176
Views
12
CrossRef citations to date
0
Altmetric
Review

Insulin analogues: Action profiles beyond glycaemic control

&
Pages 45-53 | Received 21 Jan 2008, Accepted 07 Feb 2008, Published online: 10 Oct 2008

References

  • Anderson J H, Jr., Brunelle R L, Koivisto V A, Pfutzner A, Trautmann M E, Vignati L, DiMarchi R. Reduction of postprandial hyperglycemia and frequency of hypoglycemia in IDDM patients on insulin-analog treatment. Multicenter Insulin Lispro Study Group. Diabetes 1997; 46: 265–270
  • Barnett A H. How well do rapid-acting insulins work in obese individuals. Diabetes Obes Metab 2006; 8: 388–395
  • Becker R H, Frick A D, Burger F, Potgieter J H, Scholtz H. Insulin glulisine, a new rapid-acting insulin analogue, displays a rapid time-action profile in obese non-diabetic subjects. Exp Clin Endocrinol Diabetes 2005; 113: 435–443
  • Berti L, Kellerer M, Bossenmaier B, Seffer E, Seipke G, Haring H U. The long acting human insulin analog HOE 901: characteristics of insulin signalling in comparison to Asp(B10) and regular insulin. Horm Metab Res 1998; 30: 123–129
  • Bornfeldt K E, Gidlof R A, Wasteson A, Lake M, Skottner A, Arnqvist H J. Binding and biological effects of insulin, insulin analogues and insulin-like growth factors in rat aortic smooth muscle cells. Comparison of maximal growth promoting activities. Comparison of maximal growth promoting activities. Diabetologia 1991; 34: 307–313
  • Boskovic R, Feig D S, Derewlany L, Knie B, Portnoi G, Koren G. Transfer of insulin lispro across the human placenta: in vitro perfusion studies. Diabetes Care 2003; 26: 1390–1394
  • Brunelle B L, Llewelyn J, Anderson J H, Jr., Gale E A, Koivisto V A. Meta-analysis of the effect of insulin lispro on severe hypoglycemia in patients with type 1 diabetes. Diabetes Care 1998; 21: 1726–1731
  • Bruning J C, Gautam D, Burks D J, Gillette J, Schubert M, Orban P C, Klein R, Krone W, Muller-Wieland D, Kahn C R. Role of brain insulin receptor in control of body weight and reproduction. Science 2000; 289: 2122–2125
  • Brunner G A, Hirschberger S, Sendlhofer G, Wutte A, Ellmerer M, Balent B, Schaupp L, Krejs G J, Pieber T R. Post-prandial administration of the insulin analogue insulin aspart in patients with Type 1 diabetes mellitus. Diabet Med 2000a; 17: 371–375
  • Brunner G A, Sendhofer G, Wutte A, Ellmerer M, Sogaard B, Siebenhofer A, Hirschberger S, Krejs G J, Pieber T R. Pharmacokinetic and pharmacodynamic properties of long-acting insulin analogue NN304 in comparison to NPH insulin in humans. Exp Clin Endocrinol Diabetes 2000b; 108: 100–105
  • Brunton S A. Nocturnal Hypoglycemia: Answering the Challenge With Long-acting Insulin Analogs. MedGenMed 2007; 9: 38
  • Calle-Pascual A L, Bagazgoitia J, Calle J R, Charro A, Maranes J P. Use of insulin lispro in pregnancy. Diabetes Nutr Metab 2000; 13: 173–177
  • Chapman T M, Perry C M. Spotlight on insulin detemir in type 1 and 2 diabetes mellitus. BioDrugs 2005; 19: 67–69
  • Ciaraldi T P, Carter L, Seipke G, Mudaliar S, Henry R R. Effects of the long-acting insulin analog insulin glargine on cultured human skeletal muscle cells: comparisons to insulin and IGF-I. J Clin Endocrinol Metab 2001; 86: 5838–5847
  • Ciaraldi T P, Phillips S A, Carter L, Aroda V, Mudaliar S, Henry R R. Effects of the rapid-acting insulin analog glulisine on cultured human skeletal muscle cells: Comparisons with insulin and insulin-like growth factor I. J Clin Endocrinol Metab 2005; 90: 5551–5558
  • Dailey G, Rosenstock J, Moses R G, Ways K. Insulin glulisine provides improved glycemic control in patients with type 2 diabetes. Diabetes Care 2004; 27: 2363–2368
  • Di Cianni G, Volpe L, Ghio A, Lencioni C, Cuccuru I, Benzi L, Del Prato S. Maternal metabolic control and perinatal outcome in women with gestational diabetes mellitus treated with lispro or aspart insulin: comparison with regular insulin. Diabetes Care 2007; 30: e11
  • Dornhorst A, Luddeke H J, Honka M, Ackermann R W, Merilainen M, Gallwitz B, Sreenan S, Group O B. Safety and efficacy of insulin detemir basal-bolus therapy in type 1 diabetes patients: 14-week data from the European cohort of the PREDICTIVE study. Curr Med Res Opin 2007; 24: 369–376
  • Drejer K. The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake. Diabetes Metab Rev 1992; 8: 259–285
  • Dreyer M, Prager R, Robinson A, Busch K, Ellis G, Souhami E, Van Leendert R. Efficacy and safety of insulin glulisine in patients with type 1 diabetes. Horm Metab Res 2005; 37: 702–707
  • Duckworth W, Davis S N. Comparison of insulin glargine and NPH insulin in the treatment of type 2 diabetes: a review of clinical studies. J Diabetes Complications 2007; 21: 196–204
  • Eckardt K, May C, Koenen M, Eckel J. IGF-1 receptor signalling determines the mitogenic potency of insulin analogues in human smooth muscle cells and fibroblasts. Diabetologia 2007; 50: 2534–2543
  • Eckel J. Insulin analogs revisited. Current Medicinal Chemistry – Immunology, Endocrine & Metabolic Agents. 2005; 5: 475–484
  • Ellmerer M, Schaupp L, Brunner G A, Sendlhofer G, Wutte A, Wach P, Pieber T R. Measurement of interstitial albumin in human skeletal muscle and adipose tissue by open-flow microperfusion. Am J Physiol Endocrinol Metab 2000; 278: E352–E356
  • Fulcher G R, Gilbert R E, Yue D K. Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy. Intern Med J 2005; 35: 536–542
  • Galloway J A, Chance R E. Improving insulin therapy: achievements and challenges. Horm Metab Res 1994; 26: 591–598
  • Garg S K, Anderson J H, Gerard L A, Mackenzie T A, Gottlieb P A, Jennings M K, Chase H P. Impact of insulin lispro on HbA1c values in insulin pump users. Diabetes Obes Metab 2000; 2: 307–311
  • Garg S K, Frias J P, Anil S, Gottlieb P A, MacKenzie T, Jackson W E. Insulin lispro therapy in pregnancies complicated by type 1 diabetes: glycemic control and maternal and fetal outcomes. Endocr Pract 2003; 9: 187–193
  • Garg S K, Rosenstock J, Ways K. Optimized Basal-bolus insulin regimens in type 1 diabetes: insulin glulisine versus regular human insulin in combination with Basal insulin glargine. Endocr Pract 2005; 11: 11–17
  • Gerich J, Becker R H, Zhu R, Bolli G B. Fluctuation of serum Basal insulin levels following single and multiple dosing of insulin glargine. Diabetes Technol Ther 2006; 8: 237–243
  • Griffen S C, Oostema K, Stanhope K L, Graham J, Styne D M, Glaser N, Cummings D E, Connors M H, Havel P J. Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetes. J Clin Endocrinol Metab 2006; 91: 485–491
  • Havelund S, Plum A, Ribel U, Jonassen I, Volund A, Markussen J, Kurtzhals P. The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin. Pharm Res 2004; 21: 1498–1504
  • Haycox A. Insulin aspart: an evidence-based medicine review. Clin Drug Investig 2004; 24: 695–717
  • Hedman C A, Lindstrom T, Arnqvist H J. Direct comparison of insulin lispro and aspart shows small differences in plasma insulin profiles after subcutaneous injection in type 1 diabetes. Diabetes Care 2001; 24: 1120–1121
  • Heinemann L, Starke A A, Hohmann A, Berger M. Timing between the subcutaneous administration of insulin and consumption of a carbohydrate rich meal. Horm Metab Res 1992; Suppl 26: 137–139
  • Heise T, Nosek L, Spitzer H, Heinemann L, Niemoller E, Frick A D, Becker R H. Insulin glulisine: a faster onset of action compared with insulin lispro. Diabetes Obes Metab 2007; 9: 746–753
  • Heller S R, Amiel S A, Mansell P. Effect of the fast-acting insulin analog lispro on the risk of nocturnal hypoglycemia during intensified insulin therapy. U.K. Lispro Study Group. Diabetes Care 1999; 22: 1607–1611
  • Hennige A M, Lehmann R, Weigert C, Moeschel K, Schauble M, Metzinger E, Lammers R, Haring H U. Insulin glulisine: insulin receptor signaling characteristics in vivo. Diabetes 2005a; 54: 361–366
  • Hennige A M, Sartorius T, Tschritter O, Preissl H, Fritsche A, Ruth P, Haring H U. Tissue selectivity of insulin detemir action in vivo. Diabetologia 2006; 49: 1274–1282
  • Hennige A M, Strack V, Metzinger E, Seipke G, Haring H U, Kellerer M. Effects of new insulin analogues HMR1964 (insulin glulisine) and HMR1423 on insulin receptors. Diabetologia 2005b; 48: 1891–1897
  • Hod M, Damm P, Kaaja R, Visser G H, Dunne F, Demidova I, Hansen A S, Mersebach H. Fetal and perinatal outcomes in type 1 diabetes pregnancy: a randomized study comparing insulin aspart with human insulin in 322 subjects. Am J Obstet Gynecol 2007; 198: 186.e1–186.e7
  • Holcberg G, Tsadkin-Tamir M, Sapir O, Wiznizer A, Segal D, Polachek H, Ben Zvi Z. Transfer of insulin lispro across the human placenta. Eur J Obstet Gynecol Reprod Biol 2004; 115: 117–118
  • Homko C, Deluzio A, Jimenez C, Kolaczynski J W, Boden G. Comparison of insulin aspart and lispro: pharmacokinetic and metabolic effects. Diabetes Care 2003; 26: 2027–2031
  • Homko C J, Reece E A. Insulins and oral hypoglycemic agents in pregnancy. J Matern Fetal Neonatal Med 2006; 19: 679–686
  • Hordern S V, Wright J E, Umpleby A M, Shojaee-Moradie F, Amiss J, Russell-Jones D L. Comparison of the effects on glucose and lipid metabolism of equipotent doses of insulin detemir and NPH insulin with a 16-h euglycaemic clamp. Diabetologia 2005; 48: 420–426
  • Howey D C, Bowsher R R, Brunelle R L, Woodworth J R. [Lys(B28), Pro(B29)]-human insulin. A rapidly absorbed analogue of human insulin. Diabetes 1994; 43: 396–402
  • Kacerovsky-Bielesz G, Dressler A, Freunscht R. Long-term glycaemic control with insulin glargine in Type 2 diabetes. Diabetes Res Clin Pract 2005; 71: 184–191
  • Kaiyala K J, Prigeon R L, Kahn S E, Woods S C, Schwartz M W. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes 2000; 49: 1525–1533
  • Knott G W, Dziegielewska K M, Habgood M D, Li Z S, Saunders N R. Albumin transfer across the choroid plexus of South American opossum (Monodelphis domestica). J Physiol 1997; 499(1)179–194
  • Koster I, von Ferber L, Ihle P, Schubert I, Hauner H. The cost burden of diabetes mellitus: The evidence from Germany – the CoDiM study. Diabetologia 2006; 49: 1498–1504
  • Kurtzhals P, Schaffer L, Sorensen A, Kristensen C, Jonassen I, Schmid C, Trub T. Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. Diabetes 2000; 49: 999–1005
  • Lepore M, Pampanelli S, Fanelli C, Porcellati F, Bartocci L, Di Vincenzo A, Cordoni C, Costa E, Brunetti P, Bolli G B. Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. Diabetes 2000; 49: 2142–2148
  • Lindholm A, McEwen J, Riis A P. Improved postprandial glycemic control with insulin aspart. A randomized double-blind cross-over trial in type 1 diabetes. Diabetes Care 1999; 22: 801–805
  • Lingohr M K, Dickson L M, McCuaig J F, Hugl S R, Twardzik D R, Rhodes C J. Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Diabetes 2002; 51: 966–976
  • Luzio S, Peter R, Dunseath G J, Mustafa L, Owens D R. A comparison of preprandial insulin glulisine versus insulin lispro in people with Type 2 diabetes over a 12-h period. Diabetes Res Clin Pract 2007; 79: 269–275
  • Markussen J, Havelund S, Kurtzhals P, Andersen A S, Halstrom J, Hasselager E, Larsen U D, Ribel U, Schaffer L, Vad K, Jonassen I. Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs. Diabetologia 1996; 39: 281–288
  • Mathiesen E R, Kinsley B, Amiel S A, Heller S, McCance D, Duran S, Bellaire S, Raben A. Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy: A randomized trial of insulin aspart versus human insulin in 322 pregnant women. Diabetes Care 2007; 30: 771–776
  • Melki V, Renard E, Lassmann-Vague V, Boivin S, Guerci B, Hanaire-Broutin H, Bringer J, Belicar P, Jeandidier N, Meyer L, Blin P, Augendre-Ferrante B, Tauber J P. Improvement of HbA1c and blood glucose stability in IDDM patients treated with lispro insulin analog in external pumps. Diabetes Care 1998; 21: 977–982
  • Murase Y, Yagi K, Sugihara M, Chujo D, Otsuji M, Muramoto H, Mabuchi H. Lispro is superior to regular insulin in transient intensive insulin therapy in type 2 diabetes. Intern Med 2004; 43: 779–786
  • Perriello G, Pampanelli S, Porcellati F, Avogaro A, Bosi E, Petrella G, Squatrito S, Furneri S, Marra G, Vitali L, Previti M, Cucinotta D. Insulin aspart improves meal time glycaemic control in patients with Type 2 diabetes: A randomized, stratified, double-blind and cross-over trial. Diabetic Medicine 2005; 22: 606–611
  • Pfutzner A, Kustner E, Forst T, Schulze-Schleppinghoff B, Trautmann M E, Haslbeck M, Schatz H, Beyer J. Intensive insulin therapy with insulin lispro in patients with type 1 diabetes reduces the frequency of hypoglycemic episodes. Exp Clin Endocrinol Diabetes 1996; 104: 25–30
  • Pieber T R, Treichel H C, Hompesch B, Philotheou A, Mordhorst L, Gall M A, Robertson L I. Comparison of insulin detemir and insulin glargine in subjects with Type 1 diabetes using intensive insulin therapy. Diabet Med 2007; 24: 635–642
  • Plank J, Bodenlenz M, Sinner F, Magnes C, Gorzer E, Regittnig W, Endahl L A, Draeger E, Zdravkovic M, Pieber T R. A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir. Diabetes Care 2005; 28: 1107–1112
  • Porte D., Jr. Central regulation of energy homeostasis: the key role of insulin. Diabetes 55 Suppl 2 2006; S155–S160
  • Rakatzi I, Ramrath S, Ledwig D, Dransfeld O, Bartels T, Seipke G, Eckel J. A novel insulin analog with unique properties: LysB3,GluB29 insulin induces prominent activation of insulin receptor substrate 2, but marginal phosphorylation of insulin receptor substrate 1. Diabetes 2003a; 52: 2227–2238
  • Rakatzi I, Seipke G, Eckel J. [LysB3, GluB29] insulin: a novel insulin analog with enhanced beta-cell protective action. Biochem Biophys Res Commun 2003b; 310: 852–859
  • Raskin P, Klaff L, Bergenstal R, Halle J P, Donley D, Mecca T. A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with type 1 diabetes. Diabetes Care 2000; 23: 1666–1671
  • Raslova K, Tamer S C, Clauson P, Karl D. Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass index. Clin Drug Investig 2007; 27: 279–285
  • Renner R, Pfutzner A, Trautmann M, Harzer O, Sauter K, Landgraf R. Use of insulin lispro in continuous subcutaneous insulin infusion treatment. Results of a multicenter trial. German Humalog-CSII Study Group. Diabetes Care 1999; 22: 784–788
  • Rhodes C J. Type 2 diabetes – a matter of beta-cell life and death. Science 2005; 307: 380–384
  • Riddle M C, Rosenstock J, Gerich J. The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care 2003; 26: 3080–3086
  • Rosenfalck A M, Thorsby P, Kjems L, Birkeland K, Dejgaard A, Hanssen K F, Madsbad S. Improved postprandial glycaemic control with insulin Aspart in type 2 diabetic patients treated with insulin. Acta Diabetol 2000; 37: 41–46
  • Rosenstock J, Park G, Zimmerman J. Basal insulin glargine (HOE 901) versus NPH insulin in patients with type 1 diabetes on multiple daily insulin regimens. U.S. Insulin Glargine (HOE 901) Type 1 Diabetes Investigator Group. Diabetes Care 2000; 23: 1137–1142
  • Rosenstock J, Schwartz S L, Clark C M, Jr., Park G D, Donley D W, Edwards M B. Basal insulin therapy in type 2 diabetes: 28-week comparison of insulin glargine (HOE 901) and NPH insulin. Diabetes Care 2001; 24: 631–636
  • Rossetti P, Porcellati F, Busciantella R N, Candeloro P, Cioli P, Bolli G B, Fanelli G G. Different brain responses to hypoglycemia induced by equipotent doses of the long-acting insulin analog detemir and human regular insulin in humans. Diabetes 2007; 57: 746–756
  • Schwartz M W, Woods S C, Porte D, Jr., Seeley R J, Baskin D G. Central nervous system control of food intake. Nature 2000; 404: 661–771
  • Seyfert S, Kunzmann V, Schwertfeger N, Koch H C, Faulstich A. Determinants of lumbar CSF protein concentration. J Neurol 2002; 249: 1021–1026
  • Shymko R M, Dumont E, De Meyts P, Dumont J E. Timing-dependence of insulin-receptor mitogenic versus metabolic signalling: a plausible model based on coincidence of hormone and effector binding. Biochem J 1999; 339(3)675–683
  • Slieker L J, Brooke G S, DiMarchi R D, Flora D B, Green L K, Hoffmann J A, Long H B, Fan L, Shields J E, Sundell K L, Surface P L, Chance R E. Modifications in the B10 and B26-30 regions of the B chain of human insulin alter affinity for the human IGF-I receptor more than for the insulin receptor. Diabetologia 1997; 40: S54–S61
  • Staiger K, Staiger H, Schweitzer M A, Metzinger E, Balletshofer B, Haring H U, Kellerer M. Insulin and its analogue glargine do not affect viability and proliferation of human coronary artery endothelial and smooth muscle cells. Diabetologia 2005; 48: 1898–1905
  • Stammberger I, Seipke G, Bartels T. Insulin glulisine-a comprehensive preclinical evaluation. Int J Toxicol 2006; 25: 25–33
  • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977–986
  • Tibaldi J. Actions of insulin beyond glycemic control: A perspective on insulin detemir. Adv Ther 2007; 24: 868–882
  • Torlone E, Fanelli C, Rambotti A M, Kassi G, Modarelli F, Di Vincenzo A, Epifano L, Ciofetta M, Pampanelli S, Brunetti P. Pharmacokinetics, pharmacodynamics and glucose counterregulation following subcutaneous injection of the monomeric insulin analogue [Lys(B28), Pro(B29)] in IDDM. Diabetologia 1994; 37: 713–720
  • Tschritter O, Hennige A M, Preissl H, Porubska K, Schafer S A, Lutzenberger W, Machicao F, Birbaumer N, Fritsche A, Haring H U. Cerebrocortical Beta activity in overweight humans responds to insulin detemir. PLoS ONE 2007; 2: e1196
  • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). The Lancet 1998; 352: 837–853
  • Vajo Z, Fawcett J, Duckworth W C. Recombinant DNA technology in the treatment of diabetes: Insulin analogs. Endocr Rev 2001; 22: 706–717
  • White M F. The insulin signalling system and the IRS proteins. Diabetologia 1997; 40: S2–17
  • Woods S C, Seeley R J, Baskin D G, Schwartz M W. Insulin and the blood-brain barrier. Curr Pharm Des 2003; 9: 795–800
  • Yki-Jarvinen H, Dressler A, Ziemen M. Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetesHOE 901/3002 Study Group. Diabetes Care 2000; 23: 1130–1136

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.