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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 130, 2024 - Issue 2
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Review Article

Crosstalk between obesity and cancer: a role for adipokines

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 155-168 | Received 21 Jun 2021, Accepted 27 Sep 2021, Published online: 13 Oct 2021

References

  • Abraham, M.A., et al., 2018. Leptin enhances hypothalamic lactate dehydrogenase A (LDHA)–dependent glucose sensing to lower glucose production in high-fat–fed rats. Journal of biological chemistry, 293 (11), 4159–4166.
  • Adekola, K., Rosen, S.T., and Shanmugam, M., 2012. Glucose transporters in cancer metabolism. Current opinion in oncology, 24 (6), 650–654.
  • Adya, R., et al., 2008. Nuclear factor-κB induction by visfatin in human vascular endothelial cells: its role in MMP-2/9 production and activation. Diabetes care, 31 (4), 758–760.
  • Akin, S., et al., 2017. Serum chemerin level in breast cancer. International journal of hematology & oncology, 27 (2). doi:10.15344/ijcii/2015/102
  • Al-Harithy, R., and Al-Otaibi, W., 2015. Apelin-12 levels in obese patients with colon cancer. International journal of cancer immunology & immunotherapy, 1 (2).
  • Aleksandrova, K., et al., 2014. Adiposity, mediating biomarkers and risk of colon cancer in the European prospective investigation into cancer and nutrition study. International journal of cancer, 134 (3), 612–621.
  • Alkady, M.M., Abdel-Messeih, P.L., and Nosseir, N.M., 2018. Assessment of serum levels of the adipocytokine chemerin in colorectal cancer patients. Journal of medical biochemistry, 37 (3), 313–319.
  • Altinkaya, S.O., et al., 2015. Apelin levels are higher in obese patients with endometrial cancer. Journal of obstetrics and gynaecology research, 41 (2), 294–300.
  • Altomare, D.A., and Testa, J.R., 2005. Perturbations of the AKT signaling pathway in human cancer. Oncogene, 24 (50), 7455–7464.
  • Ando, S., and Catalano, S., 2012. The multifactorial role of leptin in driving the breast cancer microenvironment. Nature reviews endocrinology, 8 (5), 263–275.
  • Argyrakopoulou, G., et al., 2021. Gender differences in obesity-related cancers. Current obesity reports, 10 (2), 100–115. doi:10.1007/s13679-021-00426-0
  • Arnold, M., et al., 2015. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. The lancet oncology, 16 (1), 36–46.
  • Arroyo-Johnson, C., and Mincey, K.D., 2016. Obesity epidemiology worldwide. Gastroenterology clinics of North America, 45 (4), 571–579.
  • Ashrafian, H., et al., 2011. Metabolic surgery and cancer: protective effects of bariatric procedures. Cancer, 117 (9), 1788–1799.
  • Avtanski, D., et al., 2019. Resistin induces breast cancer cells epithelial to mesenchymal transition (EMT) and stemness through both adenylyl cyclase-associated protein 1 (CAP1)-dependent and CAP1-independent mechanisms. Cytokine, 120, 155–164.
  • Bae, S.-K., et al., 2006. Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1. FEBS letters, 580 (17), 4105–4113.
  • Bauer, L., et al., 2009. Nicotinamide phosphoribosyltransferase and prostaglandin H2 synthase 2 are up-regulated in human pancreatic adenocarcinoma cells after stimulation with interleukin-1. International journal of oncology, 35, 97–107.
  • Blüher, M., et al., 2007. Total and high–molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays. Diabetes care, 30 (2), 280–285.
  • Booth, A., et al., 2015. Adipose tissue, obesity and adipokines: role in cancer promotion. Hormone molecular biology and clinical investigation, 21 (1), 57–74.
  • Boucher, J., et al., 2005. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology, 146 (4), 1764–1771.
  • Bozaoglu, K., et al., 2007. Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology, 148 (10), 4687–4694.
  • Bråkenhielm, E., Veitonmäki, N., Cao, R., Kihara, S., Matsuzawa, Y., Zhivotovsky, B., Funahashi, T. & Cao, Y. 2004. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proceedings of the national academy of sciences, 101, 2476–2481.
  • Bray, G., et al., 2017. Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. Obesity reviews, 18 (7), 715–723.
  • Buechler, C., et al., 2019. Chemerin isoforms and activity in obesity. International journal of molecular sciences, 20 (5), 1128.
  • Byeon, J.S., et al., 2010. Adiponectin and adiponectin receptor in relation to colorectal cancer progression. International Journal of Cancer, 127 (12), 2758–2767.
  • Calgani, A., et al., 2016. Leptin contributes to long-term stabilization of HIF-1α in cancer cells subjected to oxygen limiting conditions. Cancer letters, 376 (1), 1–9.
  • Carmeliet, P., and Jain, R.K., 2011. Molecular mechanisms and clinical applications of angiogenesis. Nature, 473 (7347), 298–307.
  • Cea, M., et al., 2009. APO866 activity in hematologic malignancies: a preclinical in vitro study. Blood, 113, 6035–6037.
  • Ceddia, R., et al., 2005. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia, 48 (1), 132–139.
  • Chang, S.S., et al., 2016. Chemerin activation in human obesity. Obesity, 24 (7), 1522–1529.
  • Chang, Y.H., et al., 2011. Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta‐analysis and systemic review. Diabetes/metabolism research and reviews, 27 (6), 515–527.
  • Chen, H., et al., 2015. Silencing of plasminogen activator inhibitor-1 suppresses colorectal cancer progression and liver metastasis. Surgery, 158 (6), 1704–1713.
  • Chen, W.-L., et al., 2016. Enhanced fructose utilization mediated by SLC2A5 is a unique metabolic feature of acute myeloid leukemia with therapeutic potential. Cancer cell, 30 (5), 779–791.
  • Cheong, K.C., et al., 2015. The discriminative ability of waist circumference, body mass index and waist-to-hip ratio in identifying metabolic syndrome: variations by age, sex and race. Diabetes & metabolic syndrome, 9 (2), 74–78.
  • Cinti, S., 2018. Pink adipocytes. Trends in endocrinology and metabolism, 29 (9), 651–666.
  • Coelho, M., Oliveira, T., and Fernandes, R., 2013. Biochemistry of adipose tissue: an endocrine organ. Archives of medical science, 9 (2), 191–200.
  • Collaboration, G.B.M., 2016. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet, 388 (10046), 776–786. doi:10.1016/S0140-6736(16)30175-1
  • Cordero, M.D., Williams, M.R., and Ryffel, B., 2018. AMP-activated protein kinase regulation of the NLRP3 inflammasome during aging. Trends in endocrinology and metabolism, 29 (1), 8–17.
  • Corrêa, L.H., Heyn, G.S., and Magalhaes, K.G., 2019. The impact of the adipose organ plasticity on inflammation and cancer progression. Cells, 8, 662.
  • Dalamaga, M., Diakopoulos, K.N., and Mantzoros, C.S., 2012. The role of adiponectin in cancer: a review of current evidence. Endocrine reviews, 33 (4), 547–594.
  • De Henau, O., et al., 2016. Signaling properties of chemerin receptors CMKLR1, GPR1 and CCRL2. PLOS one, 11 (10), e0164179.
  • De Pergola, G., and Silvestris, F., 2013. Obesity as a major risk factor for cancer. Journal of obesity, 2013, 1–11.
  • Di Lonardo, A., Nasi, S., and Pulciani, S., 2015. Cancer: we should not forget the past. Journal of cancer, 6 (1), 29–39.
  • Dieudonne, M.-N., et al., 2006. Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochemical and biophysical research communications, 345 (1), 271–279.
  • Dos Santos, E., et al., 2008. Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cells. Oncology reports, 20 (4), 971–977.
  • Drewa, A., and Zorena, K., 2017. Prevention of overweight and obesity in children and adolescents in European countries. Pediatric endocrinology diabetes and metabolism, 23 (3), 152–158.
  • Endo, H., et al., 2011. Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. Gut, 60 (10), 1363–1371.
  • Fang, H., Placencio, V.R., and Declerck, Y.A., 2012. Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function. Journal of the national cancer institute, 104 (19), 1470–1484.
  • Faubert, B., et al., 2013. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell metabolism, 17 (1), 113–124.
  • Fazeli, M.S., et al., 2013. Circulating levels of novel adipocytokines in patients with colorectal cancer. Cytokine, 62 (1), 81–85.
  • Feng, M., et al., 2016. Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer. BMC cancer, 16 (1), 1–8.
  • Feng, Z., and Zhang, H., 2011. Resistin and cancer risk: a mini-review. Endocrinol metabol syndrome, 4, 003.
  • Froy, O., and Garaulet, M., 2018. The circadian clock in white and brown adipose tissue: mechanistic, endocrine, and clinical aspects. Endocrine reviews, 39 (3), 261–273.
  • Fukuhara, A., et al., 2005. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science, 307 (5708), 426–430.
  • Galon, J., et al., 2013. The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures. Immunity, 39 (1), 11–26.
  • García-Robles, M.J., Segura-Ortega, J.E., and Fafutis-Morris, M., 2013. The biology of leptin and its implications in breast cancer: a general view. Journal of interferon & cytokine research, 33 (12), 717–727.
  • Garg, M., Dutta, M., and Mahalle, N., 2012. Adipokines (adiponectin and plasminogen activator inhhibitor-1) in metabolic syndrome. Indian journal of endocrinology and metabolism, 16 (1), 116.
  • Garten, A., et al., 2009. Nampt: linking NAD biology, metabolism and cancer. Trends in endocrinology and metabolism, 20 (3), 130–138.
  • Ghaemmaghami, S., et al., 2013. Resistin and visfatin expression in HCT-116 colorectal cancer cell line. International journal of molecular and cellular medicine, 2 (3), 143–150.
  • Giacoia, E.G., et al., 2014. PAI-1 leads to G1-phase cell-cycle progression through cyclin D3/cdk4/6 upregulation. Molecular cancer research, 12 (3), 322–334.
  • Goncalves, M.D., Hopkins, B.D., and Cantley, L.C., 2019. Dietary fat and sugar in promoting cancer development and progression. Annual review of cancer biology, 3 (1), 255–273.
  • Györffy, B., et al., 2010. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast cancer research and treatment, 123 (3), 725–731.
  • Győrffy, B., et al., 2013. Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. PLOS one., 8 (12), e82241.
  • Halabis, M., et al., 2015. Omentin-a new adipokine with many roles to play. Current issues in pharmacy and medical sciences, 28 (3), 176–180.
  • Harris, H.R., et al., 2011. Plasma leptin levels and risk of breast cancer in premenopausal women. Cancer prevention research, 4 (9), 1449–1456.
  • Hashimoto, Y., et al., 2005. G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility. International journal of molecular medicine, 16 (5), 787–792.
  • Hebbard, L.W., et al., 2008. T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. Cancer research, 68 (5), 1407–1416.
  • Heidemann, C., et al., 2008. Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women. Annals of internal medicine, 149 (5), 307–316.
  • Herová, M., et al., 2015. ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages. The journal of immunology, 194 (5), 2330–2337.
  • Hoffmann, M., Fiedor, E., and Ptak, A., 2017. Bisphenol A and its derivatives tetrabromobisphenol A and tetrachlorobisphenol A induce apelin expression and secretion in ovarian cancer cells through a peroxisome proliferator-activated receptor gamma-dependent mechanism. Toxicology letters, 269, 15–22.
  • Hsieh, Y.-Y., et al., 2014. Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activation of p38 MAPK/NFκB signaling pathway in gastric cancer cells. Journal of biomedical science, 21 (1), 59.
  • Hursting, S.D., et al., 2013. Calorie restriction and cancer prevention: a mechanistic perspective. Cancer & metabolism, 1 (1), 1–11.
  • Jayson, G.C., et al., 2016. Antiangiogenic therapy in oncology: current status and future directions. The lancet, 388 (10043), 518–529.
  • Jiang, Y., et al., 2016. A sucrose-enriched diet promotes tumorigenesis in mammary gland in part through the 12-lipoxygenase pathway. Cancer research, 76 (1), 24–29.
  • Joshi, R.K., Kim, W.J., and Lee, S.-A., 2014. Association between obesity-related adipokines and colorectal cancer: a case-control study and meta-analysis. World journal of gastroenterology, 20 (24), 7941.
  • Joshi, R.K., and Lee, S.-A., 2014. Obesity related adipokines and colorectal cancer: a review and meta-analysis. Asian Pacific journal of cancer prevention, 15 (1), 397–405.
  • Kadowaki, T., and Yamauchi, T., 2005. Adiponectin and adiponectin receptors. Endocrine reviews, 26 (3), 439–451.
  • Kalvøy, H., and Sauter, A.R., 2016. Detection of intraneural needle-placement with multiple frequency bioimpedance monitoring: a novel method. Journal of clinical monitoring and computing, 30 (2), 185–192.
  • Kaur, J., et al., 2010. Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. Biochemical and biophysical research communications, 391 (4), 1762–1768.
  • Kawamata, Y., et al., 2001. Molecular properties of apelin: tissue distribution and receptor binding. Biochimica et biophysica acta, 1538 (2–3), 162–171.
  • Kim, S.-R., et al., 2007. Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. Biochemical and biophysical research communications, 357 (1), 150–156.
  • Kim, S.-R., et al., 2008. Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-κB activation in endothelial cells. Biochimica et biophysica acta, 1783 (5), 886–895.
  • Kubala, M.H., and Declerck, Y.A., 2019. The plasminogen activator inhibitor-1 paradox in cancer: a mechanistic understanding. Cancer metastasis reviews, 38 (3), 483–492.
  • Kubala, M.H., et al., 2018. Plasminogen activator inhibitor-1 promotes the recruitment and polarization of macrophages in cancer. Cell reports, 25 (8), 2177–2191. e7.
  • Lademann, U.A., and Rømer, M.U., 2008. Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1). Thrombosis and haemostasis, 100 (6), 1041–1046.
  • Lage, R., et al., 2019. Omentin protects H9c2 cells against docetaxel cardiotoxicity. PLOS one, 14 (2), e0212782.
  • Lee, K.N., et al., 2014. The role of leptin in gastric cancer: clinicopathologic features and molecular mechanisms. Biochemical and biophysical research communications, 446 (4), 822–829.
  • Lee, M.-W., Lee, M., and Oh, K.-J., 2019. Adipose tissue-derived signatures for obesity and type 2 diabetes: adipokines, batokines and microRNAs. Journal of clinical medicine, 8 (6), 854.
  • Lee, W., et al., 2009. Visfatin-induced expression of inflammatory mediators in human endothelial cells through the NF-κB pathway. International journal of obesity, 33 (4), 465–472.
  • Li, J.-B., et al., 2019. Longitudinal associations between BMI change and the risks of colorectal cancer incidence, cancer-relate and all-cause mortality among 81,388 older adults. BMC cancer, 19 (1), 1–13.
  • Li, J.-J., et al., 2018. Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis. British journal of cancer, 118 (10), 1337–1348.
  • Liberti, M.V., and Locasale, J.W., 2016. The Warburg effect: how does it benefit cancer cells? Trends in biochemical sciences, 41 (3), 211–218.
  • Lin, H., et al., 2020. Therapeutics targeting the fibrinolytic system. Experimental & molecular medicine, 52 (3), 367–379.
  • Liu, F., and Zhu, L., 2015. Expression of adiponectin in non-small cell lung cancer and its relationship with MMP-9 and angiogenesis. Zhong nan da xue xue bao yi xue ban, 40, 579–584.
  • Lunt, S.Y., and Vander Heiden, M.G., 2011. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annual review of cell and developmental biology, 27, 441–464.
  • Luo, J., et al., 2019. Intentional weight loss and obesity-related cancer risk. JNCI cancer spectrum, 3 (4), pkz054.
  • Lv, D., et al., 2016. PAK 1‐cofilin phosphorylation mediates human lung adenocarcinoma cells migration induced by apelin‐13. Clinical and experimental pharmacology and physiology, 43 (5), 569–579.
  • Mcbrayer, S.K., et al., 2012a. Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. Blood, 119, 4686–4697.
  • Mcbrayer, S.K., et al., 2012b. Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. Blood, 119 (20), 4686–4697.
  • Mceachron, T.A., Church, F.C., and Mackman, N., 2011. Regulation of thrombin-induced plasminogen activator inhibitor-1 in 4T1 murine breast cancer cells. Blood coagulation & fibrinolysis, 22, 576–582.
  • Mehta, T., et al., 2014. Obesity and mortality: are the risks declining? Evidence from multiple prospective studies in the United States. Obesity reviews, 15 (8), 619–629.
  • Miyashita, T., et al., 2015. Metastasis-promoting role of extravasated platelet activation in tumor. Journal of surgical research, 193 (1), 289–294.
  • Miyazaki, T., et al., 2005. Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3. Biochemical and biophysical research communications, 333 (1), 79–87.
  • Miyoshi, Y., et al., 2003. Association of serum adiponectin levels with breast cancer risk. Clinical cancer research, 9, 5699–5704.
  • Moodi, M., Tavakoli, T., and Tahergorabi, Z., 2021. Crossroad between obesity and gastrointestinal cancers: a review of molecular mechanisms and interventions. International journal of preventive medicine, 12, 18.
  • Münzberg, H., and Morrison, C.D., 2015. Structure, production and signaling of leptin. Metabolism, 64 (1), 13–23.
  • Muto, J., et al., 2014. The apelin–APJ system induces tumor arteriogenesis in hepatocellular carcinoma. Anticancer research, 34, 5313–5320.
  • Nagaraju, G.P., Aliya, S., and Alese, O.B., 2015. Role of adiponectin in obesity related gastrointestinal carcinogenesis. Cytokine & growth factor reviews, 26 (1), 83–93.
  • Nakajima, T.E., et al., 2009. Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer. Journal of gastroenterology, 44 (7), 685–690.
  • Nakajima, T.E., et al., 2010. Adipocytokines as new promising markers of colorectal tumors: adiponectin for colorectal adenoma, and resistin and visfatin for colorectal cancer. Cancer science, 101 (5), 1286–1291.
  • Nakamura, N., et al., 2018. Chemerin promotes angiogenesis in vivo. Physiological reports, 6 (24), e13962.
  • Nepal, S., et al., 2015. Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis. Oncotarget, 6 (9), 7166–7181.
  • Niu, J., et al., 2013. The association between leptin level and breast cancer: a meta-analysis. PLOS one, 8 (6), e67349.
  • Nowak, D., et al., 2010. Subcellular distribution and expression of cofilin and ezrin in human colon adenocarcinoma cell lines with different metastatic potential. European journal of histochemistry, 54 (2), 14.
  • Nuttall, F.Q., 2015. Body mass index: obesity, BMI, and health: a critical review. Nutrition today, 50 (3), 117–128.
  • O'Carroll, A.-M., et al., 2013. The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis. The journal of endocrinology, 219 (1), R13–35.
  • Olesen, U.H., et al., 2008. Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochemical and biophysical research communications, 367 (4), 799–804.
  • Otvos, L., et al., 2011. Design and development of a peptide-based adiponectin receptor agonist for cancer treatment. BMC biotechnology, 11 (1), 1–14.
  • Ouchi, N., et al., 2004. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. The journal of biological chemistry, 279 (2), 1304–1309.
  • Pavone, C., et al., 2018. Postoperative complications and 90-day mortality in radical cystectomy in high-risk patients: a monocentric retrospective observational study. Urologia journal, 85 (3), 111–117.
  • Peng, C., et al., 2019. Leptin stimulates the epithelial‑mesenchymal transition and pro‑angiogenic capability of cholangiocarcinoma cells through the miR‑122/PKM2 axis. International journal of oncology, 55 (1), 298–308.
  • Pérez-Pérez, A., et al., 2020. Role of leptin in inflammation and vice versa. International journal of molecular sciences, 21 (16), 5887.
  • Pham, D.-V., and Park, P.-H., 2021. Tumor metabolic reprogramming by adipokines as a critical driver of obesity-associated cancer progression. International journal of molecular sciences, 22 (3), 1444.
  • Pham, D.-V., et al., 2020. Globular adiponectin inhibits breast cancer cell growth through modulation of inflammasome activation: critical role of Sestrin2 and AMPK signaling. Cancers, 12 (3), 613.
  • Podgórska, M., et al., 2021. The role of apelin and apelin receptor expression in migration and invasiveness of colon cancer cells. Anticancer research, 41 (1), 151–161.
  • Raut, P.K., et al., 2019. Growth of breast cancer cells by leptin is mediated via activation of the inflammasome: critical roles of estrogen receptor signaling and reactive oxygen species production. Biochemical pharmacology, 161, 73–88.
  • Reinicke, K., et al., 2012. Cellular distribution of Glut-1 and Glut-5 in benign and malignant human prostate tissue. Journal of cellular biochemistry, 113 (2), 553–562.
  • Rennier, K., et al., 2020. Chemerin reactivates PTEN and suppresses PD-L1 in tumor cells via modulation of a novel CMKLR1-mediated signaling cascade. Clinical cancer research, 26 (18), 5019–5035.
  • Rivera, L.B., and Bergers, G., 2015. Tumor angiogenesis, from foe to friend. Science, 349 (6249), 694–695.
  • Rodríguez‐Enríquez, S., et al., 2009. Kinetics of transport and phosphorylation of glucose in cancer cells. Journal of cellular physiology, 221, 552–559.
  • Ryan, S., and Kridel, S., 2008. Visfatin/Nampt: a potential regulator of prostate tumor cell proliferation, metabolism, and survival. AACR.
  • Samad, N., and Rao, T., 2019. Role of leptin in cancer-a systematic review. Biomedical journal of scientific & technical research, 18 (1), 13226–13235.
  • Šenolt, L., et al., 2010. Vaspin and omentin: new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis. Annals of the rheumatic diseases, 69 (7), 1410–1411.
  • Shin, W.J., Zabel, B.A., and Pachynski, R.K., 2018. Mechanisms and functions of chemerin in cancer: potential roles in therapeutic intervention. Frontiers in immunology, 9, 2772.
  • Siegel, R.L., Miller, K.D., and Jemal, A., 2019. Cancer statistics, 2019. CA: a cancer journal for clinicians, 69, 7–34.
  • Silswal, N., et al., 2005. Human resistin stimulates the pro-inflammatory cytokines TNF-α and IL-12 in macrophages by NF-κB-dependent pathway. Biochemical and biophysical research communications, 334 (4), 1092–1101.
  • Simpson, F., and Whitehead, J.P., 2010. Adiponectin—it's all about the modifications. The international journal of biochemistry & cell biology, 42 (6), 785–788.
  • Sotiropoulos, G.P., et al., 2018. Chemerin as a biomarker at the intersection of inflammation, chemotaxis, coagulation, fibrinolysis and metabolism in resectable non-small cell lung cancer. Lung cancer, 125, 291–299.
  • Su, K.-Z., et al., 2019. Relation of circulating resistin to insulin resistance in type 2 diabetes and obesity: a systematic review and meta-analysis. Frontiers in physiology, 10, 1399.
  • Sun, Z., Lei, H., and Zhang, Z., 2013. Pre-B cell colony enhancing factor (PBEF), a cytokine with multiple physiological functions. Cytokine & growth factor reviews, 24 (5), 433–442.
  • Surendar, J., et al., 2019. Adiponectin limits IFN-γ and IL-17 producing CD4 T cells in obesity by restraining cell intrinsic glycolysis. Frontiers in immunology, 10, 2555.
  • Tahergorabi, Z., and Khazaei, M., 2015. Leptin and its cardiovascular effects: focus on angiogenesis. Advanced biomedical research, 4:79.
  • Tahergorabi, Z., et al., 2016. From obesity to cancer: a review on proposed mechanisms. Cell biochemistry and function, 34 (8), 533–545.
  • Tahergorabi, Z., et al., 2018. Metabolic syndrome and the risk of gastrointestinal cancer: a case-control study. Asian pacific journal of cancer prevention, 19, 2205.
  • Taliaferro-Smith, L., et al., 2013. Integral role of PTP1B in adiponectin-mediated inhibition of oncogenic actions of leptin in breast carcinogenesis. Neoplasia, 15 (1), 23–IN11.
  • Tan, B., et al., 2013. Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD + biosynthesis, in human cancer cells: metabolic basis and potential clinical implications. The journal of biological chemistry, 288 (5), 3500–3511.
  • Tarn, C., et al., 2006. Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms. Cancer research, 66 (10), 5477–5486.
  • Tee, M.C., et al., 2013. Effect of bariatric surgery on oncologic outcomes: a systematic review and meta-analysis. Surgical endoscopy, 27 (12), 4449–4456.
  • Than, A., et al., 2012. Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways. Molecular and cellular endocrinology, 362 (1–2), 227–241.
  • Thorens, B., and Mueckler, M., 2010. Glucose transporters in the 21st century. American journal of physiology. endocrinology and metabolism, 298 (2), E141–E145.
  • Tolkach, Y., et al., 2019. Apelin and apelin receptor expression in renal cell carcinoma. British journal of cancer, 120 (6), 633–639.
  • Treeck, O., Buechler, C., and Ortmann, O., 2019. Chemerin and cancer. International journal of molecular sciences, 20 (15), 3750.
  • Trujillo, M., et al., 2005. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia, 48 (6), 1084–1087.
  • Tsao, T.-S., et al., 2003. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity: different oligomers activate different signal transduction pathways. Journal of biological chemistry, 278 (50), 50810–50817.
  • Unamuno, X., et al., 2018. Adipokine dysregulation and adipose tissue inflammation in human obesity. European journal of clinical investigation, 48 (9), e12997.
  • Uribesalgo, I., et al., 2019. Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy. EMBO molecular medicine, 11 (8), e9266.
  • Uyeturk, U., et al., 2014. Serum omentin level in patients with prostate cancer. Medical oncology, 31 (4), 923.
  • Vitali, A., et al., 2012. The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes. Journal of lipid research, 53 (4), 619–629.
  • Wang, C., et al., 2018a. Resistin facilitates breast cancer progression via TLR4-mediated induction of mesenchymal phenotypes and stemness properties. Oncogene, 37 (5), 589–600.
  • Wang, C., et al., 2014. Increased serum chemerin level promotes cellular invasiveness in gastric cancer: a clinical and experimental study. Peptides, 51, 131–138.
  • Wang, L., et al., 2018b. PAI-1 exacerbates white adipose tissue dysfunction and metabolic dysregulation in high fat diet-induced obesity. Frontiers in pharmacology, 9, 1087.
  • Wang, N., et al., 2018c. CXCL1 derived from tumor-associated macrophages promotes breast cancer metastasis via activating NF-κB/SOX4 signaling. Cell death & disease, 9, 1–18.
  • Wang, Y.-Y., et al., 2020. Visfatin enhances breast cancer progression through CXCL1 induction in tumor-associated macrophages. Cancers, 12 (12), 3526.
  • Wang, Y., et al., 2006. Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. The journal of biological chemistry, 281 (24), 16391–16400.
  • Wiedmann, M.K., et al., 2017. Overweight, obesity and height as risk factors for meningioma, glioma, pituitary adenoma and nerve sheath tumor: a large population-based prospective cohort study. Acta oncologica, 56 (10), 1302–1309.
  • Wysocka, M.B., Pietraszek-Gremplewicz, K., and Nowak, D., 2018. The role of apelin in cardiovascular diseases, obesity and cancer. Frontiers in physiology, 9, 557.
  • Xia, S., et al., 2016. An update on inflamm-aging: mechanisms, prevention, and treatment. Journal of immunology research, 2016, 1–12. 2016.
  • Xu, S., et al., 2019. Inflammasome inhibitors: promising therapeutic approaches against cancer. Journal of hematology & oncology, 12 (1), 1–13.
  • Xu, Y., et al., 2020. Leptin receptor mediates the proliferation and glucose metabolism of pancreatic cancer cells via AKT pathway activation. Molecular medicine reports, 21 (2), 945–952.
  • Yadav, A., et al., 2011. IL-6 promotes head and neck tumor metastasis by inducing epithelial–mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway. Molecular cancer research, 9 (12), 1658–1667.
  • Yang, C.-C., et al., 2014. Activation of AMP-activated protein kinase attenuates hepatocellular carcinoma cell adhesion stimulated by adipokine resistin. BMC cancer, 14 (1), 1–9.
  • Yang, C., et al., 2019. CXCL1 stimulates migration and invasion in ER‑negative breast cancer cells via activation of the ERK/MMP2/9 signaling axis. International journal of oncology, 55 (3), 684–696.
  • Yang, L.P., et al., 2012. Expression of vascular endothelial growth factor C correlates with lymphatic vessel density and prognosis in human gastroesophageal junction carcinoma. Oncology research and treatment, 35, 88–93.
  • Yang, R.-Z., et al., 2006. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. American journal of physiology-endocrinology and metabolism, 290 (6), E1253–E1261.
  • Zahid, H., et al., 2018. Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells: a novel mechanism for the obesity–breast cancer link. International journal of obesity, 42 (4), 711–720.
  • Zhang, W., et al., 2018. Endothelial cells promote triple‐negative breast cancer cell metastasis via PAI‐1 and CCL5 signaling. FASEB journal, 32 (1), 276–288.
  • Zhang, X., et al., 2017. Obesity paradox in lung cancer prognosis: evolving biological insights and clinical implications. Journal of thoracic oncology, 12 (10), 1478–1488.
  • Zhang, Y.-Y., and Zhou, L.-M., 2013. Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells. European journal of pharmacology, 698 (1–3), 137–144.
  • Zhao, X., et al., 2019. The association between Chinese patients’ elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer. International journal of clinical and experimental pathology, 12 (6), 2264–2274.
  • Zorena, K., et al., 2020. Adipokines and obesity. Potential link to metabolic disorders and chronic complications. International journal of molecular sciences, 21 (10), 3570.

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