458
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Cytotoxic Effects of Flavonol Glycosides and Nonflavonoid Constituents of Epimedium koreanum. on Primary Osteoblasts

, , , , &
Pages 185-190 | Accepted 03 Aug 2007, Published online: 07 Oct 2008

References

  • Aubin J E. Advances in the osteoblast lineage. Biochem Cell Biol 1998; 76: 899–910
  • Carmichael J, Degraff W G, Gazdar A F, Minna J D, Mitchell. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing. Cancer Res 1987; 47: 936–942
  • Chen K M, Ge B F, Ma H P, Zheng R L. The serum of rats administered flavonoid extract from Epimedium sagittatum. but not the extract itself enhances the development of rat calvarial osteoblast-like cells in vitro.. Pharmazie 2004; 59: 61–64
  • Chen T, Fry D. Hormonal regulation of the osteoblastic phenotype expression in neonatal murine calvarial cells. Calcif Tissue Int 1999; 64: 304–309
  • Davison S, Davis S R. Hormone replacement therapy: Current controversies. Clin Endocrinol 2003; 58: 249–261
  • Harada S I, Rodan G A. Control of osteoblast function and regulation of bone mass. Nature 2003; 423: 349–355
  • Hidaka S, Okamoto Y, Nakajima K. Preventive effects of traditional Chinese medicines on experimental osteoporosis induced by ovariectomy in rats. Calcif Tissue Int 1997; 61: 239–246
  • Huang H F, You J S. The use of Chinese herbal medicine on experimental fracture healing. Am J Chin Med 1997; 25: 351–356
  • Ji H, Liu K, Gong X J, Li S P, Zhang M F. Effect of Epimedium koreanum. flavonoids on osteoporosis in ovariectomized rats. Chin J Osteoporosis 2001; 7: 4–8
  • Jiang Y N, Mo H Y, Chen J M. Effects of Epimedium. total flavonoids phytosomes on preventing and treating bone loss of ovariectomized rats. Chin J Chin Materia Medica 2002; 27: 221–224
  • Katzburg S, Lieberherr M, Ornoy A, Klein B Y, Hendel D, Somjen D. Isolation and hormonal responsiveness of primary cultures of human bone-derived cells: gender and age differences. Bone 1999; 25: 667–673
  • Li T, Li E, An S. Effect of kidney-tonifying herbs on ovary function and bone mass in postmenopausal women. Chin J Osteoporosis 2000; 6: 55–59
  • Liu H C, Chen R M, Jian W C, Lin Y L. Cytotoxic and antioxidant effects of the water extract of the traditional Chinese herb gusuibu (Drunaria fortunei.) on rat osteoblasts. J Formos Med Assoc 2001; 100: 383–388
  • Meng F H, Li Y B, Xiong Z L, Jiang Z M, Li F M. Osteoblastic proliferative activity of Epimedium brevicornum. Maxim. Phytomedicine 2005a; 12: 189–193
  • Meng F H, Xiong Z L, Jiang Z M, Li F M. Osteoblastic proliferation stimulating activity of Epimedium koreanum. Nakai extracts and its flavonol glycosides. Pharm Biol 2005b; 43: 92–95
  • Mizuno M, Sakakibara N, Hanioka S, Iinuma M, Tanaka T, Liu X S, Shi D W. Flavonol glycosides from Epimedium sagittatum.. Phytochemistry 1988; 27: 3641–3643
  • Nelson H D, Humphrey L L, Nygren P, Teutsch S M, Allan J D. Postmenopausal hormone replacement therapy: Scientific review. JAMA 2002; 288: 872–881
  • Pinkerton J V, Santen R. Alternatives to the use of estrogen in postmenopausal women. Endocr Rev 1999; 20: 308–320
  • Rodriguez J P, Garat S, Gajardo H. Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics. J Cell Biochem 1999; 75: 414–423
  • Sun P Y, Wen Y, Xu Y, Pei Y P, Chen Y J. The chemical constituents of Epimedium koreanum. Nakai. Acta Pharm Sin 1998; 33: 919–922
  • Wlodarski K H. Properties and origin of osteoblasts. Clin Orthop Relat Res 1990; 252: 276–293
  • Xie F, Wu C F, Lai W P, Yang X J, Cheung P Y, Yao X S, Leung P C, Wong M S. The osteoprotective effect of Herba epimedii. (HEP) extract in vivo in vitro.. eCAM 2005; 2: 353–361
  • Zhang D W, Cheng Y, Wang N L, Zhang J C, Yang M S, Yao X S. Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts. Phytomedicine 2008; 15: 55–61
  • Zhang G, Shi W Z, Shi Y Y. Effect of a compound ‘kidney tonifying’Chinese herbal preparation on femur cortical and trabecular bone loss induced by aging in aged male rats. Chin J Osteoporosis 1999; 5: 51–55

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.