63: 317–332
   PubMed Web of Science ®Google Scholar
• Najjar S M, Blakesley V A, Li Calzi S, Kato H, LeRoith D, Choice C V. Differential phosphorylation of pp120 by insulin and insulin-like growth factor I receptors: role for the C-terminal domain of the beta-subunit. Biochemistry 1997; 36: 6827–6834
   PubMed Web of Science ®Google Scholar
• Nakae J, Kido Y, Accili D. Distinct and overlapping functions of insulin and IGF-I receptors. Endocrine Rev 2001; 22: 818–835
   PubMed Web of Science ®Google Scholar
• Powell-Braxton L, Hollingshead P, Warburton C, Dowd M, Pitts-Meek S, Dalton D, Gillett N, Stewart T A. IGF-I is required for normal embryonic growth in mice. Genes and Development 1993; 7: 2609–2617
   PubMed Web of Science ®Google Scholar
• Rechler M, Zapf J, Nissley S, Froesch E, Moses A, Podskalny J, Schilling E, Humbel R. Interactions of insulin-like growth factors I and II and multiplication-stimulating activity with receptors and serum carrier proteins. Endocrinology 1980; 107: 1451–1458
   PubMed Web of Science ®Google Scholar
• Resnicoff M, Abraham D, Yutanawiboonchai W, Rotman H L, Kajstura J, Rubin R, Zoltick P, Baserga R. The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res 1995; 55: 2463–2469
   PubMed Web of Science ®Google Scholar
• Rinderknecht E, Humbel R E. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem 1978; 253: 2769–2776
   PubMed Web of Science ®Google Scholar
• Rosenfeld R G. The IGF system: new developments relevant to pediatric practice. Endocr Dev 2005; 9: 1–10
   PubMedGoogle Scholar
• Rubini M, Hongo A, D'Ambrosio C, Baserga R. The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Exp Cell Res 1997; 230: 284–292
   PubMed Web of Science ®Google Scholar
• Salmon W D, Daughaday W H. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med 1957; 49: 825–836
   PubMed Web of Science ®Google Scholar
• Seino S, Seino M, Nishi S, Bell G I. Structure of the human insulin receptor gene and characterization of its promoter. Proc Natl Acad Sci USA 1989; 86: 114–118
   PubMed Web of Science ®Google Scholar
• Sell C, Baserga R, Rubin R. Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Res 1995; 55: 303–306
   PubMedGoogle Scholar
• Shier P, Watt V M. Primary structure of a putative receptor for a ligand of the insulin family. J Biol Chem 1989; 264: 14605–14608
   PubMed Web of Science ®Google Scholar
• Tollefsen S E, Thompson K. The structural basis for insulin-like growth factor I receptor high affinity binding. J Biol Chem 1988; 263: 16267–16273
   PubMed Web of Science ®Google Scholar
• Ullrich A, Bell J R, Chen E Y, Herrera R, Petruzzeli L M, Dull T J, Gray A, Coussens L, Liao Y-C, Tsubokawa M, et al. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 1985; 313: 756–761
   PubMed Web of Science ®Google Scholar
• Ullrich A, Gray A, Tam A W, Yang-Feng T, Tsubowka M, Collins C, Henzel W, Lebon T, Kathuria S, Chen F, et al. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests determinants that define functional specificity. EMBO J 1986; 5: 2503–2512
   PubMed Web of Science ®Google Scholar
• Werner H, LeRoith D. New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia. Cell Mol Life Sci 2000; 57: 932–942
   PubMed Web of Science ®Google Scholar
• Werner H, Woloschak M, Stannard B, Shen-Orr Z, Roberts C T, Jr, LeRoith D. Insulin-like growth factor receptor: Molecular biology, heterogeneity, and regulation. Insulin-like Growth Factors: Molecular and Cellular Aspects, D LeRoith. CRC Press, Boca Raton, FL 1991; 17–47
   Google Scholar
• Yakar S, Liu J L, Stannard B, Butler A, Accili D, Sauer B, LeRoith D. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA 1999; 96: 7324–7329
   PubMed Web of Science ®Google Scholar
• Yakar S, Sun H, Zhao H, Pennisi P, Toyoshima Y, Setser J, Stannard B, Scavo L, LeRoith D. Metabolic effects of IGF-I deficiency: lessons from mouse models. Pediatr Endocrinol Rev 2005; 3: 11–19
   PubMedGoogle Scholar
• Zapf A, Hsu D, Olefsky J M. Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts. Endocrinology 1994; 134: 2445–2452
   PubMed Web of Science ®Google Scholar