Inhibitors of the Lyase Activity of DNA Polymerase β

References

• Barr JR, Murty VS, Yamaguchi KY, Smith DH, Hecht SM (1988): 5-Alkylresorcinols from Hakea Amplexicaulis that Cleave DNA. Chem Res Toxicol 1: 204–207.
   PubMed Web of Science ®Google Scholar
• Beard WA, Wilson SH (2000): Structural Design of a Eukary-otic DNA Repair Polymerase: DNA Polymerase Beta. Mut Res 460: 231–244.
   PubMedGoogle Scholar
• Chaturvedula VSP, Gao Z, Hecht SM, Jones SH, Kingston DGI (2003): A New Acylated Oleanane Triterpenoid from Couepia polyandra that Inhibits the Lyase Activity of DNA Polymerase 13. J Nat Prod in press.
   Google Scholar
• Chen J, ZhangYH, Wang LK, Sucheck SJ, Snow AM, Hecht SM (1998): Inhibitors of DNA Polymerase 13 from Schoepfia Californica. J C S Chem Commun: 2769–2770.
   Google Scholar
• Date T, Yamaguchi F, Hirose F, Nishimoto Y, Tanihara K, Matsukage A (1988): Expression of Active Rat DNA Poly-merase 13 in Escherichia coli. Biochemistry 27: 2983–2990.
   PubMed Web of Science ®Google Scholar
• Deng JZ, Starck SR, Hecht SM, Ijames CF, Hemling M (1999a): Harbinatic Acid, a Novel and Potent DNA Polymerase 13 Inhibitor from Hardwickia Binata. J Nat Prod 62: 1000–1002.
   Google Scholar
• Deng JZ, Starck SR, Hecht SM (1999b): Bis-5-Alkylresorcinols from Panopsis rubescens that Inhibit DNA Polymerase 13. J Nat Prod 62: 477–480.
   PubMed Web of Science ®Google Scholar
• Deng JZ, Starck SR, Hecht SM (2000a): Pentacyclic Triter-penoids from Freziera sp. that Inhibit DNA Polymerase 13. Bio Org Med Chem 8: 247–250.
   Google Scholar
• Deng JZ, Starck SR, Sun DA, Sabat M, Hecht SM (2000b): A New 7,8-Euphadien-type Triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that Inhibits DNA Poly-merase 13. J Nat Prod 63: 1356–1360.
   PubMed Web of Science ®Google Scholar
• Deng JZ, Sun DA, Starck SR, Hecht RM, Cerny RL, Engen JR (1999b): Chrysochlamic Acid, A New Diterpenoid Substi-tuted Quinol from Chrysochlamys Ulei that Inhibits DNA Polymerase 13. J Chem Soc, Perkin Trans 1: 1147–1149.
   Google Scholar
• Deterding U, Prasad R, Mullen GP, Wilson SH, Tomer KB (2000): Mapping of the 5'-2-Deoxyribose-5-phosphate Lyase Active Site in DNA Polymerase 13 by Mass Spec-trometry. J Biol Chem 275: 10463–10471.
   PubMed Web of Science ®Google Scholar
• DiGiuseppe JA, Dresler SL (1989): Bleomycin-induced DNA Repair Synthesis in Permeable Human Fibroblasts: Media-tion of Long-patch and Short-patch Repair by Distinct DNA Polymerases. Biochemistry 28: 9515–9520.
   PubMed Web of Science ®Google Scholar
• Fornace AJ Jr., Zmudzka B, Hollander MC, Wilson SH (1989): Induction of Beta-Polymerase Messenger-RNA by DNA-Damaging Agents in Chinese-Hamster Ovary Cells. Mol Cell Biol 9: 851–853.
   PubMed Web of Science ®Google Scholar
• Garcia-Diaz M, Bebenek K, Kunkel TA, Blanco L (2001): Identification of an Intrinsic 5'-Deoxyribose-5-phosphate Lyase Activity in Human DNA Polymerase X. J Biol Chem 276: 34659–34663.
   PubMed Web of Science ®Google Scholar
• Hoffmann JS, Pillaire MJ, Maga G, Podust V, Hilbscher U, Villani G (1995): DNA-Polymerase-Beta Bypasses In Vitro a Single d(GpG)-Cisplatin Adduct Placed on Codon-13 of the HRAS Gene. Proc Natl Acad Sci USA 92: 5356–5360.
   PubMed Web of Science ®Google Scholar
• Hsiang YH, Hertzberg R, Hecht SM, Liu LF (1985): Camp-tothecin Induces Protein-Linked DNA Breaks via Mam-malian DNA Topoisomerase I. J Biol Chem 260: 14873–14878.
   PubMed Web of Science ®Google Scholar
• Hilbsacher U, Maga G, Spadari S (2002): Eukaryotic DNA Polymerases. Annu Rev Biochem 71: 133–163.
   PubMed Web of Science ®Google Scholar
• Idriss HT, Al-Assar, O, Wilson SH (2002): DNA Polymerase Beta. J Biochem Cell Biol 34: 321–324.
   PubMed Web of Science ®Google Scholar
• Jezewska MJ, Galletto R, Bujalowski W (2003): Rat Polymerase Beta Gapped DNA Interactions: Antagonistic Effects of the 5' Terminal POTI. Group and Magnesium on the Enzyme Binding to the Gapped DNAs with Different ssDNA Gaps. Cell Biochem Biophys 38: 125–160.
   Google Scholar
• Kingsbury WD, Boehm JC, Jakas DR, Holden KG, Hecht SM, Gallagher G, Caranfa MJ, McCabe FL, Faucette LF, Johnson RK, Hertzberg RP (1991): Synthesis of Water-Soluble Aminoalkylcamptothecin Analogues: Inhibition of Topoisomerase I and Antitumor Activity. J Med Chem 34: 98–107.
   PubMed Web of Science ®Google Scholar
• Lyon MA, Ducruet AP, Wipf P, Lazo JS (2002): Dual-Specificity Phosphatases as Targets for Antineoplastic Agents. Nature Rev Drug Discovery 1: 961–976.
   PubMed Web of Science ®Google Scholar
• Maciejewski MW, Liu D, Prasad R, Wilson SH, Mullen GP (2000): Backbone Dynamics and Refined Solution Struc-ture of the N-Terminal Domain of DNA Polymerase Beta. Correlation with DNA Binding and dRP Lyase Activity. J Mol Biol 296: 229–253.
   Google Scholar
• Matsumoto Y, Kim K (1995): Excision of Deoxyribose Phos-phate Residues by DNA Polymerase 13 During DNA Repair. Science 269: 699–702.
   PubMed Web of Science ®Google Scholar
• Matsumoto Y, Kim K, Katz DS, Feng JA (1998): Catalytic Center of DNA Polymerase 13 for Excision of Deoxyribose Phosphate Groups. Biochemistry 37: 6456–6464.
   PubMed Web of Science ®Google Scholar
• Miller MR, Chinault DN (1982): The Roles of DNA Polymerase Alpha, Beta, and Gamma in DNA Repair Synthesis Induced in Hamster and Human Cells by Different DNA Damaging Agents. J Biol Chem 257: 10204–10209.
   PubMed Web of Science ®Google Scholar
• Nguyen LH, Barsk D, Erzberger JP, Wilson DM III (2000): Mapping the Protein-DNA Interface and the Metal-binding Site of the Major Human Apurinic/Apyrimidinic Endonu-clease. J Mol Biol 298: 447–459.
   Google Scholar
• Overhand M, Hecht SM (1994): A Concise Synthesis of the Antifungal Agent (+)-Preussin. J Org Chem 59: 4721–4722.
   Web of Science ®Google Scholar
• Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J (1996a): Crystal Structures of Human DNA Polymerase 13 Com-plexed with DNA: Implications for Catalytic Mechanism, Processivity, and Fidelity. Biochemistry 35: 12742–12761.
   PubMed Web of Science ®Google Scholar
• Pelletier H, Sawaya MR (1996b): Characterization of the Metal Ion Binding Helix-Hairpin-Helix Motifs in Human DNA Polymerase 13 by X-ray Structural Analysis. Biochemistry 35: 12778–12787.
   PubMed Web of Science ®Google Scholar
• Piersen CE, McCullough AK, Lloyd RS (2000): AP Lyases and dRPases: Commonality of Mechanism. Mut Res 459:43–53.
   PubMedGoogle Scholar
• Piersen CE, Prasad R, Wilson SH, Lloyd RS (1996): Evidence for an Imino Intermediate in the DNA Polymerase 13 Deoxyribose Phosphate Excision Reaction. J Biol Chem 271: 17811–17815.
   PubMed Web of Science ®Google Scholar
• Podlutsky AJ, Dianova II, Wilson SH, Bohr VA, Dianov GL (2001): DNA Synthesis and dRPase Activities of Poly-merase 13 are Both Essential for Single-Nucleotide Patch Base Excision Repair in Mammalian Cell Extracts. Bio-chemistry 40: 809–813.
   Google Scholar
• Prasad R, Beard WA, Chyan JY, Maciejewski MW, Mullen GP, Wilson SH (1998a): Functional Analysis of the Amino-Terminal 8-kDa Domain of DNA Polymerase 13 as Revealed by Site-Directed Mutagenesis. J Biol Chem 273: 11121–11126.
   PubMed Web of Science ®Google Scholar
• Prasad R, Beard WA, Strauss PR, Wilson SH (1998b): Human DNA Polymerase 13 Deoxyribose Phosphate Lyase. J Biol Chem 273: 15263–15270.
   PubMed Web of Science ®Google Scholar
• Scannell RT, Barr JR, Murty VS, Reddy KS, Hecht SM (1988): DNA Strand Scission by Naturally Occurring 5-Alkylre sorcinols . J Am Chem Soc 110: 3650–3651.
   Web of Science ®Google Scholar
• Seki S, Oda T (1988): An Exonuclease Possibly Involved in the Initiation of Repair of Bleomycin-Damaged DNA in Mouse Ascites Sarcoma-Cells. Carcinogensis 9: 2239–2244.
   PubMed Web of Science ®Google Scholar
• Sharpless NE, DePinho RA (2002): p53: Good Cop/Bad Cop. Cell 110: 9–12.
   PubMed Web of Science ®Google Scholar
• Singh US, Scannell RT, An H, Carter BJ, Hecht SM (1995): DNA Cleavage by Di- and Trihydroxyalkylbenzenes. Char-acterization of the Roles of 02, Cu(II) and Alkali. J Am Chem Soc 117: 12691–12699.
   Google Scholar
• Snow AM (1995) Characterization of the Cellular Loci of Bleomycin-Mediated Damage, Ph.D. Thesis, University of Virginia.
   Google Scholar
• Starck SR, Deng JZ, Hecht SM (2000): Naturally Occurring Alkylresorcinols that Mediate DNA Damage and Inhibit its Repair. Biochemistry 39: 2413–2419.
   PubMed Web of Science ®Google Scholar
• Strauss PR, Beard WA, Patterson TA, Wilson SH (1997): Sub-strate Binding by Human Apurinic/Apyrimidinic Endonu-clease Indicates a Briggs-Haldane Mechanism. J Biol Chem 272: 1302–1307.
   PubMed Web of Science ®Google Scholar
• Sun DA, Deng JZ, Starck SR, Hecht SM (1999a): Mispyric Acid, a New Monocyclic Triterpenoid with a Novel Skeleton from Mischocarpus Pyriformis that Inhibits DNA Polymerase 13. J Am Chem Soc 121: 6120–6124.
   Web of Science ®Google Scholar
• Sun DA, Starck SR, Locke EP, Hecht SM (1999b): DNA Poly-merase 13 Inhibitors from Sandoricum Koetjape. J Nat Prod 62: 1110–1113.
   PubMed Web of Science ®Google Scholar
• Widen SG, Kedar P, Wilson SH (1988): Human Beta-Polymerase Gene. Structure of the 5'-Flanking Region and Active Promoter. J Biol Chem 263: 16992–16998.
   Google Scholar