Hepatoprotection of capsaicin in alcoholic and non-alcoholic fatty liver diseases

References

• Akiba, Y., et al., 2004. Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats. Biochemical and biophysical research communications, 321 (1), 219–225.,
   PubMed Web of Science ®Google Scholar
• Alim, Z., et al., 2017. Mechanism of capsaicin inhibition of aldose reductase activity. Journal of biochemical and molecular toxicology, 31 (7), e21898.
   Web of Science ®Google Scholar
• Asgharpour, A., Dinani, A., and Friedman, S.L., 2021. Basic science to clinical trials in non-alcoholic fatty liver disease and alcohol-related liver disease: collaboration with industry. Translational gastroenterology and hepatology, 6, 5–5.
   PubMed Web of Science ®Google Scholar
• Baboota, R.K., et al., 2014. Capsaicin-induced transcriptional changes in hypothalamus and alterations in gut microbial count in high fat diet fed mice. The journal of nutritional biochemistry, 25 (9), 893–902.
   PubMed Web of Science ®Google Scholar
• Barceloux, D.G., 2009. Pepper and capsaicin (Capsicum and Piper species). Disease-a-month: DM, 55 (6), 380–390.
   PubMedGoogle Scholar
• Basith, S., et al., 2016. Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases. Molecules (Basel, Switzerland), 21 (8), 966.
   PubMed Web of Science ®Google Scholar
• Baskaran, P., et al., 2016. Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms. British journal of pharmacology, 173 (15), 2369–2389.,
   PubMed Web of Science ®Google Scholar
• Baskaran, P., et al., 2019. Assessment of pharmacology, safety, and metabolic activity of capsaicin feeding in mice. Scientific reports, 9 (1), 8588.
   PubMedGoogle Scholar
• Beaton, M.D., 2012. Current treatment options for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Canadian journal of gastroenterology and hepatology, 26 (6), 353–357.
   PubMed Web of Science ®Google Scholar
• Benedict, M., and Zhang, X., 2017. Non-alcoholic fatty liver disease: an expanded review. World journal of hepatology, 9 (16), 715–732.
   PubMed Web of Science ®Google Scholar
• Bitencourt, S., et al., 2012. Capsaicin induces de-differentiation of activated hepatic stellate cell. Biochemistry and cell biology = biochimie et biologie cellulaire, 90 (6), 683–690.
   PubMedGoogle Scholar
• Bitencourt, S., et al., 2014. Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells. Cell biochemistry and biophysics, 68 (2), 387–396.,
   PubMed Web of Science ®Google Scholar
• Boppidi, H., and Daram, S.R., 2008. Nonalcoholic fatty liver disease: hepatic manifestation of obesity and the metabolic syndrome. Postgraduate medicine, 120 (2), E01–7.
   PubMedGoogle Scholar
• Bort, A., et al., 2019. Capsaicin targets lipogenesis in HepG2 Cells through AMPK activation, AKT inhibition and PPARs regulation. International journal of molecular sciences, 20, 1660.
   PubMed Web of Science ®Google Scholar
• Brandl, K., and Schnabl, B., 2017. Intestinal microbiota and nonalcoholic steatohepatitis. Current opinion in gastroenterology, 33 (3), 128–133.
   PubMed Web of Science ®Google Scholar
• Bugianesi, E., Mccullough, A.J., and Marchesini, G., 2005. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology (Baltimore, MD.), 42 (5), 987–1000.
   PubMed Web of Science ®Google Scholar
• Cao, S., et al., 2015. Anti-cancer effects and mechanisms of capsaicin in chili peppers. American journal of plant sciences, 06 (19), 3075–3081.
   Google Scholar
• Chen, J., et al., 2015. Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca2+ influx. Cardiovascular diabetology, 14, 22–22.
   PubMed Web of Science ®Google Scholar
• Chiang, J.Y.L., 2017. Targeting bile acids and lipotoxicity for NASH treatment. Hepatology communications, 1 (10), 1002–1004.
   PubMed Web of Science ®Google Scholar
• Clark, R., and Lee, S.H., 2016. Anticancer properties of capsaicin against human cancer. Anticancer research, 36 (3), 837–843.
   PubMed Web of Science ®Google Scholar
• Cotter, T.G., and Rinella, M., 2020. Nonalcoholic fatty liver disease 2020: the state of the disease. Gastroenterology, 158 (7), 1851–1864.
   PubMed Web of Science ®Google Scholar
• Craciun, A., Lackner, C., and Cortez-Pinto, H., 2020. Nonalcoholic fatty liver disease versus alcohol-related liver disease: is it really so different? Current pharmaceutical design, 26 (10), 1093–1109.
   PubMed Web of Science ®Google Scholar
• Diepvens, K., Westerterp, K.R., and Westerterp-Plantenga, M.S., 2007. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. American journal of physiology. regulatory, integrative and comparative physiology, 292 (1), R77–85.
   PubMed Web of Science ®Google Scholar
• Divella, R., et al., 2019. Obesity, nonalcoholic fatty liver disease and adipocytokines network in promotion of cancer. International journal of biological sciences, 15 (3), 610–616.
   PubMed Web of Science ®Google Scholar
• Fan, L., et al., 2019. Combination of capsaicin and capsiate induces browning in 3T3-L1 white adipocytes via activation of the peroxisome proliferator-activated receptor γ/β(3)-adrenergic receptor signaling pathways. Journal of agricultural and food chemistry, 67 (22), 6232–6240.
   PubMed Web of Science ®Google Scholar
• Fattori, V., et al., 2016. Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses. Molecules, 21 (7), 844.
   PubMed Web of Science ®Google Scholar
• Feng, Y., et al., 2018. Enhanced oral bioavailability, reduced irritation and increased hypolipidemic activity of self-assembled capsaicin prodrug nanoparticles. Journal of functional foods, 44, 137–145.
   Web of Science ®Google Scholar
• Finelli, C., and Tarantino, G., 2013. What is the role of adiponectin in obesity related non-alcoholic fatty liver disease? World journal of gastroenterology, 19 (6), 802–812.
   PubMed Web of Science ®Google Scholar
• Fukui, H., 2019. Role of gut dysbiosis in liver diseases: what have we learned so far? Diseases, 7, 58.
   PubMedGoogle Scholar
• Gang, H.-M., et al., 2008. A study on the comparison of antioxidant effects between hot pepper extract and capsaicin. Journal of pharmacopuncture, 11 (1), 109–118.
   Google Scholar
• Hayman, M., and Kam, P.C.A., 2008. Capsaicin: a review of its pharmacology and clinical applications. Current anaesthesia & critical care, 19 (5–6), 338–343.
   Google Scholar
• Hochkogler, C.M., et al., 2018. Capsaicin and nonivamide similarly modulate outcome measures of mitochondrial energy metabolism in HepG2 and 3T3-L1 cells. Food & function, 9 (2), 1123–1132.
   PubMed Web of Science ®Google Scholar
• Hohenester, S., et al., 2018. Lifestyle intervention for morbid obesity: effects on liver steatosis, inflammation, and fibrosis. American journal of physiology-gastrointestinal and liver physiology, 315 (3), G329–g338.
   PubMed Web of Science ®Google Scholar
• Hsu, C.L., and Yen, G.C., 2007. Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells. Journal of agricultural and food chemistry, 55 (5), 1730–1736.
   PubMed Web of Science ®Google Scholar
• Hu, J., et al., 2017. Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice. Oncotarget, 8 (24), 38161–38175.
   PubMedGoogle Scholar
• Hui, S., et al., 2019. Capsaicin improves glucose tolerance and insulin sensitivity through modulation of the gut microbiota-bile acid-FXR axis in type 2 diabetic db/db mice. Molecular nutrition & food research, 63, 1900608.
   Web of Science ®Google Scholar
• Hui, S., et al., 2020. Capsaicin improves glucose homeostasis by enhancing glucagon-like peptide-1 secretion through the regulation of bile acid metabolism via the remodeling of the gut microbiota in male mice. FASEB journal, 34 (6), 8558–8573.,
   PubMed Web of Science ®Google Scholar
• Hwang, J.-T., et al., 2005. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochemical and biophysical research communications, 338 (2), 694–699.
   PubMed Web of Science ®Google Scholar
• Idalsoaga, F., et al., 2020. Non-alcoholic fatty liver disease and alcohol-related liver disease: two intertwined entities. Frontiers in medicine, 7, 448.
   PubMed Web of Science ®Google Scholar
• Janssens, P.L., Hursel, R., and Westerterp-Plantenga, M.S., 2014. Capsaicin increases sensation of fullness in energy balance, and decreases desire to eat after dinner in negative energy balance. Appetite, 77, 44–49.
   PubMed Web of Science ®Google Scholar
• Jimenez-Lopez, J.M., and Cederbaum, A.I., 2005. CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury. Expert opinion on drug metabolism & toxicology, 1 (4), 671–685.
   PubMedGoogle Scholar
• Joo, J.I., et al., 2010. Proteomic analysis for antiobesity potential of capsaicin on white adipose tissue in rats fed with a high fat diet. Journal of proteome research, 9 (6), 2977–2987.
   PubMed Web of Science ®Google Scholar
• Jung, U.J., and Choi, M.-S., 2014. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. International journal of molecular sciences, 15 (4), 6184–6223.
   PubMed Web of Science ®Google Scholar
• Kang, C., et al., 2017. Gut microbiota mediates the protective effects of dietary capsaicin against chronic low-grade inflammation and associated obesity induced by high-fat diet. mBio, 8 (3), e00470–17.
   PubMed Web of Science ®Google Scholar
• Kang, J.H., et al., 2010. Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet. Obesity (Silver Spring, MD.), 18 (4), 780–787.
   PubMed Web of Science ®Google Scholar
• Kang, J.H., et al., 2011. Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice. Journal of medicinal food, 14 (3), 310–315.
   PubMed Web of Science ®Google Scholar
• Karimi-Sales, E., Ebrahimi-Kalan, A., and Alipour, M.R., 2019. Preventive effect of trans-chalcone on non-alcoholic steatohepatitis: Improvement of hepatic lipid metabolism. Biomedicine & pharmacotherapy = biomedecine & pharmacotherapie, 109, 1306–1312.
   PubMed Web of Science ®Google Scholar
• Karimi-Sales, E., et al., 2018a. trans-Chalcone prevents insulin resistance and hepatic inflammation and also promotes hepatic cholesterol efflux in high-fat diet-fed rats: modulation of miR-34a-, miR-451-, and miR-33a-related pathways. Food & function, 9 (8), 4292–4298.
   PubMed Web of Science ®Google Scholar
• Karimi-Sales, E., Mohaddes, G., and Alipour, M.R., 2018b. Chalcones as putative hepatoprotective agents: preclinical evidence and molecular mechanisms. Pharmacological research, 129, 177–187.
   PubMed Web of Science ®Google Scholar
• Kim, J., et al., 2011. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nature cell biology, 13 (2), 132–141.
   PubMed Web of Science ®Google Scholar
• Kim, S.H., et al., 2013. Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway. Biochemical and biophysical research communications, 439 (1), 66–70.
   PubMed Web of Science ®Google Scholar
• Koneru, M., et al., 2018. Capsaicin, the pungent principle of peppers, ameliorates alcohol-induced acute liver injury in mice via modulation of matrix metalloproteinases. Canadian journal of physiology and pharmacology, 96 (4), 419–427.
   PubMed Web of Science ®Google Scholar
• Kwon, D.Y., et al., 2013. Capsiate improves glucose metabolism by improving insulin sensitivity better than capsaicin in diabetic rats. The journal of nutritional biochemistry, 24 (6), 1078–1085.
   PubMed Web of Science ®Google Scholar
• Lee, G.R., et al., 2013. Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice. Obesity (Silver Spring, MD.), 21 (1), 115–122.
   PubMed Web of Science ®Google Scholar
• Lee, M.S., et al., 2011. Effects of capsaicin on lipid catabolism in 3T3-L1 adipocytes. Phytotherapy research: PTR, 25 (6), 935–939.
   PubMed Web of Science ®Google Scholar
• Leung, F.W., 2014. Capsaicin as an anti-obesity drug. Progress in drug research. Fortschritte Der Arzneimittelforschung. Progres des recherches pharmaceutiques, 68, 171–179.
   PubMedGoogle Scholar
• Li, L., et al., 2012. TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice. PflüGers Archiv: European journal of physiology, 463( (5), 727–732.
   PubMed Web of Science ®Google Scholar
• Li, Q., et al., 2013. Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor δ activation. Pflugers archiv: European journal of physiology, 465 (9), 1303–1316.
   PubMed Web of Science ®Google Scholar
• Li, R., et al., 2020. Anti-obesity effects of capsaicin and the underlying mechanisms: a review. Food & function, 11 (9), 7356–7370.
   PubMed Web of Science ®Google Scholar
• Li, W., Yang, H., and Lu, Y., 2019. Capsaicin alleviates lipid metabolism disorder in high beef fat-fed mice. Journal of functional foods, 60, 103444.
   Web of Science ®Google Scholar
• Liu, H., et al., 2016. Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis. Journal of lipid research, 57 (10), 1831–1844.
   PubMed Web of Science ®Google Scholar
• Louvet, A., and Mathurin, P., 2015. Alcoholic liver disease: mechanisms of injury and targeted treatment. Nature reviews. gastroenterology & hepatology, 12 (4), 231–242.
   PubMed Web of Science ®Google Scholar
• Lu, M., Chen, C., et al., 2020. Capsaicin-the major bioactive ingredient of chili peppers: bio-efficacy and delivery systems. Food & function, 11 (4), 2848–2860.
   PubMed Web of Science ®Google Scholar
• Lu, M., et al., 2017a. The enhanced anti-obesity effect and reduced gastric mucosa irritation of capsaicin-loaded nanoemulsions. Food & function, 8 (5), 1803–1809.
   PubMed Web of Science ®Google Scholar
• Lu, M., et al., 2017b. Extraction, bioavailability, and bioefficacy of capsaicinoids. Journal of food and drug analysis, 25 (1), 27–36.
   PubMed Web of Science ®Google Scholar
• Lu, Y., and Cederbaum, A.I., 2008. CYP2E1 and oxidative liver injury by alcohol. Free radical biology & medicine, 44 (5), 723–738.
   PubMed Web of Science ®Google Scholar
• Ludy, M.-J., Moore, G.E., and Mattes, R.D., 2012. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chemical senses, 37 (2), 103–121.
   PubMed Web of Science ®Google Scholar
• Malnick, S., and Maor, Y., 2020. The interplay between alcoholic liver disease, obesity, and the metabolic syndrome. Visceral medicine, 36 (3), 198–205.
   PubMed Web of Science ®Google Scholar
• Manjunatha, H., and Srinivasan, K., 2007. Hypolipidemic and antioxidant effects of dietary curcumin and capsaicin in induced hypercholesterolemic rats. Lipids, 42 (12), 1133–1142.
   PubMed Web of Science ®Google Scholar
• Maurice, J., and Manousou, P., 2018. Non-alcoholic fatty liver disease. Clinical medicine (London, England), 18 (3), 245–250.
   PubMed Web of Science ®Google Scholar
• Mosqueda-Solís, A., et al., 2018. Hesperidin and capsaicin, but not the combination, prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats. Scientific reports, 8 (1), 15100,
   PubMedGoogle Scholar
• Mostafavian, M., et al., 2020. Effect of eight weeks of aerobic progressive training with capsaicin on changes in PGC-1α and UPC-1 expression in visceral adipose tissue of obese rats with diet. Complementary medicine journal, 10 (2), 106–117.
   Google Scholar
• Negulesco, J.A., et al., 1990. Effects of capsaicin (C) and dihydrocapsaicin (DC) on serum ethanol (ET) concentration of ET treated CF-1 mice. Artery, 17 (3), 144–158.
   PubMedGoogle Scholar
• Nevius, E., Srivastava, P.K., and Basu, S., 2012. Oral ingestion of Capsaicin, the pungent component of chili pepper, enhances a discreet population of macrophages and confers protection from autoimmune diabetes. Mucosal immunology, 5 (1), 76–86.
   PubMed Web of Science ®Google Scholar
• Ntandja Wandji, L.C., et al., 2020. Combined alcoholic and non-alcoholic steatohepatitis. JHEP reports: innovation in hepatology, 2 (3), 100101.
   PubMedGoogle Scholar
• Panchal, S.K., Bliss, E., and Brown, L., 2018. Capsaicin in metabolic syndrome. Nutrients, 10 (5), 630.
   PubMed Web of Science ®Google Scholar
• Papoiu, A.D., and Yosipovitch, G., 2010. Topical capsaicin. The fire of a 'hot' medicine is reignited. Expert opinion on pharmacotherapy, 11 (8), 1359–1371.
   PubMed Web of Science ®Google Scholar
• Polyzos, S.A., et al., 2010. The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease. Diabetes, obesity & metabolism, 12 (5), 365–383.
   PubMed Web of Science ®Google Scholar
• Polyzos, S.A., Kountouras, J., and Mantzoros, C.S., 2019. Obesity and nonalcoholic fatty liver disease: from pathophysiology to therapeutics. Metabolism: clinical and experimental, 92, 82–97.
   PubMed Web of Science ®Google Scholar
• Pyun, C.-W., et al., 2014. In vivo protective effects of dietary curcumin and capsaicin against alcohol-induced oxidative stress. BioFactors (Oxford, England), 40 (5), 494–500.
   PubMed Web of Science ®Google Scholar
• Reddy, M.S.K., and Manjappara, U.V., 2019. Capsaicin and genistein override the action of obestatin to decrease lipid accumulation in 3T3-L1 cells. Cell biochemistry and biophysics, 77 (3), 245–252.
   PubMed Web of Science ®Google Scholar
• Rigamonti, A.E., et al., 2018. Acute administration of capsaicin increases resting energy expenditure in young obese subjects without affecting energy intake, appetite, and circulating levels of orexigenic/anorexigenic peptides. Nutrition research, 52, 71–79.
   PubMed Web of Science ®Google Scholar
• Rohm, B., et al., 2015a. Nonivamide enhances miRNA let-7d expression and decreases adipogenesis PPARγ expression in 3T3-L1 cells. Journal of cellular biochemistry, 116 (6), 1153–1163.
   PubMed Web of Science ®Google Scholar
• Rohm, B., et al., 2015b. Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells. Food & function, 6 (1), 172–184.
   Web of Science ®Google Scholar
• Rowe, I.A., 2017. Lessons from epidemiology: the burden of liver disease. Digestive diseases (Basel, Switzerland), 35 (4), 304–309.
   PubMed Web of Science ®Google Scholar
• Saito, M., and Yoneshiro, T., 2013. Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans. Current opinion in lipidology, 24 (1), 71–77.
   PubMed Web of Science ®Google Scholar
• Sambaiah, K., and Satyanarayana, M.N., 1989. Effect of capsaicin on triglyceride accumulation & secretion in ethanol fed rats. Indian journal of medical research, 90, 154–158.
   PubMedGoogle Scholar
• Sanati, S., Razavi, B.M., and Hosseinzadeh, H., 2018. A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome. Iranian journal of basic medical sciences, 21 (5), 439–448.
   PubMed Web of Science ®Google Scholar
• Sekeroglu, V., et al., 2018. Hepatoprotective effects of capsaicin and alpha-tocopherol on mitochondrial function in mice fed a high-fat diet. Biomedicine & pharmacotherapy, 98, 821–825.
   PubMed Web of Science ®Google Scholar
• Seyithanoğlu, M., et al., 2016. The effect of dietary curcumin and capsaicin on hepatic fetuin-A expression and fat accumulation in rats fed on a high-fat diet. Archives of physiology and biochemistry, 122 (2), 94–102.
   PubMed Web of Science ®Google Scholar
• Shen, W., et al., 2017. Anti-obesity effect of capsaicin in mice fed with high-fat diet is associated with an increase in population of the gut bacterium Akkermansia muciniphila. Frontiers in microbiology, 8, 272.
   PubMed Web of Science ®Google Scholar
• Shin, K.O., and Moritani, T., 2007. Alterations of autonomic nervous activity and energy metabolism by capsaicin ingestion during aerobic exercise in healthy men. Journal of nutritional science and vitaminology, 53 (2), 124–132.
   PubMed Web of Science ®Google Scholar
• Shin, M.K., Yang, S.-M., and Han, I.-S., 2020. Capsaicin suppresses liver fat accumulation in high-fat diet-induced NAFLD mice. Animal cells and systems, 24 (4), 214–219.
   PubMed Web of Science ®Google Scholar
• Singal, A.K., 2021. Similarities and differences between non-alcoholic fatty liver disease (NAFLD) & alcohol-associated liver disease (ALD). Translational gastroenterology and hepatology, 6, 1.
   PubMed Web of Science ®Google Scholar
• Song, J.-X., et al., 2017. Dietary capsaicin improves glucose homeostasis and alters the gut microbiota in obese diabetic ob/ob mice. Frontiers in physiology, 8, 602.
   PubMed Web of Science ®Google Scholar
• Stuby, J., et al., 2019. Appetite-suppressing and satiety-increasing bioactive phytochemicals: a systematic review. Nutrients, 11 (9), 2238.
   PubMed Web of Science ®Google Scholar
• Takai, S., and Jin, D., 2018. Chymase inhibitor as a novel therapeutic agent for non-alcoholic steatohepatitis. Frontiers in pharmacology, 9, 144.
   PubMed Web of Science ®Google Scholar
• Tan, S., et al., 2014. Antiobese effects of capsaicin-chitosan microsphere (CCMS) in obese rats induced by high fat diet. Journal of agricultural and food chemistry, 62 (8), 1866–1874.
   PubMed Web of Science ®Google Scholar
• Tanrikulu-Kucuk, S., et al., 2019. Dietary curcumin and capsaicin: Relationship with hepatic oxidative stress and apoptosis in rats fed a high fat diet. Advances in clinical and experimental medicine, 28 (8), 1013–1020.
   PubMed Web of Science ®Google Scholar
• Tarantino, G., Citro, V., and Capone, D., 2019. Nonalcoholic fatty liver disease: a challenge from mechanisms to therapy. Journal of clinical medicine, 9 (1), 15.
   PubMed Web of Science ®Google Scholar
• Tilg, H., and Moschen, A., 2010. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology (Baltimore, MD.), 52 (5), 1836–1846.
   PubMed Web of Science ®Google Scholar
• Trefts, E., Gannon, M., And., and Wasserman, D.H., 2017. The liver. Current biology: CB, 27 (21), R1147–R1151.
   PubMed Web of Science ®Google Scholar
• Van Avesaat, M., et al., 2016. Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones1,2. The American journal of clinical nutrition, 103 (2), 305–313.
   PubMed Web of Science ®Google Scholar
• Wang, L., and Wan, Y.-J.Y., 2019. The role of gut microbiota in liver disease development and treatment. Liver research, 3 (1), 3–18.
   PubMedGoogle Scholar
• Wang, N., et al., 2017. Peroxisome proliferator-activated receptors associated with nonalcoholic fatty liver disease. PPAR research, 2017, 6561701.
   PubMed Web of Science ®Google Scholar
• Wang, P., et al., 2012. Transient receptor potential vanilloid 1 activation enhances gut glucagon-like peptide-1 secretion and improves glucose homeostasis. Diabetes, 61 (8), 2155–2165.
   PubMed Web of Science ®Google Scholar
• Westerterp-Plantenga, M.S., Smeets, A., and Lejeune, M.P., 2005. Sensory and gastrointestinal satiety effects of capsaicin on food intake. International journal of obesity, 29 (6), 682–688.
   Web of Science ®Google Scholar
• Wu, D., and Cederbaum, A.I., 2005. Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicology and applied pharmacology, 207 (2 Suppl), 70–76.
   PubMedGoogle Scholar
• Yang, H.J., Jang, D.-J., and Hwang, J.-T., 2012. Anti-diabetic effects of Korean red pepper via AMPK and PPAR-γ activation in C2C12 myotubes. Journal of functional foods, 4 (2), 552–558.
   Web of Science ®Google Scholar
• Younossi, Z., and Henry, L., 2016. Contribution of alcoholic and nonalcoholic fatty liver disease to the burden of liver-related morbidity and mortality. Gastroenterology, 150 (8), 1778–1785.
   PubMed Web of Science ®Google Scholar
• Yu, F.X., et al., 2014. Inhibitory effects of capsaicin on hepatic stellate cells and liver fibrosis. Biochemistry and cell biology = biochimie et biologie cellulaire, 92 (5), 406–412.
   PubMed Web of Science ®Google Scholar
• Yuan, L.J., et al., 2016. Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns. Clinical nutrition, 35 (2), 388–393.
   PubMed Web of Science ®Google Scholar
• Zhang, L.L., et al., 2007. Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circulation research, 100 (7), 1063–1070.
   PubMed Web of Science ®Google Scholar
• Zhang, S., et al., 2017. Capsaicin reduces blood glucose by increasing insulin levels and glycogen content better than capsiate in streptozotocin-induced diabetic rats. Journal of agricultural and food chemistry, 65 (11), 2323–2330.
   PubMed Web of Science ®Google Scholar
• Zheng, J., et al., 2017. Dietary capsaicin and its anti-obesity potency: from mechanism to clinical implications. Bioscience reports, 37 (3), BSR20170286.
   PubMedGoogle Scholar
• Zuo, C., et al., 2021. The alleviation of lipid deposition in steatosis hepatocytes by capsaicin-loaded α-lactalbumin nanomicelles via promoted endocytosis and synergetic multiple signaling pathways. Journal of functional foods, 79, 104396.
   Web of Science ®Google Scholar