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Pharmaceutical Biology Volume 41, 2003 - Issue sup1
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Research Article

New Anticancer Drugs from Cultured and Collected Marine Organisms

William Fenical Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.
,
Paul Jensen Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.
,
Christopher Kauffman Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.
,
Stephanie Mayhead Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.
,
D. Faulkner Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.
,
Catherine Sincich Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.
,
M. Rao Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.
,
Eric Kantorowski Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.
,
Lyndon West Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.
,
Wendy Strangman Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.
,
Yuzuru Shimizu Departmental of Biomedical Sciences, School of Pharmacy, University of Rhode, Island, Kingston, RI, 02881, U.S.A.
,
Bo Li Departmental of Biomedical Sciences, School of Pharmacy, University of Rhode, Island, Kingston, RI, 02881, U.S.A.
,
Sudhakararao Thammana Departmental of Biomedical Sciences, School of Pharmacy, University of Rhode, Island, Kingston, RI, 02881, U.S.A.
,
Katherine Drainville Departmental of Biomedical Sciences, School of Pharmacy, University of Rhode, Island, Kingston, RI, 02881, U.S.A.
,
Michael Davies-Coleman Department of Chemistry, Rhodes University, Grahamstown, South Africa
,
Robert Kramer Oncology Drug Discovery Program, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, 08543-4000, U.S.A.
,
Craig Fairchild Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.
,
William Rose Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.
,
Robert Wild Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.
,
Gregory Vite Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.
&
Russell Peterson Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.
 show all
Pages 6-14 | Published online: 20 Oct 2008

References

  • Bauer IL, Maranda L, Shimizu Y, Peterson RW, Cornell L, Steiner JR, Clardy J (1994): The Structures of Amphidino-lide B Isomers: Strongly Cytotoxic Macrolides Produced by a Free-Swimming Dinoflagellate, Amphidinium sp. J Am Chem Soc 116: 2657–2658.
  • Bauer I, Maranda L, Young KA, Shimizu Y, Fairchild C, Cornell L, MacBeth J, Huang S (1996): Isolation and Structure of Caribenolide I, a Highly Potent Antitumor Macrolide from a Cultured Free-Swimming Caribbean Dinoflagellate, Amphidinium sp. S1-36-5. J Org Chem 60: 1084–1086.
  • Feling RH, Buchanan GO, Mincer TJ, Kauffman CA, Jensen P, Fenical W (2003): Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora. Angew Chem Int Ed 42(3): 355–357.
  • Lindel T, Jensen P, Fenical W, Long BH, Casazza AM, Carboni J, Fairchild CR (1997): Eleutherobin, A New Cytotoxin that Mimics Paclitaxel (Taxol) by Stabilizing Microtubules. J Am Chem Soc 119(37): 8744–8745.
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  • Mincer TJ, Jensen PR, Kauffman CA, Fenical W (2002): Wide-spread and Persistent Populations of a Major New Marine Actinomycete Taxon in Ocean Sediments. Appl Envir Microbiol 68(10): 5005–5011.
  • Qian-Cutrone J, Huang S, ShuY-Z, Vyas D, Fairchild C, Menen-dez A, Krampitz K, Dalterio R, Klohr SE, Gao Q (2002): Stephacidin A and B: Two Structurally Novel, Selective Inhibitors of the Testosterone-dependent Prostate LNCaP cells. J Am Chem Soc 124(49): 14556–14557.
  • Round FE (1980): The Evolution of Pigmented and Unpig-mented Unicells — A Reconsideration of the Protista. Biosystems 12(1-2): 61–69.
  • Schmidt EW (1999): Marine Sponges and Symbionts: Chemi-cal and Biological Studies. Ph.D. Thesis, University of California, San Diego.
  • Shimizu Y, Fairchild CR (1996): Caribenolide I. US Patent # 5,494,930 issued 27 February.

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